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21. 发明授权

US07235667B2 N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation 有权
标题翻译： N-苯基芳基磺酰胺化合物，包含该化合物作为活性成分的药物组合物，该化合物的合成中间体及其制备方法
公开(公告)号：US07235667B2
公开(公告)日：2007-06-26
申请号：US10471673
申请日：2002-03-11
申请人： Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
发明人： Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
IPC分类号： C07D277/04 , A61K31/425
CPC分类号： C07D213/70 , C07D277/36 , C07D307/64 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
摘要翻译：式（I）的N-苯基芳基磺酰胺化合物（R 1）是COOH等; R 2是氢，甲基等; R 3 O >和R 4是甲基和甲基等的组合; R 5是异丙基等; Ar是噻唑基，吡啶基，5-甲基-2-呋喃基任选被甲基取代; n为0或1），化合物的合成中间体及其制备方法。式（I）化合物与前列腺素E 2受体结合，特别是EP 1亚型受体，并拮抗它。蛋白质结合的影响较小，因此具有令人满意的体内活性。因此，认为可用作止痛剂，解热剂，治疗尿频（尿频）和/或下尿路疾病综合征或抗肿瘤药物的药剂。

22. 发明申请

US20060030713A1 N-phenylarylsulfonamide compound, pharmaceutical composition comprising the compound as active ingredient, synthetic intermediate for the compound and process for its preparation 失效
标题翻译： N-苯基芳基磺酰胺化合物，包含该化合物作为活性成分的药物组合物，该化合物的合成中间体及其制备方法
公开(公告)号：US20060030713A1
公开(公告)日：2006-02-09
申请号：US11239406
申请日：2005-09-30
申请人： Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
发明人： Atsushi Naganawa , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
IPC分类号： A61K31/44 , C07C309/28 , C07D277/36 , C07D285/18
CPC分类号： C07D213/70 , C07D277/36 , C07D307/64 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.
摘要翻译：式（I）的N-苯基芳基磺酰胺化合物（R 1）是COOH等; R 2是氢，甲基等; R 3 O >和R 4是甲基和甲基等的组合; R 5是异丙基等; Ar是噻唑基，吡啶基，5-甲基-2-呋喃基任选被甲基取代; n为0或1），化合物的合成中间体及其制备方法。式（I）化合物与前列腺素E 2受体结合，特别是EP 1亚型受体，并拮抗它。蛋白质结合的影响较小，因此具有令人满意的体内活性。因此，认为可用作止痛剂，解热剂，治疗尿频（尿频）和/或下尿路疾病综合征或抗肿瘤药物的药剂。

23. 发明申请

US20050207263A1 Magnetic non-volatile memory element 有权
标题翻译：磁性非易失性存储元件
公开(公告)号：US20050207263A1
公开(公告)日：2005-09-22
申请号：US10519895
申请日：2003-07-02
申请人： Katsumi Okayama , Kaoru Kobayashi , Makoto Motoyoshi
发明人： Katsumi Okayama , Kaoru Kobayashi , Makoto Motoyoshi
IPC分类号： G11C11/15 , G11C8/02 , G11C11/16 , H01L21/76 , H01L21/8246 , H01L27/105 , H01L27/22 , H01L43/02 , H01L43/08
CPC分类号： G11C11/16 , H01L27/228 , Y10S977/935
摘要： A non-volatile magnetic memory device is proposed, which provides sufficient magnetic shielding performance for external magnetic fields. A first magnetic shield layer 60a and a second magnetic shield layer 60b, both made of a soft magnetic metal, are formed respectively on the bottom surface of the transistor section 20, which is the mounting side of the MRAM device 10, and on the top surface of the bit line 50, which is opposite to the bottom surface of the mounting side of the MRAM device 10. On the second magnetic shield layer 60a, a passivation film 70 is formed. The magnetic flux penetrated from the external magnetic field, is suppressed below the inversion strength of the MRAM device 10, thereby improving reliability. Moreover, by using soft magnetic metal as the magnetic shield layers 60a, 60b, the magnetic shield layers can be formed by the sputtering technique, particularly composing elements can be partly shared as elements of the targets to be used for forming various layers composing the MRAM device 10 by the sputtering technique, thereby enabling to form various layers of the MRAM device 10 in a single sputtering chamber efficiently.
摘要翻译：提出了一种非易失性磁存储器件，为外部磁场提供了足够的磁屏蔽性能。分别在作为MRAM器件10的安装侧的晶体管部分20的底表面上分别形成由软磁性金属制成的第一磁屏蔽层60a和第二磁屏蔽层60b，并且在位线50的与MRAM装置10的安装侧的底面相反的顶面。在第二磁屏蔽层60a上形成钝化膜70。从外部磁场穿透的磁通被抑制在MRAM装置10的反转强度以下，从而提高可靠性。此外，通过使用软磁性金属作为磁屏蔽层60a，60b，可以通过溅射技术形成磁屏蔽层，特别地，组成元件可以部分地作为用于形成构成各种层的靶的元素 MRAM器件10通过溅射技术，从而能够有效地在单个溅射室中形成MRAM器件10的各个层。

