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21. 发明申请

WO9938191A3 TIME OF FLIGHT MASS SPECTROMETER AND DETECTOR THEREFOR 审中-公开
标题翻译：飞行时间大型光谱仪及其检测器
公开(公告)号：WO9938191A3
公开(公告)日：1999-10-07
申请号：PCT/GB9900250
申请日：1999-01-25
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , GILBERT ANTHONY JAMES , MERREN THOMAS OLIVER , HOYES JOHN BRIAN , COTTRELL JONATHAN CHARLES
发明人： BATEMAN ROBERT HAROLD , GILBERT ANTHONY JAMES , MERREN THOMAS OLIVER , HOYES JOHN BRIAN , COTTRELL JONATHAN CHARLES
IPC分类号： H01J49/02 , H01J49/06 , H01J49/40
CPC分类号： H01J49/0036 , H01J49/025 , H01J49/40
摘要： An ion detector (27) for use in a time-of-flight mass spectrometer (1) is disclosed. The ion detector (27), which has an extended dynamic range, comprises collection electrodes (36, 38; 39) of different surface areas. In one embodiment the collection electrodes (36, 38; 39) are formed in an array consisting of a larger plate-like collection electrode (36, 38) and a smaller plate-like collection electrode (39). Microchannel multiplier plates (31, 32) may be arranged in front of the collection electrodes (36, 38; 39). In an alternative embodiment the collection electrodes consist of a grid (42) or, more preferably, a wire electrode (50) disposed in front of a plate-like electrode (43).
摘要翻译：公开了一种用于飞行时间质谱仪（1）的离子检测器（27）。具有扩展动态范围的离子检测器（27）包括具有不同表面积的收集电极（36,38; 39）。在一个实施例中，收集电极（36,38; 39）形成为由更大的板状收集电极（36,38）和较小的板状收集电极（39）组成的阵列。微通道乘法器板（31,32）可以布置在收集电极（36,38; 39）的前面。在替代实施例中，收集电极由设置在板状电极（43）前面的格栅（42）或更优选地布线电极（50）组成。

22. 发明申请

WO9938190A3 TIME OF FLIGHT MASS SPECTROMETER AND DUAL GAIN DETECTOR THEREFOR 审中-公开
标题翻译：飞行时间质谱仪和双增益探测器的时间
公开(公告)号：WO9938190A3
公开(公告)日：1999-10-07
申请号：PCT/GB9900248
申请日：1999-01-25
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , GILBERT ANTHONY JAMES , MERREN THOMAS OLIVER , HOYES JOHN BRIAN , COTTRELL JONATHAN CHARLES
发明人： BATEMAN ROBERT HAROLD , GILBERT ANTHONY JAMES , MERREN THOMAS OLIVER , HOYES JOHN BRIAN , COTTRELL JONATHAN CHARLES
IPC分类号： H01J49/02 , H01J49/06 , H01J49/40
CPC分类号： H01J49/0036 , H01J49/025 , H01J49/40
摘要： An ion detector (27) for use in a time-of-flight mass spectrometer (1) is disclosed. The ion detector (27), which has an extended dynamic range, comprises at least one microchannel plate electron multiplier (42, 32) together with first and second collection electrodes (36, 38; 39). The second collection electrode (36, 38) is arranged such that in receives more electrons per ion entering the ion detector (27) than the first collection electrode (39). In one embodiment the collection electrodes (36, 38; 39) are formed in an array consisting of a larger plate-like collection electrode (36, 38) and a smaller plate-like collection electrode (39). In an alternative embodiment a second microchannel plate electron multiplier is arranged between the first collection electrode (46) and the second collection electrode (47). In this embodiment the first collection electrode consists either of a grid electrode (42) or more preferably of a wire electrode, and the second collection electrode consists of a plate-like electrode (43).
摘要翻译：公开了用于飞行时间质谱仪（1）的离子检测器（27）。具有扩展的动态范围的离子检测器（27）包括与第一和第二收集电极（36,38; 39）一起的至少一个微通道板电子倍增器（42,32）。第二收集电极（36,38）被布置为使得与第一收集电极（39）相比，每个离子进入离子检测器（27）接收更多的电子。在一个实施例中，收集电极（36,38; 39）形成为由较大的板状收集电极（36,38）和较小的板状收集电极（39）组成的阵列。在替代实施例中，第二微通道板电子倍增器被布置在第一收集电极（46）和第二收集电极（47）之间。在该实施例中，第一收集电极由网格电极（42）或更优选为线电极组成，并且第二收集电极由板状电极（43）组成。

