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21. 发明申请

WO2014087248A3 ANTI-CD47 ANTIBODIES AND METHODS OF USE THEREOF 审中-公开
标题翻译：抗CD47抗体及其使用方法
公开(公告)号：WO2014087248A3
公开(公告)日：2014-11-06
申请号：PCT/IB2013003164
申请日：2013-12-03
申请人： NOVIMMUNE SA
发明人： MASTERNAK KRZYSZTOF , FISCHER NICOLAS , ROUSSEAU FRANCOIS , DHEILLY ELIE , KOSCO-VILBOIS MARIE
IPC分类号： C07K16/28 , A61K39/00
CPC分类号： C07K16/468 , A61K2039/505 , C07K16/2803 , C07K16/2896 , C07K16/461 , C07K2317/30 , C07K2317/31 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： The invention relates to monoclonal and/or monovalent antibodies that bind CD47. The invention relates to monoclonal and/or monovalent antibodies that bind CD19. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD47. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD19.
摘要翻译：本发明涉及结合CD47的单克隆和/或单价抗体。本发明涉及结合CD19的单克隆和/或单价抗体。本发明还涉及对免疫球蛋白分子的每个结合位点具有不同特异性的新的双特异性单克隆抗体，其中结合位点之一对CD47是特异性的。本发明还涉及对免疫球蛋白分子的每个结合位点具有不同特异性的新的双特异性单克隆抗体，其中一个结合位点对CD19是特异性的。

22. 发明公开

EP2185719A4 ANTI-RANTES ANTIBODIES AND METHODS OF USE THEREOF 有权
标题翻译： RANTES抗体及使用方法
公开(公告)号：EP2185719A4
公开(公告)日：2012-01-04
申请号：EP08840836
申请日：2008-08-04
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , KOSCO-VILBOIS MARIE , MACH FRANCOIS
IPC分类号： C12P21/06 , A61K38/16 , C07K16/24
CPC分类号： C07K16/24 , A61K2039/505 , C07K2317/21 , C07K2317/30 , C07K2317/33 , C07K2317/52 , C07K2317/565 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C07K2319/00

23. 发明公开

EP2513312A4 SYNTHETIC POLYPEPTIDE LIBRARIES AND METHODS FOR GENERATING NATURALLY DIVERSIFIED POLYPEPTIDE VARIANTS 有权
标题翻译：于产生NATURALLY多样性的多肽合成多肽库和方法
公开(公告)号：EP2513312A4
公开(公告)日：2013-05-15
申请号：EP10842428
申请日：2010-11-23
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , KOSCO-VILBOIS MARIE , RAVN ULLA , GUENEAU FRANCK , VENET-BONNOT SOPHIE
IPC分类号： C12N15/10
CPC分类号： C12N15/70 , C07K16/005 , C07K16/249 , C07K16/42 , C07K2317/21 , C07K2317/565 , C07K2317/567 , C07K2317/622 , C07K2317/76 , C07K2317/92 , C12N15/1034

24. 发明申请

WO2007051823A2 METHOD FOR SECURING DATA EXCHANGED BETWEEN A MULTIMEDIA PROCESSING DEVICE AND A SECURITY MODULE 审中-公开
标题翻译：用于保护多媒体处理设备和安全模块之间交换数据的方法
公开(公告)号：WO2007051823A2
公开(公告)日：2007-05-10
申请号：PCT/EP2006068041
申请日：2006-11-02
申请人： NAGRAVISION SA , MOREILLON GUY , FISCHER NICOLAS , KEYCHENKO NIKOLAI , WENGER JOEL
发明人： MOREILLON GUY , FISCHER NICOLAS , KEYCHENKO NIKOLAI , WENGER JOEL
IPC分类号： H04N7/16
CPC分类号： H04N21/4181 , H04N7/163 , H04N21/26613 , H04N21/4367
摘要： The aim of the invention is to provide a method for forming a secured and authenticated channel between a multimedia processing device and a security module dividable among several entities in such a way that the data transmitted to one entity does not affect the other entities. The aim is attained by a method for securing data exchanged between a multimedia processing device (STB) and a security module (M) managed by a management center, wherein said multimedia processing device (STB) receives the encrypted multimedia data flow for decrypting said data flow and converting it in such a way that it is readable and provided with a personal key (RK). The inventive method consists in obtaining an identifier (CAS ID) assigned to an entity which represents a group of multimedia processing devices by said multimedia processing device (STB), in computing a security key (VK) formed by a one-way operation which is based on the personal key (RK) of the multimedia processing device (STB) and the entity identifier (CAS ID), in transmitting said security key (VK) to the security module (M) assigned to the entity, in forming the security key (VK) with the aid of the processing device (STB) by receiving the entity identifier (CAS ID) thereby, in computing said security key (VK) by the multimedia processing device (STB) using the one-way operation which is based on the personal key (RK) thereof and the entity identifier (CAS ID) and in using said security key (VK) for securing the data exchanged between a multimedia processing device (STB) and the security module (M).
摘要翻译：本发明的目的是提供一种用于在多媒体处理设备和在多个实体之间可分割的安全模块之间形成安全和认证的信道的方法，使得发送到一个实体的数据不影响其他实体。目的是通过一种用于保护在管理中心管理的多媒体处理设备（STB）和安全模块（M）之间交换的数据的方法来实现，其中所述多媒体处理设备（STB）接收用于解密所述数据的加密的多媒体数据流流动并将其转换成可读取和提供个人密钥（RK）的方式。本发明的方法在于在计算由单向操作形成的安全密钥（VK）时，由所述多媒体处理设备（STB）获得分配给表示一组多媒体处理设备的实体的标识符（CAS ID）基于多媒体处理装置（STB）的个人密钥（RK）和实体标识符（CAS ID），在分配给该实体的安全模块（M）发送所述安全密钥（VK）时，形成安全密钥（STB）通过接收实体标识符（CAS ID），在由多媒体处理设备（STB）计算所述安全密钥（VK）的情况下，借助于处理设备（STB），使用基于其个人密钥（RK）和实体标识符（CAS ID）以及使用所述安全密钥（VK）来确保在多媒体处理设备（STB）和安全模块（M）之间交换的数据。

