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21. 发明授权

US08148137B2 Mutant microorganism having improved production ability of branched amino acid and method for preparing branched amino acid using the same 有权
标题翻译：具有提高支链氨基酸生产能力的突变体微生物及使用其制备支链氨基酸的方法
公开(公告)号：US08148137B2
公开(公告)日：2012-04-03
申请号：US12097099
申请日：2007-03-14
申请人： Sang Yup Lee , Jin Hwan Park , Kwang Ho Lee , Tae Yong Kim
发明人： Sang Yup Lee , Jin Hwan Park , Kwang Ho Lee , Tae Yong Kim
IPC分类号： C12N1/21 , C12P13/08
CPC分类号： C12P13/08 , C12N9/1014 , C12Y201/02011
摘要： The present invention relates to mutant microorganisms having improved productivity of branched-chain amino acids, and a method for producing branched-chain amino acids using the mutant microorganisms. More specifically, relates to mutant microorganisms having improved productivity of L-valine, which are produced by attenuating or deleting a gene encoding an enzyme involved in L-isoleucine biosynthesis, a gene encoding an enzyme involved in L-leucine, and a gene encoding an enzyme involved in D-pantothenic acid biosynthesis, and mutating a gene encoding an enzyme involved in L-valine biosynthesis, such that the expression thereof is increased, as well as a method for producing L-valine using the mutant microorganisms. The inventive mutant microorganisms produced by site-specific mutagenesis and metabolic pathway engineering can produce branched-chain amino acids, particularly L-valine, with high efficiency, and thus will be useful as industrial microorganisms for producing L-valine.
摘要翻译：本发明涉及具有提高的支链氨基酸生产率的突变微生物，以及使用突变微生物生产支链氨基酸的方法。更具体地，涉及通过减弱或缺失编码参与L-异亮氨酸生物合成的酶的基因，编码L-亮氨酸的酶的基因和编码L-亮氨酸的基因而产生的L-缬氨酸的生产率提高的突变体微生物涉及D-泛酸生物合成的酶，以及编码参与L-缬氨酸生物合成的酶的基因的突变，使得其表达增加，以及使用突变微生物产生L-缬氨酸的方法。通过位点特异性诱变和代谢途径工程产生的本发明的突变体微生物可以高效地产生支链氨基酸，特别是L-缬氨酸，因此可用作生产L-缬氨酸的工业微生物。

22. 发明授权

US08091333B2 Flexible wire for removing scale in pipe 有权
标题翻译：用于去除管道中的垢的柔性线
公开(公告)号：US08091333B2
公开(公告)日：2012-01-10
申请号：US12675559
申请日：2008-09-02
申请人： Kwang Ho Lee
发明人： Kwang Ho Lee
IPC分类号： D02G3/02 , D02G3/22
CPC分类号： B08B9/045 , B08B7/02 , D07B5/00
摘要： Provided is a flexible wire to be inserted in a pipe and rotated in a high speed to remove scales in the pipe by striking the scales. The flexible wire includes a main wire line which is formed by alternately winding a central wire line with clockwise and counterclockwise wires along a longitudinal direction of the central wire line, an auxiliary wire line which is a single line having a diameter smaller than that of the main wire line and extends in a longitudinal direction of the main wire line, and an outermost wire which winds the auxiliary wire line so as to bind the auxiliary wire line and the main wire line.
摘要翻译：本发明提供一种插入管中的柔性线，并且高速旋转以通过冲击鳞片去除管中的鳞屑。柔性线包括主线，其通过沿着中心线线的纵向交替地绕中心线线顺时针和逆时针方向地缠绕而形成，辅助线线是直径小于主线路并且在主线路的纵向方向上延伸，并且最外面的线材缠绕辅助线路线以使辅助线路线路和主线路线路结合。

23. 发明授权

US07078222B2 Microorganism for producing riboflavin and method for producing riboflavin using the same 有权
标题翻译：用于生产核黄素的微生物及使用其生产核黄素的方法
公开(公告)号：US07078222B2
公开(公告)日：2006-07-18
申请号：US10454220
申请日：2003-06-04
申请人： Kwang Ho Lee , Young Hoon Park , Jong Kwon Han , Jang Hee Park , Kyung Han Lee , Hyang Choi
发明人： Kwang Ho Lee , Young Hoon Park , Jong Kwon Han , Jang Hee Park , Kyung Han Lee , Hyang Choi
IPC分类号： C12N1/20 , C12P25/00
CPC分类号： C12R1/125 , C12P25/00
摘要： Riboflavin-producing Bacillus subtilis which is resistant to threonine analogue, and a method for producing riboflavin using the Bacillus subtilis are provided.The subject Bacillus subtilis referred to as Bacillus subtilis CJKB0002 has the accession number KCCM-10446, having been deposited in Korean Culture Center of Microorganisms (KCCM), 361-221, Yurim B/D, Hongie-1-dong, Seodaemun-gut, Seoul 120-091 Republic of Korea, on Nov. 18, 2002.
摘要翻译：提供了对苏氨酸类似物具有抗性的产生核黄素的枯草芽孢杆菌，以及使用枯草芽孢杆菌生产核黄素的方法。被称为枯草芽孢杆菌CJKB0002的枯草芽孢杆菌具有保藏在韩国微生物培养中心（KCCM），361-221，Yurim B / D，Hongie-1-dong，Seodaemun-gut的登录号KCCM-10446，汉城120-091大韩民国，2002年11月18日。