23. 发明申请

WO2007060427A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007060427A3
公开(公告)日：2008-05-08
申请号：PCT/GB2006004370
申请日：2006-11-23
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD
发明人： BATEMAN ROBERT HAROLD
IPC分类号： H01J49/42
CPC分类号： H01J49/0045 , B82Y30/00
摘要： A method is disclosed of identifying parent ions by matching daughter ions found to be produced at substantially the same time that the parent ions elute from a mixture. Ions emitted from an ion source (1) are transmitted to a fragmentation device (4) comprising an Electron Capture Dissociation, an Electron Transfer Dissociation or a Surface Induced Dissociation fragmentation device. The fragmentation device (4) is alternately and repeatedly switched between a first mode wherein the ions are substantially fragmented to produce daughter ions and a second mode wherein the ions are not substantially fragmented. Mass spectra are taken in both modes. At the end of an experimental run parent and daughter ions are recognised by comparing the mass spectra obtained in the two different modes. Daughter ions are matched to particular parent ions on the basis of the closeness of fit of their elution times, and this enables parent ions then to be identified.
摘要翻译：公开了一种通过匹配发现在母体离子从混合物中洗脱出的基本上同时产生的子离子来鉴定亲本离子的方法。从离子源（1）发射的离子被传输到包括电子俘获解离，电子转移解离或表面诱导解离破碎装置的断裂装置（4）。碎片装置（4）在其中离子基本上分裂以产生子离子的第一模式和第二模式之间交替地和重复地切换，其中离子基本上不分散。质谱采用两种模式。在实验运行结束时，通过比较在两种不同模式中获得的质谱来识别母体和子体离子。基于其洗脱时间的拟合程度，子离子与特定的母体离子相匹配，这使得母体离子可以被鉴别。

24. 发明申请

WO2006129094A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006129094A3
公开(公告)日：2008-03-06
申请号：PCT/GB2006001996
申请日：2006-06-01
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY MARK , GREEN MARTIN , WILDGOOSE JASON LEE
IPC分类号： H01J49/02 , G06F19/00 , H01J49/00
CPC分类号： H01J49/0036
摘要： A method of mass spectrometry is disclosed wherein voltage signals from an ion detector are analysed. A second differential of each voltage signal is obtained and the start and end times of observed voltage peaks are determined. The intensity and average time of each voltage peak is then determined and the intensity and time values are stored. An intermediate composite mass spectrum is then formed by combining the intensity and time values which relate to each voltage peak observed from multiple experimental runs. The various pairs of time and intensity data are then integrated to produce a smooth continuum mass spectrum. The continuum mass spectrum may then be further processed by determining the second differential of the continuum mass spectrum. The start and end times of mass peaks observed in the continuum mass spectrum may be determined. The intensity and mass to charge ratio of each mass peak observed in the continuum mass spectrum may then determined. A final discrete mass spectrum comprising just of an intensity value and mass to charge ratio per species of ion may then be displayed or output.
摘要翻译：公开了一种质谱法，其中分析了来自离子检测器的电压信号。获得每个电压信号的第二差分，并且确定观察到的电压峰值的开始和结束时间。然后确定每个电压峰值的强度和平均时间，并存储强度和时间值。然后通过组合与多个实验运行中观察到的每个电压峰值相关的强度和时间值来形成中间复合质谱。然后将各种时间和强度数据对被整合以产生平滑的连续质谱。然后可以通过确定连续质谱的第二差分来进一步处理连续质谱。可以确定在连续质谱中观察到的质量峰的开始和结束时间。然后可以确定在连续质谱中观察到的每个质量峰的强度和质荷比。然后可以显示或输出包括仅每个离子种类的强度值和质荷比的最终离散质谱。

