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21. 发明申请

US20090047687A1 Indane Acetic Acid Derivatives and Their Use as Pharmaceutical Agents, Intermediates, and Method of Preparation 审中-公开
标题翻译：吲哚乙酸衍生物及其作为药剂，中间体和制备方法的用途
公开(公告)号：US20090047687A1
公开(公告)日：2009-02-19
申请号：US12059706
申请日：2008-03-31
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号： G01N33/53 , C07C69/76 , C07C63/00 , C07D263/30 , C07D277/20 , C07C229/00
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C67/303 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12 , Y02P20/582
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
摘要翻译：本发明涉及可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。

22. 发明申请

US20070141161A1 Liquid ganaxolone formulations and methods for the making and use thereof 有权
标题翻译：液体甘那星酮制剂及其制备和使用方法
公开(公告)号：US20070141161A1
公开(公告)日：2007-06-21
申请号：US11605700
申请日：2006-11-28
申请人： Kenneth Shaw , Mingbao Zhang
发明人： Kenneth Shaw , Mingbao Zhang
IPC分类号： A61K31/58 , A61K9/14
CPC分类号： A61K31/573 , A61K9/0019 , A61K9/10 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1676 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4891 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/57 , A61K47/02 , A61K47/26 , Y10S977/773 , Y10S977/775 , Y10S977/906 , Y10S977/915
摘要： In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.
摘要翻译：在某些实施方案中，本发明涉及包含稳定的颗粒的组合物，所述稳定颗粒包含加纳西酮，其中颗粒的体积加权中位数直径（D50）为约50nm至约500nm。

23. 发明授权

US07091228B2 Preparation and use of aryl alkyl acid derivatives for the treatment of obesity 失效
公开(公告)号：US07091228B2
公开(公告)日：2006-08-15
申请号：US10839833
申请日：2004-05-06
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： A61K31/428 , A61K31/426 , C07D277/82 , C07D277/42
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.

24. 发明授权

US08552203B2 Indane acetic acid derivatives and their use as pharmaceutical agents, intermediates, and method of preparation 有权
公开(公告)号：US08552203B2
公开(公告)日：2013-10-08
申请号：US13035638
申请日：2011-02-25
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号： C07D277/22 , C07D263/30
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.

25. 发明授权

US08455002B2 Stable corticosteroid nanoparticulate formulations and methods for the making and use thereof 有权
公开(公告)号：US08455002B2
公开(公告)日：2013-06-04
申请号：US12777920
申请日：2010-05-11
申请人： Kenneth Shaw , Mingbao Zhang
发明人： Kenneth Shaw , Mingbao Zhang
IPC分类号： A61K9/14 , A61K47/14 , A61K47/28 , C07J71/00 , A61K8/63
CPC分类号： A61K9/145 , A61K9/007 , A61K9/0073 , A61K9/0075 , A61K9/0078 , A61K9/008 , A61K9/1623 , A61K9/1652 , A61K9/2886 , A61K9/5078 , A61K31/58 , A61K47/14 , A61K47/6949 , B82Y5/00 , C07J71/00 , Y10S977/773 , Y10S977/906
摘要： Disclosed are stable corticosteroid nanoparticulate formulations, methods of making and therapeutic uses thereof.

26. 发明申请

US20120052098A1 LIQUID GANAXOLONE FORMULATIONS AND METHODS FOR THE MAKING AND USE THEREOF 有权
标题翻译：液体GANAXOLONE制剂及其制备和使用方法
公开(公告)号：US20120052098A1
公开(公告)日：2012-03-01
申请号：US13217384
申请日：2011-08-25
申请人： Kenneth SHAW , Mingbao Zhang
发明人： Kenneth SHAW , Mingbao Zhang
IPC分类号： A61K9/10 , A61P25/00 , A61P25/20 , A61P3/00 , A61K31/57 , A61P25/08 , B82Y5/00
CPC分类号： A61K31/573 , A61K9/0019 , A61K9/10 , A61K9/143 , A61K9/145 , A61K9/146 , A61K9/1676 , A61K9/2054 , A61K9/2059 , A61K9/2077 , A61K9/282 , A61K9/2846 , A61K9/2866 , A61K9/4808 , A61K9/4891 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/57 , A61K47/02 , A61K47/26 , Y10S977/773 , Y10S977/775 , Y10S977/906 , Y10S977/915
摘要： In certain embodiments, the invention is directed to composition comprising stable particles comprising ganaxolone, wherein the volume weighted median diameter (D50) of the particles is from about 50 nm to about 500 nm.
摘要翻译：在某些实施方案中，本发明涉及包含稳定的颗粒的组合物，所述稳定颗粒包含加纳西酮，其中颗粒的体积加权中位数直径（D50）为约50nm至约500nm。