24. 发明授权

US5929083A Oxazolidinone derivatives and a method for the preparation thereof and an antibacterial composition containing the same 失效
标题翻译：恶唑烷酮衍生物及其制备方法和含有它们的抗菌组合物
公开(公告)号：US5929083A
公开(公告)日：1999-07-27
申请号：US891835
申请日：1997-07-14
申请人： Yeo Hong Yoon , Hak Sung Kim , Kwang Ho Lee , Kwang Hyuk Lee , Jin Ah Kang , Youn Ha Lee
发明人： Yeo Hong Yoon , Hak Sung Kim , Kwang Ho Lee , Kwang Hyuk Lee , Jin Ah Kang , Youn Ha Lee
IPC分类号： C07D413/10 , C07D413/14 , C07D491/10 , A61K31/435 , C07D221/20 , C07D221/22
CPC分类号： C07D413/10 , C07D491/10
摘要： An antibacterially effective compound of formula I: ##STR1## or a salt or hydrate thereof in which R1, R2, R3, R4, R5, X are as defined herein. Further, a process for producing the compound of formula I and an antibacterial composition containing antibacterially effective amount of the compound of formula I are disclosed.
摘要翻译：式I的抗菌有效化合物或其盐或水合物，其中R 1，R 2，R 3，R 4，R 5，X如本文所定义。此外，公开了制备式I化合物的方法和含有抗菌有效量的式I化合物的抗菌组合物。

25. 发明申请

US20140057311A1 Device For High Throughput Investigations Of Multi-Cellular Interactions 有权
标题翻译：多通道相互作用的高通量调查装置
公开(公告)号：US20140057311A1
公开(公告)日：2014-02-27
申请号：US13876293
申请日：2011-09-29
申请人： Roger Dale Kamm , Haruhiko Harry Asada , Waleed Ahmed Farahat , Ioannis K. Zervantonakis , Levi B. Wood , Chandrasekhar Kothapalli , Seok Chung , Jeffrey D. Macklis , Suzanne Tharin , Johanna Varner , Young Kum Park , Kwang Ho Lee , Le Thanh Tu Nguyen , Choong Kim
发明人： Roger Dale Kamm , Haruhiko Harry Asada , Waleed Ahmed Farahat , Ioannis K. Zervantonakis , Levi B. Wood , Chandrasekhar Kothapalli , Seok Chung , Jeffrey D. Macklis , Suzanne Tharin , Johanna Varner , Young Kum Park , Kwang Ho Lee , Le Thanh Tu Nguyen , Choong Kim
IPC分类号： G01N33/50
CPC分类号： G01N33/5008 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/0668 , B01L2300/0681 , B01L2300/069 , B01L2300/0816 , C12M23/16 , C12M23/22 , C12M25/14 , C12M29/04 , G01N33/5011 , G01N33/5029 , G01N33/5058 , G01N33/5064
摘要： Provided herein are microfluidic devices that can be used as a 3D bioassay, e.g., for drug screening, personalized medicine, tissue engineering, wound healing, and other applications. The device has a series of channels {e.g., small fluid channels) in a small polymer block wherein one or more of the channels can be filled with a biologically relevant gel, such as collagen, which is held in place by posts. As shown herein, when the device is plated with cells such as endothelial cells, new blood vessels grow in the gel, which is thick enough for the cells to grow in three dimensions. Other channels, e.g., fluid channels, allow drugs or biological material to be exposed to the 3D cell growth. Cells, such as endothelial cells, can be cultured and observed as they grow on the surface of a 3D gel scaffold, where e.g., rates of angiogenesis can be measured, as well as intervascularization and extravascularization of cancerous cells.
摘要翻译：本文提供的微流体装置可用作3D生物测定，例如用于药物筛选，个性化医学，组织工程，伤口愈合和其它应用。该装置在小聚合物嵌段中具有一系列通道（例如，小的流体通道），其中一个或多个通道可以填充生物相关凝胶，例如通过柱保持在适当位置的胶原。如本文所示，当装置镀有诸如内皮细胞的细胞时，新的血管在凝胶中生长，其足够厚以使细胞在三维中生长。其他通道，例如流体通道，允许药物或生物材料暴露于3D细胞生长。可以在3D凝胶支架的表面上生长细胞，例如内皮细胞，并且观察细胞，其中例如可以测量血管发生的速率，以及癌细胞的血管间血管形成和血管外再造。

