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21. 发明申请

US20090213991A1 Radiotherapeutic apparatus 有权
标题翻译：放射治疗仪
公开(公告)号：US20090213991A1
公开(公告)日：2009-08-27
申请号：US12297891
申请日：2006-04-27
申请人： Kevin Brown , Ralph Streamer , Paul Boxall , Duncan Bourne
发明人： Kevin Brown , Ralph Streamer , Paul Boxall , Duncan Bourne
IPC分类号： A61N5/10 , H05G1/42
CPC分类号： A61N5/103 , A61N5/1036 , A61N5/1042 , A61N5/1047
摘要： A radiotherapeutic apparatus comprises a source able to emit a beam of therapeutic radiation along a beam axis, a multi-leaf collimator arranged to collimate the beam to a desired shape, wherein the source is rotateable about a rotation axis that is substantially orthogonal and intersects with the beam axis thereby to describe an arc around that axis, and further comprises a control means able to control the dose/time rate of the source, the rotation speed of the source, and the multi-leaf collimator position. The control means is arranged to receive a treatment plan in which the arc is divided into a plurality of notional arc-segments, and specifying the total dose for the arc-segment and a start and end MLC position. It then controls the source in accordance with that plan over an first arc-segment such that at least one of the rotation speed and dose rate are constant and the multi-leaf collimator changes shape, and a second arc segment such that at least one of the rotation speed and dose rate are constant at a level different to the constant level adopted during the first arc-segment. It achieves this by calculating the total time required for the arc segment for a plurality of factors including an MLC leaf movement from a prescribed position at the start of the arc-segment to a prescribed position at the end of the arc-segment, at a maximum leaf speed, rotation of the source from the start to the end of the arc-segment at a maximum source rotation speed, delivery of the dose at a maximum dose rate per time, selecting the factor dictating the longest time, and controlling the apparatus so that the selected factor operates at its respective maximum and the remaining factors are operated at a reduced rate selected to match that longest time.
摘要翻译：放射治疗装置包括能够沿着光束轴发射治疗辐射束的源，多叶准直器，其布置成将光束准直到期望的形状，其中源可绕旋转轴线旋转，旋转轴线基本正交并与光束轴由此描述围绕该轴的弧，并且还包括能够控制源的剂量/时间速率，源的旋转速度和多叶准直器位置的控制装置。控制装置被设置成接收处理计划，其中弧被分成多个概念弧段，并且指定弧段的总剂量以及开始和结束MLC位置。然后，它根据该计划在第一弧段上控制源，使得旋转速度和剂量率中的至少一个恒定，并且多叶准直器改变形状;以及第二弧段，使得至少一个旋转速度和剂量率恒定在与第一弧段期间采用的恒定水平不同的水平。它通过计算多个因素所需的总弧时间来实现，其包括从弧段开始处的规定位置到弧段末端处的规定位置的MLC叶移动，最大叶片速度，源以最大源旋转速度从弧段的开始到结束的旋转，以每时间最大剂量率递送剂量，选择规定最长时间的因子，以及控制装置使得所选择的因子在其各自的最大值下操作，并且剩余因子以选择以匹配最长时间的降低的速率操作。

