专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明专利

NO20052478L 未知
公开(公告)号：NO20052478L
公开(公告)日：2005-05-23
申请号：NO20052478
申请日：2005-05-23
申请人： LEO PHARMA AS
发明人： CALVERLEY MARTIN JOHN , BINDERUP ERNST TORNDAL , HANSEN KAI HOLST , BRETTING CLAUS AAGE SVENSGAARD
IPC分类号： C07C401/00 , A61K31/59 , A61K31/593 , A61P5/20
摘要： Compounds according to formula I: in which formula R1 and R2, which may be the same or different, represent halogen, (C1-C6) hydrocarbyl, optionally substituted with one or two hydroxyl group on one or more fluorine atoms, or, together with the carbon atom to which they are both attached, R1 and R2 form a (C3-C6)carbocyclic ring, or one of R1 and R2 taken together with R3 forms a direct bond, such that a triple bond is constituted, or R1 and R2 represent both hydrogen; R3 when not forming a direct bond with one of R1 and R2 represents hydrogen or (C1-C3)hydrocarbyl; X represents (E)-ethylene, (Z)-ethylene, ethynylene, or a bond; Y and Z independently represent hydrogen or methyl; the bond between C#16 and C#17 is depicted with a dotted line to illustrate that said bond may be either a single bond, in which case the projection of the ring substituents is beta, or a double bond; A represents hydroxyl, fluorine or hydrogen; B represents CH2 or H2; the configuration is the 3-position corresponds to the same configuration as in natural vitamine D3 (normal), or the configuration in the configuration in the 3-position is opposite to that of natural vitamin D3(epi); with the proviso that when X represents (E)-ethylene or (Z)-ethylene, one of R1 and R2 taken together with R3 may not form a direct bond, such that a triple bond is constituted; with the further proviso that when X represents a bond R1 ands R2 are nor hydrogen; with the further proviso that the compound of formula I is not 3(S)-hyroxy-9, 10-secocholesta-5(Z),7(E),10(19),22(E),24-penta-ene; and prodrugs and stereo isomeric forms thereof are provided together with their use in therapy, and their use in the manufacture of medicaments.

22. 发明专利

AU2003223932A1 CYANOGUANIDINE PRODUGS 未知
公开(公告)号：AU2003223932A1
公开(公告)日：2003-12-02
申请号：AU2003223932
申请日：2003-05-15
申请人： LEO PHARMA AS
发明人： BINDERUP ERNST TORNDAL
IPC分类号： C07D213/02 , A61K31/4425 , A61K31/444 , A61K45/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07D213/75 , C07D401/12
摘要： Pyridyl cyanoguanidine compounds according to formula I wherein A, R 1 , R 2 , R 5 , R 6 , X 1 , X 2 , X 3 , X 4 , Y 1 , Y 2 , Y 3 , Y 4 and n are as indicated in the description are useful as prodrugs in human veterinary therapy of proliferative diseases such as cancers.

23. 发明专利

MY144065A EPIMERISATION OF ALLYLIC ALCOHOLS. 未知
公开(公告)号：MY144065A
公开(公告)日：2011-08-15
申请号：MYPI20054076
申请日：2005-08-30
申请人： LEO PHARMA AS
发明人： BINDERUP ERNST TORNDAL , BRETTING CLAUS AAGE SVENSGAARD , PEDERSON HENRIK
IPC分类号： C07C401/00
摘要： EPIMERISATION OF ALLYLIC ALCOHOLS THE PRESENT INVENTION RELATES TO PROCESSES FOR ELPINNERISING ALCOHOLS OF COMPOUNDS HAVING A HYDROXYL SUBSTITUENL ON AN ASYMMETRIC ALLYLIC CARBON, SUCH AS COMPOUNDS USEFUL FOR 5 THE SYNTHESIS OF VITAMIN D ANALOGUES WHERE THE EPIMERIC HYDROXYL SUBSTITUENT IS AT THE 24 POSITION. THE INVENTION FURTHER RELATES LO METHODS OF PRODUCING INTERMEDIATES USEFUL FOR THE SYNTHESIS OF CALCIPOTRIOL BY SAID EPINIERISATION PROCESSES.

