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21. 发明授权

US07591185B1 Pressure sensor configurations for implantable medical electrical leads 有权
标题翻译：用于植入式医疗电线的压力传感器配置
公开(公告)号：US07591185B1
公开(公告)日：2009-09-22
申请号：US12108212
申请日：2008-04-23
申请人： Kamal Deep Mothilal , Michael A. Schugt , David A. Ruben , Jonathan P. Roberts , Clark B. Norgaard , Lary R. Larson
发明人： Kamal Deep Mothilal , Michael A. Schugt , David A. Ruben , Jonathan P. Roberts , Clark B. Norgaard , Lary R. Larson
IPC分类号： G01L9/12 , A61N1/00
CPC分类号： A61N1/056 , A61B5/0215 , A61B2562/0247 , A61B2562/028 , A61B2562/182 , A61N1/0573
摘要： An implantable pressure sensor, which may be incorporated within an implantable medical electrical lead, includes an insulative sidewall, which contains a gap capacitor and an integrated circuit. The insulative sidewall of the pressure sensor includes a pressure sensitive diaphragm portion, and the gap capacitor includes a first electrode plate, which is attached to an interior surface of the diaphragm portion of the sidewall, and a second electrode plate, which is spaced apart from the first electrode plate and coupled to the integrated circuit, which is coupled, through the sidewall, to a supply contact and a ground contact. A conductive layer extends over one of the interior surface of the diaphragm portion of the sidewall and an exterior surface of the diaphragm portion; and the conductive layer is coupled to the ground contact to either shield or ground the first electrode plate.
摘要翻译：可植入的压力传感器，其可并入可植入医疗电引线内，包括绝缘侧壁，其包含间隙电容器和集成电路。压力传感器的绝缘侧壁包括压敏膜部分，并且间隙电容器包括附接到侧壁的隔膜部分的内表面的第一电极板和与侧壁隔膜部分隔开的第二电极板第一电极板并且耦合到集成电路，其通过侧壁耦合到电源触点和接地触点。导电层在侧壁的隔膜部分的内表面和隔膜部分的外表面之一上延伸; 并且所述导电层耦合到所述接地触头以屏蔽或接地所述第一电极板。

22. 发明授权

US06944488B2 Normalization method for a chronically implanted optical sensor 失效
标题翻译：长期植入的光学传感器的归一化方法
公开(公告)号：US06944488B2
公开(公告)日：2005-09-13
申请号：US10426496
申请日：2003-04-30
申请人： Jonathan P. Roberts
发明人： Jonathan P. Roberts
IPC分类号： A61B5/00
CPC分类号： A61B5/1495 , A61B5/14532 , A61B5/1459
摘要： A system and method are provided for accurately estimating blood oxygen saturation independent of tissue encapsulation of the optical sensor. The method includes determining a tissue overgrowth correction factor that accounts for the optical properties of the tissue that cause scattering of the emitted light to a light detector and the relative amplitudes of the emitted light wavelengths. A corrected time interval measured for infrared light is based on an infrared signal returned from fluid with no tissue overgrowth. A corrected time interval for red light is determined by subtracting a red light signal attributed to the presence of tissue overgrowth. The amount of red light signal attributed to the presence of tissue overgrowth is proportional to the total infrared signal less the nominal infrared signal. Oxygen saturation is estimated based on standard calibration factors and the ratio of the corrected infrared time interval and the corrected red time interval.
摘要翻译：提供了一种系统和方法，用于精确地估计血液氧饱和度，而与光学传感器的组织封装无关。所述方法包括确定考虑到所述组织的光学特性导致发射的光到达光检测器的散射和所发射的光波长的相对振幅的组织过度生长校正因子。对于红外光测量的校正时间间隔基于从没有组织过度生长的流体返回的红外信号。通过减去归因于组织过度生长的红色光信号来确定红光的校正时间间隔。归因于组织过度生长的红光信号的量与总红外信号成比例，较小的标称红外信号。氧饱和度是根据标准校准因子和校正的红外线时间间隔与校正的红色时间间隔的比率来估计的。