25. 发明申请

WO2006056572A2 DIGITAL AUDIO/VIDEO DATA PROCESSING UNIT AND METHOD FOR CONTROLLING ACCESS TO SAID DATA 审中-公开
标题翻译：数字音频/视频数据处理单元以及用于控制访问数据的方法
公开(公告)号：WO2006056572A2
公开(公告)日：2006-06-01
申请号：PCT/EP2005056145
申请日：2005-11-22
申请人： NAGRAVISION SA , PUIATTI JEAN-MICHEL , GREMAUD FABIEN , MOREILLON GUY , FISCHER NICOLAS , NICOULIN ANDRE , HILL MICHAEL JOHN
发明人： PUIATTI JEAN-MICHEL , GREMAUD FABIEN , MOREILLON GUY , FISCHER NICOLAS , NICOULIN ANDRE , HILL MICHAEL JOHN
IPC分类号： H04N7/16 , H04N7/167
CPC分类号： H04N5/913 , H04N7/163 , H04N7/1675 , H04N21/26613 , H04N21/4181 , H04N21/4405 , H04N21/4408 , H04N21/4627 , H04N21/835 , H04N2005/91364
摘要： The invention relates to a digital audio/video data processing unit and to a method for controlling access to said data. The unit (UT) for processing digital audio/video data encrypted with control words (CW) emanating from control messages (ECM) comprises a unit (DMx) for decrypting the audio/video data (DT), a decompression unit (MPEG), an input/output interface for the processed audio/video data and means for communicating with a security module (SM). The decryption (DMX) and decompression (MPEG) units respectively comprise and encryption unit (EC) and a decryption unit (DC) both of which are provided with at least one personal key (Kec, Kdc) and a common encryption key (Ki). The invention is characterized in that it comprises means for secure transmission of the common key (Ki) and control word (CW) extracted from a control message (ECM) between the security module (SM), wherein the decryption unit (DMX) and encryption unit (EC) use the personal key (Kec) of the encryption unit (EC). Decryption, by the decryption unit (DMX), of audio/video data (DT) with the control word (CW) and re-encryption, by the encryption unit (EC), of said decrypted data with the common key (Ki) are only possible after successful verification of the control word (CW) and the common key (Ki). After temporary storage, the re-encrypted audio/video data (DT) can only be decrypted by the decryption unit (DC) if the common key (Ki) is positively verified by the security module (SM) with the aid of a random number (AL) generated by the decryption unit (DC).
摘要翻译：本发明涉及一种数字音频/视频数据处理单元和一种用于控制对所述数据的访问的方法。用于处理由控制消息（ECM）发出的控制字（CW）加密的数字音频/视频数据的单元（UT）包括用于解密音频/视频数据（DT）的单元（DMx），解压缩单元（MPEG）用于处理的音频/视频数据的输入/输出接口和用于与安全模块（SM）通信的装置。解密（DMX）和解压缩（MPEG）单元分别包括和加密单元（EC）和解密单元（DC），两者都具有至少一个个人密钥（Kec，Kdc）和公共加密密钥（Ki）。本发明的特征在于它包括用于在安全模块（SM）之间从控制消息（ECM）提取的公共密钥（Ki）和控制字（CW）的安全传输的装置，其中解密单元（DMX）和加密单元（EC）使用加密单元（EC）的个人密钥（Kec）。通过解密单元（DMX）解密具有控制字（CW）的音频/视频数据（DT）并且由加密单元（EC）用公共密钥（Ki）对所述解密数据重新加密只有在成功验证控制字（CW）和公共密钥（Ki）之后才可能。在临时存储之后，如果通过安全模块（SM）借助于随机数来肯定地验证了公共密钥（Ki），那么再加密的音频/视频数据（DT）只能被解密单元（DC）解密（AL）由解密单元（DC）生成。