24. 发明专利

ES2315895T3 EPIMERIZACION DE ALCOHOLES ALILICOS. 未知
公开(公告)号：ES2315895T3
公开(公告)日：2009-04-01
申请号：ES05770141
申请日：2005-08-22
申请人： LEO PHARMA AS
发明人： PEDERSEN HENRIK , BRETTING CLAUS AAGE , BINDERUP ERNST TORNDAL
IPC分类号： C07C401/00 , C07J9/00
摘要： Un método para epimerizar un epímero o mezcla epimérica de un compuesto que comprende una cadena lateral de estructura general A y/o B, (Ver fórmula) en la posición del átomo de carbono al que están unidos el grupo hidroxi y R3; poniendo en contacto dicho epímero o mezcla epimérica con un ácido en presencia de agua; donde R3 es alquilo(C1-C12), alquenilo(C2-C10), alquinilo(C2-C20), o cicloalquilo(C3-C20), opcionalmente sustituido con uno o más sustituyentes seleccionados entre el grupo compuesto por alquilo(C1-C12), -C(O)-O-alquilo(C1-C12), halógeno, hidroxi, metoxi, y etoxi; donde el carbono marcado con un asterisco está conectado por un enlace sencillo al átomo de carbono C-17 de un fragmento del análogo de vitamina D; o donde el carbono marcado con un asterisco está conectado por un enlace sencillo a un fragmento de un precursor para la síntesis de un análogo de vitamina D en su posición análoga C-17; donde el fragmento de un precursor para la síntesis de un análogo de vitamina D es un fragmento de un sistema de anillos esteroide o un fragmento de un sistema de anillos CD de un esteroide; donde el fragmento del sistema de anillos esteroide está representado por la estructure Q o R (Ver fórmula) donde el fragmento de un sistema de anillos CD de un esteroide está representado por la estructura E o P (Ver fórmula) donde PG representa hidrógeno o un grupo protector de hidroxi; donde el fragmento del análogo de vitamina D está representado por uno cualquiera de los fragmentos F, G, H, J, K, o L (Ver fórmula) donde R1 y/o R2 pueden ser iguales o diferentes y representan hidrógeno o un grupo protector de hidroxi.

25. 发明专利

HK1076812A1 CYANOGUANIDINE PRODRUGS 未知
公开(公告)号：HK1076812A1
公开(公告)日：2006-01-27
申请号：HK05108938
申请日：2005-10-10
申请人： LEO PHARMA AS
发明人： BINDERUP ERNST TORNDAL , DUVOLD TORE
IPC分类号： C07D211/22 , A61K20090101 , A61K31/196 , A61K31/198 , A61K31/282 , A61K31/337 , A61K31/4425 , A61K31/4545 , A61K31/475 , A61K31/513 , A61K31/593 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K45/00 , A61P20090101 , A61P1/04 , A61P1/16 , A61P7/00 , A61P11/00 , A61P13/02 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , C07C271/16 , C07D20090101 , C07D211/62 , C07D213/02 , C07D213/75 , C07D401/12
摘要： Pyridyl cyanoguanidine compounds of the general formula I wherein A, X 1 , X 2 , X 3 , Y 1 , Y 2 , Y 3 , R 1 , R 2 , R 5 , R 6 and n are as indicated in the description are suitable as prodrugs in human and veterinary therapy of proliferative diseases such as cancers.

26. 发明专利

BR0309996A 未知
公开(公告)号：BR0309996A
公开(公告)日：2005-02-22
申请号：BR0309996
申请日：2003-05-15
申请人： LEO PHARMA AS
发明人： BINDERUP ERNST TORNDAL , DUVOLD TORE
IPC分类号： C07D211/22 , A61K31/196 , A61K31/198 , A61K31/282 , A61K31/337 , A61K31/4425 , A61K31/4545 , A61K31/475 , A61K31/513 , A61K31/593 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K33/24 , A61K45/00 , A61P1/04 , A61P1/16 , A61P7/00 , A61P11/00 , A61P13/02 , A61P13/08 , A61P13/10 , A61P13/12 , A61P15/00 , A61P17/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P35/02 , C07C271/16 , C07D211/62 , C07D213/02 , C07D213/75 , C07D401/12
摘要： Pyridyl cyanoguanidine compounds of the general formula I wherein A, X 1 , X 2 , X 3 , Y 1 , Y 2 , Y 3 , R 1 , R 2 , R 5 , R 6 and n are as indicated in the description are suitable as prodrugs in human and veterinary therapy of proliferative diseases such as cancers.

