专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明授权

US06395877B1 14273 receptor, a novel G-protein coupled receptor 有权
标题翻译： 14273受体，一种新型的G蛋白偶联受体
公开(公告)号：US06395877B1
公开(公告)日：2002-05-28
申请号：US09261599
申请日：1999-02-26
申请人： Maria Alexandra Glucksmann , Fong-Ying Tsai
发明人： Maria Alexandra Glucksmann , Fong-Ying Tsai
IPC分类号： C07K100
CPC分类号： C07K14/705 , C07K14/723
摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases, including congestive heart failure. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.
摘要翻译：本发明涉及属于G蛋白偶联受体的超家族的新鉴定的受体。本发明还涉及编码受体的多核苷酸。本发明还涉及使用受体多肽和多核苷酸作为受体介导的障碍，特别是心血管疾病包括充血性心力衰竭的诊断和治疗的靶标的方法。本发明还涉及使用受体多肽和多核苷酸鉴定用于诊断和治疗的激动剂和拮抗剂的药物筛选方法。本发明还包括基于受体多肽和多核苷酸的激动剂和拮抗剂。本发明还涉及产生受体多肽和多核苷酸的方法。

22. 发明授权

US5256558A Gene encoding plant asparagine synthetase 失效
标题翻译：基因编码植物天冬酰胺合成酶
公开(公告)号：US5256558A
公开(公告)日：1993-10-26
申请号：US514816
申请日：1990-04-26
申请人： Gloria M. Coruzzi , Fong-Ying Tsai
发明人： Gloria M. Coruzzi , Fong-Ying Tsai
IPC分类号： C07K16/40 , C12N1/21 , C12N9/00 , C12N15/82 , C12N5/10 , C12N1/19 , C12N15/52
CPC分类号： C12N9/93 , C07K16/40 , C12N15/8209 , C12N15/8222 , C12N15/8227 , C12N15/8237 , C12N15/8273
摘要： The identification and cloning of the gene(s) for plant asparagine synthetase (AS), an important enzyme involved in the formation of asparagine, a major nitrogen transport compound of higher plants is described. Expression vectors constructed with the AS coding sequence may be utilized to produce plant AS; to engineer herbicide resistant plants, salt/drought tolerant plants or pathogen resistant plants; as a dominant selectable marker; or to select for novel herbicides or compounds useful as agents that synchronize plant cells in culture.The promoter for plant AS, which directs high levels of gene expression and is induced in an organ specific manner and by darkness, is also described. The AS promoter may be used to direct the expression of heterologous coding sequences in appropriate hosts.
摘要翻译：描述了用于植物天冬酰胺合成酶（AS）的基因的鉴定和克隆，其是参与天冬酰胺形成的重要酶，其是高等植物的主要氮转运化合物。用AS编码序列构建的表达载体可用于产生植物AS; 设计除草剂抗性植物，耐盐/耐旱植物或抗病原性植物; 作为显性选择标记; 或选择用作使培养物中的植物细胞同步的试剂的新型除草剂或化合物。还描述了引导高水平基因表达并以器官特异性方式和黑暗诱导的植物AS的启动子。 AS启动子可用于将异源编码序列的表达指导在合适的宿主中。