26. 发明申请

WO0148185A3 TRANSCRIPTION REGULATORY SEQUENCES DERIVED FROM CHLAMYDOMONAS REINHARDTII 审中-公开
标题翻译：从CHLAMYDOMONAS REINHARDTII衍生的转录调节序列
公开(公告)号：WO0148185A3
公开(公告)日：2002-05-02
申请号：PCT/EP0013274
申请日：2000-12-27
申请人： UNIV GENEVE , FISCHER NICOLAS , ROCHAIX JEAN DAVID
发明人： FISCHER NICOLAS , ROCHAIX JEAN-DAVID
IPC分类号： C07K14/415 , C12N1/13 , C12N15/79 , C12N15/82 , A01H3/00 , C12N1/12 , C12R1/89
CPC分类号： C12N15/8209 , C07K14/415 , C12N15/79 , C12N15/8216 , C12N15/8257
摘要： The invention concerns a transcription regulatory element, characterised in that it comprises: i) the nucleic acid sequence illustrated in Figure 7 (Seq ID n DEG 2), or ii) a fragment thereof, or iii) a sequence having at least 70 % identity with the sequence of Figure 7 (Seq ID n DEG 2).
摘要翻译：本发明涉及转录调节元件，其特征在于其包含：i）图7所示的核酸序列（Seq ID n DEG 2），或ii）其片段，或iii）具有至少70％同一性的序列按照图7的顺序（Seq ID n DEG 2）。

27. 发明专利

ES2752054T3 Método para optimizar el ensamble y producción de complejos de proteínas heteromultiméricas 未知
公开(公告)号：ES2752054T3
公开(公告)日：2020-04-02
申请号：ES16715820
申请日：2016-03-31
申请人： NOVIMMUNE SA
发明人： MAGISTRELLI GIOVANNI , MALINGE PAULINE , POITEVIN YVES , FISCHER NICOLAS
IPC分类号： C12N15/67 , C07K16/46 , C12P21/02
摘要： Un método para aumentar el rendimiento de producción de un complejo de proteínas que comprende: (a) identificar uno o más polipéptidos en el complejo que se expresan más abundantemente en una célula en comparación con los otros polipéptidos en el complejo; (b) modificar al menos una molécula de ácido nucleico que codifica los polipéptidos más abundantemente expresados en el complejo, en el que las moléculas de ácido nucleico se modifican al alterar la composición de codón de las moléculas de ácido nucleico que resulta en una reducción de la expresión de los polipéptidos que codifica; (c) introducir las moléculas de ácido nucleico en una célula; y (d) cultivar la célula bajo condiciones que permiten la expresión de todos los polipéptidos del complejo de proteínas; en el que dicha reducción de la expresión se logra mediante el reemplazo de ciertos codones con codones que se utilizan con menos frecuencia en la célula, al codificar un cambio en la estructura secundaria del ARNm o codificar un cambio en la tasa de traducción, y en el que el complejo de proteínas es un anticuerpo biespecífico.

28. 发明专利

AU2018272311A1 Anti-CD47 x anti-mesothelin antibodies and methods of use thereof 未知
公开(公告)号：AU2018272311A1
公开(公告)日：2019-12-19
申请号：AU2018272311
申请日：2018-05-29
申请人： NOVIMMUNE SA
发明人： MASTERNAK KRZYSZTOF , FISCHER NICOLAS
IPC分类号： C07K16/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30 , C07K16/46
摘要： The invention also relates to novel bispecific antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD47 and the second is specific for mesothelin (MSLN).

29. 发明专利

CA3093330A1 ANTI-CD3 EPSILON ANTIBODIES AND METHODS OF USE THEREOF 未知
公开(公告)号：CA3093330A1
公开(公告)日：2019-09-19
申请号：CA3093330
申请日：2019-03-14
申请人： NOVIMMUNE SA
发明人： MAGISTRELLI GIOVANNI , GUENEAU FRANCK , RAVIN ULLA , FISCHER NICOLAS
IPC分类号： C07K16/28 , A61P35/00 , C07K16/46
摘要： The disclosure relates to monoclonal antibodies and antigen binding fragments, variants, multimeric versions, or bispecifics thereof that specifically bind CD3 epsilon (CDe), as well as methods of making and using these anti-CDe antibodies and antigen binding fragments thereof in a variety of therapeutic, diagnostic and prophylactic indications.

30. 发明专利

AU2013353763B2 Anti-CD47 antibodies and methods of use thereof 未知
公开(公告)号：AU2013353763B2
公开(公告)日：2018-09-13
申请号：AU2013353763
申请日：2013-12-03
申请人： NOVIMMUNE SA
发明人： FISCHER NICOLAS , ROUSSEAU FRANCOIS , DHEILLY ELIE , KOSCO-VILBOIS MARIE , MASTERNAK KRZYSZTOF
IPC分类号： C07K16/28 , A61K39/00
摘要： The invention relates to monoclonal and/or monovalent antibodies that bind CD47. The invention relates to monoclonal and/or monovalent antibodies that bind CD19. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD47. The invention also relates to novel bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, where one of the binding sites is specific for CD19.

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