专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2005116047A3 2-SUBSTITUTED 17-IMINO ESTROGEN COMPOUNDS FOR CYTOPROTECTION 审中-公开
标题翻译： 2-取代的17-IMINO ESTROGEN化合物用于CYTOPROTECTION
公开(公告)号：WO2005116047A3
公开(公告)日：2006-03-16
申请号：PCT/US2005018688
申请日：2005-05-26
申请人： MIGENIX CORP , PEI YAZHONG
发明人： PEI YAZHONG
IPC分类号： A61K31/47 , C07J20060101 , C07J41/00 , A61K31/565 , A61P39/06
CPC分类号： C07J41/00 , C07J41/0005 , C07J41/0016
摘要： Compounds, compositions and methods for treating degenerative diseases and disor ders are disclosed see the compounds below, the compounds having cytoprotective properties and belonging to a class of cyclopentanophenanthrene-related steroids having derivatized estrogen-like structures and conferring cytoprotection witho ut possessing significant feminizing activity, thereby avoiding undesired side-e ffects when therapeutically administered, for example, in the treatment of degen erative disorders including neurodegenerative, ophthalmic, cardiovascular, mitoc hondrial, bone, joint, connective tissue or cartilage disorders, or a disorder a ssociated with altered activity of an excitotoxic pathway, or for use in tissue transplantation, or for other diseases, disorders or conditions.
摘要翻译：公开了用于治疗退行性疾病和疾病的化合物，组合物和方法，具体涉及具有细胞保护性质的化合物，并且属于具有衍生化的雌激素样结构并赋予具有显着女性化活性的细胞保护作用的一类环戊烷 - 菲类相关类固醇，从而避免在治疗性给药时避免不希望的副作用，例如治疗包括神经变性，眼科，心血管，线粒体细胞，骨骼，关节，结缔组织或软骨疾病在内的发生疾病或与改变的活动相关的病症兴奋性毒性途径，或用于组织移植，或用于其他疾病，病症或病症。

22. 发明专利

AU2003286755A1 BENZODIAZEPINE DERIVATIVES FOR THE TREATMENT OF DIABETES MELLITUS 未知
公开(公告)号：AU2003286755A1
公开(公告)日：2004-06-07
申请号：AU2003286755
申请日：2003-10-27
申请人： MITOKOR INC
发明人： GHOSH SOUMITRA S , PEI YAZHONG , YU JINGHUA
IPC分类号： A61K31/5513 , A61P3/10 , C07D243/24

23. 发明专利

AU2003210975A1 COMPOUNDS FOR INHIBITING INSULIN SECRETION AND METHODS RELATED THERETO 未知
公开(公告)号：AU2003210975A1
公开(公告)日：2003-09-02
申请号：AU2003210975
申请日：2003-02-10
申请人： MITOKOR
发明人： PEI YAZHONG , JAMES IAN W , GHOSH SOUMITRA S
IPC分类号： C07D295/18 , A61K31/135 , A61K31/136 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/192 , A61K31/216 , A61K31/22 , A61K31/223 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/417 , A61K31/4184 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/5375 , A61K45/00 , A61P3/10 , A61P7/12 , A61P43/00 , C07C45/46 , C07C45/67 , C07C205/56 , C07C211/29 , C07C229/14 , C07C229/34 , C07C233/11 , C07C237/04 , C07C237/10 , C07C237/14 , C07C317/44 , C07C323/29 , C07C323/40 , C07C323/41 , C07C323/42 , C07C323/44 , C07C323/49 , C07C323/52 , C07C323/60 , C07C335/18 , C07D207/32 , C07D207/335 , C07D211/20 , C07D211/24 , C07D211/96 , C07D213/38 , C07D213/70 , C07D213/73 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/20 , C07D233/54 , C07D233/61 , C07D235/06 , C07D271/06 , C07D277/28 , C07D277/64 , C07D295/185 , C07D317/68 , C07D333/20 , C07D413/12 , A61K31/10 , A61K31/13
摘要： Compounds, compositions and methods for altering insulin secretion, particularly in the context of treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein W 1 , W 2 , X, R 1 , R 2 , R 3 , R 4 , m and n are defined herein.

24. 发明专利

AU3959502A Compounds for altering mitochondrial function and cellular responses 未知
公开(公告)号：AU3959502A
公开(公告)日：2002-06-24
申请号：AU3959502
申请日：2001-12-14
申请人： MITOKOR
发明人： PEI YAZHONG , MOOS WALTER H , GHOSH SOUMITRA S
IPC分类号： A61P25/00 , A61P35/00 , C07C235/20 , C07C237/22 , C07C237/42 , C07D307/68 , C07D307/56 , A61K31/165 , A61K31/34
摘要： Compounds for treating diseases by altering mitochondrial function that affects cellular processes, as well as to compositions and methods related thereto. The compounds have the structurewherein R1, R2, R3 and A are as defined herein.