23. 发明申请

US20070059730A1 Novel 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 molecules and uses therefor 失效
标题翻译：小分子25869,25934,26335,5049,21117,38692,46508,16816,16839,49937,49931和49933分子及其用途
公开(公告)号：US20070059730A1
公开(公告)日：2007-03-15
申请号：US11445606
申请日：2006-06-02
申请人： Rory Curtis , Thomas Logan , Maria Glucksmann , Rachel Meyers , Mark Williamson , Laura Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
发明人： Rory Curtis , Thomas Logan , Maria Glucksmann , Rachel Meyers , Mark Williamson , Laura Rudolph-Owen , Miyoung Chun , Fong-Ying Tsai
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/00 , C07K14/705
CPC分类号： C07K14/705 , A01K2217/05 , A61K38/00 , C07K14/395 , C07K14/43545 , C07K14/43581 , C07K14/43595 , C07K14/463 , C07K14/465 , C07K14/47 , C07K2319/00 , C12N9/00 , C12N9/0071 , C12N9/0083 , C12N9/1205 , C12N9/18 , C12N9/20 , C12N9/88 , C12N2310/3513 , C12Y207/01001 , C12Y301/04003
摘要： The invention provides isolated nucleic acids molecules, designated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 and 49933 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 gene has been introduced or disrupted. The invention still further provides isolated 25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 proteins, fusion proteins, antigenic peptides and anti-25869, 25934, 26335, 50365, 21117, 38692, 46508, 16816, 16839, 49937, 49931 or 49933 antibodies. Diagnostic and therapeutic methods utilizing compositions of the invention are also provided.
摘要翻译：本发明提供分离的核酸分子，命名为25869,25934,26335,50516,21117,38692,46508,16816,16839,49937,49931和49933核酸分子。本发明还提供反义核酸分子，包含25869,25934,26335,50521,21117,38692,46508,16816,16839,4467,49931或49933核酸分子的重组表达载体，已经引入了表达载体的宿主细胞，以及引入或破坏25869,25934,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933基因的非人类转基因动物。本发明还进一步提供了分离的25869,2593,26335,50365,21117,38692,46508,16816,16839,49937,49931或49933蛋白，融合蛋白，抗原肽和抗-25869,25934,26335,50365,211117,38692 ，46508,16816,16839,49937,49931或49933抗体。还提供了利用本发明组合物的诊断和治疗方法。

24. 发明授权

US07037668B2 Methods for the treatment and diagnosis of tumorigenic and angiogenic disorders using 32616 失效
公开(公告)号：US07037668B2
公开(公告)日：2006-05-02
申请号：US10283013
申请日：2002-10-29
申请人： Fong-Ying Tsai
发明人： Fong-Ying Tsai
IPC分类号： G01N33/574 , G01N33/567 , G01N33/53 , C12Q1/34
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to methods and compositions for the treatment and diagnosis of tumorigenic and/or angiogenic disorders, including, but not limited to, lung tumors, breast tumors, ovary tumors, colon tumors, hemangioma, and metastatic and angiogenic tumors. The invention further provides methods for identifying a compound capable of treating a tumorigenic and/or angiogenic disorder or modulating tumorigenesis and/or angiogenesis. The invention also provides methods for modulating tumorigenesis and/or angiogenesis, e.g., modulating tumorigenesis and/or angiogenesis in a subject. In addition, the invention provides a method for treating a subject having a tumorigenic and/or angiogenic disorder characterized by aberrant 32616 polypeptide activity or aberrant 32616 nucleic acid expression.

25. 发明授权

US5595896A Expression of heterologous genes in transgenic plants and plant cells using plant asparagine synthetase promoters 失效
标题翻译：使用植物天冬酰胺合成酶启动子在转基因植物和植物细胞中表达异源基因
公开(公告)号：US5595896A
公开(公告)日：1997-01-21
申请号：US58700
申请日：1993-05-03
申请人： Gloria M. Coruzzi , Fong-Ying Tsai
发明人： Gloria M. Coruzzi , Fong-Ying Tsai
IPC分类号： C07K16/40 , C12N1/21 , C12N9/00 , C12N15/82 , C12N15/00 , A01H1/04 , C12N5/14
CPC分类号： C12N9/93 , C07K16/40 , C12N15/8209 , C12N15/8222 , C12N15/8227 , C12N15/8237 , C12N15/8273
摘要： The identification and cloning of the gene(s) for plant asparagine synthetase (AS), an important enzyme involved in the formation of asparagine, a major nitrogen transport compound of higher plants is described. Expression vectors constructed with the AS coding sequence may be utilized to produce plant AS; to engineer herbicide resistant plants, salt/drought tolerant plants or pathogen resistant plants; as a dominant selectable marker; or to select for novel herbicides or compounds useful as agents that synchronize plant cells in culture.The promoter for plant AS, which directs high levels of gene expression and is induced in an organ specific manner and by darkness, is also described. The AS promoter may be used to direct the expression of heterologous coding sequences in appropriate hosts.
摘要翻译：描述了用于植物天冬酰胺合成酶（AS）的基因的鉴定和克隆，其是参与天冬酰胺形成的重要酶，其是高等植物的主要氮转运化合物。用AS编码序列构建的表达载体可用于产生植物AS; 设计除草剂抗性植物，耐盐/耐旱植物或抗病原性植物; 作为显性选择标记; 或选择用作使培养物中的植物细胞同步的试剂的新型除草剂或化合物。还描述了引导高水平基因表达并以器官特异性方式和黑暗诱导的植物AS的启动子。 AS启动子可用于将异源编码序列的表达指导在合适的宿主中。

