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21. 发明申请

US20140113314A1 Two Pore Channels as a Therapeutic Target to Protect Against Myocardial Ischemia and as an Adjuvant in Cardiac Surgery 审中-公开
标题翻译：两个孔道作为治疗心肌缺血和辅助治疗心脏手术的治疗靶点
公开(公告)号：US20140113314A1
公开(公告)日：2014-04-24
申请号：US13689722
申请日：2012-11-29
申请人： Ira S. Cohen , Zhongju Lu , Richard B. Robinson , Irvin B. Krukenkamp , Peter R. Brink , Steven J. Feinmark
发明人： Ira S. Cohen , Zhongju Lu , Richard B. Robinson , Irvin B. Krukenkamp , Peter R. Brink , Steven J. Feinmark
IPC分类号： G01N33/566
CPC分类号： G01N33/566 , A61K31/00
摘要： The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K2P channels”) as a means for inducing preconditioning protection. Such preconditioning can be used to reduce the effect of ischemia associated with ischemic heart disease, myocardial infarction or cardiac surgery. The invention is based on the discovery that the myoprotective current induced by short periods of ischemia is carried by a non-classical two-pore domain K+ channel.
摘要翻译：本发明涉及用于调节双孔结构域K +通道（“K2P通道”）作为诱导预处理保护的手段的活性的方法和组合物。这种预处理可用于减少与缺血性心脏病，心肌梗死或心脏手术相关的缺血的作用。本发明基于以下发现：由短期缺血引起的肌保护电流由非经典双孔结构域K +通道携带。

22. 发明申请

US20100048650A1 TWO PORE CHANNELS AS A THERAPEUTIC TARGET TO PROTECT AGAINST MYOCARDIAL ISCHEMIA AND AS AN ADJUVANT IN CARDIAC SURGERY 审中-公开
标题翻译：两个通道作为治疗心肌梗塞并作为心脏手术的受试者的治疗目标
公开(公告)号：US20100048650A1
公开(公告)日：2010-02-25
申请号：US12296017
申请日：2007-04-04
申请人： Ira S. Cohen , Zhongju Lu , Irvin Krukenkamp , Peter R. Brink , Richard B. Robinson , Steven J. Feinmark
发明人： Ira S. Cohen , Zhongju Lu , Irvin Krukenkamp , Peter R. Brink , Richard B. Robinson , Steven J. Feinmark
IPC分类号： A61K31/426 , A61K31/23 , A61K31/40 , A61K31/216 , C12N5/00 , G01N33/53 , C12Q1/02 , A61P9/00
CPC分类号： G01N33/566 , A61K31/00
摘要： The present invention relates to methods and compositions for modulating the activity of two-pore domain K+ channels (“K2P channels”) as a means for inducing preconditioning protection. Such preconditioning can be used to reduce the effect of ischemia associated with ischemic heart disease, myocardial infarcation or cardiac surgery. The invention is based on the discovery that the myoprotective current induced by short periods of ischemia is carried by a non-classical two-pore domain K+ channel.
摘要翻译：本发明涉及用于调节双孔结构域K +通道（“K2P通道”）作为诱导预处理保护的手段的活性的方法和组合物。这种预处理可用于减少与缺血性心脏病，心肌梗塞或心脏手术相关的局部缺血的作用。本发明基于以下发现：由短期缺血引起的肌保护电流由非经典双孔结构域K +通道携带。

