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21. 发明申请

US20110224197A1 PYRIMIDINES AND PYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES 审中-公开
标题翻译：用作蛋白激酶抑制剂的吡咯烷酮和吡啶
公开(公告)号：US20110224197A1
公开(公告)日：2011-09-15
申请号：US12878246
申请日：2010-09-09
申请人： Gregory William Henkel , Michael Liu , Timothy Neuberger
发明人： Gregory William Henkel , Michael Liu , Timothy Neuberger
IPC分类号： A61K31/541 , A61K31/517 , A61K31/506 , A61K31/5377 , A61K31/496 , A61K31/4439 , A61K31/444 , C12N9/99 , C12Q1/48 , C07D471/04 , C07D417/14 , C07D495/04 , C07D403/12 , A61P25/00 , A61P25/28 , A61P25/16 , A61P19/10 , A61P7/00 , A61P3/10 , A61P19/02 , A61P25/18 , A61P9/00
CPC分类号： A61K31/4155 , A61K31/4427 , A61K31/4436 , A61K31/506 , A61K31/517 , A61K31/519
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, such as inhibitors of GSK-3. The invention provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders. The invention provides processes for preparing compounds of the invention. The invention provides methods of identifying compounds useful for treatment of diabetes, diabetic neuropathy, osteoporosis, Alzheimer's disease, Huntington's disease, Parkinson's disease, AIDS-associated dementia, bipolar disorder, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, leukocytopenia, cardiomyocyte hypertrophy, stroke, post-stroke, spinal cord injury, traumatic brain injury, Charcot-Marie-Tooth, peripheral nerve regeneration, and rheumatoid arthritis.
摘要翻译：本发明涉及可用作蛋白激酶抑制剂的化合物，例如GSK-3的抑制剂。本发明提供包含本发明化合物的药学上可接受的组合物和使用该组合物治疗各种疾病的方法。本发明提供了制备本发明化合物的方法。本发明提供鉴定可用于治疗糖尿病，糖尿病性神经病，骨质疏松症，阿尔茨海默氏病，亨廷顿病，帕金森病，艾滋病相关性痴呆，双相情感障碍，肌萎缩性侧索硬化，多发性硬化，精神分裂症，白细胞减少，心肌细胞肥大，中风的化合物的方法，中风后，脊髓损伤，创伤性脑损伤，Charcot-Marie-Tooth，周围神经再生和类风湿性关节炎。

22. 发明申请

US20110020376A1 AMINOPYRIMIDINES USEFUL AS INHIBITORS OF PROTEIN KINASES 失效
公开(公告)号：US20110020376A1
公开(公告)日：2011-01-27
申请号：US12791976
申请日：2010-06-02
申请人： Juan-Miguel Jimenez , Andrew Miller , Jeremy Green , Huai Gao , Gregory Henkel , Michael Liu , Timothy Neuberger
发明人： Juan-Miguel Jimenez , Andrew Miller , Jeremy Green , Huai Gao , Gregory Henkel , Michael Liu , Timothy Neuberger
IPC分类号： A61K31/506 , C07D471/04 , C07D403/14 , C07D403/12 , C07D413/14 , A61K31/496 , A61K31/5377 , A61K39/00 , A61P3/10 , A61P19/10 , A61P25/28 , A61P25/16 , A61P25/00 , A61P25/18 , A61P19/02 , A61P7/00 , C12N9/99 , C12N5/02
CPC分类号： C07D471/04 , C07D403/12 , C07D405/14
摘要： The present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising those compounds and methods of using the compounds and compositions in the treatment of various disease, conditions, and disorders. The invention also provides processes for preparing compounds of the invention.