26. 发明申请

US20090275050A1 14273 receptor, a novel G-protein coupled receptor 审中-公开
公开(公告)号：US20090275050A1
公开(公告)日：2009-11-05
申请号：US12384953
申请日：2009-04-10
申请人： Maria Alexandra Glucksmann , Fong-Ying Tsai
发明人： Maria Alexandra Glucksmann , Fong-Ying Tsai
IPC分类号： G01N33/567 , C12Q1/00 , C12Q1/44 , C12Q1/02 , C12N9/00 , G01N33/566 , G01N33/536 , G01N33/68 , C07K16/28 , C07K16/46
CPC分类号： C07K14/723
摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases, including congestive heart failure. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.

27. 发明申请

US20070087375A1 Methods and compositions for treating cancer using 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 审中-公开
标题翻译：用于治疗癌症的方法和组合物，使用2192,2133,6568,8895,9138,9217,9609,9857,9882,10025,20657,21163,25848,25968,32603,32670,33794,5446和94710
公开(公告)号：US20070087375A1
公开(公告)日：2007-04-19
申请号：US11633986
申请日：2006-12-05
申请人： John Hunter , Mark Williamson , Kyle MacBeth , Laura Rudolph-Owen , Fong-Ying Tsai
发明人： John Hunter , Mark Williamson , Kyle MacBeth , Laura Rudolph-Owen , Fong-Ying Tsai
IPC分类号： C12Q1/68 , G01N33/574
CPC分类号： G01N33/5011 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 2192, 2193, 6568, 8895, 9138, 9217, 9609, 9857, 9882, 10025, 20657, 21163, 25848, 25968, 32603, 32670, 33794, 54476 and 94710 genes in tissues relating to cancer, relative to their expression in normal, or non-cancer disease states, and/or in response to manipulations relevant to a cancer. The present invention describes methods for the diagnostic evaluation and prognosis of various cancers, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a cancer or cancer. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cancer.
摘要翻译：本发明涉及癌症或癌症的诊断和治疗方法。具体而言，本发明鉴定组织中的2192,2133,6568,8895,9138,9217,9609,9857,9882,10025,20657,21163,25848,25968,32603,32670,3797,45476和94710基因的差异表达涉及癌症，相对于它们在正常或非癌症疾病状态中的表达，和/或响应于与癌症相关的操作。本发明描述了各种癌症的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。本发明还提供了鉴定能够调节癌症或癌症的化合物的方法。本发明还提供了鉴定和治疗化合物作为癌症治疗的方法。