23. 发明授权

US07886608B2 Pressure sensor configurations for implantable medical electrical leads 有权
标题翻译：用于植入式医疗电线的压力传感器配置
公开(公告)号：US07886608B2
公开(公告)日：2011-02-15
申请号：US12544342
申请日：2009-08-20
申请人： Kamal Deep Mothilal , Michael A. Schugt , David A. Ruben , Jonathan P. Roberts , Clark B. Norgaard , Lary R. Larson
发明人： Kamal Deep Mothilal , Michael A. Schugt , David A. Ruben , Jonathan P. Roberts , Clark B. Norgaard , Lary R. Larson
IPC分类号： G01L9/12
CPC分类号： A61N1/056 , A61B5/0215 , A61B2562/0247 , A61B2562/028 , A61B2562/182 , A61N1/0573
摘要： An implantable pressure sensor, which may be incorporated within an implantable medical electrical lead, includes an insulative sidewall, which contains a gap capacitor and an integrated circuit. The insulative sidewall of the pressure sensor includes a pressure sensitive diaphragm portion, and the gap capacitor includes a first electrode plate, which is attached to an interior surface of the diaphragm portion of the sidewall, and a second electrode plate, which is spaced apart from the first electrode plate and coupled to the integrated circuit, which is coupled, through the sidewall, to a supply contact and a ground contact. A conductive layer extends over one of the interior surface of the diaphragm portion of the sidewall and an exterior surface of the diaphragm portion; and the conductive layer is coupled to the ground contact to either shield or ground the first electrode plate.
摘要翻译：可植入的压力传感器，其可并入可植入医疗电引线内，包括绝缘侧壁，其包含间隙电容器和集成电路。压力传感器的绝缘侧壁包括压敏膜部分，并且间隙电容器包括附接到侧壁的隔膜部分的内表面的第一电极板和与侧壁隔膜部分隔开的第二电极板第一电极板并且耦合到集成电路，其通过侧壁耦合到电源触点和接地触点。导电层在侧壁的隔膜部分的内表面和隔膜部分的外表面之一上延伸; 并且所述导电层耦合到所述接地触头以屏蔽或接地所述第一电极板。

24. 发明授权

US6163723A Circuit and method for implantable dual sensor medical electrical lead 失效
标题翻译：可植入双传感器医用电线的电路和方法
公开(公告)号：US6163723A
公开(公告)日：2000-12-19
申请号：US177540
申请日：1998-10-22
申请人： Jonathan P. Roberts , Glenn M. Roline , Brian B. Lee
发明人： Jonathan P. Roberts , Glenn M. Roline , Brian B. Lee
IPC分类号： A61N1/365
CPC分类号： A61N1/36585
摘要： An implantable dual transducer apparatus for use with an implantable medical device and control method are disclosed. The dual transducer assembly includes two physiologic sensors coupled to the medical device via a pair of lead conductors. Switching circuitry is controlled by the medical device to selectively activate and deactivate the two physiologic sensors by application of a supply voltage of an appropriate polarity. Each sensor of the dual transducer assembly is connected to the pair of lead conductors through a respective power switch. In response to the polarity of the supply voltage applied to the lead conductors, the power switches activate or deactivate their respective sensor in an alternating manner. Selective activation of one of the sensor while concurrently deactivating the other sensor of the dual transducer assembly provides for reduced power consumption and reliable communication of sensor data and other information transmitted over the pair of lead conductors. The power switches may be constructed using diodes, including discrete or substrate diodes, or transistors, such as n-channel and p-channel transistors. A wide variety of physiologic sensors may be incorporated into the dual transducer assembly.
摘要翻译：公开了一种用于可植入医疗装置和控制方法的可植入双传感器装置。双传感器组件包括经由一对引线导体耦合到医疗装置的两个生理传感器。切换电路由医疗设备控制，以通过施加适当极性的电源电压来选择性地激活和去激活两个生理传感器。双传感器组件的每个传感器通过相应的电源开关连接到一对引线导体。响应于施加到引线导体的电源电压的极性，功率开关以交替方式激活或去激活它们各自的传感器。在同时禁用双重传感器组件的另一个传感器的同时，选择性地激活传感器之一，可以降低传感器数据和通过一对引线导体传输的其他信息的功耗和可靠的通信。功率开关可以使用二极管构成，包括分立或衬底二极管，或晶体管，例如n沟道和p沟道晶体管。可以将多种生理传感器并入双重换能器组件中。

