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21. 发明授权

US5413910A Measuring non-dystrophin proteins and diagnosing muscular dystrophy 失效
标题翻译：测量非肌营养不良蛋白和诊断肌营养不良症
公开(公告)号：US5413910A
公开(公告)日：1995-05-09
申请号：US958015
申请日：1992-10-07
申请人： Kevin P. Campbell , James M. Ervasti , Kay Ohlendieck , Mitchell G. Gaver , Steven D. Kahl
发明人： Kevin P. Campbell , James M. Ervasti , Kay Ohlendieck , Mitchell G. Gaver , Steven D. Kahl
IPC分类号： A61K39/395 , A61K38/00 , A61K39/00 , C07K1/22 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12P21/08 , G01N33/53 , G01N33/68 , G01N33/567
CPC分类号： C07K16/28 , C07K14/4707 , C07K14/705 , C07K16/18 , G01N33/6887 , A61K38/00 , A61K39/00 , G01N2800/2878 , G01N2800/2885 , Y10S436/811
摘要： The invention pertains to the dystrophin-glycoprotein complex of mammalian skeletal muscle and a method of isolating said complex. The components of the complex and methods of separating and isolating said components also pertain to the invention. In addition, the invention further relates to a method of diagnosing muscular dystrophy by detecting and quantifying the loss of a non-dystrophin component of the dystrophin-glycoprotein complex with said loss being indicative of muscular dystrophy.
摘要翻译：本发明涉及哺乳动物骨骼肌的肌营养不良蛋白 - 糖蛋白复合物和分离所述复合物的方法。复合物的组分和分离和分离所述组分的方法也适用于本发明。此外，本发明还涉及通过检测和定量肌营养不良蛋白 - 糖蛋白复合物的非肌营养不良蛋白组分的损失来诊断肌营养不良的方法，所述损失指示肌营养不良症。

22. 发明授权

US06331405B1 Receptor for Mycobacterium leprae and methods of use thereof 失效
标题翻译：分枝杆菌的受体及其使用方法
公开(公告)号：US06331405B1
公开(公告)日：2001-12-18
申请号：US09209108
申请日：1998-12-10
申请人： Anura Rambukkana , Vincent A. Fischetti , Kevin P. Campbell
发明人： Anura Rambukkana , Vincent A. Fischetti , Kevin P. Campbell
IPC分类号： G01N3353
CPC分类号： C07K14/35 , C12Q1/18 , G01N33/5695 , G01N2333/35 , G01N2500/10
摘要： The present invention relates to the discovery that the &agr;-dystroglycan receptor is required for Mycobacterium leprae entry into cells, assays for high throughput screening of drugs for use in treatments against leprosy, and methods for studying the role of the receptor in neurodegenerative and musculodegenerative diseases, and the like.
摘要翻译：本发明涉及α-螺旋藻聚糖受体是分离细菌进入细胞所需的发现，用于治疗麻风的药物的高通量筛选测定法和研究受体在神经变性和肌肉退行性疾病中的作用的方法，等等。

23. 发明授权

US06207878B1 Sarcospan-deficient mouse as a model for clinical disorders associated with sarcospan mutations 失效
标题翻译：作为与谷氨酸突变相关的临床疾病的模型的萨哥斯坦缺陷型小鼠
公开(公告)号：US06207878B1
公开(公告)日：2001-03-27
申请号：US09422762
申请日：1999-10-21
申请人： Kevin P. Campbell , Connie Lebakken , Rachelle Crosbie , Roger Williamson
发明人： Kevin P. Campbell , Connie Lebakken , Rachelle Crosbie , Roger Williamson
IPC分类号： A01K67027
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/05 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , C12N2800/30
摘要： Disclosed is a transgenic knockout mouse whose genome has a homozygous disruption in its endogenous sarcospan gene, wherein the disruption prevents the synthesis of functional sarcospan in cells of the mouse. The mouse is characterized as exhibiting from 1.4 to 6.8 fold larger epididymal fat pad deposits as compared to the epididymal fat pad deposits of a wild type mouse. Methods for production of the mouse are presented. Also disclosed are cells derived from the transgenic knockout mouse. The mouse can be used in a method for identifying therapeutic agents for the treatment of an individual diagnosed with a metabolic disorder associated with a reduction or loss of expression of wild-type sarcospan. An example of such a disorder is weight gain in the individual associated with a reduction or loss of expression of wild-type sarcospan. These specific methods are also provided.
摘要翻译：公开了一种转基因敲除小鼠，其基因组在其内源性脊液螺旋体基因中具有纯合性破坏，其中该破坏阻止了小鼠细胞中功能性谷氨酸的合成。与野生型小鼠的附睾脂肪垫沉积物相比，小鼠的特征在于表现出1.4至6.8倍的附睾脂肪垫沉积物。介绍了生产小鼠的方法。还公开了衍生自转基因敲除小鼠的细胞。该小鼠可用于鉴定用于治疗被诊断患有与野生型脊索动物的表达减少或丧失相关的代谢紊乱的个体的治疗剂的方法。这种疾病的一个例子是与野生型脊索动物的表达减少或丧失相关的个体体重增加。还提供了这些具体方法。