23. 发明申请

US20100153037A1 Battery-capacity supervisory control device and method thereof 有权
标题翻译：电池容量监控装置及其方法
公开(公告)号：US20100153037A1
公开(公告)日：2010-06-17
申请号：US12316483
申请日：2008-12-12
申请人： Michael Liu
发明人： Michael Liu
IPC分类号： G01R31/36
CPC分类号： G01R31/362
摘要： A battery-capacity supervisory control device includes a DC current/DC voltage detecting loop, a microprocessor and a display unit. The DC current/DC voltage detecting loop is connected between a battery and a power inverter for detecting a first voltage value before the battery electrically discharges, and a second voltage value as well as an output current value of the battery after electrically discharging for a time unit of the battery, to calculate the available capacity of the battery and to calculate the available time of the battery under loading according to the available capacity of the battery through the microprocessor. The display simultaneously displays the available time of the battery under loading and the available capacity of the battery. Therefore, a user effectively supervises and assures the battery is in the usable state.
摘要翻译：电池容量监控装置包括DC电流/ DC电压检测回路，微处理器和显示单元。直流电流/直流电压检测回路连接在电池和电力逆变器之间，用于检测在电池放电之前的第一电压值，以及第二电压值以及在放电一段时间后的电池的输出电流值计算电池的可用容量，并根据电池通过微处理器的可用容量计算负载下电池的可用时间。显示屏同时显示电池正在加载的可用时间和电池的可用容量。因此，用户有效地监督并确保电池处于可用状态。

24. 发明申请

US20080034328A1 Navigation Method 审中-公开
标题翻译：导航方法
公开(公告)号：US20080034328A1
公开(公告)日：2008-02-07
申请号：US11757682
申请日：2007-06-04
申请人： Paul Cahill , Michael Liu
发明人： Paul Cahill , Michael Liu
IPC分类号： G06F3/048 , G06F17/30 , G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0601
摘要： A method for navigating to information includes: displaying a first geographic image; receiving input from an input device that selects a location on the first geographic image; and retrieving an information segment related to the selected location.
摘要翻译：用于导航到信息的方法包括：显示第一地理图像; 从输入设备接收选择第一地理图像上的位置的输入; 以及检索与所选位置相关的信息段。

25. 发明申请

US20070242537A1 Radiation-hardened memory element with multiple delay elements 有权
标题翻译：具有多个延迟元件的辐射硬化存储元件
公开(公告)号：US20070242537A1
公开(公告)日：2007-10-18
申请号：US11389767
申请日：2006-03-27
申请人： Keith Golke , Harry Liu , Michael Liu , David Nelson
发明人： Keith Golke , Harry Liu , Michael Liu , David Nelson
IPC分类号： G11C7/00
CPC分类号： G11C11/4125 , G11C5/005
摘要： A radiation hardened memory element includes at least two delay elements for maintaining radiation hardness. In an example, the memory element is an SRAM cell. Both delays are coupled together in series so that if either one of the delays fails, a delay will still be maintained within the SRAM cell. The critical areas of the delays may be positioned so that a common line of sight cannot be made between each delay and a circuit node.
摘要翻译：辐射硬化的存储元件包括用于保持辐射硬度的至少两个延迟元件。在一个示例中，存储器元件是SRAM单元。两个延迟都串联在一起，使得如果任一个延迟失败，则在SRAM单元内仍将保持延迟。延迟的关键区域可以定位成使得在每个延迟和电路节点之间不能产生共同的视线。

26. 发明授权

US07200031B2 Proton and heavy ion SEU resistant SRAM 有权
标题翻译：质子和重离子SEU抗性SRAM
公开(公告)号：US07200031B2
公开(公告)日：2007-04-03
申请号：US11082161
申请日：2005-03-16
申请人： Michael Liu , Harry Liu
发明人： Michael Liu , Harry Liu
IPC分类号： G11C11/00
CPC分类号： G11C11/4125
摘要： A method and system is disclosed for reducing proton and heavy ion SEU sensitivity of a static random access memory (SRAM) cell. A first passive delay element has been inserted in series with an active delay element in a first feedback path of the SRAM cell, and a second passive delay element has been inserted in a second feedback path of the SRAM cell. The passive delay elements reduce the proton SEU sensitivity of the SRAM cell, and the active delay element reduces the heavy ion sensitivity of the SRAM cell. The passive delay elements also protect the SRAM cell against SEUs that may occur when the SRAM cell is in dynamic mode.
摘要翻译：公开了用于降低静态随机存取存储器（SRAM）单元的质子和重离子SEU灵敏度的方法和系统。第一被动延迟元件已经与SRAM单元的第一反馈路径中的有源延迟元件串联插入，并且第二被动延迟元件已经插入到SRAM单元的第二反馈路径中。被动延迟元件降低了SRAM单元的质子SEU灵敏度，并且主动延迟元件降低了SRAM单元的重离子灵敏度。被动延迟元件还保护SRAM单元免受当SRAM单元处于动态模式时可能发生的SEU。