27. 发明申请

US20110065129A1 INDANE ACETIC ACID DERIVATIVES AND THEIR USE AS PHARMACEUTICAL AGENTS, INTERMEDIATES, AND METHOD OF PREPARATION 审中-公开
标题翻译：吲哚乙酸衍生物及其作为药物代谢物，中间体和制备方法的用途
公开(公告)号：US20110065129A1
公开(公告)日：2011-03-17
申请号：US12369736
申请日：2009-02-11
申请人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
发明人： Derek B. Lowe , Philip L. Wickens , Xin Ma , Mingbao Zhang , William H. Bullock , Philip D. G. Coish , Ingo A. Mugge , Andreas Stolle , Ming Wang , Yamin Wang , Chengzhi Zhang , Hai-Jun Zhang , Lei Zhu , Manami Tsutsumi , James N. Livingston
IPC分类号： G01N33/567 , C07C51/36 , C07D263/32 , C07D413/12 , C07D413/10 , C07D277/30 , C07D417/10
CPC分类号： C07D277/32 , C07B2200/07 , C07C51/412 , C07C51/44 , C07C59/72 , C07C69/732 , C07C69/734 , C07C69/738 , C07C2602/08 , C07D263/32 , C07D277/24 , C07D277/40 , C07D413/04 , C07D413/10 , C07D413/12
摘要： This invention relates to novel indane acetic acid derivatives which are useful in the treatment of diseases such as diabetes, obesity, hyperlipidemia, and atherosclerotic diseases. The invention also relates to intermediates useful in preparation of indane acetic derivatives and to methods of preparation.
摘要翻译：本发明涉及可用于治疗疾病如糖尿病，肥胖症，高脂血症和动脉粥样硬化疾病的新型茚满乙酸衍生物。本发明还涉及可用于制备茚满乙酸衍生物的中间体及其制备方法。

28. 发明授权

US07531550B2 Pseudobase benzo[c]phenanthridines with improved efficacy, stability, and safety 有权
标题翻译：具有改善功效，稳定性和安全性的假碱性苯并[c]菲啶
公开(公告)号：US07531550B2
公开(公告)日：2009-05-12
申请号：US11831498
申请日：2007-07-31
申请人： Kenneth Shaw , Mingbao Zhang
发明人： Kenneth Shaw , Mingbao Zhang
IPC分类号： A61K31/4741 , C07D491/113
CPC分类号： C07D491/04
摘要： Pseudobase benzo[c]phenanthridines and the pharmaceutically acceptable salts thereof of Formula I are provided herein. The variables R, R1, R2, R3, and R4 are defined herein. Certain pseudobase benzo[c]phenanthridines provided herein act as prodrugs, targeting the parent benzo[c]phenanthridinium alkaloid to hydrophilic or hydrophobic regions in the body. Pharmaceutical compositions comprising a pseudobase benzo[c]phenanthridine and a carrier, excipient, or diluent are provided herein. Methods of treating or preventing microbial, fungal and or viral infections and methods of treating diseases and disorders responsive to protein kinase C modulation, topoisomerase I, and/or topoisomerase II modulation are also provided.
摘要翻译：本文提供了假碱性苯并[c]菲啶及其式I的药学上可接受的盐。变量R，R1，R2，R3和R4在本文中定义。本文提供的某些假碱性苯并[c]菲啶用作前药，将母体苯并[c]菲啶生物碱靶向体内的亲水或疏水区域。本文提供了包含假碱性苯并[c]菲啶和载体，赋形剂或稀释剂的药物组合物。还提供了治疗或预防微生物，真菌和/或病毒感染的方法以及治疗对蛋白激酶C调节，拓扑异构酶I和/或拓扑异构酶II调节的疾病和病症的方法。

29. 发明授权

US07423156B2 Preparation and use of aryl alkyl acid derivatives for the treatment of obesity 失效
标题翻译：芳基烷基酸衍生物的制备和用途用于治疗肥胖症
公开(公告)号：US07423156B2
公开(公告)日：2008-09-09
申请号：US11341197
申请日：2006-01-27
申请人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
发明人： Roger Smith , Ann-Marie Campbell , Philip Coish , Miao Dai , Susan Jenkins , Derek Lowe , Stephen O'Connor , Ning Su , Gan Wang , Mingbao Zhang , Lei Zhu
IPC分类号： C07D277/42 , C07D277/62 , C07D263/34 , C07D263/58
CPC分类号： C07D263/58 , C07D235/30 , C07D263/60 , C07D277/42 , C07D277/58 , C07D277/82 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.
摘要翻译：本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。

30. 发明授权

US06340773B1 Preparation of halogenated primary amines 失效
标题翻译：卤代伯胺的制备
公开(公告)号：US06340773B1
公开(公告)日：2002-01-22
申请号：US09396686
申请日：1999-09-14
申请人： Mingbao Zhang , Michael A. Kocur , Mary Frances Martin
发明人： Mingbao Zhang , Michael A. Kocur , Mary Frances Martin
IPC分类号： C07C21103
CPC分类号： C07C209/40 , C07C211/29
摘要： A method of preparing a halogenated primary amine comprising hydrogenating a halogenated oxime in the presence of a catalyst comprising a non-palladium noble metal or a base metal under conditions sufficient to produce a halogenated primary amine.
摘要翻译：一种制备卤代伯胺的方法，包括在足以产生卤化伯胺的条件下，在包含非钯贵金属或碱金属的催化剂存在下，使卤代肟氢化。

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