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21. 发明申请

US20070037813A1 Serine Protease Inhibitors 审中-公开
标题翻译：丝氨酸蛋白酶抑制剂
公开(公告)号：US20070037813A1
公开(公告)日：2007-02-15
申请号：US11537482
申请日：2006-09-29
申请人： Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
发明人： Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
IPC分类号： A61K31/50 , A61K31/44 , A61K31/165 , C07D237/02
CPC分类号： C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要： Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.
摘要翻译：具有如下结构的化合物可用于抑制丝氨酸蛋白酶，例如TF /因子VIIa，因子Xa，凝血酶和激肽释放酶。这些化合物可用于预防和/或治疗凝血障碍的方法。

22. 发明申请

US20080261989A1 Quinoxaline Inhibitors of the Hedgehog Signalling 失效
标题翻译：刺猬信号的喹喔啉抑制剂
公开(公告)号：US20080261989A1
公开(公告)日：2008-10-23
申请号：US11587963
申请日：2005-04-29
申请人： Michael F.T. Koehler , Richard Goldsmith , Daniel P. Sutherlin
发明人： Michael F.T. Koehler , Richard Goldsmith , Daniel P. Sutherlin
IPC分类号： A61K31/498 , C07D241/42 , A61P35/04
CPC分类号： C07D413/12 , C07D241/42 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I wherein A is a carbocycle or heterocycle; X is alkylene, NR4C(O), NR4C(S), NR4C(NH), NR4SO, NR4SO2, NR4C(O)NH, NR4C(S)NH, C(O)NR4, C(S)NR4, C(NH)NR4, NR4PO or NR4PO(OH) wherein R4 is H or alkyl; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl or a heterocycle each of which is optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; R2 is halogen, hydroxyl, alkyl, acyl or alkoxy each optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; R3 is halogen, hydroxyl, alkyl, acyl or alkoxy each optionally substituted with hydroxyl, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; m is 0-3; n is 0-3; and salts and solvates thereof.
摘要翻译：本发明提供了可用作治疗恶性肿瘤的治疗剂的刺猬蛋白信号传导新型抑制剂，其中化合物具有通式I，其中A是碳环或杂环; X是亚烷基，NR 4 C（O），NR 4 C（S），NR 4 C（NH），NR 4 SO 4，NR 4 SO 2，NR 4 C（O）NH，NR 4， C（S）NH，C（O）NR 4，C（S）NR 4，C（NH）NR 4，其中R 4是H或烷基;其中R 4是氢或烷基;其中R 4是氢或烷基; R 1选自烷基，环烷基，芳基或杂环，其各自任选被羟基，卤素，氨基，硝基，烷基，酰基，烷基磺酰基或烷氧基取代; R 2是卤素，羟基，烷基，酰基或烷氧基，其各自任选被羟基，卤素，氨基，硝基，烷基，酰基，烷基磺酰基或烷氧基取代; R 3是卤素，羟基，烷基，酰基或烷氧基，其各自任选被羟基，卤素，氨基，硝基，烷基，酰基，烷基磺酰基或烷氧基取代; m为0-3; n为0-3; 及其盐和溶剂合物。

23. 发明申请

US20100262428A1 PRINT PLATFORM FOR MOBILE MARKETING 审中-公开
标题翻译：打印移动营销平台
公开(公告)号：US20100262428A1
公开(公告)日：2010-10-14
申请号：US12757753
申请日：2010-04-09
申请人： Richard Goldsmith
发明人： Richard Goldsmith
IPC分类号： G06Q30/00 , G06F17/30
CPC分类号： G06Q30/02
摘要： Systems and processes are provided that merge print and/or direct mailing marketing with mobile marketing to assist marketers to identify an interested consumer with the desired product/service in which messages are transmitted between mobile units and at least one market server to identify and provide specific messages identifying users of the mobile units and offers related to a desired product and/or service. The market server identifies such messages through the use of a market database containing unique keywords and consumer information.
摘要翻译：提供了将打印和/或直接邮寄营销与移动营销相结合的系统和流程，以协助营销人员用所需的产品/服务识别感兴趣的消费者，消费在移动单元和至少一个市场服务器之间传送，以识别和提供具体的识别移动单元的用户的消息和与期望的产品和/或服务相关的提供的消息。市场服务器通过使用包含唯一关键字和消费者信息的市场数据库来识别这样的消息。

