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21. 发明授权

US08703130B2 Bispecific anti-VEGF/anti-ANG-2 antibodies 有权
标题翻译：双特异性抗VEGF /抗ANG-2抗体
公开(公告)号：US08703130B2
公开(公告)日：2014-04-22
申请号：US13570333
申请日：2012-08-09
申请人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
发明人： Monika Baehner , Ulrich Brinkmann , Guy Georges , Remko Albert Griep , Sabine Imhof-Jung , Anita Kavlie , Hubert Kettenberger , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer , Werner Scheuer , Stefan Seeber , Markus Thomas
IPC分类号： A61K39/395
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。

22. 发明申请

US20130060011A1 FC-FREE ANTIBODIES COMPRISING TWO FAB FRAGMENTS AND METHODS OF USE 审中-公开
标题翻译：包含两个FAB片段的FC-FREE抗体及其使用方法
公开(公告)号：US20130060011A1
公开(公告)日：2013-03-07
申请号：US13591010
申请日：2012-08-21
申请人： Peter Bruenker , Christiane Jaeger , Christian Klein , Wolfgang Schaefer , Pablo Umana
发明人： Peter Bruenker , Christiane Jaeger , Christian Klein , Wolfgang Schaefer , Pablo Umana
IPC分类号： C07K16/46 , C12N1/19 , C12N1/00 , C12N1/15 , C12P21/00 , C12N5/10
CPC分类号： C07K16/468 , C07K2317/55 , C07K2317/66
摘要： The present invention relates to bispecific antibodies comprising at least two fab fragments, wherein the first Fab fragment comprises at least one antigen binding site specific for a first antigen; and the second Fab fragment comprises at least one antigen binding site specific for a second antigen, wherein either the variable regions or the constant regions of the second Fab heavy and light chain are exchanged; and wherein the bispecific antibody is devoid of a Fc domain; methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及包含至少两个fab片段的双特异性抗体，其中第一Fab片段包含至少一个对第一抗原特异的抗原结合位点; 并且所述第二Fab片段包含至少一个针对第二抗原特异性的抗原结合位点，其中所述第二Fab重链和轻链的可变区或恒定区被交换; 并且其中所述双特异性抗体缺乏Fc结构域; 其制备方法，含有所述抗体的药物组合物及其用途。

23. 发明申请

US20130058937A1 Bispecific antigen binding molecules 审中-公开
标题翻译：双特异性抗原结合分子
公开(公告)号：US20130058937A1
公开(公告)日：2013-03-07
申请号：US13591028
申请日：2012-08-21
申请人： Johannes Auer , Peter Bruenker , Tanja Fauti , Christiane Jaeger , Christian Klein , Wolfgang Schaefer , Claudio Sustmann , Pablo Umana
发明人： Johannes Auer , Peter Bruenker , Tanja Fauti , Christiane Jaeger , Christian Klein , Wolfgang Schaefer , Claudio Sustmann , Pablo Umana
IPC分类号： A61K39/395 , C12N15/63 , C12N5/10 , A61P35/00 , C12N1/21 , C12P21/02 , C07K16/46 , C12N15/13 , C12N1/19
CPC分类号： C07K16/2809 , C07K16/3053 , C07K16/468 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/626 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/92 , C07K2319/00
摘要： The present invention generally relates to novel bispecific antigen binding molecules. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
摘要翻译：本发明一般涉及新的双特异性抗原结合分子。此外，本发明涉及编码这种双特异性抗原结合分子的多核苷酸，以及包含这种多核苷酸的载体和宿主细胞。本发明还涉及用于产生本发明的双特异性抗原结合分子的方法以及在治疗疾病中使用这些双特异性抗原结合分子的方法。

24. 发明授权

US08242247B2 Bivalent, bispecific antibodies 有权
公开(公告)号：US08242247B2
公开(公告)日：2012-08-14
申请号：US12332514
申请日：2008-12-11
申请人： Christian Klein , Wolfgang Schaefer
发明人： Christian Klein , Wolfgang Schaefer
IPC分类号： C12P21/08 , A61K39/00
CPC分类号： C07K16/468 , C07K16/22 , C07K16/2863 , C07K2317/21 , C07K2317/31 , C07K2319/00
摘要： The present invention relates to novel domain exchanged, bivalent, bispecific antibodies, their manufacture and use.