22. 发明授权

US07574001B2 Internet protocol telephone system 有权
标题翻译：互联网协议电话系统
公开(公告)号：US07574001B2
公开(公告)日：2009-08-11
申请号：US11407986
申请日：2006-04-21
申请人： Siavash Fallahi , Kevin Brown
发明人： Siavash Fallahi , Kevin Brown
IPC分类号： H04M9/00
CPC分类号： H04M1/2535 , H03H7/06 , H03H7/075 , H03H7/38 , H04M11/066
摘要： An internet protocol telephone includes a substrate having an input and an output that are capable of being connected to the internet protocol (IP) network. A relay is disposed on the substrate and is connected between the input and the output of the substrate. The relay includes first and second native FETs that have a threshold voltage of approximately zero volts. Therefore, the relay is nominally turned-on, even when little or no voltage (or power) is applied to the IP telephone substrate, as during the discovery mode of IP telephone operation. During discovery mode, The IP phone is configured to be responsive to extended link pulses and block data packets that are associated with legacy devices. Data packets have a higher signal duration and are more continuous than extended link pulses. The IP phone includes a switchable ground that is connected to the gates of the native devices, and is controlled by a rectifier and filter circuit that are connected to the substrate input. If the IP phone receives legacy data packets during discovery mode, then the high signal duration and continuous nature of the data packets are sufficient to cause the rectifier to generate a rectified signal having sufficient amplitude to activate the switchable ground, so as to ground the gates of the native devices and therefore turn-off the native devices. Therefore, the data packets are rejected and are not passed back to the switch. Extended link pulses have a frequency that is too low to generate a rectified signal that is sufficient to activate the switchable ground, and therefore the native devices remain turned-on. Accordingly, the extended link pulses are passed back to the switch.
摘要翻译：互联网协议电话包括具有能够连接到因特网协议（IP）网络的输入和输出的基板。继电器设置在基板上并且连接在基板的输入和输出之间。继电器包括具有大约零伏的阈值电压的第一和第二天然FET。因此，即使在IP电话操作的发现模式期间，即使对IP电话基板施加很少或没有电压（或电力），继电器也被标称接通。在发现模式期间，IP电话被配置为响应于扩展链路脉冲和阻止与传统设备相关联的数据分组。数据包具有更高的信号持续时间，并且比扩展链路脉冲更连续。 IP电话包括可连接到本地设备的门的可切换接地，并且由连接到衬底输入的整流器和滤波器电路控制。如果IP电话在发现模式期间接收传统数据分组，则数据分组的高信号持续时间和连续性质足以使整流器产生具有足够振幅的整流信号以激活可切换接地，从而对门的本地设备，因此关闭本机设备。因此，数据包被拒绝，不会传回交换机。扩展链路脉冲的频率太低，无法产生足以激活可切换接地的整流信号，因此本机设备保持接通。因此，扩展链路脉冲被传回给开关。

23. 发明授权

US07558280B2 Apparatus and method for auto-negotiation in a communication system 有权
公开(公告)号：US07558280B2
公开(公告)日：2009-07-07
申请号：US11003739
申请日：2004-12-06
申请人： Walter Hurwitz , Richard G. Thousand , Kevin Brown , Garry Huff
发明人： Walter Hurwitz , Richard G. Thousand , Kevin Brown , Garry Huff
IPC分类号： H04L12/28
CPC分类号： H04L12/44 , H04L29/06 , H04L69/24
摘要： A communication system includes a first device and a second device that can advertise multiple capabilities using communication links. A first type of auto-negotiation between the first and second devices is performed using a first communication link between the devices. A second communication link between the devices is used to facilitate a second type of auto-negotiation. For example, the first communication link can include pairs A and B of an IEEE Std. 802.3 four twisted pair cable. The second communication link can include pairs C and D of the cable.

