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21. 发明授权

US09676995B2 Fracturing fluids and methods for treating hydrocarbon-bearing formations 有权
公开(公告)号：US09676995B2
公开(公告)日：2017-06-13
申请号：US13537800
申请日：2012-06-29
申请人： Hong Sun , Frances DeBenedictis , Jia Zhou , Scott Nelson , Tom N. Royce , Qi Qu
发明人： Hong Sun , Frances DeBenedictis , Jia Zhou , Scott Nelson , Tom N. Royce , Qi Qu
IPC分类号： C09K8/88 , C09K8/68 , E21B43/25 , C09K8/72
CPC分类号： C09K8/882 , C09K8/68 , C09K8/725 , C09K2208/24 , C09K2208/26 , C09K2208/28
摘要： Disclosed herein is a fracturing fluid comprising a carrier fluid; a polymer that is soluble in the carrier fluid; the polymer being a synthetic polymer; the synthetic polymer being operative to increase the viscosity of the carrier fluid to about 5 to about 50 centipoise; the fracturing fluid being operative to reduce friction during a downhole fracturing operation and to transport a proppant during the downhole fracturing operation.

22. 发明申请

US20160289541A1 USE OF SUPERABSORBENT POLYMERS FOR PRESSURE CONTROL AND DIVERSION APPLICATIONS 审中-公开
标题翻译：用于压力控制和分流应用的超吸收聚合物的使用
公开(公告)号：US20160289541A1
公开(公告)日：2016-10-06
申请号：US15084598
申请日：2016-03-30
申请人： Jia Zhou , Harold Dean Brannon , Paul S. Carman , Leiming Li , Thomas Ray Starks, II , D.V. Satyanarayana Gupta , Harold G. Hudson , Scott G. Nelson
发明人： Jia Zhou , Harold Dean Brannon , Paul S. Carman , Leiming Li , Thomas Ray Starks, II , D.V. Satyanarayana Gupta , Harold G. Hudson , Scott G. Nelson
IPC分类号： C09K8/62 , E21B43/26 , E21B33/138 , C09K8/76
CPC分类号： E21B37/06 , C09K8/035 , C09K8/12 , C09K8/34 , C09K8/52 , C09K8/5756 , C09K8/62 , C09K8/64 , C09K8/68 , C09K8/685 , C09K8/70 , C09K8/703 , C09K8/706 , C09K8/76 , C09K8/80 , C09K8/82 , C09K8/88 , C09K8/887 , C09K8/90 , C09K2208/26 , E21B21/00 , E21B21/003 , E21B33/134 , E21B33/138 , E21B43/04 , E21B43/26 , E21B43/267
摘要： A method of hydraulically fracturing a subterranean formation penetrated by a wellbore comprises: providing a diverting fluid comprising a carrier fluid, a first superabsorbent polymer and a second superabsorbent polymer, the second superabsorbent polymer having a shape, or a composition, or a combination thereof different from that of the first superabsorbent polymer; injecting the diverting fluid into the subterranean formation; and injecting a fracturing fluid into the formation after injecting the diverting fluid. A viscosity modifying agent can be present in the diverting fluid. Superabsorbent polymers can also be used to develop a temporary filter cake at the formation face to reduce or eliminate the fluid leakoff out of the wellbore.
摘要翻译：由井筒渗透的地层的水力压裂的方法包括：提供包含载体流体，第一超吸收聚合物和第二超吸收聚合物的转向流体，所述第二超吸收聚合物具有不同的形状或组合物或其组合与第一超吸收性聚合物的相同; 将转向流体注入地层; 并且在注射转向流体之后将压裂流体注入到地层中。粘性改性剂可以存在于转向流体中。超吸收性聚合物也可以用于在地层表面形成临时滤饼，以减少或消除从井筒流出的液体泄漏。

