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21. 发明申请

WO1995006456A1 METHODS AND COMPOSITIONS FOR BINDING TAU AND MAP2c PROTEINS 审中-公开
标题翻译：用于结合TAU和MAP2c蛋白的方法和组合物
公开(公告)号：WO1995006456A1
公开(公告)日：1995-03-09
申请号：PCT/US1994008881
申请日：1994-08-05
申请人： DUKE UNIVERSITY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MEDICAL RESEARCH COUNCIL , STRITTMATTER, Warren, J. , ROSES, Allen, D. , GOEDERT, Michel , WEISGRABER, Karl, H. , SAUNDERS, Ann, M. , SCHMECHEL, Donald, E.
发明人： DUKE UNIVERSITY , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , MEDICAL RESEARCH COUNCIL
IPC分类号： A61K07/46
CPC分类号： A61K38/1709 , A61K48/00 , C07K14/775 , G01N33/6896 , G01N2333/4709 , G01N2800/2821
摘要： A method of combatting Alzheimer's disease which comprises increasing the binding of the tau protein in nerve cells of that subject, and/or the binding or MAP2c protein in nerve cells of that subject, to either Apolipoprotein E or an Apolipoprotein E fragment capable of binding tau and/or MAP2c. In one embodiment, the method comprises administering the ApoE or ApoE fragment to the subject; in another embodiment, the method comprises administering to the subject a vector capable of entering nerve cells, which vector then upregulates the expression of an ApoE or an ApoE fragment capable of binding tau and/or MAP2c in nerve cells. Compositions useful for carrying out these methods are also disclosed.
摘要翻译：一种抗阿尔茨海默氏病的方法，其包括增加该受试者的神经细胞中的tau蛋白和/或该受试者的神经细胞中的结合或MAP2c蛋白与能够结合tau的载脂蛋白E或载脂蛋白E片段的结合和/或MAP2c。在一个实施方案中，所述方法包括对受试者施用ApoE或ApoE片段; 在另一个实施方案中，该方法包括向受试者施用能够进入神经细胞的载体，该载体然后上调神经细胞中能够结合tau和/或MAP2c的ApoE或ApoE片段的表达。还公开了用于实施这些方法的组合物。

22. 发明申请

WO1994028151A1 GENE THERAPY FOR HAEMOPHILIA 审中-公开
标题翻译：天疱疮基因治疗
公开(公告)号：WO1994028151A1
公开(公告)日：1994-12-08
申请号：PCT/GB1994001114
申请日：1994-05-20
申请人： ROYAL FREE HOSPITAL SCHOOL OF MEDICINE , MEDICAL RESEARCH COUNCIL , GOLDSPINK, Geoffrey , LEE, Christine , TUDDENHAM, Edward
发明人： ROYAL FREE HOSPITAL SCHOOL OF MEDICINE , MEDICAL RESEARCH COUNCIL
IPC分类号： C12N15/85
CPC分类号： C12N15/85 , A61K38/00 , C07K14/755 , C07K2319/02 , C12N2830/008 , C12N2830/30 , C12N2830/85
摘要： The invention provides a recombinant nucleic acid construct comprising: (i) a mammalian myosin heavy chain promoter; (ii) nucleic acid encoding a signal sequence; and (iii) nucleic acid encoding a functional blood clotting protein; the elements (i)-(iii) being operably linked to provide for expression of the functional protein. The construct is useful for the treatment of diseases such as haemophilia by introducing it into muscle cells. The activity of the promoter can be enhanced by exercise or stimulation of the muscle cells.
摘要翻译：本发明提供重组核酸构建体，其包含：（i）哺乳动物肌球蛋白重链启动子; （ii）编码信号序列的核酸; 和（iii）编码功能性凝血蛋白的核酸; 元件（i） - （iii）可操作地连接以提供功能性蛋白质的表达。该构建体可用于通过将其引入肌细胞来治疗诸如血友病的疾病。通过肌肉细胞的运动或刺激可以增强启动子的活性。