26. 发明授权

US08494779B2 Method for screening essential metabolites in growth of microorganisms 有权
标题翻译：筛选微生物生长中重要代谢物的方法
公开(公告)号：US08494779B2
公开(公告)日：2013-07-23
申请号：US12519791
申请日：2007-12-21
申请人： Sang Yup Lee , Hawoong Jeong , Tae Yong Kim , Pan-Jun Kim , Kwang Ho Lee
发明人： Sang Yup Lee , Hawoong Jeong , Tae Yong Kim , Pan-Jun Kim , Kwang Ho Lee
IPC分类号： G06F19/10 , G06F19/12
CPC分类号： C12Q1/18 , G01N33/5038
摘要： The present invention disclosed is a method for screening metabolites essential for the growth of microorganism using metabolic flux analysis. More specifically, the present invention relates to the method for screening metabolites essential for the growth of microorganism, by selecting a target microorganism, constructing a metabolic network model of the selected microorganism, inactivating the consumption reaction of each of metabolites in the constructed metabolic network model, analyzing the metabolic flux of the metabolites to select metabolites essential for the growth of the microorganism, and confirming the selected metabolites using the utilization of each of the metabolites, defined as flux sum (Φ). According to the present invention, metabolites essential for the growth of microorganism, and genes involved in the essential metabolites, can be screened in a convenient manner, and drug-target genes against pathogenic microorganisms can be predicted by deleting genes associated with the metabolites screened according to the method.
摘要翻译：所公开的本发明是使用代谢通量分析来筛选微生物生长所必需的代谢物的方法。更具体地说，本发明涉及通过选择靶微生物，构建所选择的微生物的代谢网络模型，在构建的代谢网络模型中灭活各代谢物的消费反应来筛选微生物生长所必需的代谢物的方法分析代谢物的代谢通量以选择对于微生物生长至关重要的代谢物，并且使用定义为通量总和（Phi）的每种代谢物来确认所选择的代谢物。根据本发明，可以以便利的方式筛选微生物生长所必需的代谢物和基本代谢物所涉及的基因，并且可以通过删除与代谢物相关的基因来预测针对病原微生物的药物靶基因的方法。

27. 发明授权

US08261397B2 Flexible wire for removing pipe scale 有权
标题翻译：用于去除管道的柔性线
公开(公告)号：US08261397B2
公开(公告)日：2012-09-11
申请号：US12298515
申请日：2007-04-20
申请人： Kwang Ho Lee
发明人： Kwang Ho Lee
IPC分类号： B08B9/02
CPC分类号： B08B9/045
摘要： The present invention relates to a flexible wire (100), which is inserted in a pipe and rotated in a high speed to remove scale produced in a pipe by striking. A flexible wire (100) for removing pipe scales comprising: a main wire (110) having plural wires twisted in a spiral direction as one body, wherein the main wire (110) has an overall straight shape; and an auxiliary wire (120) having plural wires twisted in a spiral direction as one body, of which a diameter is substantially smaller than a diameter of the main wire (110), wherein the auxiliary wire (120) is secured to the main wire (110) and has an overall repeated S-shape.
摘要翻译：本发明涉及一种柔性线（100），其插入管中并高速旋转以通过冲击除去在管中产生的垢。一种用于除去管鳞的柔性线（100），包括：主线（110），其具有沿着螺旋方向扭曲的多条线作为一体，其中所述主线（110）具有整体直线形状; 以及辅助线（120），其具有沿着螺旋方向扭绞的多根线，作为一体，其直径大致小于所述主线（110）的直径，其中所述辅助线（120）固定到所述主线（110）并且具有总体重复的S形。