25. 发明授权

US07512431B2 Normalization method for a chronically implanted optical sensor 失效
标题翻译：长期植入的光学传感器的归一化方法
公开(公告)号：US07512431B2
公开(公告)日：2009-03-31
申请号：US11225591
申请日：2005-09-13
申请人： Jonathan P. Roberts
发明人： Jonathan P. Roberts
IPC分类号： A61B5/1455
CPC分类号： A61B5/1459
摘要： A system and method are provided for estimating blood oxygen saturation independent of optical sensor encapsulation due to placement in blood, where the blood includes a blood flow characteristic of: a relatively low, a stasis, a stagnant value. The method includes determining tissue overgrowth correction factor that includes optical properties of the tissue that cause scattering of the emitted light to a detector and relative amplitudes of the emitted light wavelengths. A corrected time interval measured for infrared light is based on an infrared signal and a corrected time interval for red light is determined by subtracting red light signal due to presence of tissue overgrowth. The red light signal due to tissue overgrowth is proportional to total infrared signal less nominal infrared signal. Oxygen saturation is estimated based on standard calibration factors and the ratio of the corrected infrared time interval and the corrected red time interval.
摘要翻译：提供了一种系统和方法，用于估计血液氧饱和度，而不考虑由于放置在血液中而导致的光学传感器封装，其中血液包括血流特征：血液相对较低，停滞，停滞的值。该方法包括确定组织过度生长校正因子，该组织过度生长校正因子包括导致发射的光到检测器的散射的组织的光学特性和发射的光波长的相对幅度。对于红外线测量的校正时间间隔基于红外信号，并且通过从存在组织过度生长减去红光信号来确定用于红光的校正时间间隔。由于组织过度生长引起的红灯信号与总红外信号较小的标称红外信号成比例。氧饱和度是根据标准校准因子和校正的红外线时间间隔与校正的红色时间间隔的比率来估计的。

26. 发明授权

US06650939B2 Universal interface for implantable medical device data management 有权
标题翻译：用于植入式医疗设备数据管理的通用接口
公开(公告)号：US06650939B2
公开(公告)日：2003-11-18
申请号：US09809914
申请日：2001-03-16
申请人： Robert T. Taepke, II , Jonathan P. Roberts , Tom D. Bennett , Robert C. Beck , Richard J. Shaw , D. Curtis Deno
发明人： Robert T. Taepke, II , Jonathan P. Roberts , Tom D. Bennett , Robert C. Beck , Richard J. Shaw , D. Curtis Deno
IPC分类号： A61N130
CPC分类号： A61N1/372 , A61B5/002 , A61B2560/045
摘要： Medical device data is transferred using a universal adaptor between an implanted medical device and hospital monitoring systems. The universal adaptor is an interface compatible with various built-in hospital monitoring network comprised of equipment from a variety of manufacturers. The universal adaptor includes a telemetry circuitry, a calibration system for atmospheric pressure and an analog interface. The calibration system relates to barometric correction and includes an external pressure reference system.
摘要翻译：医疗设备数据使用通用适配器在植入式医疗设备和医院监控系统之间传输。通用适配器是与来自各种制造商的设备组成的各种内置医院监控网络兼容的接口。通用适配器包括遥测电路，大气压校准系统和模拟接口。校准系统涉及气压校正，并包括外部压力参考系统。