28. 发明申请

US20070078088A1 Methods and compositions for treating cancer using 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480, 20893, 33230, 1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 or 66428 molecules 审中-公开
标题翻译：使用140,1470,1686,2089,2427,3702,5891,6428,7181,7660,25641,69583,49863,8897,1682,17677,9235,3703,14171,10359,1660,1450的治疗癌症的方法和组合物，18894,2088,32427,2160,9252,9389,1642,85269,10277,1584,9595,14124,4469,88990,2100,92988,64698,104080,20893,33230,1586,99943,16334,68862,99011 ，14031,6178,21225,1420,32236,2099,2155,56583,2784,8891,998,117444,50566或66428分子
公开(公告)号：US20070078088A1
公开(公告)日：2007-04-05
申请号：US11603696
申请日：2006-11-22
申请人： John Hunter , Kyle MacBeth , Fong-Ying Tsai , Andrea Lesoon , Eric Lightcap , Mark Williamson , Laura Rudolph-Owen
发明人： John Hunter , Kyle MacBeth , Fong-Ying Tsai , Andrea Lesoon , Eric Lightcap , Mark Williamson , Laura Rudolph-Owen
IPC分类号： A61K38/17 , A61K48/00 , C12Q1/68 , G01N33/574
CPC分类号： G01N33/574 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , C12Q2600/158 , G01N33/5011 , G01N2500/00
摘要： The present invention relates to methods for the diagnosis and treatment of a cancer or cancer. Specifically, the present invention identifies the differential expression of 140, 1470, 1686, 2089, 2427, 3702, 5891, 6428, 7181, 7660, 25641, 69583, 49863, 8897, 1682, 17667, 9235, 3703, 14171, 10359, 1660, 1450, 18894, 2088, 32427, 2160, 9252, 9389, 1642, 85269, 10297, 1584, 9525, 14124, 4469, 8990, 2100, 9288, 64698, 10480, 20893, 33230, 1586, 9943, 16334, 68862, 9011, 14031, 6178, 21225, 1420, 32236, 2099, 2150, 26583, 2784, 8941, 9811, 27444, 50566 and 66428 genes in tissues relating to cancer, relative to their expression in normal, or non-cancer disease states, and/or in response to manipulations relevant to a cancer. The present invention describes methods for the diagnostic evaluation and prognosis of various cancers, and for the identification of subjects exhibiting a predisposition to such conditions. The invention also provides methods for identifying a compound capable of modulating a cancer or cancer. The present invention also provides methods for the identification and therapeutic use of compounds as treatments of cancer.
摘要翻译：本发明涉及癌症或癌症的诊断和治疗方法。具体地说，本发明鉴定了140,1470,1686,2089,2427,3702,5891,62828,7181,7660,25641,69583,49863,8897,1682,17676,92935,3703,14171,10359的差异表达， 1660,1450,18894,2088,32427,2160,9252,9389,1642,85269,10297,1584,9525,14124,4469,8990,2100,92988,64698,104080,20893,33230,1586,99943,16334， 68862,9011,14031,6178,21225,1420,32236,2099,2150,26583,2784,8891,99811,27444,50566和66428个基因在与癌症有关的组织中相对于它们在正常或非癌症疾病中的表达状态和/或响应于与癌症相关的操作。本发明描述了各种癌症的诊断评估和预后的方法，以及用于鉴定表现出这种病症倾向的受试者。本发明还提供了鉴定能够调节癌症或癌症的化合物的方法。本发明还提供了鉴定和治疗化合物作为癌症治疗的方法。

29. 发明申请

US20060177899A1 14273 receptor, a novel G-protein coupled receptor 有权
公开(公告)号：US20060177899A1
公开(公告)日：2006-08-10
申请号：US11283567
申请日：2005-11-18
申请人： Maria Glucksmann , Fong-Ying Tsai
发明人： Maria Glucksmann , Fong-Ying Tsai
IPC分类号： C07K14/705 , C07H21/04 , C12P21/06
CPC分类号： C07K14/723
摘要： The present invention relates to a newly identified receptor belonging to the superfamily of G-protein-coupled receptors. The invention also relates to polynucleotides encoding the receptor. The invention further relates to methods using the receptor polypeptides and polynucleotides as a target for diagnosis and treatment in receptor-mediated disorders, specifically, cardiovascular diseases, including congestive heart failure. The invention further relates to drug-screening methods using the receptor polypeptides and polynucleotides to identify agonists and antagonists for diagnosis and treatment. The invention further encompasses agonists and antagonists based on the receptor polypeptides and polynucleotides. The invention further relates to procedures for producing the receptor polypeptides and polynucleotides.

30. 发明申请

US20060141520A1 Methods for the treatment of metabolic disorders, including obesity and diabetes 审中-公开
公开(公告)号：US20060141520A1
公开(公告)日：2006-06-29
申请号：US11331549
申请日：2006-01-13
申请人： Ruth Gimeno , Fong-Ying Tsai
发明人： Ruth Gimeno , Fong-Ying Tsai
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C07K14/705 , C07K14/723 , C12Q2600/156 , C12Q2600/158
摘要： The present invention relates to methods and compositions for the diagnosis and treatment of metabolic disorders, including, but not limited to, obesity, diabetes, overweight, anorexia, or cachexia. The invention further provides methods for identifying a compound capable of treating a metabolic disorder. The invention also provides methods for identifying a compound capable of modulating a metabolic activity. Yet further, the invention provides a method for modulating a metabolic activity. In addition, the invention provides a method for treating a subject having a metabolic disorder characterized by aberrant 14273 polypeptide activity or aberrant 14273 nucleic acid expression. In another aspect, the invention provides methods for modulating lipogenesis in a subject and methods for modulating lipolysis in a subject. In yet another aspect, the invention provides methods for regulating endogenous glucose levels.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式