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21. 发明申请

US20080221212A1 TOPICAL FORMULATION 审中-公开
标题翻译：主题配方
公开(公告)号：US20080221212A1
公开(公告)日：2008-09-11
申请号：US11682412
申请日：2007-03-06
申请人： Edward T. Kisak , John M. Newsam , Dominic King-Smith , Pankaj Karande , Samir Mitragotri
发明人： Edward T. Kisak , John M. Newsam , Dominic King-Smith , Pankaj Karande , Samir Mitragotri
IPC分类号： A61K31/195 , A61P17/00 , A61P29/00
CPC分类号： A61K31/195 , A61K9/0014 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/20
摘要： There is described a topical formulation. The topical formulation includes: (i) diclofenac or a pharmaceutically acceptable salt thereof, (ii) a first compound, and (iii) a second compound. The first compound and second compound are different, and each is selected from the group consisting essentially of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate and sodium lauryl sulfoacetate. It has been discovered that certain combination of compounds are excellent penetration enhancers and, as such, can be incorporated in a topical formulation to facilitate administration of diclofenac or a pharmaceutically acceptable salt thereof. The increased penetration enhancement can also lead to a reduction in the total concentration of skin irritants in the formulation.
摘要翻译：描述了一种局部制剂。局部制剂包括：（i）双氯芬酸或其药学上可接受的盐，（ii）第一化合物和（iii）第二化合物。第一化合物和第二化合物是不同的，并且各自选自基本上由N-月桂酰肌氨酸，辛基硫酸钠，月桂酸甲酯，肉豆蔻酸异丙酯，油酸，油酸甘油酯和月桂基磺基乙酸钠组成的组。已经发现，化合物的某些组合是优异的渗透增强剂，因此，可以掺入局部制剂以促进双氯芬酸或其药学上可接受的盐的给药。渗透增加的增加也可能导致制剂中皮肤刺激物的总浓度降低。

22. 发明授权

US5116590A Crystalline zeolite ECR-35 and a method for producing same 失效
标题翻译：结晶沸石ECR-35及其制备方法
公开(公告)号：US5116590A
公开(公告)日：1992-05-26
申请号：US727202
申请日：1991-07-09
申请人： David E. W. Vaughan , Karl G. Strohmaier , Michael M. J. Treacy , John M. Newsam
发明人： David E. W. Vaughan , Karl G. Strohmaier , Michael M. J. Treacy , John M. Newsam
IPC分类号： B01J29/70 , C01B39/20 , C01B39/48
CPC分类号： C01B39/205 , B01J29/70 , B01J2229/26 , B01J2229/42 , Y10S423/21
摘要： A synthetic large pore crystalline metalsilicate zeolite composition, designated as ECR-35, having the formula, expressed in term of mole ratio of oxides: ##STR1## where T is an organic cation selected from the group consisting of tetraethylammonium and methyltriethyl ammonium, and mixtures thereof and X is Al or Ga; wherein the composition consists of an X-ray diffraction pattern having the line intensities:______________________________________ Line # d(.ANG.) Intensity ______________________________________ (1) 15.00 .+-. 0.2 weak to very strong (2) 14.20 .+-. 0.2 very strong (3) 13.40 .+-. 0.2 weak to medium (4) 8.70 .+-. 0.2 medium (5) 8.03 .+-. 0.2 zero to medium (6) 7.40 .+-. 0.15 medium (7) 5.65 .+-. 0.15 medium-strong ______________________________________ and wherein the intensity of line (2) is greater than line (1) which is substantially greater than the intensity of line (3); and wherein the intensity of line (4) is substantially greater than the intensity of line (6) which is greater than the intensity of line (5) and a method for preparing same.