27. 发明授权

US06292697B1 Testing sterile packaged components of an implantable medical device prior to chronic implantation 有权
标题翻译：在慢性植入之前测试可植入医疗器械的无菌包装组件
公开(公告)号：US06292697B1
公开(公告)日：2001-09-18
申请号：US09504596
申请日：2000-02-15
申请人： Jonathan P. Roberts
发明人： Jonathan P. Roberts
IPC分类号： A61N137
CPC分类号： A61N1/372 , A61N1/3706 , A61N2001/37294
摘要： Apparatus, systems and methods for coupling components of an implantable medical device that are contained within separate sterile packages together and testing operation thereof prior to chronic implantation are disclosed. In particular, testing of the integrity of the lead conductors and other electrical components coupled therewith and the testing and calibration of an implantable sensor, e.g., an implantable pressure sensor, coupled to a programmable, implantable hemodynamic monitor (IHM) or implantable pulse generator (IPG) while in respective sterile packages are disclosed. The lead and IPG/IHM sterile packages are provided with package connectors that couple the terminals of the IPG/IHM and lead to external package connector arrays. The package connector arrays are coupled together, and a programmer is employed to downlink telemetered commands to the IPG or IHM to test the sensor and/or lead conductors and uplink via telemetery the results to the programmer for display. When a lead borne pressure sensor is under test, the uplink telemetered pressure readings are compared to a reference pressure reading. A correction factor is determined if the uplink telemetered and reference pressure readings differ, and the correction factor is downlink telemetered from the programmer into memory of the IPG or IHM for use in adjusting the sensor pressure readings. The pressure test may be conducted both at atmospheric pressure and at elevated pressures correlated to typical systolic blood pressures, and the correction factor may be derived from all tests.
摘要翻译：公开了用于将包含在单独的无菌包装内的可植入医疗装置的组件耦合在一起并在慢性植入之前测试其操作的装置，系统和方法。特别地，测试引线导体和与其耦合的其它电气部件的完整性以及耦合到可编程可植入血液动力学监测器（IHM）或可植入脉冲发生器（I）的可植入传感器（例如植入式压力传感器）的测试和校准 IPG），同时公开了各自的无菌包装。引线和IPG / IHM无菌封装配有封装连接器，可连接IPG / IHM的端子并连接到外部封装连接器阵列。封装连接器阵列耦合在一起，并且使用编程器将遥测命令下行到IPG或IHM，以测试传感器和/或引线导体和上行链路，将结果通过遥测结果传送给编程器进行显示。当检测到铅负压传感器时，将上行链路测力压力读数与参考压力读数进行比较。如果上行链路遥测和参考压力读数不同，则确定校正因子，并且将校正因子从编程器下行传输到IPG或IHM的存储器中，以用于调整传感器压力读数。压力测试可以在大气压力和与典型的收缩压相关的升高的压力下进行，并且校正因子可以来自所有测试。

