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21. 发明授权

US09950017B2 Pharmaceutical composition for protection from allergies and inflammatory disorders 有权
公开(公告)号：US09950017B2
公开(公告)日：2018-04-24
申请号：US12041553
申请日：2008-03-03
申请人： Albrecht Bufe , Otto Holst , Harald Renz , Erika Von Mutius , Johann Bauer , Nicole Blumer , Jennifer Debarry , Markus Ege , Susanne Friedrich , Holger Garn , Soren Gatermann , Anna Hanuszkiewicz , Holger Heine , Michael Wegmann
发明人： Albrecht Bufe , Otto Holst , Harald Renz , Erika Von Mutius , Johann Bauer , Nicole Blumer , Jennifer Debarry , Markus Ege , Susanne Friedrich , Holger Garn , Soren Gatermann , Anna Hanuszkiewicz , Holger Heine , Michael Wegmann
IPC分类号： A61K35/74 , A61K35/744
CPC分类号： A61K35/74 , A61K35/744 , A61K2300/00
摘要： The present invention relates to a pharmaceutical composition which includes naturally occurring, non-transgenic isolated bacteria from the group of Lactococcus and Acinetobacter or fragments thereof or mixtures thereof, to such a bacterium as a medicament for the prevention and/or treatment of allergic or chronic inflammatory disorders and to a process for producing this composition.

22. 发明授权

US09655979B2 RNA trans-splicing molecule (RTM) for use in the treatment of cancer 有权
公开(公告)号：US09655979B2
公开(公告)日：2017-05-23
申请号：US14438625
申请日：2013-10-31
申请人： Johann Bauer
发明人： Johann Bauer , Christina Gruber , Ulrich Koller
IPC分类号： A61K48/00 , C12N15/11 , C12N15/113 , C12N9/12
CPC分类号： A61K48/0058 , A61K48/00 , C12N9/1211 , C12N15/111 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/3519 , C12N2320/33
摘要： The present invention pertains to a novel pre-mRNA trans-splicing molecule (RTM) comprising a binding region which is complementary to a pre mRNA of a tumor associated gene, and a coding domain which encodes for a suicide gene. Specific embodiments of the present invention relate to RTMs which mediate trans-splicing of a suicide gene, such as thymidine kinase from herpes simplex virus (HSV-tk), with the pre mRNA of the squamous cell carcinoma associated gene solute carrier organic anion transporter family member 1B3 (SLCO1B3). The invention provides RTMs which selectively kill cells expressing SLCO1B3 and which are thus useful in the treatment of cancer, specifically squamous cell carcinoma associated with epidermolysis bullosa. Also provided are methods, kits and pharmaceutical compositions relating to the RTMs in accordance to the invention.

23. 发明申请

US20150017190A1 USE OF EPITOPES INDUCING SPECIFIC TOLERANCE FOR THE PREVENTION OF TISSUE REJECTION 审中-公开
标题翻译：诱发特异性耐药性预防组织免疫的用途
公开(公告)号：US20150017190A1
公开(公告)日：2015-01-15
申请号：US14233622
申请日：2012-07-26
申请人： Johann Bauer , Monika Ettinger , Iris Gratz , Doris Schmid
发明人： Johann Bauer , Monika Ettinger , Iris Gratz , Doris Schmid
IPC分类号： A61K48/00 , A61K38/39
CPC分类号： A61K48/005 , A61K38/39 , A61K39/0008 , A61K48/0075 , A61K2039/505 , A61K2039/53 , A61K2039/54
摘要： The present invention relates to a composition for use in the prevention of the rejection of skin tissue, comprising an effective amount of a peptide comprising an epitope of an antigen selected from the group of the polypeptides type XVII collagen, VII collagen, integrin alpha 6, integrin beta 4, chains of laminin, chains of laminin 322, type IV collagen, plectin, plakoglobin, bullous pemphigoid antigen 1, periplakin, envoplakin, desmoglein 1, desmoglein 3, a desmocollin and human bullous pemphigoid antigen 2 (hBPAG2) wherein said epitope induces immunological tolerance against its underlying polypeptide, and/or a nucleic acid for expressing a peptide comprising an epitope of said antigen as well as a gene therapy based on the composition, in the context of autoimmune blistering diseases, such as bullous pemphigoid or genetic skin diseases such as epidermolysisbullosa.
摘要翻译：本发明涉及一种用于预防皮肤组织排斥的组合物，其包含有效量的肽，其包含抗原表位，所述抗原选自XVII型胶原多肽，VII胶原，整联蛋白α6，整联蛋白β4，层粘连蛋白链，层粘连蛋白322链，IV型胶原，plectin，plakoglobin，大疱性类天疱疮抗原1，periplakin，envoplakin，桥粒蛋白1，脱骨髓蛋白3，脱纤毛蛋白和人大疱性类天疱疮抗原2（hBPAG2），其中所述表位在自身免疫性起泡疾病如大疱性类天疱疮或遗传性皮肤的情况下，诱导针对其潜在多肽的免疫学耐受性，和/或用于表达包含所述抗原表位的肽的核酸以及基于组合物的基因治疗疾病如表皮松解症。

