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21. 发明授权

US5278042A Method for detecting inhibitors of tat protein 失效
标题翻译：检测tat蛋白抑制剂的方法
公开(公告)号：US5278042A
公开(公告)日：1994-01-11
申请号：US306612
申请日：1989-02-06
申请人： Flossie Wong-Staal , Jay Rappaport , James R. Rusche
发明人： Flossie Wong-Staal , Jay Rappaport , James R. Rusche
IPC分类号： C12N15/09 , A61K38/00 , A61K49/00 , C07K14/00 , C07K14/155 , C07K14/16 , C12P21/02 , C12Q1/68 , C12R1/19 , G01N33/569
CPC分类号： C07K14/005 , A61K38/00 , C12N2740/16322
摘要： A method for evaluating the inhibitory effect of a substance on tat-protein TAR RNA binding is described. A test system for determining the association of tat-protein with TAR RNA is also included within the scope of the invention.
摘要翻译：描述了用于评估物质对tat蛋白TAR RNA结合的抑制作用的方法。用于确定tat蛋白与TAR RNA的关联的测试系统也包括在本发明的范围内。

22. 发明授权

US4963497A Isolation and purification of the eighth gene of HTLV-III 失效
标题翻译：分离和纯化HTLV-III的第八个基因
公开(公告)号：US4963497A
公开(公告)日：1990-10-16
申请号：US920780
申请日：1986-10-20
申请人： Flossie Wong-Staal , Pranab K. Chanda , John Ghrayeb
发明人： Flossie Wong-Staal , Pranab K. Chanda , John Ghrayeb
IPC分类号： A61K38/00 , C07K14/16 , C07K16/10 , C12N15/48
CPC分类号： C07K14/005 , C07K16/10 , A61K38/00 , C12N2740/16322
摘要： The present invention is the isolation and purification of a newly discovered gene of the AIDS virus, HTLV-III, which encodes a protein which is immunogenic and recognized by sera of some HTLV-III seropositive people. Furthermore, the gene is highly conserved among all known HTLV-III isolates and exhibits a polymorphism at the 3' end which distinguishes molecular clones of the HTLV-III cell line from viral genomes of related viruses (i.e., other HTLV-III isolates, LAV, ARV, etc.).
摘要翻译：本发明是新发现的艾滋病病毒基因HTLV-III的分离和纯化，HTLV-III编码免疫原性并被一些HTLV-III血清阳性人血清识别的蛋白质。此外，该基因在所有已知的HTLV-III分离物中是高度保守的，并且在3'末端显示多态性，其区分HTLV-III细胞系的分子克隆与相关病毒的病毒基因组（即，其他HTLV-III分离株，LAV ，ARV等）。

23. 发明申请

US20050095581A1 Detection of HIV-1 DNA 审中-公开
标题翻译：检测HIV-1 DNA
公开(公告)号：US20050095581A1
公开(公告)日：2005-05-05
申请号：US10634165
申请日：2003-08-05
申请人： Nancy Chang , Robert Gallo , Flossie Wong-Staal
发明人： Nancy Chang , Robert Gallo , Flossie Wong-Staal
IPC分类号： A61K38/00 , C07K14/16 , C07K16/10 , C12N5/24 , C12P21/08 , C12Q1/70 , C07H21/02 , C12N15/86
CPC分类号： C12Q1/702 , A61K38/00 , C07K14/005 , C07K16/1054 , C07K16/1063 , C07K2319/00 , C12N2740/14022 , C12N2740/16122 , C12Q1/703
摘要： The determination of the nucleotide sequence of HTLV-III DNA; identification, isolation and expression of HTLV-III sequences which encode immunoreactive polypeptides by recombinant,DNA methods and production of viral RNA are disclosed. Such polypeptides can be employed in immunoassays to detect HTLV-III.
摘要翻译：测定HTLV-III DNA的核苷酸序列; 公开了通过重组，DNA方法和病毒RNA的产生编码免疫反应性多肽的HTLV-III序列的鉴定，分离和表达。这些多肽可用于免疫测定以检测HTLV-III。