24. 发明授权

US06201168B1 Pathogenesis of cardiomyopathy 失效
标题翻译：心肌病发病机制
公开(公告)号：US06201168B1
公开(公告)日：2001-03-13
申请号：US09378418
申请日：1999-08-20
申请人： Kevin P. Campbell , Ramon Coral , Ronald Cohn , Roger Williamson , Madeleine Durbeej
发明人： Kevin P. Campbell , Ramon Coral , Ronald Cohn , Roger Williamson , Madeleine Durbeej
IPC分类号： A01K67027
CPC分类号： C12N15/8509 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , A01K2267/0375 , A61K48/00 , C07K14/4707
摘要： Disclosed is a mouse, cells derived therefrom, and methods for using the mouse, the mouse being homozygous for a disrupted &dgr;-sarcoglycan gene, the disruption in the gene having been introduced into the mouse or an ancestor of the mouse at an embryonic stage. The disruption prevents the synthesis of functional &dgr;-sarcoglycan in cells of the mouse and results in the mouse having a reduced amount of &bgr;- and &egr;-sarcoglycan and sarcospan, and a disruption of the sarcoglycan-sarcospan complex in smooth muscle of the mouse. Also disclosed is a mouse, cells derived therefrom, and methods for using the mouse, the mouse being homozygous for a disrupted &bgr;-sarcoglycan gene, the disruption in the gene having been introduced into the mouse or an ancestor of the mouse at an embryonic stage. The disruption prevents the synthesis of functional &bgr;-sarcoglycan in cells of the mouse and results in the mouse having a reduced amount of &dgr;-and &egr;-sarcoglycan and sarcospan and &agr;-dystroglycan in smooth muscle of the mouse.
摘要翻译：公开了一种小鼠，其衍生的细胞，以及使用该小鼠的方法，该小鼠对于破坏的δ-色氨酸聚糖基因是纯合的，该基因在胚胎阶段被导入小鼠或该小鼠祖先的破坏。这种破坏阻止了小鼠细胞中功能性δ-糖聚糖的合成，并导致小鼠β-谷氨酸和唾液酸和焦糖的量减少，并且导致小鼠平滑肌中的slegoglycan-sarcospan复合物的破坏。还公开了一种小鼠，由其衍生的细胞，以及使用该小鼠的方法，该小鼠对于破坏的β-唾液酸聚糖基因是纯合的，该基因在胚胎阶段被导入小鼠或小鼠祖先的破坏。破坏阻止了小鼠细胞中功能性β-sogoglycan的合成，并导致小鼠的平滑肌中δ-和ε-唾液酸和谷氨酸和α-依托莫多糖的量减少。