24. 发明申请

US20130059901A1 Pre-MRNA Trans-Splicing Molecule (RTM) Molecules and Their Uses 有权
标题翻译：前MRNA转接分子（RTM）分子及其用途
公开(公告)号：US20130059901A1
公开(公告)日：2013-03-07
申请号：US13056449
申请日：2009-07-30
申请人： Johann Bauer , Lloyd G. Mitchell
发明人： Johann Bauer , Lloyd G. Mitchell
IPC分类号： A61K31/7088 , A61P37/00 , C12N5/10 , A61P17/00 , C12N15/113 , C12N15/85
CPC分类号： C12N15/85 , A61K48/005 , C07K14/78 , C12N2740/13043 , C12N2840/445
摘要： The present invention relates to specific and markedly improved pre-mRNA trans-splicing molecule (RTM) molecules which are designed to correct specific genes expressed within cells to be targeted, and which are associated with epidermolysis bullosa, cystic fibrosis, pachyonychia congenital, and psoriasis or neurodermitis, as well as cancers of the skin. In particular, the RTMs of the present invention are genetically engineered to interact with a specific target pre-mRNA expressed in cells to be targeted so as to result in correction of genetic defects or reprogramming of gene expression responsible for a variety of different skin disorders.
摘要翻译：本发明涉及特异性和显着改进的mRNA前转录分子（RTM），其被设计用于校正在靶细胞内表达的特异性基因，并且其与大疱性表皮松解，囊性纤维化，先天性先天性和牛皮癣相关或神经性皮炎，以及皮肤癌。特别地，本发明的RTM被遗传工程改造以与待靶向的细胞中表达的特异性靶mRNA前体相互作用，从而导致基因缺陷的校正或负责各种不同皮肤病症的基因表达的重新编程。

25. 发明授权

US06870450B2 Electromagnetic switching device, in particular a contactor 失效
标题翻译：电磁开关装置，特别是接触器
公开(公告)号：US06870450B2
公开(公告)日：2005-03-22
申请号：US10221321
申请日：2001-03-12
申请人： Johann Bauer , Stephan Faber , Bardo Koppmann , Manuela Lüftl , Markus Meier
发明人： Johann Bauer , Stephan Faber , Bardo Koppmann , Manuela Lüftl , Markus Meier
IPC分类号： H01H47/06 , H01H50/02 , H01H50/04 , H01H50/44 , H01H50/54 , H01H67/02
CPC分类号： H01H50/543 , H01H47/06 , H01H50/021 , H01H50/042 , H01H50/045
摘要： The invention relates to an electromagnetic switching device, in particular a contactor, comprising a switching device housing (2) and a plug-in module which can be inserted into the latter and which contains a coil form (12) for a coil. A tripping element (60) is mounted on a housing section (40) of the plug-in module (4). Said element is designed to mechanically actuate the contact unit (30) of an electric switch (24) for producing an economy connection. The switch (24) is mounted on a support structure (printed-circuit board (22)) that is located in the plug-in module (4), with a supporting contour (70) of said switch adjoining a bearing contour (72) of the housing section (40).
摘要翻译：本发明涉及一种电磁开关装置，特别是电磁开关装置，特别是一种接触器，它包括一个开关装置壳体（2）和一个插入式模块，插入式模块可以插入到该开关装置壳体和插入式模块中，该模块包含用于线圈的线圈形式（12）。脱扣元件（60）安装在插件模块（4）的壳体部分（40）上。所述元件被设计成机械地致动用于产生经济性连接的电开关（24）的接触单元（30）。开关（24）安装在位于插件模块（4）中的支撑结构（印刷电路板（22））上，所述开关的支撑轮廓（70）与轴承轮廓（72）相邻，（40）。

26. 发明授权

US06649854B1 Vacuum contactor with movable guide element 失效
标题翻译：具有可移动导向元件的真空接触器
公开(公告)号：US06649854B1
公开(公告)日：2003-11-18
申请号：US10148290
申请日：2002-05-29
申请人： Johann Bauer , Hans Brandl , Markus Meier , Peter Schlegl
发明人： Johann Bauer , Hans Brandl , Markus Meier , Peter Schlegl
IPC分类号： H01H3366
CPC分类号： H01H33/666 , H01H2033/66246 , H01H2033/66253
摘要： A vacuum contactor includes a stationary contact and a moving contact, which can be moved in order to produce a current-carrying connection. In order to guide the moving contact during its movement in the enclosure, at least one guide element, which can be moved in a groove, is provided on the moving contact.
摘要翻译：真空接触器包括固定触点和可移动的触点，其可移动以产生载流连接。为了引导移动接触件在其在外壳中运动时，可移动的接触件上提供至少一个可在凹槽中移动的引导元件。

