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21. 发明申请

US20050066751A1 Motor driven sampling apparatus for material collection 失效
标题翻译：用于材料收集的电机驱动取样装置
公开(公告)号：US20050066751A1
公开(公告)日：2005-03-31
申请号：US10673287
申请日：2003-09-30
申请人： Joel Harris
发明人： Joel Harris
IPC分类号： G01N1/08
CPC分类号： G01N1/08
摘要： An apparatus to excise a sample of material and temporarily store sample has a hollow clamshell casing with a blended grip under which is a tubular sample sleeve extends downwards from the base of the grip. Within the casing an electric motor is housed which drives, via juxtaposed spur gears, the sample sleeve in a rotational manner. The end of the sample sleeve, distal from the clamshell casing, forms a cutting edge circumscribing a circular region. An ejection rod slides reciprocally within the sample sleeve between a stowed position and an expulsion position. When the ejection rod moves from the stowed position to the expulsion position it will extend past the cutting edge and expel any material sample contained within the sample sleeve. A user cuts a sample from a source material resting on a pliable substrate, using the cutting edge of the sample sleeve when the ejection rod is in the stowed position. A sample is cut when the cutting blade contacts the source material while gentle downward pressure is applied. The thumb activates the electric drive which rotates the cutting sleeve. Once the source material has been cut it is simultaneously extracted and lodged within the tubular sample sleeve. The extracted sample remains lodged in the hollow of the sample sleeve until the user extends the ejection rod through the sample sleeve to the expulsion position to eject the sample of source material. The automatic return of the eject rod is comprised of a compression spring that biases the ejection shaft which holds the ejection rod in the retracted and stowed positions.
摘要翻译：用于切除材料样品并临时储存样品的装置具有中空的蛤壳式壳体，其具有混合夹紧器，管状样品套筒从该把手的底部向下延伸。在壳体内容纳有电动马达，通过并置的正齿轮以旋转的方式驱动样品套筒。样品套筒的端部远离蛤壳式壳体形成一个围绕圆形区域的切割边缘。排出杆在收起位置和排出位置之间在样品套筒内往复滑动。当排出杆从收起位置移动到排出位置时，其将延伸超过切割边缘并排出包含在样品套筒内的任何材料样品。使用者在弹出杆处于收起位置时，使用样品套筒的切割边缘将样品从放置在柔韧基底上的源材料切下。当切割刀片接触源材料同时施加温和的向下压力时，切割样品。拇指启动旋转切割套筒的电动驱动器。一旦源材料被切割，它被同时提取并存放在管状样品套筒内。提取的样品保持在样品套筒的中空部分中，直到使用者将排出杆通过样品套筒延伸到排出位置以排出源材料样品。弹出杆的自动返回由压缩弹簧构成，该压缩弹簧将将排出杆保持在缩回和收起位置的弹出轴偏压。

22. 发明授权

US06317093B1 Satellite communication antenna pointing system 失效
标题翻译：卫星通信天线指向系统
公开(公告)号：US06317093B1
公开(公告)日：2001-11-13
申请号：US09635937
申请日：2000-08-10
申请人： Joel Harris
发明人： Joel Harris
IPC分类号： H01Q300
CPC分类号： H01Q19/19 , G01S3/38 , H01Q1/1257 , H01Q3/08 , H01Q19/132
摘要： An antenna pointing system automatically aligns an antenna with a geo-synchronous satellite using a Ku band signal, which has a relatively broad bandwidth, with sufficient accuracy for Ka band signal transmission, which has a relatively narrow bandwidth. Initially, the antenna is pointed at the selected satellite so as to receive the Ku band signal. The system obtains a series of signal strength readings over a predetermined azimuth (or elevation) region, such as plus/minus two degrees, from which a new peak location is selected. Signal strength data is then obtained over a predetermined elevation (or azimuth) region. Another signal peak location is selected based on the elevation data. Azimuth and elevation data are alternately collected for refining the peak of the Ku signal so as to optimize Ka signal transmission capability.
摘要翻译：天线指向系统使用具有相对宽的带宽的Ku波段信号自动对准天线与地球同步卫星，对于具有相对较窄带宽的Ka波段信号传输具有足够的精度。最初，天线指向所选择的卫星，以便接收Ku波段信号。该系统在预定的方位角（或高度）区域上获得一系列信号强度读数，例如正/负两度，从中选择新的峰值位置。然后在预定的高度（或方位））区域获得信号强度数据。基于高程数据选择另一个信号峰值位置。交替收集方位角和高程数据，以便优化Ku信号的峰值，从而优化Ka信号传输能力。