23. 发明申请

WO1994024309A1 POLYMORPHISMS IN HUMAN PHOSPHOGLUCOMUTASE-1 审中-公开
标题翻译：人类磷酸化酶-1的多态性
公开(公告)号：WO1994024309A1
公开(公告)日：1994-10-27
申请号：PCT/GB1994000809
申请日：1994-04-18
申请人： MEDICAL RESEARCH COUNCIL , HOPKINSON, David, Albert , EDWARDS, Yvonne, Hermione , WHITEHOUSE, David, Bertram
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12Q01/68
CPC分类号： G01N33/573 , C07K16/40 , C12N9/90 , C12Q1/6858 , C12Q1/6862
摘要： Polymorphisms in human PGM1 have been identified at both DNA and protein levels. Test processes and reagents for detecting these polymorphisms are claimed.
摘要翻译：已经在DNA和蛋白质水平上鉴定了人PGM1中的多态性。要求用于检测这些多态性的测试方法和试剂。

24. 发明申请

WO1994018593A1 DETECTING MEANS FOR A SCANNING OPTICAL MICROSCOPE 审中-公开
标题翻译：用于扫描光学显微镜的检测手段
公开(公告)号：WO1994018593A1
公开(公告)日：1994-08-18
申请号：PCT/GB1994000249
申请日：1994-02-09
申请人： MEDICAL RESEARCH COUNCIL , AMOS, William, Bradshaw
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： G02B21/00
CPC分类号： G02B27/1013 , G02B21/0064 , G02B27/145
摘要： A scanning, confocal, optical microscope assembly has a detecting means (16) for receiving multi-wavelength light transmitted through a specimen located in the microscope (14). This detecting means (16) comprises beam splitters (46, 48) for splitting the multi-wavelength transmitted light into three components corresponding to different wavelength ranges, and three optical sensors (56, 58, 60) for receiving the respective components. The outputs of the sensors may be processed and a full transmission colour image displayed on a television monitor (64).
摘要翻译：扫描共焦光学显微镜组件具有用于接收透射通过位于显微镜（14）中的试样的多波长光的检测装置（16）。该检测装置（16）包括用于将多波长透射光分解成对应于不同波长范围的三个分量的分束器（46,48）和用于接收各个部件的三个光学传感器（56,58,60）。传感器的输出可以被处理，并且在电视监视器（64）上显示全传输彩色图像。

25. 发明申请

WO1994011513A1 HEAT SHOCK PROTEINS AND THE TREATMENT OF TUMOURS 审中-公开
标题翻译：热休克蛋白和肿瘤治疗
公开(公告)号：WO1994011513A1
公开(公告)日：1994-05-26
申请号：PCT/GB1993002339
申请日：1993-11-15
申请人： MEDICAL RESEARCH COUNCIL , COLSTON, Michael, Joseph , LOWRIE, Douglas , LUKACS, Katalin, Veronika
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N15/31
CPC分类号： C07K14/35 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K48/00 , C12N2799/027
摘要： An expression vector is provided for use in the treatment of neoplasms which vector comprises nucleic acid including at least one sequence which encodes in expressible form a polypeptide which is a heat shock polypeptide (hsp) or a chaperone.
摘要翻译：提供用于治疗肿瘤的表达载体，其载体包含核酸，其包含至少一个编码可表达形式的热休克多肽（hsp）或伴侣的多肽的序列。

26. 发明申请

WO1994010307A1 TRANSCRIPTION FACTOR DP-1 审中-公开
标题翻译：转录因子DP-1
公开(公告)号：WO1994010307A1
公开(公告)日：1994-05-11
申请号：PCT/GB1993002227
申请日：1993-10-29
申请人： MEDICAL RESEARCH COUNCIL , LA THANGUE, Nicholas, Barrie
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N15/12
CPC分类号： G01N33/5091 , A61K39/00 , C07K14/4738 , C07K16/18 , C12N15/81 , C12Q1/6897 , G01N33/5008 , G01N33/5011 , G01N33/6872 , G01N2500/00
摘要： The invention provides a polynucleotide in substantially isolated form which comprises a contiguous sequence of nucleotides which is capable of selectively hybridizing to Seq. ID No. 1 or to the complement of Seq. ID No. 1, and a polypeptide in substantially isolated form which comprises: (a) the protein of Seq. ID No. 2; or (b) an allelic variant or species homologue thereof; or c) a protein at least 70 % homologous to (a); or (d) a fragment of any one of (a) to (c) capable of forming a complex with the E2F-1 protein or related family member; or (e) a fragment of any one of (a) to (c) of at least 15 amino acids.
摘要翻译：本发明提供基本上分离形式的多核苷酸，其包含能够选择性地与Seq杂交的连续的核苷酸序列。 ID号1或Seq的补充。 ID号1和基本上分离形式的多肽，其包含：（a）Seq的蛋白质。身份证号码2; 或（b）等位基因变体或其物种同系物; 或c）与（a）至少70％同源的蛋白质; 或（d）能够与E2F-1蛋白质或相关家族成员形成复合物的（a）至（c）中任一项的片段; 或（e）至少15个氨基酸的（a）至（c）中任一项的片段。