24. 发明授权

US06555107B2 Lentiviral nucleic acids and uses thereof 有权
标题翻译：慢病毒核酸及其用途
公开(公告)号：US06555107B2
公开(公告)日：2003-04-29
申请号：US09837644
申请日：2001-04-17
申请人： Eric M. Poeschla , David J. Looney , Flossie Wong-Staal
发明人： Eric M. Poeschla , David J. Looney , Flossie Wong-Staal
IPC分类号： A61K4800
CPC分类号： C12N15/86 , C12N2740/15043 , C12N2840/20
摘要： The invention provides non-primate lentiviral vectors, packaging cells and packaging plasmids based, for example, on feline and ungulate retroviruses. In particular, the packaging plasmids are designed for expression in human cells (which are also used as packaging cells). The vectors of the invention transduce human cells, including difficult to target non-dividing cells of the hematopoietic and nervous system, in vitro and in vivo. The vectors are suitable for general gene transfer to these cells and for gene therapy to treat conditions mediated by these non-dividing cells including cancer and HIV infection.
摘要翻译：本发明提供非灵长类慢病毒载体，包装细胞和包装质粒，其基于例如猫和有蹄类型的逆转录病毒。特别地，包装质粒设计用于在人细胞中表达（其也用作包装细胞）。本发明的载体在体外和体内转导人细胞，包括难以靶向造血和神经系统的非分裂细胞。这些载体适合于一般的基因转移到这些细胞和用于基因治疗以治疗由这些非分裂细胞（包括癌症和HIV感染）介导的病症。

25. 发明授权

US06200811B1 Cell transformation vector comprising an HIV-2 packaging site nucleic acid and an HIV-1 GAG protein 失效
标题翻译：包含HIV-2包装位点核酸和HIV-1GAG蛋白的细胞转化载体
公开(公告)号：US06200811B1
公开(公告)日：2001-03-13
申请号：US08822516
申请日：1997-03-24
申请人： Pierre Corbeau , Gunter Kraus , Flossie Wong-Staal
发明人： Pierre Corbeau , Gunter Kraus , Flossie Wong-Staal
IPC分类号： C12N1586
CPC分类号： C12N7/00 , A61K38/00 , A61K48/00 , C07K14/005 , C12N15/86 , C12N2740/16052 , C12N2740/16122
摘要： By transducing cells with an HIV-1-MN molecular clone deleted in the major packaging sequence, a stable HIV-1 packaging cell line, &psgr;422 was produced. &psgr;422 cells form syncytia with CD4 positive cells, correctly express HIV-1 structural proteins, and produce large amount of mature particles with normal RT activity. These particles are not infectious. When stably transfected with an HIV-based retroviral vector, the &psgr;422 cell line produces hybrid virions capable of transducing CD4 positive cells with high efficiency (e.g., 105 cells/ml). The availability of this stable, noninfectious HIV-1 packaging cell line capable of generating high titer HIV vectors enables the use of HIV-1 based nucleic acids delivery systems, for example, in gene therapy. An HIV-2 based vector is packaged by the packaging cell lines, demonstrating that HIV-2 cell transformation vectors are packaged by the packaging cell line. HIV based vectors packaged by the high efficiency cell lines are shown to have anti-HIV activity per se.
摘要翻译：通过在主要包装序列中缺失的HIV-1-MN分子克隆转导细胞，产生稳定的HIV-1包装细胞系psi422。 psi422细胞与CD4阳性细胞形成合胞体，正确表达HIV-1结构蛋白，并产生大量具有正常RT活性的成熟颗粒。这些颗粒不感染。当用HIV-型逆转录病毒载体稳定转染时，psi422细胞系产生能够以高效率（例如，105个细胞/ ml）转导CD4阳性细胞的杂合病毒体。能够产生高滴度的HIV载体的这种稳定的，非感染性的HIV-1包装细胞系的可用性使得能够使用基于HIV-1的核酸递送系统，例如在基因治疗中。通过包装细胞系包装基于HIV-2的载体，证明HIV-2细胞转化载体被包装细胞系包装。由高效细胞系包装的基于HIV的载体显示出具有抗HIV活性本身。