23. 发明授权

US07028726B2 Rotary-drive dispenser 失效
标题翻译：旋转驱动分配器
公开(公告)号：US07028726B2
公开(公告)日：2006-04-18
申请号：US10761681
申请日：2004-01-21
申请人： Ilya Feygin , John M. Newsam
发明人： Ilya Feygin , John M. Newsam
IPC分类号： B65B1/04
CPC分类号： G01N35/1083 , B01F13/1058 , B01F13/1072 , B01F2215/0032 , B01F2215/005 , B05B7/066 , B05B12/18 , G01N35/1002 , G01N35/1065 , G01N2035/1088
摘要： A liquid dispenser that uses rotary motion to create a relative movement between one or more dispensing elements and one or more receivers is disclosed. The dispensing elements are fluidically coupled to one or more reservoirs, which contain ingredients that are to be dispensed by the dispensing elements into one or more receivers. The receivers are disposed on a receiver support structure that is located beneath the dispensing elements. In some embodiments, the dispenser operates according to a quasi-continuous dispensing protocol or quasi-simultaneous dispensing protocol, or both quasi-continuous and quasi-simultaneous dispensing protocol.
摘要翻译：公开了一种使用旋转运动以在一个或多个分配元件和一个或多个接收器之间产生相对运动的液体分配器。分配元件流体地联接到一个或多个储存器，其包含将由分配元件分配到一个或多个接收器中的成分。接收器设置在位于分配元件下方的接收器支撑结构上。在一些实施方案中，分配器根据准连续分配方案或准同时分配方案或准连续和准同步分配方案进行操作。

24. 发明授权

US06742549B1 Method and apparatus for quasi-continuous and quasi-simultaneous dispensing 失效
标题翻译：准连续和准同时分配的方法和装置
公开(公告)号：US06742549B1
公开(公告)日：2004-06-01
申请号：US10348769
申请日：2003-01-21
申请人： Ilya Feygin , John M. Newsam
发明人： Ilya Feygin , John M. Newsam
IPC分类号： B65B300
CPC分类号： B01F15/0404 , B01F13/1055 , B01F13/1072 , B01F15/0441 , B01F2215/0037 , B01J2219/00306 , B01J2219/0036 , B01L3/0293 , B01L2200/14 , C40B60/14
摘要： A system and for creating multiple mixtures is disclosed. The illustrative system described herein includes dispensing elements that are moved into alignment with various receivers (or vice versa) to deliver ingredients. In some embodiments, the system requires only one dispensing element (e.g., valve, nozzle, orifice, etc.) per ingredient dispensed, irrespective of the number of receivers in the system. In accordance with the principles of this invention, the system is operated such that a plurality of ingredients are incrementally added to the receivers. Incremental addition is performed in such a way that, from the “perspective” of the mixture being formed, the ingredients are added quasi-continuously (i.e., a near-continuous flow of an ingredient) or quasi-simultaneously (i.e., all ingredients are added at nearly the same time), or both.
摘要翻译：公开了一种用于产生多种混合物的系统。本文描述的说明性系统包括分配元件，其移动成与各种接收器对准（或反之亦然）以输送成分。在一些实施例中，不管系统中的接收器的数量如何，系统仅需要分配每种成分的一个分配元件（例如，阀，喷嘴，孔口等）。根据本发明的原理，操作系统使得多个成分被递增地添加到接收器。以这样的方式进行增量添加：从形成的混合物的“角度”中，准备连续（即，成分的近连续流）或准同时添加成分（即，所有成分为几乎同时添加）或两者兼而有之。

25. 发明授权

US06733252B2 Fluid-handling systems and components comprising a bladder pump, a methods therefor 失效
标题翻译：流体处理系统和包括膀胱泵的组件及其方法
公开(公告)号：US06733252B2
公开(公告)日：2004-05-11
申请号：US10143403
申请日：2002-05-10
申请人： Ilya Feygin , John M. Newsam
发明人： Ilya Feygin , John M. Newsam
IPC分类号： F04B4310
CPC分类号： B67D7/00 , B67D7/62 , B67D7/741 , F04B43/10
摘要： A fluid-handling system capable, in various embodiments, of storing, mixing, and dispensing fluids, and also regulating the flow of fluids. The system includes a cartridge having a non-expandable housing, and a bladder within the housing. In some variations, a drive-liquid is introduced into a region between the housing and the bladder, which causes fluid contained within the bladder to dispense. In some other variations, the drive-liquid is introduced into the bladder, which causes the bladder to expand and expel fluid that is contained with the housing.
摘要翻译：在各种实施例中，能够存储，混合和分配流体以及还调节流体流动的流体处理系统。该系统包括具有不可扩张壳体的盒，以及壳体内的囊。在一些变型中，驱动液体被引入到壳体和囊之间的区域中，这导致包含在囊内的流体分配。在一些其他变型中，驱动液体被引入到囊中，这使得膀胱膨胀并排出与壳体一起容纳的流体。

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