24. 发明申请

US20050124577A1 8-Azaprostaglandin derivative compounds and drugs containing the compounds as the active ingredient 失效
标题翻译： 8-Azaprostaglandin衍生物化合物和含有这些化合物作为活性成分的药物
公开(公告)号：US20050124577A1
公开(公告)日：2005-06-09
申请号：US10506536
申请日：2003-03-04
申请人： Kousuke Tani , Kaoru Kobayashi , Toru Maruyama , Tohru Kambe , Mikio Ogawa , Tsutomu Shiroya
发明人： Kousuke Tani , Kaoru Kobayashi , Toru Maruyama , Tohru Kambe , Mikio Ogawa , Tsutomu Shiroya
IPC分类号： C07D207/27 , A61P1/00 , A61P1/16 , A61P7/00 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P15/06 , A61P15/10 , A61P19/02 , A61P19/08 , A61P19/10 , A61P25/00 , A61P27/02 , A61P29/00 , A61P35/00 , A61P37/02 , A61P43/00 , C07D207/26 , C07D263/24 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06 , C07D417/12 , A61K31/724 , A61K31/557 , C07D413/02 , C07D417/02
CPC分类号： C07D413/06 , C07D207/26 , C07D263/24 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/06 , C07D417/12
摘要： An 8-azaprostaglandin represented by formula (I) (wherein all symbols have the same meanings as described in the specification), a pharmaceutically acceptable salt thereof or a cyclodextrin clathrate thereof. Since the compound represented by formula (I) binds to EP2 subtype among PGE receptor strongly, it is useful for preventive and/or treatment for immune diseases, allergic diseases, neuronal cell death, dysmenorrhea, premature birth, abortion, baldness, retinal neuropathy such as glaucoma, erectile dysfunction, arthritis, pulmonary injury, pulmonary fibrosis, pulmonary emphysema, bronchitis, chronic obstructive pulmonary disease, hepatic injury, acute hepatitis, liver cirrhosis, shock, nephritis, renal failure, circulatory diseases, systemic inflammatory response syndrome, sepsis, hemophagocytosis syndrome, macrophage activation syndrome, still disease, Kawasaki Disease, burn, systemic granuloma, ulcerative colitis, Crohn disease, hypercytokinemia at dialysis, multiple organ failure, or bone diseases etc.
摘要翻译：由式（I）（其中所有符号具有与说明书中所述相同的含义）表示的8-氮杂前列腺素，其药学上可接受的盐或其环糊精包合物。由于式（I）表示的化合物强烈地与PGE受体中的EP2亚型结合，因此可用于免疫疾病，过敏性疾病，神经元细胞死亡，痛经，早产，流产，秃发，视网膜神经病变等的预防和/或治疗青光眼，勃起功能障碍，关节炎，肺损伤，肺纤维化，肺气肿，支气管炎，慢性阻塞性肺病，肝损伤，急性肝炎，肝硬化，休克，肾炎，肾衰竭，循环系统疾病，全身性炎症反应综合征，败血症，血细胞增多综合征，巨噬细胞活化综合征，静止病，川崎病，烧伤，全身肉芽肿，溃疡性结肠炎，克罗恩病，透析中的高细胞因子血症，多器官功能衰竭或骨骼疾病等。