25. 发明申请

WO2007060437A2 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2007060437A2
公开(公告)日：2007-05-31
申请号：PCT/GB2006004387
申请日：2006-11-23
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD
发明人： BATEMAN ROBERT HAROLD
IPC分类号： H01J49/42
CPC分类号： H01J49/0045 , B82Y30/00
摘要： A method of mass spectrometry is disclosed wherein an Electron Collision Dissociation, Electron Transfer Dissociation or Surface Induced Dissociation fragmentation device is repeatedly switched between a high fragmentation mode and a low fragmentation mode. Parent ions from a first sample are passed through the device and parent ion mass spectra and fragmentation ion mass spectra are obtained. Parent ions from a second sample are then passed through the device and a second set of parent ion mass spectra and fragmentation ion mass spectra are obtained. The mass spectra are then compared and if either certain parent ions or certain fragmentation ions in the two samples are expressed differently then further analysis is performed to seek to identify the ions which are expressed differently in the two different samples.
摘要翻译：公开了一种质谱法，其中电子碰撞解离，电子转移解离或表面诱导解离断裂装置在高分裂模式和低碎裂模式之间重复切换。来自第一个样品的亲本离子通过器件，并获得亲本离子质谱和碎片离子质谱。然后将来自第二个样品的母离子通过该装置，并获得第二组母离子质谱和碎裂离子质谱。然后比较质谱，并且如果两个样品中的某些亲本离子或某些断裂离子不同地表达，则进行进一步分析以寻找在两个不同样品中不同表达的离子。

26. 发明申请

WO2006008537A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2006008537A3
公开(公告)日：2007-01-18
申请号：PCT/GB2005002874
申请日：2005-07-21
申请人： MICROMASS LTD , BATEMAN ROBERT HAROLD , BROWN JEFFERY , GREEN MARTIN
发明人： BATEMAN ROBERT HAROLD , BROWN JEFFERY , GREEN MARTIN
IPC分类号： H01J49/04 , H01J49/40 , H01J49/42
CPC分类号： H01J49/062 , H01J49/027 , H01J49/422 , H01J49/4245
摘要： A mass spectrometer is disclosed comprising a segmented linear ion guide or ion trap. Ions are confined radially within the ion guide or ion trap by the application of an AC or RF voltage to the electrodes forming the ion guide or ion trap. A quadratic DC potential is applied along the axial length of the ion guide or ion trap in order to cause trapped ions to perform simple harmonic motion within the ion guide or ion trap. The frequency of the oscillations of the ions is detected using one or more inductive detectors. The mass to charge ratio of the ions can then be determined from the determined frequency of oscillations.
摘要翻译：公开了一种质谱仪，其包括分段线性离子导向器或离子阱。通过对形成离子导向器或离子阱的电极施加AC或RF电压，离子导向器或离子阱中的离子被径向限制。沿着离子导向器或离子阱的轴向长度施加二次直流电位，以使被捕获的离子在离子导向器或离子阱内进行简单的谐波运动。使用一个或多个感应检测器检测离子振荡的频率。然后可以从确定的振荡频率确定离子的质荷比。

27. 发明申请

WO2005104178A3 MASS SPECTROMETER 审中-公开
标题翻译：质谱仪
公开(公告)号：WO2005104178A3
公开(公告)日：2006-10-12
申请号：PCT/GB2005001585
申请日：2005-04-26
申请人： MICROMASS LTD , GREEN MARTIN , BATEMAN ROBERT HAROLD
发明人： GREEN MARTIN , BATEMAN ROBERT HAROLD
IPC分类号： H01J49/02 , H01J9/00 , H01J31/00 , H01J37/00 , H01J43/24 , H01J49/10 , H04N5/00
CPC分类号： H01J43/246 , H01J49/025
摘要： An ion detector for a mass spectrometer is provided wherein a mask (10) is provided between a first microchannel plate (2a) and a second microchannel plate (2b). The mask (10) prevents ion arrival events causing a cloud of secondary electrons to be from the second microchannel plate (2b) which would illuminate two collection anodes (5,6) at substantially the same time. The mask (10) also prevents electron clouds emitted which would otherwise vary significantly in intensity.
摘要翻译：提供了一种用于质谱仪的离子检测器，其中掩模（10）设置在第一微通道板（2a）和第二微通道板（2b）之间。掩模（10）防止导致二次电子云的离子到达事件来自第二微通道板（2b），其将基本上同时照射两个收集阳极（5,6）。掩模（10）还防止了发射的电子云，否则其强度将显着变化。