23. 发明授权

US09040567B2 BAX agonist, compositions, and methods related thereto 有权
标题翻译： BAX激动剂，组合物和与之有关的方法
公开(公告)号：US09040567B2
公开(公告)日：2015-05-26
申请号：US14239177
申请日：2012-08-17
申请人： Xingming Deng , Jia Zhou , Chunyong Ding
发明人： Xingming Deng , Jia Zhou , Chunyong Ding
IPC分类号： A61K31/05 , C07D213/73 , C07D213/74 , C07C271/16 , C07C205/11 , C07C205/25 , C07C205/35 , C07C309/65 , C07C311/21 , C07C211/52 , C07C215/88 , C07C217/20 , C07C217/26 , C07C217/94 , C07C233/18 , C07C233/25 , C07C233/80 , C07D209/10 , C07D295/088 , C07D211/46 , C07D295/185 , C07D295/26 , C07D213/61 , C07D213/64 , A61K31/085 , A61K31/138 , A61K31/404 , A61K31/44 , A61K31/4412 , A61K31/4465 , A61K31/495 , A61K31/5375 , A61K45/06 , C07C217/60 , C07D209/12 , C07D213/643
CPC分类号： A61K31/5375 , A61K31/05 , A61K31/085 , A61K31/138 , A61K31/404 , A61K31/44 , A61K31/4412 , A61K31/4465 , A61K31/495 , A61K45/06 , C07C205/11 , C07C205/25 , C07C205/35 , C07C211/52 , C07C215/88 , C07C217/20 , C07C217/26 , C07C217/60 , C07C217/94 , C07C233/18 , C07C233/25 , C07C233/80 , C07C271/16 , C07C309/65 , C07C311/21 , C07C2601/02 , C07C2603/18 , C07D209/10 , C07D209/12 , C07D211/46 , C07D213/61 , C07D213/64 , C07D213/643 , C07D213/73 , C07D213/74 , C07D295/088 , C07D295/185 , C07D295/26
摘要： The disclosure relates to BAX activators and therapeutic uses relates thereto. In certain embodiments, the disclosure relates to methods of treating or preventing cancer, such as lung cancer, comprising administering a therapeutically effective amount of a pharmaceutical composition comprising a compound disclosed herein or pharmaceutically acceptable salt to a subject in need thereof.
摘要翻译：本公开涉及BAX活化剂和治疗用途。在某些实施方案中，本公开涉及治疗或预防癌症（例如肺癌）的方法，包括向有需要的受试者施用治疗有效量的包含本文公开的化合物或药学上可接受的盐的药物组合物。

24. 发明申请

US20150057248A1 BIVALENT AMPA RECEPTOR POSITIVE ALLOSTERIC MODULATORS 有权
标题翻译：双极AMPA受体阳性独立调制器
公开(公告)号：US20150057248A1
公开(公告)日：2015-02-26
申请号：US14474258
申请日：2014-09-01
申请人： Jia Zhou , Haijun Chen , Kenneth M. Johnson , Cheng Z. Wang
发明人： Jia Zhou , Haijun Chen , Kenneth M. Johnson , Cheng Z. Wang
IPC分类号： C07F5/02 , C07D213/82 , C07C311/03 , C07D401/06 , C07D209/14 , C07D471/04 , C07D209/08
CPC分类号： C07F5/025 , C07C311/03 , C07D207/27 , C07D209/08 , C07D209/14 , C07D213/82 , C07D231/56 , C07D401/06 , C07D401/12 , C07D471/04
摘要： Embodiments of the invention are directed to compounds that are positive allosteric modulators of AMPA receptors.
摘要翻译：本发明的实施方案涉及作为AMPA受体的正变构调节剂的化合物。

25. 发明申请

US20140332214A1 HYDRAULIC FRACTURING COMPOSITION, METHOD FOR MAKING AND USE OF SAME 有权
标题翻译：液压破碎组合物，其制造和使用方法
公开(公告)号：US20140332214A1
公开(公告)日：2014-11-13
申请号：US14169698
申请日：2014-01-31
申请人： Jia Zhou , Qi Qu , Scott G. Nelson , Hong Sun , Leiming Li
发明人： Jia Zhou , Qi Qu , Scott G. Nelson , Hong Sun , Leiming Li
IPC分类号： C09K8/80 , E21B43/267
CPC分类号： E21B43/267 , C09K8/685 , C09K2208/26
摘要： A hydraulic fracturing composition includes: a superabsorbent polymer in an expanded state; a plurality of proppant particles disposed in the superabsorbent polymer; an additive comprising a surfactant, a viscose polymer, or a combination thereof, and a fluid to expand the superabsorbent polymer into the expanded state. A process for disposing a plurality of proppant particles in a fracture comprises: disposing a hydraulic fracturing composition in a downhole environment; forming a fracture; disposing the hydraulic fracturing composition in the fracture; breaking the superabsorbent polymer after forming the fracture; and releasing the plurality of proppant particles from superabsorbent polymer. The process also comprises injecting a proppant-free fluid and a proppant-containing fluid in an alternating order into a subterranean formation.
摘要翻译：水力压裂组合物包括：膨胀状态的超吸收性聚合物; 设置在超吸收性聚合物中的多个支撑剂颗粒; 包含表面活性剂，粘胶聚合物或其组合的添加剂以及将超吸收性聚合物膨胀成膨胀状态的流体。在断裂中配置多个支撑剂颗粒的方法包括：在井下环境中设置水硬性压裂组合物; 形成骨折; 将水力压裂组合物置于裂缝中; 在形成断裂之后破坏超吸收性聚合物; 并从超吸收聚合物中释放多个支撑剂颗粒。该方法还包括将不含支撑剂的流体和含支撑剂的流体以交替顺序注入到地层中。