24. 发明授权

US08273743B2 Quinoxaline inhibitors of the hedgehog signalling 失效
标题翻译：刺猬信号的喹喔啉抑制剂
公开(公告)号：US08273743B2
公开(公告)日：2012-09-25
申请号：US11587963
申请日：2005-04-29
申请人： Michael F. T. Koehler , Richard Goldsmith , Daniel P. Sutherlin
发明人： Michael F. T. Koehler , Richard Goldsmith , Daniel P. Sutherlin
IPC分类号： A61K31/495 , A61K31/44
CPC分类号： C07D413/12 , C07D241/42 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D409/12
摘要： The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A is a carbocycle or heterocycle; X is alkylene, NR4C(O), NR4C(S), NR4C(NH), NR4SO, NR4SO2, NR4C(O)NH, NR4C(S)NH, C(O)NR4, C(S)NR4, C(NH)NR4, NR4PO or NR4PO(OH) wherein R4 is H or alkyl; R1 is selected from the group consisting of alkyl, cycloalkyl, aryl or a heterocycle each of which is optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; R2 is halogen, hydroxy, alkyl, acyl or alkoxy each optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; R3 is halogen, hydroxy, alkyl, acyl or alkoxy each optionally substituted with hydroxy, halogen, amino, nitro, alkyl, acyl, alkylsulfonyl or alkoxy; m is 0-3; n is 0-3; and salts and solvates thereof. The invention also provides methods of using these compounds for therapy and/or prophylaxis in a mammal of hyperproliferative diseases and angiogenesis mediated diseases due to their activity for inhibiting the hedgehog signaling pathway.
摘要翻译：本发明提供了可用作治疗恶性肿瘤的治疗剂的刺猬蛋白信号传导的新型抑制剂，其中化合物具有通式I：其中A是碳环或杂环; X是亚烷基，NR4C（O），NR4C（S），NR4C（NH），NR4SO，NR4SO2，NR4C（O）NH，NR4C（S）NH，C（O）NR4，C（S）NR4，C ）NR4，NR4PO或NR4PO（OH），其中R4是H或烷基; R1选自烷基，环烷基，芳基或杂环，其各自任选被羟基，卤素，氨基，硝基，烷基，酰基，烷基磺酰基或烷氧基取代; R2是卤素，羟基，烷基，酰基或烷氧基，各自任选被羟基，卤素，氨基，硝基，烷基，酰基，烷基磺酰基或烷氧基取代; R3是卤素，羟基，烷基，酰基或烷氧基，各自任选被羟基，卤素，氨基，硝基，烷基，酰基，烷基磺酰基或烷氧基取代; m为0-3; n为0-3; 及其盐和溶剂合物。本发明还提供了使用这些化合物治疗和/或预防哺乳动物由于其抑制刺猬蛋白信号通路的活性而引起的过度增殖性疾病和血管生成介导的疾病的方法。

25. 发明申请

US20050186198A1 Serine protease inhibitors 审中-公开
公开(公告)号：US20050186198A1
公开(公告)日：2005-08-25
申请号：US11088511
申请日：2005-03-24
申请人： Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
发明人： Ignacio Aliagas-Martin , Dean Artis , Michael Dina , John Flygare , Richard Goldsmith , Regina Munroe , Alan Olivero , Richard Pastor , Thomas Rawson , Kirk Robarge , Daniel Sutherlin , Kenneth Weese , Aihe Zhou , Yan Zhu
IPC分类号： C07D333/34 , A61K31/18 , A61K31/196 , A61K31/216 , A61K31/381 , A61P7/02 , A61P9/10 , C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51 , A61K38/48 , A61K31/445 , A61K31/54 , A61K31/60
CPC分类号： C07C257/18 , C07C311/05 , C07C311/08 , C07C311/13 , C07C311/18 , C07C311/29 , C07C311/51
摘要： Compounds having the structure shown below are useful to inhibit serine protease enzymes, such as TF/factor VIIa, factor Xa, thrombin and kallikrein. These compounds may be used in methods of preventing and/or treating clotting disorders.

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