23. 发明授权

US07122307B2 High throughput biological heart rate monitor that is molecularly determined 失效
标题翻译：分子确定的高通量生物心率监测仪
公开(公告)号：US07122307B2
公开(公告)日：2006-10-17
申请号：US09898417
申请日：2001-07-03
申请人： Michael R. Rosen , Richard B. Robinson , Ira S. Cohen , Han-Gang Yu
发明人： Michael R. Rosen , Richard B. Robinson , Ira S. Cohen , Han-Gang Yu
IPC分类号： C12Q1/68
CPC分类号： G01N33/5061 , A61K38/1709 , A61K48/00 , G01N33/5008 , G01N33/502 , G01N33/6872
摘要： This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells. Cardiac myocytes disaggregated from neonatal animals are plated onto the bottom of each well and grown under standard tissue culture conditions. When drugs are to be assayed, the cells in each well are loaded with a calcium sensitive dye and the beating rate in each is monitored with a photodiode. A drug is added in graded concentrations to each well, and equilibrated and effects on rate are observed. This construct permits use of a cell based bioassay for the study of drugs or agents that may alter cardiac rate. This invention can be used in high throughput screening of drugs to evaluate/predict their effects on cardiac rate and rhythm.
摘要翻译：本发明提供了一种设计用于测定药物对心率的影响的室和系统。房间由一系列井组成。将从新生儿动物分解的心肌细胞接种在每个孔的底部并在标准组织培养条件下生长。当要测定药物时，每个孔中的细胞装载有钙敏感染料，并且用光电二极管监测每个孔中的搏动速率。将药物以逐级浓度加入每个孔中，并平衡并观察其对速率的影响。该构建允许使用基于细胞的生物测定法来研究可能改变心率的药物或药剂。本发明可用于药物的高通量筛选以评估/预测其对心率和节律的影响。

24. 发明授权

US06849611B2 Implantation of biological pacemaker that is molecularly determined 有权
标题翻译：植入分子确定的生物起搏器
公开(公告)号：US06849611B2
公开(公告)日：2005-02-01
申请号：US09875388
申请日：2001-06-06
申请人： Michael R. Rosen , Richard B. Robinson , Ira S. Cohen , Han-Gang Yu
发明人： Michael R. Rosen , Richard B. Robinson , Ira S. Cohen , Han-Gang Yu
IPC分类号： A61K38/17 , A61K48/00 , C12N15/861
CPC分类号： C12N15/86 , A61K38/177 , A61K48/00 , A61K48/005 , C12N2710/10343 , C12N2800/30 , A61K2300/00
摘要： This invention provides for a method of inducing a current in the heart in a subject which comprises contacting a cell of the heart of a subject with a compound in a sufficient amount to induce a current in the cell of the heart of a subject. This invention also provides a method of treating a cardiac condition in a subject which comprises contacting a cell of the heart of the subject with a compound in an amount sufficient to increase the current expression of the cell, thereby treating the cardiac condition in the subject.
摘要翻译：本发明提供了诱导受试者心脏中的电流的方法，其包括使受试者的心脏细胞与足够量的化合物接触以诱导受试者心脏细胞中的电流。本发明还提供了治疗受试者心脏病症的方法，其包括使受试者心脏的细胞与足以增加细胞当前表达量的化合物接触，从而治疗受试者的心脏病状。

25. 发明授权

US07794702B2 Mesenchymal stem cells as a vehicle for ion channel transfer in syncytial structures 有权
标题翻译：间充质干细胞作为合胞体结构中离子通道转移的载体
公开(公告)号：US07794702B2
公开(公告)日：2010-09-14
申请号：US10342506
申请日：2003-01-15
申请人： Michael R. Rosen , Richard B. Robinson , Ira S. Cohen , Peter Brink
发明人： Michael R. Rosen , Richard B. Robinson , Ira S. Cohen , Peter Brink
IPC分类号： A61K48/00
CPC分类号： C12N5/0663 , A61K48/00 , C07K14/705
摘要： This invention provides a composition for delivery of a gene to a syncytial structure comprising stem cells incorporated with the gene. This invention also provides a composition for ion channel transfer which comprises stem cells incorporated with a compound in an amount sufficient to create ion channels. This invention also provides for a method of expressing a functional gene product in a syncytial structure comprising administering a composition, comprising stem cells that have been incorporated with a gene, to the syncytial structure. This invention further provides a method of expressing a functional ion channel in a syncytial structure comprising administering a composition, comprising stem cells that have been incorporated with a compound in an amount sufficient to create ion channels, to the syncytial structure. This invention also provides a composition for delivery of small molecules comprising stem cells incorporated with the small molecules or genes encoding the small molecules.
摘要翻译：本发明提供了用于将基因递送至合成结构的组合物，其包括掺入该基因的干细胞。本发明还提供了用于离子通道转移的组合物，其包含与足以产生离子通道的量的化合物结合的干细胞。本发明还提供了一种在合胞体结构中表达功能基因产物的方法，其包括将包含基因的干细胞组合物施用于合胞体结构。本发明进一步提供一种在合胞体结构中表达功能性离子通道的方法，其包括向合成结构施用包含与足以产生离子通道的化合物结合的干细胞的组合物。本发明还提供了用于递送小分子的组合物，其包括与小分子结合的干细胞或编码小分子的基因。