26. 发明申请

US20140332213A1 HYDRAULIC FRACTURING COMPOSITION, METHOD FOR MAKING AND USE OF SAME 有权
标题翻译：液压破碎组合物，其制造和使用方法
公开(公告)号：US20140332213A1
公开(公告)日：2014-11-13
申请号：US13888457
申请日：2013-05-07
申请人： Jia Zhou , Hong Sun , Qi Qu , Michael Guerin
发明人： Jia Zhou , Hong Sun , Qi Qu , Michael Guerin
IPC分类号： C09K8/80
CPC分类号： C09K8/805 , C09K8/685
摘要： A hydraulic fracturing composition includes: a superabsorbent polymer in an expanded state and configured to break in response to a breaking condition; a plurality of proppant particles disposed in the superabsorbent polymer prior to release of the plurality of proppant particles from the superabsorbent polymer in response to breaking the superabsorbent polymer; and a fluid to expand the superabsorbent polymer into the expanded state. The hydraulic fracturing composition can be made by contacting a superabsorbent polymer with a fluid to expand the superabsorbent polymer into an expanded state; and disposing a plurality of proppant particles in the superabsorbent polymer to make the hydraulic fracturing composition. A process for disposing a plurality of proppant particles in a fracture comprises: disposing a hydraulic fracturing composition in a downhole environment; forming a fracture in the downhole environment; disposing the hydraulic fracturing composition in the fracture; breaking the superabsorbent polymer after forming the fracture; and releasing the plurality of proppant particles from superabsorbent polymer to dispose the plurality of proppant particles in the fracture.
摘要翻译：水力压裂组合物包括：膨胀状态的超吸收性聚合物，其构造成响应于断裂条件而断裂; 在响应于破坏超吸收性聚合物之前，从超吸收性聚合物释放多个支撑剂颗粒之前，将多个支撑剂颗粒设置在超吸收聚合物中; 以及将超吸收性聚合物膨胀成膨胀状态的流体。水解压裂组合物可以通过使超吸收性聚合物与流体接触来制造，以将超吸收性聚合物膨胀成膨胀状态; 并将多个支撑剂颗粒设置在超吸收聚合物中以制造水力压裂组合物。在断裂中配置多个支撑剂颗粒的方法包括：在井下环境中设置水硬性压裂组合物; 在井下环境中形成裂缝; 将水力压裂组合物置于裂缝中; 在形成断裂之后破坏超吸收性聚合物; 并且从超吸收性聚合物中释放多个支撑剂颗粒以将多个支撑剂颗粒置于断裂中。

27. 发明申请

US20140055428A1 METHOD AND DEVICE FOR IMPLEMETING ORIGINAL CALLIGRAPHY OF HANDWRITING 有权
标题翻译：用于实施手写原件的方法和装置
公开(公告)号：US20140055428A1
公开(公告)日：2014-02-27
申请号：US13981083
申请日：2012-01-18
申请人： Xueping Zou , Jia Zhou , Guoying Du
发明人： Xueping Zou , Jia Zhou , Guoying Du
IPC分类号： G06F3/0354
CPC分类号： G06F3/03545 , G06F3/04883 , G06T11/203
摘要： Provided are a method and device for implementing the original calligraphy of handwriting. The method comprises: carrying out a real time sampling of a contact to obtain position information about the sampling point and the pen width at the sampling point; determining a central line of the stroke determined by adjacent sampling points; determining position information about a key point of the corresponding stroke according to the central line and the pen width at the sampling point; dividing the key point of the stroke into groups to determine the type thereof; generating a calligraphy outline of the corresponding stroke by drawing an arc and/or a line according to the type of the key point and the position information about the same; and finally filling the outline for displaying. The displayed handwriting trace has the same calligraphy of handwriting as characters written on paper.
摘要翻译：提供了一种用于实现原始书法书法的方法和装置。该方法包括：对接触点进行实时取样以获取关于取样点的位置信息和采样点的笔宽度; 确定由相邻采样点确定的行程的中心线; 根据中心线和采样点的笔宽确定关于相应笔画的关键点的位置信息; 将笔画的关键点划分成组，以确定其类型; 通过根据关键点的类型和关于该关键点的位置信息绘制圆弧和/或线来产生相应笔画的书法轮廓; 最后填写轮廓显示。显示的手写痕迹具有与写在纸上的字符相同的笔迹书法。