25. 发明授权

US06618917B2 Complex machining tools 失效
标题翻译：复杂加工工具
公开(公告)号：US06618917B2
公开(公告)日：2003-09-16
申请号：US09939745
申请日：2001-08-28
申请人： Hitoshi Sugiura , Yoshinobu Yasuda , Masami Funamoto , Kaoru Kobayashi
发明人： Hitoshi Sugiura , Yoshinobu Yasuda , Masami Funamoto , Kaoru Kobayashi
IPC分类号： B23Q3900
CPC分类号： B23Q39/024 , B23B3/162 , B23F9/08 , B23P23/02 , B23Q2039/008 , Y10T29/5114 , Y10T82/10 , Y10T82/25 , Y10T82/2508 , Y10T82/2524 , Y10T409/10159 , Y10T409/101749
摘要： A headstock 10 having a chuck 12 and a tailstock 20 having a shaft 21 are mounted on a bed 1 and can move with respect to each other in the direction of the Z-axis, A carriage 50 is slidably mounted on the bad 1 and can move in the Z-axis direction with respect to the rotational axis of a spindle 11. A turning device (lathe tool) 30 is provided to perform a turning operation on a workpiece and a gear cutting device 40 is provided to perform a gear cutting on the workpiece. The turning device 30 and the gear cutting device are preferably slidably mounted on the carriage 50 in a side-by-side relationship. The turning device 30 and the gear cutting device 40 may have respective traverse slide bases 31 and 41. The traverse slide bases 31 and 41 are mounted on the carriage 50 and can move independently in the direction of the X-axis perpendicular to the axis of the spindle 11, i.e. in a traverse sliding direction.
摘要翻译：具有卡盘12和具有轴21的尾架20的主轴箱10安装在床1上，并且可以在Z轴方向上相对于彼此移动，滑架50可滑动地安装在坏1上，并且可以相对于主轴11的旋转轴线在Z轴方向上移动。设置有转动装置（车刀）30，以对工件进行转动操作，并且设置齿轮切割装置40以进行齿轮切割工件。转动装置30和齿轮切割装置优选地并排地可滑动地安装在滑架50上。转动装置30和齿轮切割装置40可以具有各自的横动滑动基座31和41.横动滑动基座31和41安装在滑架50上，并且可以沿与X轴垂直的轴线的X轴方向独立地移动主轴11，即横移滑动方向。

26. 发明授权

US6096904A Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives 失效
标题翻译：多羟基，二烯基内酯衍生物的合成技术和中间体
公开(公告)号：US6096904A
公开(公告)日：2000-08-01
申请号：US121551
申请日：1998-07-23
申请人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi , Thomas J. Beauchamp
发明人： Amos B. Smith, III , Yuping Qiu , Michael Kaufman , Hirokazu Arimoto , David R. Jones , Kaoru Kobayashi , Thomas J. Beauchamp
IPC分类号： C07D263/22 , A61K31/047 , A61K31/12 , A61K31/27 , A61K31/336 , A61K31/351 , A61K31/366 , A61K31/422 , A61K31/427 , A61K31/5355 , A61K31/7028 , A61P35/00 , A61P37/06 , C07C29/38 , C07C33/02 , C07C33/42 , C07C239/06 , C07C271/12 , C07D303/16 , C07D309/10 , C07D309/30 , C07D309/32 , C07D319/06 , C07D413/06 , C07D413/12 , C07D417/06 , C07F7/18 , C07F9/54 , C07H23/00 , C07F9/02
CPC分类号： C07C239/06 , C07D263/22 , C07D309/30 , C07D319/06 , C07D407/06 , C07D413/06 , C07D413/12 , C07F7/1856 , C07F7/1892 , Y02P20/55
摘要： Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.
摘要翻译：提供了含内酯化合物如脱氧胆甾醇的合成方法，以及模拟其化学和/或生物活性的化合物，以及可用于其制备的方法和中间体。