25. 发明授权

US6083911A Arenavirus receptor and methods of use 失效
公开(公告)号：US6083911A
公开(公告)日：2000-07-04
申请号：US208707
申请日：1998-12-10
申请人： Kevin P. Campbell , Michael Henry , Hiroki Yamada , Roger Williamson , Wei Cao , Michael Oldstone
发明人： Kevin P. Campbell , Michael Henry , Hiroki Yamada , Roger Williamson , Wei Cao , Michael Oldstone
IPC分类号： A61K38/17 , A61K35/34 , A61K38/16
CPC分类号： A61K38/177
摘要： Disclosed is a method for inhibiting the binding of an arenavirus to a cellular receptor. The method involves providing, in soluble form, a reagent comprising .alpha.-dystroglycan or a portion thereof, the reagent being characterized by the ability to bind to the arenavirus thereby inhibiting the binding of the arenavirus to the cellular receptor. The reagent is contacted with an arenavirus particle prior to infection of a cell by the arenavirus particle. Also disclosed are methods for treating an arenavirus infection in a patient and preventing an arenavirus infection in an individual at risk. These methods involve providing a therapeutic composition comprising .alpha.-dystroglycan or a portion thereof which is characterized by the ability to bind to arenaviruses, thereby inhibiting the binding of arenaviruses to a cellular receptor; and administering the composition to the patient or individual at risk. Arenaviruses to which the methods of the present invention apply include, without limitation, Lymphocyte Choriomeningitis Virus, Lassa fever virus, Mobala, and Oliveros. In another aspect, the disclosure relates to an embryonic stem cell line, and cells derived therefrom, which is homozygous for a disrupted dystroglycan gene, wherein the disruption prevents the synthesis of functional dystroglycan in the cells. Applications of the dystroglycan null embryonic stem cells include producing dystroglycan or a portion thereof in the cells and also for identifying portions of dystroglycan necessary for arenavirus infection. Also disclosed is a method for identifying antiviral compounds which interfere specifically with the binding of arenavirus and .alpha.-dystroglycan, comprising providing a binding assay system for the determination of binding of arenavirus and .alpha.-dystroglycan. The candidate antiviral compounds are introduced into the binding assay system and antiviral compounds which substantially inhibit binding of arenavirus to .alpha.-dystroglycan are identified.

26. 发明授权

US5462857A Diagnosing malignant hyperthermia susceptibility by detection of abnormal proteolytic enzyme digestion fragments of the ryanodine receptor 失效
标题翻译：通过检测兰诺定受体的异常蛋白水解酶消化片段来诊断恶性高热敏感性
公开(公告)号：US5462857A
公开(公告)日：1995-10-31
申请号：US104330
申请日：1993-08-09
申请人： Kevin P. Campbell , C. Michael Knudson , Steven D. Kahl , Charles F. Louis , James R. Mickelson
发明人： Kevin P. Campbell , C. Michael Knudson , Steven D. Kahl , Charles F. Louis , James R. Mickelson
IPC分类号： C12Q1/37 , G01N33/567 , G01N33/68 , G01N33/543 , G01N33/544
CPC分类号： G01N33/6887 , C12Q1/37 , G01N33/567
摘要： The present invention relates to a method of diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of abnormal ryanodine receptor fragments is indicative of malignant hyperthermia susceptibility.
摘要翻译：本发明涉及一种通过检测从哺乳动物骨骼肌肌浆网分离的兰诺定受体的蛋白水解酶消化后检测异常兰诺定受体片段来诊断恶性高热敏感性的方法。异丙肾上腺素受体片段的检测表明恶性高热敏感性。

27. 发明授权

US5386025A Calcium channel compositions and methods 失效
标题翻译：钙通道组成和方法
公开(公告)号：US5386025A
公开(公告)日：1995-01-31
申请号：US482384
申请日：1990-02-20
申请人： Scott D. Jay , Steven B. Ellis , Michael M. Harpold , Kevin P. Campbell
发明人： Scott D. Jay , Steven B. Ellis , Michael M. Harpold , Kevin P. Campbell
IPC分类号： A61K38/00 , A61P43/00 , C07H21/02 , C07H21/04 , C07K14/00 , C07K14/705 , C07K19/00 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C12R1/91
CPC分类号： C07K14/705 , C12Q1/6876
摘要： Calcium channel .gamma.-subunit-encoding cDNAs, and related compositions and methods, are provided.
摘要翻译：提供钙通道γ-亚基编码cDNA，以及相关组合物和方法。