28. 发明申请

US20140000890A1 Fracturing Fluids and Methods For Treating Hydrocarbon-Bearing Formations 有权
标题翻译：压裂液和处理含烃层的方法
公开(公告)号：US20140000890A1
公开(公告)日：2014-01-02
申请号：US13537800
申请日：2012-06-29
申请人： Hong Sun , Frances DeBenedictis , Jia Zhou , Scott Nelson , Tom N. Royce , Qi Qu
发明人： Hong Sun , Frances DeBenedictis , Jia Zhou , Scott Nelson , Tom N. Royce , Qi Qu
IPC分类号： C09K8/62 , E21B43/22
CPC分类号： C09K8/882 , C09K8/68 , C09K8/725 , C09K2208/24 , C09K2208/26 , C09K2208/28
摘要： Disclosed herein is a fracturing fluid comprising a carrier fluid; a polymer that is soluble in the carrier fluid; the polymer being a synthetic polymer; the synthetic polymer being operative to increase the viscosity of the carrier fluid to about 5 to about 50 centipoise; the fracturing fluid being operative to reduce friction during a downhole fracturing operation and to transport a proppant during the downhole fracturing operation.
摘要翻译：本文公开了一种包含载体流体的压裂流体; 可溶于载体流体的聚合物; 该聚合物是合成聚合物; 合成聚合物可操作以将载体流体的粘度增加至约5至约50厘泊; 压裂流体可操作以在井下压裂操作期间减少摩擦并且在井下压裂操作期间输送支撑剂。

29. 发明申请

US20130041587A1 Using polymer elasticity to scale up the lab characteristics to field application of friction reducers 审中-公开
标题翻译：使用聚合物弹性将实验室特性扩大到摩擦减速器的现场应用
公开(公告)号：US20130041587A1
公开(公告)日：2013-02-14
申请号：US13562030
申请日：2012-07-30
申请人： Ahmed Mohamed Mohamed Gomaa , Jia Zhou , Hong Sun , Qi Qu
发明人： Ahmed Mohamed Mohamed Gomaa , Jia Zhou , Hong Sun , Qi Qu
IPC分类号： G06F19/00
CPC分类号： E21B43/26
摘要： A method of determining the friction pressure drop gradient of at least one drag-reducing polymer passing through a tubing in an underground well includes determining the pressure drop, velocity and relaxation time of the drag-reducing polymer as it passes through a length of small diameter straight tubing at multiple injection rates in the lab. For each data set, the variables x=(Relaxation Time×Velocity) and y=(Pressure Drop Gradient×Diameter4×(1+De2)1.5) are calculated, wherein De is the Deborah number. Each x, y data point is plotted on a graph where the x-axis represents (Relaxation Time×Velocity) and the y-axis represents (Pressure Drop Gradient×Diameter4×(1+De2)1.5), wherein the curve formed by the plotted data approximates the x and y data for the drag-reducing polymer as it passes through the tubing in the underground well.
摘要翻译：确定穿过地下井中的管道的至少一种减阻聚合物的摩擦压降梯度的方法包括确定减阻聚合物在通过一小段直径时的压降，速度和松弛时间在实验室中以多次注射速率的直管。对于每个数据集，计算变量x =（松弛时间×速度）和y =（压降梯度×直径4×（1 + De2）1.5），其中De是Deborah数。每个x，y数据点绘制在x轴表示（松弛时间×速度）和y轴表示（压降梯度×直径4×（1 + De2）1.5）的曲线图上，其中由当减阻聚合物通过地下井的管道时，绘图数据近似于减阻聚合物的x和y数据。

30. 发明授权

US10975059B2 Small molecule BRD4 modulators for HIV epigenetic regulation 有权
公开(公告)号：US10975059B2
公开(公告)日：2021-04-13
申请号：US16441748
申请日：2019-06-14
申请人： Haitao Hu , Jia Zhou , Zhiqing Liu
发明人： Haitao Hu , Jia Zhou , Zhiqing Liu
IPC分类号： C07D403/02 , C07D403/06 , A61P31/18 , C07D207/48 , C07D401/06
摘要： The invention relates generally to novel small molecule BRD4 modulators for HIV, the preparation thereof as well as the use thereof.

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