26. 发明授权

US5801056A Nucleic acid encoding HIV-1 tat protein 失效
标题翻译：编码HIV-1 tat蛋白的核酸
公开(公告)号：US5801056A
公开(公告)日：1998-09-01
申请号：US131898
申请日：1993-10-05
申请人： William Alan Haseltine , Craig A. Rosen , Joseph Gerald Sodroski , Flossie Wong-Staal , Suresh K. Arya
发明人： William Alan Haseltine , Craig A. Rosen , Joseph Gerald Sodroski , Flossie Wong-Staal , Suresh K. Arya
IPC分类号： C07K14/15 , C07K14/16 , C12N15/49 , C12N15/85 , C12N15/63 , C12N15/86
CPC分类号： C07K14/005 , C12N15/85 , C12N2740/14022 , C12N2740/16322 , C12N2800/108 , Y10S930/221
摘要： Nucleic acid encoding a functional HTLV-III/LAV (HIV-1) protein having trans-activating ability, and expression vectors comprising this nucleic acid are described.
摘要翻译：描述了编码具有反式激活能力的功能性HTLV-III / LAV（HIV-1）蛋白质的核酸和包含该核酸的表达载体。

27. 发明授权

US5674705A Productive of human T-cell leukemia (lymphotropic) retrovirus (HTLV-1) envelope protein fragments in bacteria and use in seroepidemiological studies 失效
标题翻译：在细菌中生产人类T细胞白血病（嗜淋巴细胞性）逆转录病毒（HTLV-1）包膜蛋白片段，用于血清流行病学研究
公开(公告)号：US5674705A
公开(公告)日：1997-10-07
申请号：US194818
申请日：1994-02-14
申请人： Takis S. Papas , Kenneth Samuel , James A. Lautenberger , Flossie Wong-Staal
发明人： Takis S. Papas , Kenneth Samuel , James A. Lautenberger , Flossie Wong-Staal
IPC分类号： C07K14/15 , C12P21/06 , C07K1/00 , C12Q1/70 , G01N33/53
CPC分类号： C07K14/005 , C12N2740/14022
摘要： Antigenic proteins may be expressed in bacteria by use of vectors having inserted therein DNA fragments from an envelope gene. The DNA fragments employed in the example are coding sequences found in the HTLV-I envelope gene. The bacteria used was E. coli. The antigenic proteins are useful in identifying antibodies to the organisms from which the DNA fragments were originally obtained.
摘要翻译：抗原性蛋白质可以通过使用其中插入有来自包膜基因的DNA片段的载体在细菌中表达。实施例中使用的DNA片段是在HTLV-1包膜基因中发现的编码序列。所使用的细菌是大肠杆菌。抗原蛋白质可用于鉴定最初获得DNA片段的生物体的抗体。

28. 发明授权

US5510238A Production of human T-cell leukemia (lymphotropic) retrovirus (HTLV-I) envelope protein fragments in bacteria and use in seroepidemiological studies 失效
标题翻译：在细菌中生产人类T细胞白血病（嗜淋巴细胞性）逆转录病毒（HTLV-1）包膜蛋白片段，用于血清流行病学研究
公开(公告)号：US5510238A
公开(公告)日：1996-04-23
申请号：US193510
申请日：1994-02-07
申请人： Takis S. Papas , Kenneth Samuel , James A. Lautenberger , Flossie Wong-Staal
发明人： Takis S. Papas , Kenneth Samuel , James A. Lautenberger , Flossie Wong-Staal
IPC分类号： C07K14/15 , C12P21/06 , C07K1/00 , C12Q1/70 , G01N33/53
CPC分类号： C07K14/005 , C12N2740/14022
摘要： Antigenic proteins may be expressed in bacteria by use of vectors having inserted therein DNA fragments from an envelope gene. The DNA fragments employed in the example are coding sequences found in the HTLV-I envelope gene. The bacteria used was E. coli. The antigenic proteins are useful in identifying antibodies to the organisms from which the DNA fragments were originally obtained.
摘要翻译：抗原性蛋白质可以通过使用其中插入有来自包膜基因的DNA片段的载体在细菌中表达。实施例中使用的DNA片段是在HTLV-1包膜基因中发现的编码序列。所使用的细菌是大肠杆菌。抗原蛋白质可用于鉴定最初获得DNA片段的生物体的抗体。