27. 发明专利

IS7563A Sýanógúanidínforlyf 未知
公开(公告)号：IS7563A
公开(公告)日：2004-11-29
申请号：IS7563
申请日：2004-11-29
申请人： LEO PHARMA AS
发明人： BINDERUP ERNST TORNDAL
IPC分类号： C07D213/02 , A61K31/4425 , A61K31/444 , A61K45/00 , A61P29/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07D213/75 , C07D401/12

28. 发明专利

PL362864A1 CYANOGUANIDINE PRODRUGS 未知
公开(公告)号：PL362864A1
公开(公告)日：2004-11-02
申请号：PL36286401
申请日：2001-11-14
申请人： LEO PHARMA AS
发明人： BINDERUP ERNST TORNDAL , HJARNAA PERNILL-JULIA VIG
IPC分类号： A61K31/196 , A61K31/198 , A61K31/282 , A61K31/337 , A61K31/4422 , A61K31/4425 , A61K31/475 , A61K31/513 , A61K31/675 , A61K31/704 , A61K31/7048 , A61K31/7068 , A61K45/00 , A61P35/00 , A61P35/02 , A61P43/00 , C07D211/84 , C07D213/50 , C07D213/74 , C07D213/75 , C07D217/22 , A61K31/44
摘要： The invention relates to compounds formula I or formula II wherein R 1 -R 5 , X 1 -X 2 , Y 1 -Y 3 , A, Z - , n, m and r are as defined herein. The compounds are well suited as prodrugs in human and veterinary therapy.

29. 发明专利

AU776755B2 Use of vitamin D-derivatives in the treatment of osteoporosis and related bone disorders, as well as novel vitamin D3-derivatives 未知
公开(公告)号：AU776755B2
公开(公告)日：2004-09-23
申请号：AU2832901
申请日：2001-01-31
申请人： LEO PHARMA AS
发明人： GRUE-SORENSEN GUNNAR , PEDERSEN HENRIK , BINDERUP ERNST TORNDAL , TRANHOLM MIKAEL
IPC分类号： A61K31/59 , A61K31/593 , A61P3/10 , A61P13/12 , A61P17/00 , A61P17/06 , A61P17/12 , A61P17/16 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/28 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , C07C323/15 , C07C323/19 , C07C323/20 , C07C401/00
摘要： Compounds of the formula I wherein X represents hydrogen or hydroxy; Y represents oxygen or sulphur or oxidized sulphur selected from the groups S(O) and S(O 2 ); R 1 and R 2 , which may be the same or different, represent hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsaturated, C 1 -C 6 -hydrocarbon; or R 1 and R 2 , together with the carbon atom to which they are attached (marked with an asterisk in formula I), bearing the group X, form a C 3 -C 8 carbocyclic ring; Q represents a diradical residue after removal of 2 hydrogen atoms from a straight, branched or cyclic, saturated or unsaturated C 1 -C 8 -hydrocarbon; and R 3 represents hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsaturated C 1 -C 6 -hydrocarbon; may be used for the preparation of a medicament for the treatment and/or prophylaxis of osteoporosis and related bone disorders.

30. 发明专利

PL356366A1 USE OF VITAMIN D-DERIVATIVES IN THE TREATMENT OF OSTEOPOROSIS AND RELATED BONE DISORDERS, AS WELL AS NOVEL VITAMIN D3-DERIVATIVES 未知
公开(公告)号：PL356366A1
公开(公告)日：2004-06-28
申请号：PL35636601
申请日：2001-01-31
申请人： LEO PHARMA AS
发明人： GRUESORENSEN GUNNAR , PEDERSEN HENRIK , BINDERUP ERNST TORNDAL , TRANHOLM MIKAEL
IPC分类号： A61K31/59 , A61K31/593 , A61P3/10 , A61P13/12 , A61P17/00 , A61P17/06 , A61P17/12 , A61P17/16 , A61P19/08 , A61P19/10 , A61P25/00 , A61P25/28 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , C07C323/15 , C07C323/19 , C07C323/20 , C07C401/00
摘要： Compounds of the formula I wherein X represents hydrogen or hydroxy; Y represents oxygen or sulphur or oxidized sulphur selected from the groups S(O) and S(O 2 ); R 1 and R 2 , which may be the same or different, represent hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsaturated, C 1 -C 6 -hydrocarbon; or R 1 and R 2 , together with the carbon atom to which they are attached (marked with an asterisk in formula I), bearing the group X, form a C 3 -C 8 carbocyclic ring; Q represents a diradical residue after removal of 2 hydrogen atoms from a straight, branched or cyclic, saturated or unsaturated C 1 -C 8 -hydrocarbon; and R 3 represents hydrogen or a residue after removal of 1 hydrogen atom from a straight, branched or cyclic, saturated or unsaturated C 1 -C 6 -hydrocarbon; may be used for the preparation of a medicament for the treatment and/or prophylaxis of osteoporosis and related bone disorders.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式