27. 发明授权

US5869626A Metal-encapsulated fullerene compound and a method of synthesizing such compound 失效
标题翻译：金属包封的富勒烯化合物和合成这种化合物的方法
公开(公告)号：US5869626A
公开(公告)日：1999-02-09
申请号：US606941
申请日：1996-02-26
申请人： Kazunori Yamamoto , Hideyuki Funasaka , Takeshi Takahashi , Takeshi Akasaka , Tatsuhisa Kato , Shigeru Nagase , Kaoru Kobayashi
发明人： Kazunori Yamamoto , Hideyuki Funasaka , Takeshi Takahashi , Takeshi Akasaka , Tatsuhisa Kato , Shigeru Nagase , Kaoru Kobayashi
IPC分类号： C07F7/02 , C01B31/00 , C01F1/00 , C07F5/00 , C07F7/08 , C07F7/22 , C07F7/30 , C07F19/00
CPC分类号： C07F7/0807 , C07F7/082 , Y10S977/734
摘要： A novel metal-encapsulated fullerene compound wherein a side chain is introduced in a metal-encapsulated fullerene is provided.A metal-encapsulated fullerene compound represented by the following structural formula (1) is synthesized by causing a disilirane derivative or digermirane derivative having the following structural formula (2) to react with a metal-encapsulation fullerene so as to add functional groups to the fullerene. ##STR1## Herein, M is an encapsulated metal atom, m is an integer from 1 to 3, n is an even number from 28 to 200, and R is a t-butyl group or an aromatic group having alkyl groups in the 2,6-positions, such as mesityl, 2,6-diethylphenyl or 2,6-dimethylphenyl groups.
摘要翻译：提供了一种新型金属包封的富勒烯化合物，其中侧链引入金属包封的富勒烯中。通过使具有下列结构式（2）的二异硅烷衍生物或二氢呋喃衍生物与金属包覆的富勒烯反应以便向富勒烯添加官能团来合成由以下结构式（1）表示的金属包封的富勒烯化合物。（1）l原子，m为1〜3的整数，n为28〜200的偶数，R为叔丁基或在2,6-位具有烷基的芳香族基，如三甲基甲硅烷基，2,6-二乙基苯基或2,6-二甲基苯基。

28. 发明授权

US5771333A Video signal emphasis and deemphasis method and apparatus 失效
标题翻译：视频信号强调和去加重方法和设备
公开(公告)号：US5771333A
公开(公告)日：1998-06-23
申请号：US705004
申请日：1996-08-29
申请人： Ryo Hirayama , Kaoru Kobayashi
发明人： Ryo Hirayama , Kaoru Kobayashi
IPC分类号： H04N5/783 , H04N5/923 , H04N5/937 , H04N9/793 , H04N9/81
CPC分类号： H04N9/7936 , H04N5/923 , H04N5/937 , H04N9/81 , H04N5/783
摘要： An input video signal is applied to a transmission line first through a time direction emphasizer for emphasizing the levels of time direction high frequency components of the video signal, relative to the levels of low frequency components thereof; secondary through a vertical direction emphasizer; and thirdly through a horizontal direction emphasizer. Further, the received video signal is outputted as an output video signal from the transmission line first through a horizontal direction deemphasizer for deemphasizing the levels of horizontal direction high frequency components of the video signal, relative to the levels of low frequency components thereof; secondary through a vertical direction deemphasizer; and thirdly through a time direction deemphasizer. The emphasis and deemphasis method enables the dynamic range of the transmission line to be utilized effectively, while preventing erroneous operation on the reception side.
摘要翻译：输入视频信号首先通过时间方向增强器施加到传输线，用于相对于其低频分量的电平强调视频信号的时间方向高频分量的电平; 通过垂直方向强调器辅助; 第三次通过水平方向加强器。此外，接收的视频信号作为来自传输线的输出视频信号首先通过水平方向去加噪器输出，用于相对于其低频分量的电平去强调视频信号的水平方向高频分量的电平; 次要通过垂直方向去加重; 第三，通过时间方向去强调。强调和去加重方法能够有效地利用传输线的动态范围，同时防止接收侧的错误操作。

