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21. 发明专利

DE10075400T1 Polyhydroxyalkanoatherstellung mittels Coenzym a-abhängigen Aldehyddehydrogenasepfaden 未知
公开(公告)号：DE10075400T1
公开(公告)日：2012-10-11
申请号：DE10075400
申请日：2003-09-12
申请人： METABOLIX INC
发明人： SKRALY FRANK A
IPC分类号： C12P7/62 , C12N1/21 , C12N9/02 , C12N15/52
摘要： Verfahren zur Erzeugung von Polyhydroxyalkanoat(PHA)-Polymeren, die wenigstens ein Hydroxyacylmonomer umfassen, das aus der aus 3-Hydroxypropionat, 3-Hydroxyvalerat, 4-Hydroxybutyrat, 4-Hydroxyvalerat, 5-Hydroxyvalerat und 3-Hydroxyhexanoat bestehenden Gruppe ausgewählt ist, wobei das Verfahren umfasst: Exprimieren von Genen, die für eine Polyhydroxyalkanoat(PHA)-Synthase und eine CoA-abhängige Aldehyddehydrogenase codieren, in einem Organismus, Verfüttern einer Chemikalie, die durch den Organismus über einen enzymkatalysierten Weg, der die Aktivität der CoA-abhängigen Aldehyddehydrogenase beinhaltet und die Polymerisation des wenigstens einen Hydroxyacyl-CoA-Monomers durch die PHA-Synthase unter Bildung von PHA-Polymeren ermöglicht, in wenigstens ein Hydroxyacyl-CoA-Monomer überführt wird, und Gewinnen der so erzeugten PHA-Polymere, wobei der Organismus aus einem Wildtyp-Organismus mit einem endogenen Gen der CoA-abhängigen Aldehyddehydrogenase, das durch eine Genmutation zur Erhöhung der Aktivität der CoA-abhängigen Aldehyddehydrogenase modifiziert wird, erzeugt wird, oder wobei der Organismus ein rekombinanter Organismus ist, in dem ein Gen zur Codierung der CoA-abhängigen Aldehyddehydrogenase rekombinant exprimiert wird.

22. 发明专利

DE69942799D1 未知
公开(公告)号：DE69942799D1
公开(公告)日：2010-11-11
申请号：DE69942799
申请日：1999-05-21
申请人： METABOLIX INC
发明人： SKRALY FRANK A , PEOPLES OLIVER P
IPC分类号： C12N15/09 , C12N15/52 , C08G63/06 , C12N1/21 , C12N9/00 , C12N9/10 , C12N15/54 , C12N15/70 , C12P7/62 , C12R1/19

23. 发明专利

DE69841579D1 未知
公开(公告)号：DE69841579D1
公开(公告)日：2010-05-06
申请号：DE69841579
申请日：1998-12-22
申请人： METABOLIX INC
发明人： MARTIN DAVID P , SKRALY FRANK A , WILLIAMS SIMON F
IPC分类号： C08G63/06 , A61K9/16 , A61K47/34 , A61K47/48 , A61L17/00 , A61L17/12 , A61L24/00 , A61L26/00 , A61L27/00 , A61L27/18 , A61L27/58 , A61L29/06 , A61L31/00 , A61L31/06 , A61L31/14 , C08G63/60 , C08G63/64 , C08G63/664 , C08G63/685 , C08G63/688 , C08G63/91 , C08J9/26 , C08J9/28 , C08K3/00 , C08K5/00 , C08L67/04 , C08L101/16 , C12P7/62 , D06M15/507

