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21. 发明授权

US06858773B2 Transgenic mice comprising transcription control elements associated with mouse eosinophil peroxidase expression 有权
标题翻译：包含与小鼠嗜酸性粒细胞过氧化物酶表达相关的转录控制元件的转基因小鼠
公开(公告)号：US06858773B2
公开(公告)日：2005-02-22
申请号：US10126912
申请日：2002-04-19
申请人： Hongbing Zhang , Pamela Contag , Anthony Purchio , Amy Holt
发明人： Hongbing Zhang , Pamela Contag , Anthony Purchio , Amy Holt
IPC分类号： A01K67/027 , C12N15/85 , A01K67/00 , A01K67/033
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , A01K2267/0381 , A01K2267/0393 , C12N2830/008
摘要： The present invention relates to novel transcription control elements derived from a mouse eosinophil peroxidase gene. The novel transcription control elements described in the disclosure may comprise isolated polynucleotides, expression cassettes, vectors, recombinant cells, and transgenic animals.
摘要翻译：本发明涉及来自小鼠嗜酸性粒细胞过氧化物酶基因的新型转录控制元件。本公开中描述的新型转录控制元件可以包含分离的多核苷酸，表达盒，载体，重组细胞和转基因动物。

22. 发明授权

US08239585B2 Systems and methods for improved hardware device connectivity 有权
标题翻译：改进硬件设备连接的系统和方法
公开(公告)号：US08239585B2
公开(公告)日：2012-08-07
申请号：US11992862
申请日：2005-09-29
申请人： Brett Wang , Minqiang Wu , Winters Zhang , Hongbing Zhang
发明人： Brett Wang , Minqiang Wu , Winters Zhang , Hongbing Zhang
IPC分类号： G06F3/00 , G06F13/00 , G06F13/20
CPC分类号： G06F13/4291
摘要： Systems and methods are described herein to provide for improved hardware device connectivity. Other embodiments include apparatus and system for receiving messages from an operating system and sending messages to one or more hardware devices. Further embodiments include methods for receiving messages from an operating system regarding operations on a hardware device and responding to those messages. Other embodiments include methods for receiving interrupt messages and mapping those interrupt messages to hardware devices. Other embodiments are described and claimed.
摘要翻译：本文描述了系统和方法以提供改进的硬件设备连接性。其他实施例包括用于从操作系统接收消息并向一个或多个硬件设备发送消息的装置和系统。另外的实施例包括用于从操作系统接收关于硬件设备上的操作并响应于那些消息的消息的方法。其他实施例包括用于接收中断消息并将这些中断消息映射到硬件设备的方法。描述和要求保护其他实施例。

23. 发明授权

US06872750B2 Modulating angiogenesis 有权
公开(公告)号：US06872750B2
公开(公告)日：2005-03-29
申请号：US10068591
申请日：2002-02-06
申请人： Duojia Pan , Gerald M. Rubin , Hongbing Zhang
发明人： Duojia Pan , Gerald M. Rubin , Hongbing Zhang
IPC分类号： G01N33/48 , A61K31/198 , A61K31/381 , A61K31/405 , A61K38/48 , A61K39/395 , A61K45/00 , A61P35/00 , A61P43/00 , C07K16/18 , C12Q1/37 , G01N33/53 , G01N33/573 , G01N33/574 , A61K31/19 , A61K38/00
CPC分类号： A61K31/405 , A61K31/198 , A61K31/381 , A61K38/4886 , A61K2039/505 , C07K16/18 , C12Q1/37 , G01N33/573 , G01N2333/96486 , G01N2500/04 , G01N2500/10
摘要： The invention provides methods and compositions relating to Kuz involvement in angiogenesis. In various embodiments, the invention provides methods for modulating angiogenesis by specifically modulating the activity of Kuz in a vertebrate animal predetermined to have a pathogenic angiogenesis; methods for modulating angiogenesis by specifically modulating the activity of Kuz in a vertebrate animal and subsequently detecting a resultant angiogenic modulation in the animal; methods for specifically detecting Kuz activity in a vertebrate animal predetermined to have a pathogenic angiogenesis; methods for specifically detecting a pathogenic angiogenesis in a vertebrate animal having a predetermined Kuz activity; and methods for identifying a modulator of angiogenesis by (a) contacting an angiogenic assay system comprising a predetermined amount of Kuz with a candidate agent, under conditions whereby but for the presence of the agent, the system provides a reference angiogenesis; and (b) detecting an agent-biased angiogenesis of the system.

24. 发明授权

US06436629B1 Modulating angiogenesis 有权
标题翻译：调节血管发生
公开(公告)号：US06436629B1
公开(公告)日：2002-08-20
申请号：US09697854
申请日：2000-10-27
申请人： Duojia Pan , Gerald M. Rubin , Hongbing Zhang
发明人： Duojia Pan , Gerald M. Rubin , Hongbing Zhang
IPC分类号： C12Q100
CPC分类号： A61K31/405 , A61K31/198 , A61K31/381 , A61K38/4886 , A61K2039/505 , C07K16/18 , C12Q1/37 , G01N33/573 , G01N2333/96486 , G01N2500/04 , G01N2500/10
摘要： The invention provides methods and compositions relating to Kuz involvement in angiogenesis. In various embodiments, the invention provides methods for modulating angiogenesis by specifically modulating the activity of Kuz in a vertebrate animal predetermined to have a pathogenic angiogenesis; methods for modulating angiogenesis by specifically modulating the activity of Kuz in a vertebrate animal and subsequently detecting a resultant angiogenic modulation in the animal; methods for specifically detecting Kuz activity in a vertebrate animal predetermined to have a pathogenic angiogenesis; methods for specifically detecting a pathogenic angiogenesis in a vertebrate animal having a predetermined Kuz activity; and methods for identifying a modulator of angiogenesis by (a) contacting an angiogenic assay system comprising a predetermined amount of Kuz with a candidate agent, under conditions whereby but for the presence of the agent, the system provides a reference angiogenesis; and (b) detecting an agent-biased angiogenesis of the system.
摘要翻译：本发明提供了关于Kuz参与血管生成的方法和组合物。在各种实施方案中，本发明提供了通过特异性调节预定具有致病性血管发生的脊椎动物中Kuz的活性来调节血管发生的方法; 通过特异性调节脊椎动物中Kuz的活性并随后检测动物中产生的血管生成调节来调节血管发生的方法; 用于特异性检测预定具有致病性血管生成的脊椎动物中的Kuz活性的方法; 用于特异性检测具有预定Kuz活性的脊椎动物中的病原性血管发生的方法; 以及通过以下步骤鉴定血管生成调节剂的方法：（a）在包含预定量的库兹的血管生成测定系统与候选试剂的接触条件下，在所述试剂的存在的条件下，所述系统提供参考血管生成; 和（b）检测系统的药剂偏向血管发生。

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