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21. 发明专利

SI3116909T1 Molekule protiteles na LAG-3 in njih uporaba 未知
公开(公告)号：SI3116909T1
公开(公告)日：2020-03-31
申请号：SI201531041
申请日：2015-03-13
申请人： NOVARTIS AG , IMMUTEP SAS
发明人： TRIEBEL FREDERIC , BRIGNONE CHRYSTELLE , BLATTLER WALTER A , MATARAZA JENNIFER MARIE , SABATOS-PEYTON CATHERINE ANNE , CHANG HWAI WEN , FREY GERHARD JOHANN
IPC分类号： C07K16/00 , A61P35/00

22. 发明专利

AU2015229103A1 Antibody molecules to LAG-3 and uses thereof 未知
公开(公告)号：AU2015229103A1
公开(公告)日：2016-08-04
申请号：AU2015229103
申请日：2015-03-13
申请人： IMMUTEP SAS , NOVARTIS AG
发明人： TRIEBEL FREDERIC , BRIGNONE CHRYSTELLE , BLATTLER WALTER A , MATARAZA JENNIFER MARIE , SABATOS-PEYTON CATHERINE ANNE , CHANG HWAI WEN , FREY GERHARD JOHANN
IPC分类号： C07K16/28 , A61P35/00
摘要： Antibody molecules that specifically bind to LAG-3 are disclosed. The anti-LAG-3 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious disorders.

23. 发明专利

AU2015229103C9 Antibody molecules to LAG-3 and uses thereof 未知
公开(公告)号：AU2015229103C9
公开(公告)日：2020-11-26
申请号：AU2015229103
申请日：2015-03-13
申请人： IMMUTEP SAS , NOVARTIS AG
发明人： TRIEBEL FREDERIC , BRIGNONE CHRYSTELLE , BLATTLER WALTER A , MATARAZA JENNIFER MARIE , SABATOS-PEYTON CATHERINE ANNE , CHANG HWAI WEN , FREY GERHARD JOHANN
IPC分类号： C07K16/28 , A61P35/00
摘要： Antibody molecules that specifically bind to LAG-3 are disclosed. The anti-LAG-3 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious disorders.

24. 发明专利

AU2020256466A1 Antibody molecules to LAG-3 and uses thereof 未知
公开(公告)号：AU2020256466A1
公开(公告)日：2020-11-12
申请号：AU2020256466
申请日：2020-10-19
申请人： IMMUTEP SAS , NOVARTIS AG
发明人： TRIEBEL FREDERIC , BRIGNONE CHRYSTELLE , BLATTLER WALTER A , MATARAZA JENNIFER MARIE , SABATOS-PEYTON CATHERINE ANNE , CHANG HWAI WEN , FREY GERHARD JOHANN
IPC分类号： C07K16/28 , A61P35/00
摘要： Antibody molecules that specifically bind to LAG-3 are disclosed. The anti-LAG-3 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious disorders.

25. 发明专利

AU2015229103B2 Antibody molecules to LAG-3 and uses thereof 未知
公开(公告)号：AU2015229103B2
公开(公告)日：2020-07-23
申请号：AU2015229103
申请日：2015-03-13
申请人： IMMUTEP SAS , NOVARTIS AG
发明人： TRIEBEL FREDERIC , BRIGNONE CHRYSTELLE , BLATTLER WALTER A , MATARAZA JENNIFER MARIE , SABATOS-PEYTON CATHERINE ANNE , CHANG HWAI WEN , FREY GERHARD JOHANN
IPC分类号： C07K16/28 , A61P35/00
摘要： Antibody molecules that specifically bind to LAG-3 are disclosed. The anti-LAG-3 antibody molecules can be used to treat, prevent and/or diagnose cancerous or infectious disorders.

26. 发明专利

LT3116909T ANTIKŪNO MOLEKULĖS PRIEŠ LAG-3 IR JŲ PANAUDOJIMAS 未知
公开(公告)号：LT3116909T
公开(公告)日：2020-02-10
申请号：LT15713290
申请日：2015-03-13
申请人： NOVARTIS AG , IMMUTEP SAS
发明人： TRIEBEL FREDERIC , BRIGNONE CHRYSTELLE , BLATTLER WALTER A , MATARAZA JENNIFER MARIE , SABATOS-PEYTON CATHERINE ANNE , CHANG HWAI WEN , FREY GERHARD JOHANN
IPC分类号： C07K16/28 , A61P35/00