29. 发明授权

US5223423A Characterization of replication competent human immunodeficiency type 2 proviral clone HIV-2.sub.SBL/ISY 失效
标题翻译：复制人类免疫缺陷型2型病毒性HIV-2SBL / ISY的特征
公开(公告)号：US5223423A
公开(公告)日：1993-06-29
申请号：US331212
申请日：1989-03-31
申请人： Genoveffa Franchini , Flossie Wong-Staal , Robert Gallo
发明人： Genoveffa Franchini , Flossie Wong-Staal , Robert Gallo
IPC分类号： C12N5/10 , C07K14/16 , C12N7/00 , C12N15/09 , C12N15/49 , C12N15/85
CPC分类号： C12N7/00 , C07K14/005 , C12N15/8509 , A01K2217/05 , A01K2267/0337 , C12N2740/16021 , C12N2740/16022 , Y10S930/221
摘要： A complete genomic clone of HIV-2 designated HIV-2.sub.SBL/ISY was cloned from DNA of the neoplastic human cell line HUT78 infected with the HIV-2.sub.SBL6669 viral isolate. The clone was sequenced and the sequence compared with those of known HIV-2 isolates. The invention is advantageous for it provides an animal model for the study of HIV infection in man.
摘要翻译：从HIV-2SBL6669病毒分离株感染的肿瘤人类细胞系HUT78的DNA中克隆了一个名为HIV-2SBL / ISY的完整的HIV-2基因组克隆。对克隆进行测序，并将序列与已知的HIV-2分离株进行比较。本发明有利于其提供用于人类中HIV感染研究的动物模型。

30. 发明申请

US20110117055A1 Methods of Treating Hepatitis C Virus with Oxoacetamide Compounds 审中-公开
标题翻译：用乙酰乙酰胺化合物治疗丙型肝炎病毒的方法
公开(公告)号：US20110117055A1
公开(公告)日：2011-05-19
申请号：US12949646
申请日：2010-11-18
申请人： James E. MacDonald , McKelvy F. Jeffrey , Flossie Wong-Staal
发明人： James E. MacDonald , McKelvy F. Jeffrey , Flossie Wong-Staal
IPC分类号： A61K38/21 , A61P31/14 , A61K31/5375 , A61K31/167 , A61K31/18 , A61K31/4418 , C07D295/088 , C07C311/08 , C07C235/84 , C07D413/12 , A61K31/5377 , C07C235/78 , C07D417/12 , A61K31/541 , A61K31/553
CPC分类号： A61K31/167 , A61K31/18 , A61K31/381 , A61K31/4402 , A61K31/4418 , A61K31/5375 , A61K31/5377 , A61K31/541 , A61K31/553 , A61K31/7056 , A61K38/21 , A61K45/06 , A61K2300/00
摘要： Provided herein are hepatitis C virus entry inhibitor oxoacetamide compounds, pharmaceutical compositions thereof, and methods for their use in treatment or prevention of hepatitis C virus infection in a subject in need thereof.
摘要翻译：本文提供的是丙型肝炎病毒进入抑制剂氧乙酰胺化合物，其药物组合物，以及用于治疗或预防有需要的受试者中丙型肝炎病毒感染的方法。

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