25. 发明专利

AU2003210975A8 Compounds for inhibiting insulin secretion and methods related thereto 未知
公开(公告)号：AU2003210975A8
公开(公告)日：2003-09-02
申请号：AU2003210975
申请日：2003-02-10
申请人： MITOKOR
发明人： JAMES IAN W , GHOSH SOUMITRA S , PEI YAZHONG
IPC分类号： C07D295/18 , A61K31/135 , A61K31/136 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/17 , A61K31/18 , A61K31/192 , A61K31/216 , A61K31/22 , A61K31/223 , A61K31/36 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/417 , A61K31/4184 , A61K31/4245 , A61K31/426 , A61K31/428 , A61K31/4402 , A61K31/4406 , A61K31/4409 , A61K31/4439 , A61K31/445 , A61K31/495 , A61K31/5375 , A61K45/00 , A61P3/10 , A61P7/12 , A61P43/00 , C07C45/46 , C07C45/67 , C07C205/56 , C07C211/29 , C07C229/14 , C07C229/34 , C07C233/11 , C07C237/04 , C07C237/10 , C07C237/14 , C07C317/44 , C07C323/29 , C07C323/40 , C07C323/41 , C07C323/42 , C07C323/44 , C07C323/49 , C07C323/52 , C07C323/60 , C07C335/18 , C07D207/32 , C07D207/335 , C07D211/20 , C07D211/24 , C07D211/96 , C07D213/38 , C07D213/70 , C07D213/73 , C07D213/80 , C07D213/81 , C07D213/82 , C07D231/14 , C07D233/20 , C07D233/54 , C07D233/61 , C07D235/06 , C07D271/06 , C07D277/28 , C07D277/64 , C07D295/185 , C07D317/68 , C07D333/20 , C07D413/12
摘要： Compounds, compositions and methods for altering insulin secretion, particularly in the context of treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. The compounds have the following structure (I): including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein W 1 , W 2 , X, R 1 , R 2 , R 3 , R 4 , m and n are defined herein.

26. 发明专利

AU2003300358A1 LIGANDS OF ADENINE NUCLEOTIDE TRANSLOCASE (ANT) AND COMPOSITIONS AND METHODS RELATED THERETO 未知
公开(公告)号：AU2003300358A1
公开(公告)日：2004-07-22
申请号：AU2003300358
申请日：2003-12-19
申请人： MITOKOR INC
发明人： GHOSH SOUMITRA S , PEI YAZHONG , TANG XIAO-QING , LIRAS SPIROS J , AHLIJANIAN MICHAEL K
IPC分类号： A61K31/185 , A61P25/00 , C07C65/24 , C07C65/30 , C07C65/40 , C07C69/94 , C07D263/56 , C07D263/57 , C07D277/66 , C07D307/80 , C07D333/16 , C07D333/24 , C07D333/56 , C07D333/60
摘要： Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein R 1 , R 2 , R 3 , R 4 , R 5 and R 6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

27. 发明专利

CA2407886A1 PRODUCTION OF ADENINE NUCLEOTIDE TRANSLOCATOR (ANT), NOVEL ANT LIGANDS AND SCREENING ASSAYS THEREFOR 未知
公开(公告)号：CA2407886A1
公开(公告)日：2001-11-15
申请号：CA2407886
申请日：2001-05-11
申请人： MITOKOR
发明人： WILEY SANDRA EILEEN , DAVIS ROBERT E , CLEVENGER WILLIAM , MILLER SCOTT W , PEI YAZHONG , CARROLL AMY K , ANDERSON CHRISTEN M , SZABO TOMAS R , GHOSH SOUMITRA S , MOOS WALTER H
IPC分类号： G01N33/53 , A61K31/704 , A61K45/00 , A61P13/12 , A61P35/00 , C07H15/24 , C07J31/00 , C07K14/47 , C07K16/18 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , G01N33/566 , C12N9/00 , C12N15/62 , C12N15/86 , G01N33/50
摘要： Compositions and methods are provided for producing adenine nucleotide translocator (ANT) polypeptides and fusion proteins, including the productio n and use of recombinant expression constructs having a regulated promoter. AN T ligands and compositions and methods for identifying ANT ligands, agents tha t bind ANT and agents that interact with ANT are also disclosed.

28. 发明专利

AU2003300360A1 LIGANDS OF ADENINE NUCLEOTIDE TRANSLOCASE (ANT) AND COMPOSITIONS AND METHODS RELATED THERETO 未知
公开(公告)号：AU2003300360A1
公开(公告)日：2004-07-22
申请号：AU2003300360
申请日：2003-12-19
申请人： MITOKOR INC
发明人： GHOSH SOUMITRA S , PEI YAZHONG , TANG XIAO-QING
IPC分类号： C07C229/38 , C07C233/81 , C07C251/24 , C07C275/42 , C07C311/08 , C07C335/16 , C07C229/00
摘要： Compounds which have utility in the treatment of conditions associated with altered mitochondrial function. The compounds have the following structure (I): including stereoisomers, prodrugs, and pharmaceutically acceptable salts thereof, wherein X, R1, R2, R3, R4, R5 and R6 are as defined herein. Pharmaceutical compositions containing a compound of structure (I), as well as methods relating to the use thereof, are also disclosed.

30. 发明专利

CA2422671A1 TREATMENT OF DIABETES MELLITUS BY INHIBITION OF MITOCHONDRIAL CALCIUM/SODIUM ANTIPORTER 未知
公开(公告)号：CA2422671A1
公开(公告)日：2002-03-28
申请号：CA2422671
申请日：2001-09-20
申请人： MITOKOR
发明人： ANDERSON CHRISTEN M , DAVIS ROBERT E , GHOSH SOUMITRA S , PEI YAZHONG
IPC分类号： G01N33/53 , A61K31/553 , A61K31/554 , A61K45/00 , A61K45/06 , A61P3/10 , A61P43/00 , C07D267/14 , C07D281/10 , G01N33/543 , G01N33/566
摘要： The invention provides compositions and methods for altering insulin secreti on using an agent that inhibits calcium efflux via the mitochondrial calcium/ sodium antiporter (MCA). Methods of treatment are thereby provided, and are particularly useful for treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. Compositions and methods related to the identification of gene sequences encoding the mitochondrial calcium/ sodium antiporter, expression of such sequences and screening assays using expresse d MCA products are also provided.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式