28. 发明申请

US20100303668A1 FUSIBLE ALLOY FOR PRESSURE RELIEF DEVICES 审中-公开
标题翻译：用于压力消除装置的合金
公开(公告)号：US20100303668A1
公开(公告)日：2010-12-02
申请号：US12445822
申请日：2006-12-28
申请人： Kwang Ho Lee
发明人： Kwang Ho Lee
IPC分类号： C22C11/10 , C22C30/04
CPC分类号： C22C30/04 , C22C11/10 , F16K17/383
摘要： The present invention relates to a fusible alloy for pressure relief devices (PRDs), and the present invention provides a fusible alloy for PRD, the alloy comprising 29.0 to 33.0% by weight of Bi, 14.0 to 21.0% by weight of Sn, 2.0 to 5.0% by weight of In, and substantially Pb for the balance.The fusible alloy for PRD of the invention has a melting point appropriate for use according to the 110° C.-grade standards, and has excellent wettability upon melting.
摘要翻译：本发明涉及一种用于压力释放装置（PRD）的熔融合金，本发明提供一种用于PRD的可熔合金，该合金包含29.0至33.0重量％的Bi，14.0至21.0重量％的Sn，2.0至 5.0重量％，余量为大致Pb。本发明的PRD用熔融合金，根据110℃级标准，具有适合使用的熔点，熔融时润湿性优异。

29. 发明申请

US20100089400A1 VALVE APPARATUS FOR MOVABLE OXYGEN CYLINDER 有权
标题翻译：可移动氧气瓶的阀门设备
公开(公告)号：US20100089400A1
公开(公告)日：2010-04-15
申请号：US12385337
申请日：2009-04-06
申请人： Kwang Ho Lee
发明人： Kwang Ho Lee
IPC分类号： A62B9/02
CPC分类号： F16K1/305 , Y10T137/2544 , Y10T137/87241
摘要： Provided is a valve apparatus for a movable oxygen cylinder which has a function of a post valve for an oxygen generation system for household use and that of a post valve for general medical care, selectively. The valve apparatus includes: a valve body whose one side is combined with the movable oxygen cylinder, and which communicates with a discharge port at the other side thereof along a path from one side thereof lengthily therein, to thus discharge out the oxygen of the oxygen cylinder through the discharge port, and which includes an opening which opened outwards from an insertion space provided along the path; a post valve which is installed at the other side of the valve body and controls discharge of oxygen through the discharge port from the oxygen cylinder according to operation of a lever; and a charge adapter whose one side is detachably installed in the opening of the insertion space, and which charges oxygen supplied from the outside into the oxygen cylinder when the post valve closes the path, and discharges oxygen of the oxygen cylinder through the discharge port when the post valve opens the path.
摘要翻译：提供一种用于可动氧气瓶的阀装置，其具有用于家用氧气产生系统的柱阀和用于一般医疗保健的后阀的功能。阀装置包括：阀体，其一侧与可动氧气缸组合，并且在其另一侧与其长度方向上的排出口连通，从而排出氧气的氧气圆柱体通过排出口，其包括从沿着路径设置的插入空间向外开口的开口; 一个安装在阀体另一侧的柱阀，根据杆的操作控制通过排出口的氧气从氧气瓶排出; 以及充电适配器，其一侧可拆卸地安装在插入空间的开口中，并且当柱阀闭合路径时将从外部供应的氧充入氧气瓶中，并且当氧气瓶通过排出口排出氧气时，柱阀打开路径。

30. 发明授权

US07686036B1 Valve apparatus for movable oxygen cylinder 有权
标题翻译：可移动氧气瓶的阀门装置
公开(公告)号：US07686036B1
公开(公告)日：2010-03-30
申请号：US12385337
申请日：2009-04-06
申请人： Kwang Ho Lee
发明人： Kwang Ho Lee
IPC分类号： F15B13/04
CPC分类号： F16K1/305 , Y10T137/2544 , Y10T137/87241
摘要： The valve apparatus includes: a valve body whose one side is combined with the movable oxygen cylinder, which communicates with a discharge port at the other side thereof along a path from one side thereof lengthily therein, to thus discharge out the oxygen of the oxygen cylinder through the discharge port. An opening which opens outwards from an insertion space provided along the path, and a post valve which is installed at the other side of the valve body and controls discharge of oxygen through the discharge port from the oxygen cylinder according to operation of a lever. A charge adapter whose one side is detachably installed in the opening of the insertion space, which charges oxygen supplied from the outside into the oxygen cylinder when the post valve closes the path, and discharges oxygen of the oxygen cylinder through the discharge port when the post valve opens the path.
摘要翻译：阀装置包括：阀体，其一侧与可动氧气缸组合，其沿着其一侧的长度方向上与其另一侧的排出口连通，从而排出氧气瓶的氧气通过排放口。从沿着路径设置的插入空间向外开口的开口，以及安装在阀体另一侧的柱阀，根据杆的操作，通过排气口从氧气瓶排出氧气。一种充电适配器，其一侧可拆卸地安装在插入空间的开口中，当柱阀关闭路径时，将从外部供给的氧气充入氧气瓶中，并且当柱子在柱子上时通过排出口排出氧气瓶的氧气阀打开路径。

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