会员体验
专利管家(专利管理)
工作空间(专利管理)
风险监控(情报监控)
数据分析(专利分析)
侵权分析(诉讼无效)
联系我们
交流群
官方交流:
QQ群: 891211   
微信请扫码    >>>
现在联系顾问~
热词
    • 25. 发明授权
    • Hemoglobin-encapsulated liposome
    • 血红蛋白包封的脂质体
    • US5674528A
    • 1997-10-07
    • US490509
    • 1995-06-14
    • Yoshitaka OgataTakeshi Okamoto
    • Yoshitaka OgataTakeshi Okamoto
    • A61K9/127A61K38/42
    • A61K38/42A61K9/127
    • A hemoglobin-encapsulated liposome is provided. The hemoglobin-encapsulated liposome comprises a liposome and an enzymatically active hemoglobin solution encapsulated therein. The hemoglobin solution is supplemented with glucose; and at least one member selected from the group consisting of adenine, inosine, and adenosine triphosphate; and optionally, further with phosphoenol pyruvate. The thus supplemented hemoglobin solution encapsulated in the liposome exhibits an improved resistance to conversion to methemoglobin as well as an adequately regulated affinity for oxygen. Therefore, the hemoglobin-encapsulated liposome of the present invention is useful as a blood substitute.
    • 提供了血红蛋白包封的脂质体。 包含血红蛋白的脂质体包含脂质体和包封在其中的酶活性血红蛋白溶液。 血红蛋白溶液补充葡萄糖; 和选自腺嘌呤,肌苷和三磷酸腺苷中的至少一种; 和任选地,进一步与磷酸烯醇丙酮酸。 包裹在脂质体中的如此补充的血红蛋白溶液表现出对转化成高铁血红蛋白的改善的抗性以及对氧的适当调节的亲和力。 因此,本发明的血红蛋白包封的脂质体可用作血液代用品。