25. 发明申请

US20120149879A1 BISPECIFIC ANTI-EGFR/ANTI-IGF-1R ANTIBODIES 审中-公开
标题翻译： BISPECIFIC抗EGFR /抗IGF-1R抗体
公开(公告)号：US20120149879A1
公开(公告)日：2012-06-14
申请号：US13330724
申请日：2011-12-20
申请人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Christian Gerdes , Eike Hoffmann , Christian Klein , Klaus-Peter Kuenkele , Wolfgang Schaefer , Jan Olaf Stracke , Pablo Umana
IPC分类号： C07K16/46
CPC分类号： C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/52 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/624 , C07K2317/72 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： The present invention relates to bispecific antibodies against EGFR and against IGF-1R, methods for their production, pharmaceutical compositions containing said antibodies, and methods of treatment using the antibodies.
摘要翻译：本发明涉及针对EGFR和针对IGF-1R的双特异性抗体，其制备方法，含有所述抗体的药物组合物和使用该抗体的治疗方法。

26. 发明申请

US20110118377A1 RADIATION-CURABLE PRINTING INK OR PRINTING VARNISH 有权
标题翻译：可辐射印刷油墨或印刷版
公开(公告)号：US20110118377A1
公开(公告)日：2011-05-19
申请号：US12992395
申请日：2009-05-13
申请人： Martin Hauck , Wolfgang Schaefer , Roland Kuenzel , Klaus Meyer , Norbert Kinzel
发明人： Martin Hauck , Wolfgang Schaefer , Roland Kuenzel , Klaus Meyer , Norbert Kinzel
IPC分类号： C09D11/10
CPC分类号： C09D11/033 , B29C45/14688 , B29C2045/14704 , C08J7/047 , C08J2469/00 , C08L33/00 , C09D11/101 , C09D11/102 , C09D169/00 , Y10T428/24942 , Y10T428/31507 , C08L2666/04
摘要： The invention relates to a printing ink or printing varnish containing non-radiation-curable, preferably aromatic polycarbonate, in particular as a binder and adhesive component. According to the invention, the polycarbonate is provided with radiation-curable monomers, in particular is dissolved therein.
摘要翻译：本发明涉及包含不可辐射固化的，优选芳族聚碳酸酯，特别是作为粘合剂和粘合剂组分的印刷油墨或印刷清漆。根据本发明，聚碳酸酯被提供有可辐射固化的单体，特别是溶解在其中。

27. 发明申请

US20100316645A1 Bispecific Antigen Binding Proteins 有权
标题翻译：双特异性抗原结合蛋白
公开(公告)号：US20100316645A1
公开(公告)日：2010-12-16
申请号：US12780971
申请日：2010-05-17
申请人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
发明人： Sabine Imhof-Jung , Christian Klein , Joerg Thomas Regula , Wolfgang Schaefer , Juergen Michael Schanzer
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , C12P21/00 , C12N5/07
CPC分类号： C07K16/22 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： The present invention relates to bispecific antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及双特异性抗原结合蛋白，其制备方法，含有所述抗体的药物组合物及其用途。