27. 发明申请

US20060023854A1 Method and system for forecasting telephony traffic trends using number portability records 有权
公开(公告)号：US20060023854A1
公开(公告)日：2006-02-02
申请号：US11239995
申请日：2005-09-30
申请人： Kevin Moisan , Michael Liu , Wayne Heinmiller , Frederick Armanino
发明人： Kevin Moisan , Michael Liu , Wayne Heinmiller , Frederick Armanino
IPC分类号： H04M15/00
CPC分类号： H04Q3/005 , H04Q3/0087
摘要： A method and system for forecasting telephony traffic trends on a network of a given service provider includes storing number portability records in a database. Each record contains information regarding a corresponding telephone number having been ported between service providers. First and second images of the database are obtained at first and second times. The first and second images are indicative of the records stored in the database at the first and second times. The images are compared to determine migration of the ported telephone numbers between the service providers. Movement of telephone traffic on the network of the given service provider is forecasted as a function of the determined migration of the ported telephone numbers between the service providers.

28. 发明申请

US20050191293A1 IP-10 antibodies and their uses 审中-公开
标题翻译： IP-10抗体及其用途
公开(公告)号：US20050191293A1
公开(公告)日：2005-09-01
申请号：US11009731
申请日：2004-12-10
申请人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine Cardarelli , Changyu Wang , David Passmore , Vangipuram Rangan , Thomas Lane , Hans Keirstead , Michael Liu
发明人： Shrikant Deshpande , Haichun Huang , Mohan Srinivasan , Josephine Cardarelli , Changyu Wang , David Passmore , Vangipuram Rangan , Thomas Lane , Hans Keirstead , Michael Liu
IPC分类号： A61K39/395 , C07D20060101 , C07K14/52 , C07K16/24 , C07K16/28
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP-10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
摘要翻译：本发明提供以高亲和力结合IP-10的分离的单克隆抗体，特别是人抗体，抑制IP-10与其受体的结合，抑制IP-10诱导的钙通量并抑制IP-10诱导的细胞迁移。还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和用于表达本发明的抗体的方法。还提供了免疫偶联物，双特异性分子和包含本发明抗体的药物组合物。本发明还提供了使用本发明的抗体来抑制IP-10活性的方法，包括治疗各种炎性和自身免疫性疾病的方法。

29. 发明申请

US20050096573A1 Non-electrical driven dental hygiene pulsating sprayer 审中-公开
标题翻译：非电动牙科卫生脉动喷雾器
公开(公告)号：US20050096573A1
公开(公告)日：2005-05-05
申请号：US10696157
申请日：2003-10-29
申请人： Michael Liu
发明人： Michael Liu
IPC分类号： A61C17/02 , A61H9/00 , A61H13/00
CPC分类号： A61H13/005 , A61C17/032
摘要： A pulsating dental sprayer has a body and a turbine rotor. The body is adapted to connect to a water source and has a handle and a spraying head. The turbine rotor is rotatably received in the body and has a semicircular ring, a semicircular top plate and multiple extension blades. The semicircular top cover is attached to the ring to construct a circle in cooperation with the semicircular ring. The extension blades are formed on and extend radially from the outer periphery of the ring and the top cover. Accordingly, the sprayer can provide a pulsating massage effect, and electrical power is not needed for use of the sprayer.
摘要翻译：脉动牙科喷雾器具有主体和涡轮转子。主体适于连接到水源，并具有手柄和喷头。涡轮转子可旋转地容纳在主体中并具有半圆环，半圆顶板和多个延伸叶片。半圆形顶盖连接到环上，与半圆环配合构成一个圆。延伸叶片形成在环的外周边和顶盖的径向上并从其延伸。因此，喷雾器可以提供脉动按摩效果，并且不需要电力来使用喷雾器。

30. 外观设计

USD871013S1 Utility dolly board 有权
公开(公告)号：USD871013S1
公开(公告)日：2019-12-24
申请号：US29640030
申请日：2018-03-12
申请人： Michael Liu
设计人： Michael Liu
摘要： FIG. 1 is a top, front, right side perspective view of a utility dolly board showing my new design;
FIG. 2 is a front elevation view thereof;
FIG. 3 is a rear elevation view thereof;
FIG. 4 is a left side elevation view thereof;
FIG. 5 is a right side elevation view thereof;
FIG. 6 is a top plan view thereof; and,
FIG. 7 is a bottom plan view thereof.
The broken lines in the figures are for the purpose of illustrating portions of the utility dolly board that form no part of the claimed design.

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