26. 发明授权

US06783979B2 Vectors encoding HCN channels and MiRP1 有权
标题翻译：编码HCN通道和MiRP1的载体
公开(公告)号：US06783979B2
公开(公告)日：2004-08-31
申请号：US09875392
申请日：2001-06-06
申请人： Michael R. Rosen , Richard B. Robinson , Ira S. Cohen , Han-Gang Yu
发明人： Michael R. Rosen , Richard B. Robinson , Ira S. Cohen , Han-Gang Yu
IPC分类号： C12N1500
CPC分类号： G01N33/5061 , A61K38/1709 , A61K48/00 , G01N33/5008 , G01N33/502 , G01N33/6872
摘要： This invention provides for a chamber and system designed for use in assaying drug effects on heart rate. The chamber consists of a series of wells, each 3 mm by 3 mm in inner diameter. Cardiac myocytes disaggregated from neonatal animals are plated onto the bottom of each well and grown under standard tissue culture conditions. The chamber holds from 24-96 such wells. When drugs are to be assayed, the cells in each well are loaded with a calcium sensitive dye and the beating rate in each is monitored with a photodiode. Drug is added in graded concentrations to each well, and equilibrated and effects on rate are observed. This construct permits use of a cell based bioassay for the study of drugs or agents that may alter cardiac rate. This invention can be used in high throughput screening of drugs to evaluate/predict their effects on cardiac rate and rhythm. Further provided for by this invention is a vector which comprises a compound which encodes an ion channel.
摘要翻译：本发明提供了一种设计用于测定药物对心率的影响的室和系统。该室由一系列的孔组成，内径为3 mm×3 mm。将从新生儿动物分解的心肌细胞接种在每个孔的底部并在标准组织培养条件下生长。该厅拥有24-96个这样的井。当要测定药物时，每个孔中的细胞装载有钙敏感染料，并且用光电二极管监测每个孔中的搏动速率。将药物以分级浓度加入每个孔中，并平衡并观察其对速率的影响。该构建允许使用基于细胞的生物测定法来研究可能改变心率的药物或药剂。本发明可用于药物的高通量筛选以评估/预测其对心率和节律的影响。本发明进一步提供的是包含编码离子通道的化合物的载体。

27. 发明申请

US20100068699A1 Assay System For Monitoring The Effects Of Genetically Engineered Cells To Alter Function Of A Synctium 有权
标题翻译：用于监测遗传工程细胞影响神经系统功能的测定系统
公开(公告)号：US20100068699A1
公开(公告)日：2010-03-18
申请号：US11792426
申请日：2005-07-19
申请人： Richard B. Robinson , Michael R. Rosen , Ira S. Chen , Peter R. Brink
发明人： Richard B. Robinson , Michael R. Rosen , Ira S. Chen , Peter R. Brink
IPC分类号： C12Q1/68
CPC分类号： G01N33/5061
摘要： This invention provides methods for determining the ability of a gene construct to alter the rhythm and contractility of a syncytial cell. Furthermore, this invention provides methods for constructing a gene construct capable of altering the rhythm or contractility of a syncytial cell. Finally, this invention provides a method for constructing a gene construct capable of coupling to a syncytial cell.
摘要翻译：本发明提供了确定基因构建体改变合胞体细胞的节律和收缩能力的方法。此外，本发明提供构建能够改变合胞体的节律或收缩性的基因构建体的方法。最后，本发明提供了构建能够与合胞体偶联的基因构建体的方法。