28. 发明授权

US07655651B2 Amide derivatives of 3-phenyl-dihydropyrimido[4,5-d]pyrimidinones, their manufacture and use as pharmaceutical agents 失效
标题翻译： 3-苯基 - 二氢嘧啶并[4,5-d]嘧啶酮的酰胺衍生物，其制造和用作药剂
公开(公告)号：US07655651B2
公开(公告)日：2010-02-02
申请号：US11660198
申请日：2005-08-30
申请人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
发明人： Richard Engh , Hubert Hertenberger , Konrad Honold , Birgit Masjost , Petra Rueger , Wolfgang Schaefer , Stefan Scheiblich , Manfred Schwaiger
IPC分类号： C07D487/04 , A61K31/519 , A61K31/5355 , C07D239/38 , A61P29/00 , A61P35/00 , A61P19/08 , A61P25/00
CPC分类号： C07D487/04
摘要： The present invention relates to novel amide derivatives of 3-phenyl dihydropyrimido[4,5-d]pyrimidinones, to a process for their manufacture, medicaments containing them and their manufacture as well as the use of these compounds as pharmaceutically active agents. The present derivatives are new compounds of the general formula (I).
摘要翻译：本发明涉及3-苯基二氢嘧啶并[4,5-d]嘧啶酮的新型酰胺衍生物，其制备方法，含有它们的药物及其制备以及这些化合物作为药物活性剂的用途。本发明的衍生物是通式（I）的新化合物。

29. 发明申请

US20090030020A1 7H-Pyrido[3,4-D]Pyrimidin-8-Ones, Their Manufacture and Use as Protein Kinase Inhibitors 失效
标题翻译： 7H-吡啶并[3,4-D]嘧啶-8-酮，其制造和用作蛋白激酶抑制剂
公开(公告)号：US20090030020A1
公开(公告)日：2009-01-29
申请号：US12087420
申请日：2007-01-29
申请人： Konrad Honold , Jane Paul , Carl Roeschlaub , Wolfgang Schaefer , Stefan Scheiblich , Thomas Von Hirschheydt , Alan Whittle
发明人： Konrad Honold , Jane Paul , Carl Roeschlaub , Wolfgang Schaefer , Stefan Scheiblich , Thomas Von Hirschheydt , Alan Whittle
IPC分类号： A61K31/519 , C07D471/04 , A61P35/00
CPC分类号： C07D471/04
摘要： Objects of the present invention are the compounds of formula I their pharmaceutically acceptable salts, enantiomeric forms, diastereoisomers and racemates, the preparation of the above compounds, medicaments containing them and their manufacture, as well as the use of the above compounds in the control or prevention of illnesses such as cancer.
摘要翻译：本发明的目的是式I化合物，其药学上可接受的盐，对映体形式，非对映异构体和外消旋体，上述化合物的制备，含有它们的药物及其制备，以及上述化合物在对照或预防癌症等疾病。

30. 发明授权

US07339882B2 Method for frame and frequency synchronization of an OFDM signal and method for transmitting an OFDM signal 有权
标题翻译：用于OFDM信号的帧和频率同步的方法以及用于发送OFDM信号的方法
公开(公告)号：US07339882B2
公开(公告)日：2008-03-04
申请号：US10473631
申请日：2002-03-15
申请人： Wolfgang Schaefer , Christian Hansen
发明人： Wolfgang Schaefer , Christian Hansen
IPC分类号： H04J11/00
CPC分类号： H04L1/0056 , H04L1/0071 , H04L27/2656 , H04L27/2657 , H04L27/2675
摘要： A method for frame and frequency synchronization of an OFDM signal and a signal for transmitting an OFDM signal is described, the purpose of which is to impress a pilot phase profile that is then used at the receiving end for frame and frequency synchronization on pilots which are already contained in the OFDM signal for channel estimation. This has the advantage that no additional transmission capacity has to be used for the synchronization. The method according to the present invention is initiated by a rough time synchronization unit connected upline, which searches for the beginning of the guard interval in the OFDM signal. The comparison between a stored pilot phase profile and the received subcarrier symbol is performed using a cross-correlation, whose result is then evaluated to determine the frame and frequency synchronization.
摘要翻译：描述了一种用于OFDM信号的帧和频率同步的方法和用于发送OFDM信号的信号的方法，其目的是在导频上施加导频相位分布，该导频相位分布在接收端被用于帧和频率同步，已经包含在OFDM信号中用于信道估计。这具有不需要用于同步的附加传输容量的优点。根据本发明的方法由连续上行的粗略的时间同步单元启动，其在OFDM信号中搜索保护间隔的开始。使用互相关来执行存储的导频相位轮廓和接收的副载波符号之间的比较，然后对其结果进行评估以确定帧和频率同步。

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