27. 发明授权

US4733210A Auxiliary switch hookup assembly in a motor contactor 失效
标题翻译：电动机接触器中的辅助开关接头组件
公开(公告)号：US4733210A
公开(公告)日：1988-03-22
申请号：US922700
申请日：1986-10-24
申请人： Johann Bauer , Klaus-Dieter Paul
发明人： Johann Bauer , Klaus-Dieter Paul
IPC分类号： H01H50/64 , H01H50/04 , H01H50/54 , H01H9/02 , H01H67/02
CPC分类号： H01H50/545
摘要： An auxiliary switch hookup assembly in a motor contactor includes a slide member biased by a spring and forming a portion of the limiting wall for the reception of an auxiliary switch. The spring force exerted by the biasing spring can be greater than a total force exerted by restoring and contact compression springs of the motor contactor.
摘要翻译：电动机接触器中的辅助开关连接组件包括由弹簧偏压并形成限制壁的一部分以用于接收辅助开关的滑动构件。由偏置弹簧施加的弹簧力可以大于通过电动机接触器的压缩弹簧的恢复和接触而施加的总力。

28. 发明授权

US4117429A Electromagnetic switching apparatus 失效
标题翻译：电磁开关装置
公开(公告)号：US4117429A
公开(公告)日：1978-09-26
申请号：US795495
申请日：1977-05-10
申请人： Georg Streich , Johann Bauer
发明人： Georg Streich , Johann Bauer
IPC分类号： H01H1/20 , H01H11/00 , H01H50/54 , H01H67/02
CPC分类号： H01H11/0012 , H01H50/546
摘要： An electromagnetic switching apparatus including a housing, movable contact elements mounted on a plurality of contact bridges in the housing, electrically-connected fixed contact elements disposed on both sides of the contact bridges adapted for contact and electrical connection with the movable contacts and the contact bridges, and electrical insulation means for interrupting the electrical connection between the fixed contact elements and the contact bridges in two terminal positions of the contact bridge carrier. The improvement comprises at least one end of the contact bridges extending outwardly beyond the area of contact between the movable contacts and the fixed contacts. The electrical insulation means are movably supported in the switching apparatus housing so as to be operatively engageable in at least one position with the extended ends of the contact bridges for interrupting the electrical connection between at least one of the contact bridges and the fixed contact elements.

29. 发明授权

US4018413A Electrical equipment mounting apparatus including a movable mounting member 失效
标题翻译：电气设备安装装置，包括可移动的安装构件
公开(公告)号：US4018413A
公开(公告)日：1977-04-19
申请号：US602469
申请日：1975-08-06
申请人： Johann Bauer
发明人： Johann Bauer
IPC分类号： H01R9/26 , H02B1/052 , E04G3/00 , H01R9/00
CPC分类号： H01R9/2608 , H02B1/0523
摘要： An electrical equipment apparatus which includes an equipment housing and at least one slidable mounting member for fastening the equipment to a support rail. The member is guided by guide keys provided in the equipment housing and includes a compression spring disposed in a longitudinal recess thereof which engages the member at one end and the equipment housing at the other. Barb-like, resilient stop members are formed on the mounting member and extend transversely with respect to the direction of movement thereof, and are received by recesses in the equipment housing for limiting the movement of the mounting member and equipment with respect to the housing.
摘要翻译：一种电气设备装置，其包括设备壳体和用于将设备紧固到支撑轨道的至少一个可滑动的安装构件。构件由设置在设备壳体中的引导键引导，并且包括设置在其纵向凹部中的压缩弹簧，其一端接合该构件，另一端与设备壳体接合。棘爪状的弹性止挡构件形成在安装构件上并相对于其移动方向横向延伸，并且由设备壳体中的凹部容纳，用于限制安装构件和设备相对于壳体的移动。

30. 发明授权

US3954365A Apparatus for the preparation of foamed thermoplastic extruded profiles 失效
标题翻译：用于制备泡沫热塑性挤压型材的设备
公开(公告)号：US3954365A
公开(公告)日：1976-05-04
申请号：US519540
申请日：1974-10-31
申请人： Hansjochen Barth , Johann Bauer
发明人： Hansjochen Barth , Johann Bauer
IPC分类号： B29B7/00 , B29C44/46 , B29C44/50 , B29C47/00 , B29C47/20 , B29C47/30 , B29C47/90 , B29D7/02
CPC分类号： B29C44/468 , B29C44/50
摘要： An apparatus for the production of extruded profiles of foamed thermoplasts consisting of an extruder having an extrusion screw or helix and a form-giving extruder head having a flow channel there-through, at least part of the length of said flow channel being divided by separating walls having a thickness of 0.2 to 3 mm arranged in the axial direction into individual channels of such a length and cross-section area whereby each individual channel has a nozzle coefficient k of from 0.1 to 2mm.sup.3, characterized in that thorn-like pins are inserted into some of the individual channels; as well as the process of extrusion.
摘要翻译：一种用于生产由具有挤出螺杆或螺旋的挤出机组成的发泡热塑性塑料的挤压型材的装置以及具有流动通道的成型挤压机头部，所述流动通道的至少部分长度被分离在轴向方向上排列的厚度为0.2至3mm的壁形成这种长度和横截面积的各个通道，由此每个单独通道的喷嘴系数k为0.1至2mm3，其特征在于，插入刺状销进入一些个人渠道; 以及挤出过程。

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