28. 发明授权

US06171252B2 Pressure sensor with increased sensitivity for use with an implantable medical device 失效
标题翻译：具有增加灵敏度的压力传感器，用于可植入医疗设备
公开(公告)号：US06171252B2
公开(公告)日：2001-01-09
申请号：US09301886
申请日：1999-04-29
申请人： Jonathan P. Roberts
发明人： Jonathan P. Roberts
IPC分类号： A61B502
CPC分类号： A61N1/36564 , A61B5/0215 , A61B5/7242
摘要： An apparatus and method for obtaining pressure data using a body implantable pressure sensor includes a measurement capacitor which is responsive to pressure changes of a body fluid. Non-constant, multiple current source charging of the measurement capacitor provides for a significant increase in sensitivity to conditions of pressure of a body fluid. Pressure data is obtained by charging the measurement capacitor at a first charge rate during a first charge period of an integration cycle and, during a second charge period of the integration cycle, charging the measurement capacitor at a second charge rate. The first charge rate is preferably greater than the second charge rate. The duration of the first and second charge periods may be varied. A signal indicative of a pressure change of a body fluid imparted to the measurement capacitor is produced by the pressure sensor. The signal may be a signal indicative of a change in a time of integration. The signal, indicative of a time of integration, has a sensitivity to pressure changes which is greater than a mechanical capacitive sensitivity of the measurement capacitor to such pressure changes. The signal may alternatively be a signal indicative of a change in capacitance of the measurement capacitor, such as a voltage signal, or a signal having a duty cycle indicative of the pressure change. The pressure sensor may be implemented in a pacemaker, a pacemaker/cardioverter/defibrillator (PCD) or a hemodynamic monitor.
摘要翻译：使用身体植入式压力传感器获得压力数据的装置和方法包括响应体液压力变化的测量电容器。测量电容器的非恒定的多电流源充电提供对体液压力条件的敏感性的显着增加。通过在积分周期的第一充电时段期间以第一充电速率对测量电容器充电，并且在积分周期的第二充电周期期间以第二充电速率对测量电容器充电来获得压力数据。第一充电速率优选地大于第二充电速率。可以改变第一和第二充电时段的持续时间。通过压力传感器产生表示赋予测量电容器的体液的压力变化的信号。该信号可以是表示积分时间变化的信号。表示积分时间的信号对压力变化具有敏感性，其大于测量电容器对这种压力变化的机械电容灵敏度。该信号可以替代地指示测量电容器的电容变化的信号，例如电压信号，或具有指示压力变化的占空比的信号。压力传感器可以在起搏器，起搏器/心律转复器/除颤器（PCD）或血液动力学监测器中实现。

29. 发明授权

US6144866A Multiple sensor assembly for medical electric lead 有权
标题翻译：多用于医疗电源的传感器组件
公开(公告)号：US6144866A
公开(公告)日：2000-11-07
申请号：US182970
申请日：1998-10-30
申请人： Keith A. Miesel , Jonathan P. Roberts , John C. Olson , Roger LaFond , Brenda Chatelle , Eric M. Stetz
发明人： Keith A. Miesel , Jonathan P. Roberts , John C. Olson , Roger LaFond , Brenda Chatelle , Eric M. Stetz
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/03 , A61N1/05 , A61N1/365
CPC分类号： A61B5/6864 , A61B5/02154 , A61B5/031 , A61B5/14539 , A61B5/1459 , A61N1/056 , A61N1/36585
摘要： An implantable sensor assembly for use with an implantable medical device are disclosed. The sensor assembly preferably includes two or more physiologic sensors coupled to the medical device via a pair of lead conductors, or alternatively an oxygen sensor having certain features. The oxygen sensor permits more accurate and reliable measurement of oxygen saturation in blood masses flowing within the human body.
摘要翻译：公开了一种用于可植入医疗装置的植入式传感器组件。传感器组件优选地包括经由一对引线导体或具有某些特征的氧传感器耦合到医疗装置的两个或更多个生理传感器。氧气传感器可以更精确和可靠地测量人体内血液中的血氧饱和度。

30. 发明授权

US6134459A Light focusing apparatus for medical electrical lead oxygen sensor 有权
标题翻译：医用电导氧传感器用聚焦装置
公开(公告)号：US6134459A
公开(公告)日：2000-10-17
申请号：US182863
申请日：1998-10-30
申请人： Jonathan P. Roberts , Keith A. Miesel
发明人： Jonathan P. Roberts , Keith A. Miesel
IPC分类号： A61B5/00 , A61B5/03 , A61N1/365
CPC分类号： A61B5/6864 , A61B5/031 , A61B5/14539 , A61B5/1459 , A61N1/36557
摘要： An implantable sensor assembly for use with an implantable medical device are disclosed. The sensor assembly preferably includes two or more physiologic sensors coupled to the medical device via a pair of lead conductors, or alternatively an oxygen sensor having certain features. The oxygen sensor permits more accurate and reliable measurement of oxygen saturation in blood masses flowing within the human body.
摘要翻译：公开了一种用于可植入医疗装置的植入式传感器组件。传感器组件优选地包括经由一对引线导体或具有某些特征的氧传感器耦合到医疗装置的两个或更多个生理传感器。氧气传感器可以更精确和可靠地测量人体内血液中的血氧饱和度。

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