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    • 29. 发明申请
    • METHOD FOR THE PREPARATION OF 'beta'-HYDROXYKETONES
    • 制备β-羟基酮的方法
    • WO1991007369A1
    • 1991-05-30
    • PCT/JP1990001486
    • 1990-11-15
    • NIPPON SODA CO., LTD.TSUKASHIMA, KeiichiKANEKO, Akira
    • NIPPON SODA CO., LTD.
    • C07C45/72
    • C07D335/02C07C45/72C07C201/12C07C319/20C07C2601/14C07D309/06C07C49/17C07C49/245C07C49/172C07C323/22C07C205/45
    • The present invention relates to a method for the preparation of beta -hydroxyketones represented by general formula (I), (where R is an alkyl group which may have a methyl group at the alpha position, an alkyl group substituted by alkylthio group which may have a methyl group at the alpha position, an alicyclic group which may have substituents at positions other than the alpha , beta and beta ' positions, a heterocyclic group which may have substituents at positions other than the alpha , beta and beta ' positions, and phenyl group which may have an electron withdrawing group at the para position), by reacting aldehydes represented by formula (A): RCHO (where R is as defined above) with aqueous solution of alkali metal salt of acetoacetic acid represented by formula (B) (where M is an alkali metal ion), a method for the preparation of the said beta -hydroxyketones which comprises reacting (A) and (B) when a mole ratio of (A) to (B) is 1.0 to 1.5 if (A) has two hydrogen atoms, 1.5 to 2.0 if one hydrogen atom, 2.0 to 2.5 if no hydrogen atoms and 1.1 to 1.5 if R is a phenyl group with electron withdrawing group at the para position even if no hydrogen atoms, at a pH of 9 to 10.
    • 本发明涉及一种制备由通式(I)表示的β-羟基酮的方法,(其中R是在α位上可具有甲基的烷基,可被烷硫基取代的烷基 在α位上的甲基,可以在α,β和β'以外的位置具有取代基的脂环族基团,在α,β和β'以外的位置可以具有取代基的杂环基和苯基 式(A)表示的醛:RCHO(其中R如上定义)与由式(B)表示的乙酰乙酸的碱金属盐的水溶液(式 其中M +是碱金属离子),制备所述β-羟基酮的方法,其包括当(A)至(B)的摩尔比为1.0至1.5时使(A)和(B)反应,如果 (A)具有两个氢原子,1.5 如果一个氢原子为2.0,如果没有氢原子则为2.0至2.5,如果R是在对位具有吸电子基团的苯基,即使没有氢原子,则在pH为9至10的情况下为1.1至1.5。