27. 发明申请

WO1994008037A1 HUMAN HOMOLOGS OF THE TRANSDUCIN-LIKE ENHANCER OF SPLIT GENE AND METHODS BASED THEREON 审中-公开
标题翻译：分子基因转录增强子的人类HOMOLOGY及其基于方法
公开(公告)号：WO1994008037A1
公开(公告)日：1994-04-14
申请号：PCT/US1993009333
申请日：1993-09-30
申请人： YALE UNIVERSITY , MEDICAL RESEARCH COUNCIL , ARTAVANIS-TSAKONAS, Spyridon , STIFANI, Stefani , REDHEAD, Nicola, J. , HILL, Robert, E.
发明人： YALE UNIVERSITY , MEDICAL RESEARCH COUNCIL
IPC分类号： C12P21/06
CPC分类号： C07K14/47 , C07K16/18
摘要： The present invention relates to nucleotide sequences of the human transducin-like Enhancer of split ("TLE") genes, and amino acid sequences of their encoded TLE proteins. The invention further relates to fragments and other derivatives, and analogs, of human TLE proteins, as well as antibodies thereto. Nucleic acids encoding such fragments or derivatives are also within the scope of the invention. Production of the foregoing proteins and derivatives, e.g., by recombinant methods, is provided. Binding partners of TLE proteins are also provided. In particular, the invention provides sequences of four distinct human homologs of the Drosophila TLE gene, and sequences of their unique encoded TLE proteins. In specific embodiments, the invention relates to derivatives and analogs of the human TLE proteins which are functionally active, or which comprise one or more domains of a human TLE protein, including but not limited to the "Q domain", "GP domain", "CcN domain", "SP domain", "WD-40 domain", or a WD-40 repeat, casein kinase II (CK II) site, cdc2 kinase (cdc2) site, or nuclear localization sequence motif, consensus sequences for any of the foregoing, or any combination of the foregoing.
摘要翻译：本发明涉及分裂（“TLE”）基因的人转导素样增强子的核苷酸序列，以及它们编码的TLE蛋白的氨基酸序列。本发明还涉及人TLE蛋白的片段和其它衍生物和类似物，以及其抗体。编码这种片段或衍生物的核酸也在本发明的范围内。提供了上述蛋白质和衍生物的生产，例如通过重组方法。还提供了TLE蛋白的结合伙伴。特别地，本发明提供了果蝇TLE基因的四个不同的人类同源物的序列，以及它们唯一编码的TLE蛋白的序列。在具体实施方案中，本发明涉及功能上有活性或包含人TLE蛋白的一个或多个结构域的人TLE蛋白的衍生物和类似物，包括但不限于“Q域”，“GP结构域”， “CcN域”，“SP结构域”，“WD-40结构域”或WD-40重复，酪蛋白激酶II（CK II）位点，cdc2激酶（cdc2）位点或核定位序列基序，或上述的任何组合。