23. 发明授权

US09095503B2 System and method for biphasic transdermal iontophreotic delivery of therapeutic agents 有权
标题翻译：用于治疗剂的双相透皮离子电渗递送的系统和方法
公开(公告)号：US09095503B2
公开(公告)日：2015-08-04
申请号：US13430662
申请日：2012-03-26
申请人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
发明人： Mir Imran , Mir Hashim , Glen McLaughlin , Huma Arastu , Rekha Vaidyanathan , Joel Harris , Radhika Korupolu , Andrew Mangogna , Chang Ong , Sanjay Patel , Lu Wang , Timothy Williams
IPC分类号： A61N1/30 , A61K9/00 , A61N1/04 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/32
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.
摘要翻译：各种实施方案提供了用于治疗剂的双相离子电渗透皮递送的方法和系统。用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。组合件包括包含被动地扩散入皮肤的治疗剂的溶液。使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。在第二时段期间，使用具有吸引剂的特性的第二电流将试剂保持在组合中，使得药剂递送到皮肤中最小化。可以根据患者的输入要求递送剂量。实施方案可以用于递送由不希望的被动扩散引起不利影响的试剂。

24. 发明申请

US20120184894A1 Patches and Methods for the Transdermal Delivery of Agents to Treat Hair Loss 审中-公开
标题翻译：用于治疗脱发的药物的透皮递送的补片和方法
公开(公告)号：US20120184894A1
公开(公告)日：2012-07-19
申请号：US13342948
申请日：2012-01-03
申请人： Mir Imran , Phil Morgan , Mir Hashim , Joel Harris
发明人： Mir Imran , Phil Morgan , Mir Hashim , Joel Harris
IPC分类号： A61N1/30
CPC分类号： A61K8/0208 , A61K8/19 , A61K9/0009 , A61K9/0021 , A61K9/7046 , A61K33/26 , A61K33/42 , A61K2800/83 , A61Q7/00
摘要： Embodiments of the invention provide patches for the transdermal delivery of compositions to treat an individual suffering from hair loss. Many embodiments provide an iontophoretic patch for the transdermal delivery hair growth stimulating agents for the treatment of hair loss by stimulating the growth of new hair in areas of the scalp exhibiting hair loss. The patch comprises an electrode and a reservoir containing a composition comprising iron containing compound, such as a chelated iron compound for the delivery of the therapeutically effective amount of iron. The patch can be shaped to be placed and remain on the head. Various embodiments provide methods of using embodiments of the iontophoretic patch for delivering a hair growth stimulating agent such as a chelated iron compound, minoxidil and finasteride to the scalp and other areas exhibiting hair loss. Such methods can be used for re-growing hair, and/or preventing or slowing hair loss.
摘要翻译：本发明的实施方案提供了用于透皮递送组合物以治疗患有脱发的个体的贴剂。许多实施方案提供用于透皮递送毛发生长刺激剂的离子电渗贴剂，用于通过在头皮表现出脱发的区域中刺激新毛发的生长来治疗脱发。贴片包括电极和储存器，其含有包含含铁化合物的组合物，例如用于递送治疗有效量的铁的螯合铁化合物。该贴片的形状可被放置并保留在头部上。各种实施方案提供了使用离子电渗贴剂的实施方案将头发生长刺激剂如螯合铁化合物，米诺地尔和非那雄胺递送至头皮和其它出现脱发的区域的方法。这种方法可用于再生长毛发和/或预防或减缓脱发。

25. 发明申请

US20080076751A1 Azetidinone Derivatives and Methods of Use Thereof 失效
标题翻译：氮杂环丁酮衍生物及其使用方法
公开(公告)号：US20080076751A1
公开(公告)日：2008-03-27
申请号：US11854754
申请日：2007-09-13
申请人： Robert Aslanian , Chad Bennett , Duane Burnett , Tin-Yau Chan , Eugenia Kiselgof , Chad Knutson , Joel Harris , Brian McKittrick , Anandan Palani , Elizabeth Smith , Henry Vaccaro , Dong Xiao , Hyunjin Kim
发明人： Robert Aslanian , Chad Bennett , Duane Burnett , Tin-Yau Chan , Eugenia Kiselgof , Chad Knutson , Joel Harris , Brian McKittrick , Anandan Palani , Elizabeth Smith , Henry Vaccaro , Dong Xiao , Hyunjin Kim
IPC分类号： A61K31/397 , A61P25/04 , A61P3/00 , C07D471/10
CPC分类号： C07D471/10
摘要： The present invention relates to Azetidinone Derivatives, compositions comprising an Azetidinone Derivative and methods for treating or preventing a disorder of lipid metabolism, pain, diabetes, a vascular condition, demyelination or nonalcoholic fatty liver disease, comprising administering to a patient an effective amount of an Azetidinone Derivative.
摘要翻译：本发明涉及氮杂环丁酮衍生物，包含氮杂环丁酮衍生物的组合物和用于治疗或预防脂质代谢紊乱，疼痛，糖尿病，血管病症，脱髓鞘或非酒精性脂肪性肝病的方法，包括向患者施用有效量的氮杂环丁酮衍生物。

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