29. 发明授权

US5759819A Process for producing human serum albumin 失效
标题翻译：生产人血清白蛋白的方法
公开(公告)号：US5759819A
公开(公告)日：1998-06-02
申请号：US745184
申请日：1996-11-07
申请人： Kaoru Kobayashi , Kenji Tomomitsu , Shinobu Kuwae , Tomoshi Ohya , Toyoo Ohda
发明人： Kaoru Kobayashi , Kenji Tomomitsu , Shinobu Kuwae , Tomoshi Ohya , Toyoo Ohda
IPC分类号： C07K14/765 , C12N15/14 , C12N15/81 , C12P21/02 , C12N1/14 , C12P21/00
CPC分类号： C12N15/81 , C07K14/765 , Y10S435/911 , Y10S435/938 , Y10S435/942
摘要： A process for producing recombinant human serum albumin (HSA) which comprises culturing an HSA producing host prepared by gene manipulation techniques at a temperature of from 21.degree. to 29.degree. C. Culturing the HSA producing host under such a specified temperature condition makes it possible to increase productivity of HSA production, improve the growth yield of an HSA producing host, and reduce the degree of coloring in the HSA preparation.
摘要翻译：一种重组人血清白蛋白（HSA）的制备方法，其包括在21〜29℃的温度下培养通过基因操作技术制备的HSA生成宿主体。在规定的温度条件下培养产生HSA的宿主，提高HSA生产的生产力，提高HSA生产主体的生长产量，并降低HSA制剂中的着色程度。

30. 发明授权

US5631145A Process for producing human serum albumin 失效
标题翻译：生产人血清白蛋白的方法
公开(公告)号：US5631145A
公开(公告)日：1997-05-20
申请号：US348172
申请日：1994-11-28
申请人： Kaoru Kobayashi , Kenji Tomomitsu , Shinobu Kuwae , Tomoshi Ohya , Toyoo Ohda
发明人： Kaoru Kobayashi , Kenji Tomomitsu , Shinobu Kuwae , Tomoshi Ohya , Toyoo Ohda
IPC分类号： C07K14/765 , C12N15/14 , C12N15/81 , C12P21/00 , C12N1/14 , C12P21/02
CPC分类号： C12N15/81 , C07K14/765 , Y10S435/911 , Y10S435/938 , Y10S435/942
摘要： A process for producing recombinant human serum albumin (HSA) which comprises culturing an HSA producing host prepared by gene manipulation techniques at a temperature of from 21.degree. to 29.degree. C. Culturing the HSA producing host under such a specified temperature condition makes it possible to increase productivity of HSA production, improve the growth yield of an HSA producing host, and reduce the degree of coloring in the HSA preparation.
摘要翻译：一种重组人血清白蛋白（HSA）的制备方法，其包括在21〜29℃的温度下培养通过基因操作技术制备的HSA生成宿主体。在规定的温度条件下培养产生HSA的宿主，提高HSA生产的生产力，提高HSA生产主体的生长产量，并降低HSA制剂中的着色程度。

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