28. 发明申请

WO1994006920A1 RECOMBINANT VIRUSES DISPLAYING A NONVIRAL POLYPEPTIDE ON THEIR EXTERNAL SURFACE 审中-公开
标题翻译：在其外表面上显示非天然多肽的重组病毒
公开(公告)号：WO1994006920A1
公开(公告)日：1994-03-31
申请号：PCT/GB1993001992
申请日：1993-09-22
申请人： MEDICAL RESEARCH COUNCIL , RUSSELL, Stephen, James , HAWKINS, Robert, Edward , WINTER, Gregory, Paul
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12N15/86
CPC分类号： C40B40/02 , A61K48/00 , C12N15/1037 , C12N15/86 , C12N15/87 , C12N2740/13043 , C12N2740/13045 , C12N2810/859
摘要： We have made retrovirus particles displaying a functional antibody fragment. We fused the gene encoding an antibody fragment directed against a hapten with that encoding the viral envelope protein (Pr80env) of the ecotropic Moloney murine leukemia virus. The fusion gene was co-expressed in ecotropic retroviral packaging cells with a retroviral plasmid carrying the neomycin phosphotransferase gene (neo), and retroviral particles with specific hapten biding activities were recovered. Furthermore the hapten-binding particles were able to transfer the neo gene and the antibody-envelope fusion gene to mouse fibroblasts. In principle, the display of antibody fragments on the surface of recombinant retroviral particles could be used to target virus to cells for gene delivery, or to retain the virus in target tissues, or for the construction of libraries of viral display packages.
摘要翻译：我们已经制备出显示功能性抗体片段的逆转录病毒颗粒。我们将编码针对半抗原的抗体片段的基因与编码亲和性莫洛尼鼠白血病病毒的病毒包膜蛋白（Pr80env）的基因融合。融合基因在携带新霉素磷酸转移酶基因（neo）的逆转录病毒质粒的亲和逆转录病毒包装细胞中共表达，并回收具有特异性半抗原活性的逆转录病毒颗粒。此外，半抗原结合颗粒能够将neo基因和抗体 - 包膜融合基因转移至小鼠成纤维细胞。原则上，重组逆转录病毒颗粒表面上的抗体片段的显示可用于将病毒靶向到细胞进行基因递送，或将病毒保留在靶组织中，或用于构建病毒显示包的文库。

29. 发明申请

WO1994001582A1 PROCESS FOR CATEGORISING NUCLEOTIDE SEQUENCE POPULATIONS 审中-公开
标题翻译：分类核型序列群体的过程
公开(公告)号：WO1994001582A1
公开(公告)日：1994-01-20
申请号：PCT/GB1993001452
申请日：1993-07-13
申请人： MEDICAL RESEARCH COUNCIL , SIBSON, David, Ross
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12Q01/68
CPC分类号： C12Q1/683 , C12N15/1096 , C12Q1/6809 , C12Q1/6855 , C12Q1/6858 , F02B2075/027 , C12Q2525/191 , C12Q2537/143 , C12Q2521/313
摘要： A process for the categorization of nucleic acid sequences in which said sequences are linked to a population of adaptor molecules each exhibiting specificity for linking to a sequence including a predetermined nucleotide base, categorization of the resulting linked sequences being based upon selection for the base.
摘要翻译：核酸序列的分类方法，其中所述序列与衔接子分子群体连接，每个连接子分子显示出特异性连接到包含预定核苷酸碱基的序列，所得到的连锁序列的分类基于碱基的选择。

30. 发明申请

WO1993021340A1 DNA SEQUENCING METHOD 审中-公开
标题翻译： DNA序列方法
公开(公告)号：WO1993021340A1
公开(公告)日：1993-10-28
申请号：PCT/GB1993000848
申请日：1993-04-22
申请人： MEDICAL RESEARCH COUNCIL , ROSENTHAL, André , BRENNER, Sydney
发明人： MEDICAL RESEARCH COUNCIL
IPC分类号： C12Q01/68
CPC分类号： C12Q1/6869 , C12Q2537/149 , C12Q2525/186 , C12Q2521/319
摘要： There is disclosed a method for determining the sequence of a nucleic acid comprising the steps of: a) forming a single-stranded template comprising the nucleic acid to be sequenced; b) hybridising a primer to the template to form a template/primer complex; c) extending the primer by the addition of a single labelled nucleotide; d) determining the type of the labelled nucleotide added onto the primer; e) removing or neutralising the label; and f) repeating steps (c) to (e) sequentially and recording the order of incorporation of labelled nucleotides. There is also disclosed apparatus for carrying out the method.
摘要翻译：公开了一种确定核酸序列的方法，包括以下步骤：a）形成包含要测序的核酸的单链模板; b）将引物与模板杂交以形成模板/引物复合物; c）通过添加单个标记的核苷酸延伸引物; d）确定添加到引物上的标记核苷酸的类型; e）去除或中和标签; 和f）依次重复步骤（c）至（e），并记录标记核苷酸的掺入顺序。还公开了用于执行该方法的装置。

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