24. 发明专利

AU9496898A Biological systems for manufacture of polyhydroxylalkanoate polymers containing 4-hydroxyacids 未知
公开(公告)号：AU9496898A
公开(公告)日：1999-04-05
申请号：AU9496898
申请日：1998-09-18
申请人： METABOLIX INC
发明人： HUISMAN GJALT W , SKRALY FRANK A , MARTIN DAVID P , PEOPLES OLIVER P
IPC分类号： C12N15/09 , C08G63/06 , C12N1/21 , C12N9/02 , C12N9/10 , C12N15/53 , C12N15/54 , C12N15/82 , C12P7/52 , C12P7/62 , C12R1/19 , C12N15/70 , C12P1/04 , C12P7/00
摘要： The gene encoding a 4-hydroxybutyryl-Co A transferase has been isolated from bacteria and integrated into the genome of bacteria also expressing a polyhydroxyalkanoate synthase, to yield an improved production process for 4HB-containing polyhydroxyalkanoates using transgenic organisms, including both bacteria and plants. The new pathways provide means for producing 4HB containing PHAs from cheap carbon sources such as sugars and fatty acids, in high yields, which are stable. Useful strains are obtaining by screening strains having integrated into their genomes a gene encoding a 4HB-CoA transferase and/or PHA synthase, for polymer production. Processes for polymer production use recombinant systems that can utilize cheap substrates. Systems are provided which can utilize amino acid degradation pathways, α-ketoglutarate, or succinate as substrate.

25. 发明专利

BR112012020299A2 processo para produção de gama-butirolactona 未知
公开(公告)号：BR112012020299A2
公开(公告)日：2016-06-28
申请号：BR112012020299
申请日：2011-02-11
申请人： METABOLIX INC
发明人： AMBRUOSO ANN D , MIRLEY CHRISTOPHER , ANDERSON ERIK , SKRALY FRANK A , BICKMEIER JEFFREY A , WALSEM JOHAN VAN , LICATA JOHN , SPARKS KEVIN A , SIVASUBRAMANIAN M S , RAMSEIER THOMAS M , FARMER WILLIAM R , SHABTAI YOSSEF
IPC分类号： C07D307/33 , C12P7/62

26. 发明专利

AU2003200941C1 Polyhydroxyalkanoate biopolymer compositions 未知
公开(公告)号：AU2003200941C1
公开(公告)日：2008-10-23
申请号：AU2003200941
申请日：2003-03-11
申请人： METABOLIX INC
发明人： PEOPLES OLIVER P , SKRALY FRANK A
IPC分类号： C12N15/52 , C08G63/06 , C12N1/21 , C12P7/62

28. 发明专利

AU2003200941B2 Polyhydroxyalkanoate biopolymer compositions 未知
公开(公告)号：AU2003200941B2
公开(公告)日：2005-11-17
申请号：AU2003200941
申请日：2003-03-11
申请人： METABOLIX INC
发明人： PEOPLES OLIVER P , SKRALY FRANK A
IPC分类号： C12N015/52 , C08G063/06 , C12N001/21 , C12P007/62

30. 发明专利

AU4199599A Polyhydroxyalkanoate biopolymer compositions 未知
公开(公告)号：AU4199599A
公开(公告)日：1999-12-13
申请号：AU4199599
申请日：1999-05-21
申请人： METABOLIX INC
发明人： SKRALY FRANK A , PEOPLES OLIVER P
IPC分类号： C12N15/09 , C08G63/06 , C12N1/21 , C12N9/00 , C12N9/10 , C12P7/62 , C12R1/19 , C12N15/52 , C12N15/54 , C12N15/70
摘要： The present application provides a method for making poly(3-hydroxypropionate) in a biological system comprising providing one or more substrates selected from the group consisting of 3-hydroxypropionate and 1,3-propanediol, wherein the biological system is selected from the group consisting of bacteria, yeast, fungi, and plants; wherein the biological system expresses enzymes selected from the group consisting of polyhydroxyalkanoate synthase, acyl-CoA transferase, hydroxyacyl CoA transferase, and hydroxyacyl CoA synthetase such that poly(3-hydroxypropionate) accumulates. The present application also provides a method for making a polymer comprising 5-hydroxyvalerate in a biological system comprising providing one or more substrates selected from the group consisting of 5-hydroxyvalerate and 1,5-pentanediol, wherein the biological system is selected from the group consisting of bacteria, yeast, fungi, and plants; wherein the biological system expresses enzymes selected from the group consisting of polyhydroxyalkanoate synthase, acyl-CoA transferase, hydroxyacyl CoA transferase, and hydroxyacyl CoA synthetase such that a polymer comprising 5-hydroxyvalerate accumulates.

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