28. 发明授权

US08309528B2 Two pore channels as regulators of proliferation in cancer 有权
标题翻译：两孔通道作为癌症增殖的调节因子
公开(公告)号：US08309528B2
公开(公告)日：2012-11-13
申请号：US12299852
申请日：2007-05-09
申请人： Steven J. Feinmark , Richard B. Robinson
发明人： Steven J. Feinmark , Richard B. Robinson
IPC分类号： A61K48/00 , C07H21/02 , C07H21/04
CPC分类号： C07K14/705
摘要： The present invention relates to the discovery that two pore K+ channel (2PK) gene expression is increased in tumors and tumor cell lines, especially prostate tumor cells. The present invention encompasses methods for disease diagnosis, drug screening and the treatment of cancer.
摘要翻译：本发明涉及两个孔K +通道（2PK）基因表达在肿瘤和肿瘤细胞系，特别是前列腺肿瘤细胞中增加的发现。本发明包括疾病诊断，药物筛选和癌症治疗的方法。

29. 发明申请

US20070259051A1 Method of treating a condition associated with phosphorylation of TASK-1 有权
标题翻译：治疗与TASK-1磷酸化有关的病症的方法
公开(公告)号：US20070259051A1
公开(公告)日：2007-11-08
申请号：US11498343
申请日：2006-08-02
申请人： Steven J. Feinmark , Richard B. Robinson
发明人： Steven J. Feinmark , Richard B. Robinson
IPC分类号： A61K33/34 , A61K33/00 , A61K31/7076 , A61K31/277 , A61K31/195
CPC分类号： G01N33/502 , A61K31/195 , A61K31/202 , A61K31/277 , A61K31/41 , G01N33/5061
摘要： This invention provides methods and compositions for treating a condition associated with phosphorylation of TASK-1 in a subject comprising administering to the subject an amount of an agent effective to overcome the phosphorylation dependent loss of TASK-1 function so as to thereby treat the condition. In a specific embodiment of the invention the agent is a TREK-1 agonist.
摘要翻译：本发明提供用于治疗与受试者中TASK-1的磷酸化相关的病症的方法和组合物，其包括向受试者施用一定量的有效克服由TASK-1功能引起的磷酸化依赖性损失从而由此治疗该病症的药剂。在本发明的具体实施方案中，该药剂是TREK-1激动剂。

30. 发明申请

US20130040298A1 Two-pore channels as regulators of proliferation in cancer 审中-公开
标题翻译：双孔通道作为癌症增殖的调节剂
公开(公告)号：US20130040298A1
公开(公告)日：2013-02-14
申请号：US13646718
申请日：2012-10-07
申请人： Steven J. Feinmark , Richard B. Robinson
发明人： Steven J. Feinmark , Richard B. Robinson
IPC分类号： C12Q1/68 , C12Q1/04 , G01N33/574 , G01N33/566
CPC分类号： C07K14/705
摘要： The present invention relates to the discovery that two pore K+ channel (2PK) gene expression is increased in tumors and tumor cell lines, especially prostate tumor cells. The present invention encompasses methods for disease diagnosis, drug screening and the treatment of cancer.
摘要翻译：本发明涉及两个孔K +通道（2PK）基因表达在肿瘤和肿瘤细胞系，特别是前列腺肿瘤细胞中增加的发现。本发明包括疾病诊断，药物筛选和癌症治疗的方法。

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