27. 发明专利

PE20170071A1 MOLECULAS DE ANTICUERPO QUE SE UNEN A LAG-3 Y USOS DE LAS MISMAS 未知
公开(公告)号：PE20170071A1
公开(公告)日：2017-03-17
申请号：PE2016001593
申请日：2015-03-13
申请人： NOVARTIS AG , IMMUTEP SAS
发明人： FREY GERHARD JOHANN , CHANG HWAI WEN , SABATOS-PEYTON CATHERINE ANNE , TRIEBEL FREDERIC , BLATTLER WALTER A , BRIGNONE CHRYSTELLE , MATARAZA JENNIFER MARIE
IPC分类号： A61P35/00 , C07K16/28
摘要： Se refiere a moleculas de anticuerpos que se unen al gen 3 de activacion de linfocitos (LAG3). En un aspecto, se refiere a anticuerpos antiLAG3 que comprenden: (a) una region variable de cadena pesada (VH) que comprende una VHCDR1 cuya secuencia es GFTLTNY (SEQ ID NO: 4) o GFTLTNYGMN (SEQ ID NO: 286), una VHCDR2 cuya secuencia es NTDTGE (SEQ ID NO: 5), y una VHCDR3 cuya secuencia es NPPYYYGTNNAEAMDY (SEQ ID NO: 3); y (b) una region variable de cadena ligera (VL) que comprende una VLCDR1 cuya secuencia es SQDISNY (SEQ ID NO: 13), una VLCDR2 cuya secuencia es YTS (SEQ ID NO: 14), y una VLCDR3 cuya secuencia es YYNLPW (SEQ ID NO: 15). En otro aspecto, se refiere a anticuerpos antiLAG3 que comprenden (a) una VH que comprende una VHCDR1 cuya secuencia es NYGMN (SEQ ID NO: 1) o GFTLTNYGMN (SEQ ID NO: 286), una VHCDR2 cuya secuencia es WINTDTGEPTYADDFKG (SEQ ID NO: 2), y una VHCDR3 cuya secuencia es NPPYYYGTNNAEAMDY (SEQ ID NO: 3); y (b) una VL que comprende una VLCDR1 cuya secuencia es SSSQDISNYLN (SEQ ID NO: 10), una VLCDR2 cuya secuencia es YTSTLHL (SEQ ID NO: 11), y una VLCDR3 cuya secuencia es QQYYNLPWT (SEQ ID NO: 12). Tambien se refiere a composiciones farmaceuticas que comprenden dichos anticuerpos; asi como a moleculas de acidos nucleicos que codifican las cadenas pesada y ligera de dichos anticuerpos; y vectores de expresion y celulas hospederas que comprenden dichas moleculas de acidos nucleicos. Tambien se refieren a metodos para la produccion de dichos anticuerpos. Dichas moleculas de anticuerpos antiLAG3 son utiles en el tratamiento, prevencion o diagnostico de trastornos cancerosos y enfermedades infecciosas

28. 发明申请

WO2009032256A3 APC ACTIVATORS IN COMBINATION WITH A CYTOKINE-SECRETING CELL AND METHODS OF USE THEREOF 审中-公开
标题翻译： APC活化剂与细胞因子分泌细胞组合使用及其使用方法
公开(公告)号：WO2009032256A3
公开(公告)日：2009-05-07
申请号：PCT/US2008010335
申请日：2008-08-29
申请人： CELL GENESYS INC , IMMUTEP S A , JOOSS KARIN , LI BETTY , TRIEBEL FREDERIC
发明人： JOOSS KARIN , LI BETTY , TRIEBEL FREDERIC
IPC分类号： A61K38/19 , A61K38/17 , A61K39/00 , A61K39/39 , A61P35/00
CPC分类号： A61K39/0011 , A61K38/1774 , A61K38/193 , A61K2039/5152 , A61K2039/55516 , A61K2039/55522 , A61K2300/00
摘要： The present invention relates to a method of enhancing anti-tumor protection in a mammal. More particularly, the invention is concerned with combinations comprising antigen presenting cell (APC) activators and a cytokine-secreting cell and methods of administering the combination for enhanced immune response to tumor cells in a patient with a cancer.
摘要翻译：本发明涉及增强哺乳动物中抗肿瘤保护的方法。更具体地说，本发明涉及包含抗原呈递细胞（APC）激活剂和细胞因子分泌细胞的组合和施用该组合以增强对患有癌症的患者的肿瘤细胞的免疫应答的方法。

29. 发明专利

CA2995639A1 ANTI-LAG-3 ANTIBODIES 未知
公开(公告)号：CA2995639A1
公开(公告)日：2017-03-09
申请号：CA2995639
申请日：2016-09-01
申请人： IMMUTEP SAS
发明人： TRIEBEL FREDERIC , BRIGNONE CHRYSTELLE
IPC分类号： C07K16/28
摘要： Antibodies, or antigen-binding fragments thereof, that bind to Lymphocyte-activation gene-3 (LAG-3) are described, in particular antibodies, or antigen-binding fragments thereof, that are agonists of LAG-3. The antibodies bind to LAG-3 and inhibit antigen-induced CD4+ and/or CD8+ T cell proliferation, or antigen-induced CD4+ and/or CD8+ T cell activation. The antibodies may be used as medicaments, in particular for the treatment of conditions associated with proliferation and/or activation of CD4+ and/or CD8+ T cells, such as inflammatory and autoimmune disorders.

30. 发明专利

AU2022200133A1 COMBINED PREPARATIONS FOR THE TREATMENT OF CANCER OR INFECTION 未知
公开(公告)号：AU2022200133A1
公开(公告)日：2022-02-10
申请号：AU2022200133
申请日：2022-01-11
申请人： IMMUTEP SAS
发明人： TRIEBEL FREDERIC , BRIGNONE CHRYSTELLE
IPC分类号： A61K38/17 , A61K39/395 , A61P31/00 , A61P35/00
摘要： Abstract Combined Preparations for the Treatment of Cancer or Infection Combined preparations, and pharmaceutical compositions, comprising: (a) LAG-3 protein, or a derivative thereof that is able to bind to MHC class || molecules; and (b) a programmed 5 cell death protein-1 (PD-1) pathway inhibitor, are described. The PD-1 pathway inhibitor, such as an anti-PD-1 antibody or an anti-PD-L1 antibody, and a soluble derivative of LAG 3, acting as an APC activator, together synergistically activate T cells (in particular, CD8* T cells). Use of the combined preparations and compositions as medicaments, in particular for the treatment of cancer or infection, and to methods for the treatment of cancer or 10 infection, is described.

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