28. 发明专利

JP2002110081A MASS SPECTROMETRY AND DEVICE 失效
公开(公告)号：JP2002110081A
公开(公告)日：2002-04-12
申请号：JP2001175747
申请日：2001-06-11
申请人： MICROMASS LTD
发明人： BATEMAN ROBERT HAROLD , KEVIN GILES , CLAYTON EDWARD JAMES
IPC分类号： G01N27/62 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/42
摘要： PROBLEM TO BE SOLVED: To provide a method for identifying a parent ion by collating a daughter ion of which the generation is substantially confirmed at the same time as when the parent ion is eluted from a mixture. SOLUTION: An ion released from an ion source 1 is incident on a collision cell 3 which is alternately and repeatedly switched between a first mode in which the ion is substantially fragmented to generate the daughter ion and a second mode in which the ion is not substantially fragmented. A mass spectrum is taken at both modes and the parent ion and the daughter ion are recognized by comparing the mass spectrums obtained at two different modes at a final stage of a trial. The daughter ion is adapted for a specific parent ion by an adaptability of an eluting time. Thereby, an identification of the parent ion becomes possible.

29. 发明专利

JP2002100318A MASS SPECTROMETRY AND DEVICE 失效
公开(公告)号：JP2002100318A
公开(公告)日：2002-04-05
申请号：JP2001175716
申请日：2001-06-11
申请人： MICROMASS LTD
发明人： BATEMAN ROBERT HAROLD , KEVIN GILES
IPC分类号： G01N27/62 , H01J49/10 , H01J49/26 , H01J49/40 , H01J49/42
摘要： PROBLEM TO BE SOLVED: To provide an identifying method of a candidate parent ion suitable to identify the candidate parent ion in a real time and to use for a chromatography. SOLUTION: An improving method of a parent ion scanning is disclosed. In one embodiment, a quadruple mass filter 3 of an upstream of a collision cell 4 is arranged to work in a high pass mode. The parent ion passed the mass light filter 3 is fragmentized by a collision cell 4, and is discovered by an orthogonal type time of flight analyzer 5 to acquire daughter ion spectra. Ions having mass/charge ratio of not more than cutoff value of the mass light filter 3 are identified as the daughter ions, and the candidate parent ion is subsequently discovered, and by acquiring corresponding daughter ion spectra, their identifications can be confirmed. In the first embodiment, because the collision cell is switched in alternation in a space of a high or low fragmentation, and further, the candidate parent ion can be identified based on a dissipation of a prescribed ion or a neutral particle.

30. 发明专利

JP2000057989A MASS SPECTROMETER AND MASS SPECTROMETRY 失效
公开(公告)号：JP2000057989A
公开(公告)日：2000-02-25
申请号：JP17287499
申请日：1999-06-18
申请人： MICROMASS LTD
发明人： BATEMAN ROBERT HAROLD , HICKSON JOHN ANTHONY DAVID
IPC分类号： H01J49/04 , G01N27/62 , G01N30/46 , G01N30/62 , G01N30/72 , H01J49/10 , H01J49/40 , H01J49/42
摘要： PROBLEM TO BE SOLVED: To provide a multi-inlet mass spectrometer by receiving plural fluid streams including an analysis sample without introducing ion simultaneously into a mass spectrograph. SOLUTION: This mass spectrometer is equipped with a vacuum chamber 8, a sampling region 7, a sampling-orifice 5, and a mass spectrograph for receiving charged particles passing along a first axis 37. Plural charged-particle jet generation means produce charged-particle jets derived from analysis fluid, and are arranged so that the axes thereof will cross with the first axis 37 in a sampling region 7. A jet selection means 4 is arranged so that the charged particles will pass through a first aperture, enter the inside of a hollow member 36 and move toward the first axis. Apertures are lined up successively relative to a jet axis, and the charged particles are made to enter the inside of the hollow member 36 successively, and to pass from the sampling-orifice 5 into the vacuum chamber 8, and mass spectrometry thereof is executed by the mass spectrograph in succession.

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