28. 发明授权

US5260209A Nucleic acids encoding dystrophin-associated proteins 失效
标题翻译：编码肌营养不良蛋白相关蛋白的核酸
公开(公告)号：US5260209A
公开(公告)日：1993-11-09
申请号：US841654
申请日：1992-02-20
申请人： Kevin P. Campbell , Oxana Ibraghimov-Beskrovnaya , James M. Ervasti , Cynthia J. Leveille
发明人： Kevin P. Campbell , Oxana Ibraghimov-Beskrovnaya , James M. Ervasti , Cynthia J. Leveille
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/705 , C07K16/18 , C07K16/28 , C12N15/12 , G01N33/68 , C12N15/74 , C12N15/79
CPC分类号： C07K14/4707 , C07K14/4708 , C07K14/705 , C07K16/18 , C07K16/28 , G01N33/6887 , A61K38/00 , A61K39/00 , G01N2800/2878 , G01N2800/2885
摘要： The subject disclosure relates to substantially pure nucleic acid sequences encoding at least a portion of a dystrophin-associated protein. Deoxyribonucleic acid can be expressed in a DNA expression construct. Protein produced in this manner can be used for a variety of purposes including immunization to produce antibodies. Such DNA expression constructs, and the protein encoded by same, are useful in therapeutic methods to complement a genetic defect which results in muscular dystrophy.
摘要翻译：本公开涉及编码至少一部分肌营养不良蛋白相关蛋白的基本上纯的核酸序列。脱氧核糖核酸可以在DNA表达构建体中表达。以这种方式产生的蛋白质可用于各种目的，包括免疫产生抗体。这样的DNA表达构建体和由其编码的蛋白质可用于补充导致肌营养不良症的遗传缺陷的治疗方法。

29. 发明授权

US5242801A Diagnosing malignant hyperthermia susceptibility by detection of abnormal proteolytic enzyme digestion fragments of the ryanodine receptor 失效
标题翻译：通过检测兰诺定受体的异常蛋白水解酶消化片段来诊断恶性高热敏感性
公开(公告)号：US5242801A
公开(公告)日：1993-09-07
申请号：US562719
申请日：1990-08-06
申请人： Kevin P. Campbell , C. Michael Knudson , Steven D. Kahl , Charles F. Louis , James R. Mickelson
发明人： Kevin P. Campbell , C. Michael Knudson , Steven D. Kahl , Charles F. Louis , James R. Mickelson
IPC分类号： C12Q1/37 , G01N33/567 , G01N33/68
CPC分类号： G01N33/6887 , C12Q1/37 , G01N33/567
摘要： The present invention relates to a method of diagnosing malignant hyperthermia susceptibility by detecting abnormal ryanodine receptor fragments following proteolytic enzyme digestion of ryanodine receptors isolated from the sarcoplasmic reticulum of mammalian skeletal muscle. The detection of abnormal ryanodine receptor fragments is indicative of malignant hyperthermia susceptibility.
摘要翻译：本发明涉及一种通过检测从哺乳动物骨骼肌肌浆网分离的兰诺定受体的蛋白水解酶消化后检测异常兰诺定受体片段来诊断恶性高热敏感性的方法。异丙肾上腺素受体片段的检测表明恶性高热敏感性。

30. 发明授权

US5187063A Measuring non-dystrophin proteins and diagnosing muscular dystrophy 失效
标题翻译：测量非特异性蛋白质和诊断肌肉样本
公开(公告)号：US5187063A
公开(公告)日：1993-02-16
申请号：US527583
申请日：1990-05-23
申请人： Kevin P. Campbell , James M. Ervasti , Kay Ohlendieck , Mitchell G. Gaver , Steven D. Kahl
发明人： Kevin P. Campbell , James M. Ervasti , Kay Ohlendieck , Mitchell G. Gaver , Steven D. Kahl
IPC分类号： A61K39/395 , A61K38/00 , A61K39/00 , C07K1/22 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/00 , C07K16/18 , C07K16/28 , C07K19/00 , C12P21/08 , G01N33/53 , G01N33/68
CPC分类号： C07K16/28 , C07K14/4707 , C07K14/705 , C07K16/18 , G01N33/6887 , A61K38/00 , A61K39/00 , G01N2800/2878 , G01N2800/2885 , Y10S436/811
摘要： The invention pertains to the dystrophin-glycoprotein complex of mammalian skeletal muscle and a method of isolating said complex. The components of the complex and methods of separating and isolating said components also pertain to the invention. In addition, the invention further relates to a method of diagnosing muscular dystrophy by detecting and quantifying the loss of a non-dystrophin component of the dystrophin-glycoprotein complex with said loss being indicative of muscular dystrophy.
摘要翻译：本发明涉及哺乳动物骨骼肌的肌营养不良蛋白 - 糖蛋白复合物和分离所述复合物的方法。复合物的组分和分离和分离所述组分的方法也适用于本发明。此外，本发明还涉及通过检测和定量肌营养不良蛋白 - 糖蛋白复合物的非肌营养不良蛋白组分的损失来诊断肌营养不良的方法，所述损失指示肌营养不良症。

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