24. 发明申请

US20080165928A1 Radiotherapeutic Apparatus 有权
标题翻译：放射治疗仪
公开(公告)号：US20080165928A1
公开(公告)日：2008-07-10
申请号：US11886031
申请日：2006-03-01
申请人： Kevin Brown
发明人： Kevin Brown
IPC分类号： A61N5/10
CPC分类号： A61N5/1042 , A61N5/1047
摘要： The present invention seeks to provide a radiotherapeutic apparatus that mitigates the various problems found in the techniques such as tomotherapy, IMAT, IMRT and the like. It provides a radiotherapeutic apparatus comprising a source of radiation whose output is collimated by a multi-leaf collimator, and a patient support, the source being rotateable around the support and the support being translatable along the axis of rotation, thereby to move the source helically relative to a patient on the support. The leaves of the MLC are preferably oriented orthogonal to the axis of rotation, to simplify computation of the dose distribution. The apparatus thus moves the patient on the patient support system along the axis of rotation, in the longitudinal direction. Thus, the device has an effectively unlimited treatable volume in the longitudinal direction and avoids the limitations of IMAT and IMRT techniques whilst enabling the use of thin MLC leaves to give a high longitudinal resolution. The apparatus is preferably combined with an optimisation system providing a computational service similar to that provided for IMAT and IMRT devices. Essentially the same computational techniques could be used, with appropriate changes to the input conditions and characteristic equations. The long aperture length (compared to tomotherapy) makes the radiation delivery efficient and therefore the delivery of high doses a practicality; hypofractionation and radiosurgery therefore become possible over large treatable volumes.
摘要翻译：本发明寻求提供减轻诸如tomotherapy，IMAT，IMRT等技术中发现的各种问题的放射治疗装置。它提供了一种放射治疗装置，其包括辐射源，其输出由多叶准直器准直，以及患者支架，该源可围绕支撑件旋转，支撑件可沿旋转轴线平移，相对于患者的支持。 MLC的叶优选地定向为与旋转轴正交，以简化剂量分布的计算。因此，该装置使患者沿纵向方向沿旋转轴线移动患者支撑系统。因此，该装置在纵向上具有有效的无限可处理体积，并避免了IMAT和IMRT技术的限制，同时能够使用薄的MLC叶片提供高的纵向分辨率。该装置优选地与提供与为IMAT和IMRT设备提供的计算服务类似的优化系统组合。可以使用基本相同的计算技术，适当地改变输入条件和特征方程。长孔径长度（与tomotherapy相比）使得放射线递送效率高，因此高剂量的递送具有实用性; 因此，低分割和放射外科可以在大的可治疗体积上成为可能。

25. 发明申请

US20070160689A1 Compositions and methods for treatment of coughing, sneezing, rhinorrhea, and/or nasal obstruction 审中-公开
标题翻译：用于治疗咳嗽，打喷嚏，鼻漏和/或鼻塞的组合物和方法
公开(公告)号：US20070160689A1
公开(公告)日：2007-07-12
申请号：US11330351
申请日：2006-01-12
申请人： John Giordano , Kevin Brown
发明人： John Giordano , Kevin Brown
IPC分类号： A61K36/49 , A61K31/485 , A61K31/185 , A61K31/205 , A61K31/137
CPC分类号： A61K45/06 , A61K31/137 , A61K31/185 , A61K31/205 , A61K31/485 , A61K2300/00
摘要： The present invention relates to compositions that comprise an expectorant, an extended release antitussive, and an extended release decongestant. Specifically, the compositions comprise guaifenesin, phenylephrine tannate, and dextromethorphan tannate. The present invention also includes methods for using these compositions for treatment of patients suffering from, for example and without limitation, coughing, sneezing, rhinorrhea, and/or nasal obstruction.
摘要翻译：本发明涉及包含祛痰剂，延长释放止咳剂和延长释放减充血剂的组合物。具体地，组合物包含愈创甘油醚，丹宁酸去氧肾上腺素和右美沙芬丹宁酸酯。本发明还包括使用这些组合物治疗患有例如但不限于咳嗽，打喷嚏，鼻漏和/或鼻塞的患者的方法。

26. 发明申请

US20070127920A1 Method and system for speed negotiation for twisted pair links in fibre channel systems 失效
标题翻译：光纤通道系统中双绞线链路速度协商的方法和系统
公开(公告)号：US20070127920A1
公开(公告)日：2007-06-07
申请号：US11491629
申请日：2006-07-24
申请人： Ali Ghiasi , Kevin Brown
发明人： Ali Ghiasi , Kevin Brown
IPC分类号： H04B10/08
CPC分类号： H04L5/1446 , H04L29/06537 , H04L49/3054 , H04L49/357 , H04L69/24 , H04L69/323 , H04L69/324
摘要： Certain aspects of a method and system for speed negotiation for twisted pair links in fibre channel systems are disclosed. Aspects of a method may include communicating data between fibre channel host devices communicatively coupled via a twisted pair link based on a common speed negotiated between the fibre channel host devices. At least one available speed may be determined for the communication of data between the fibre channel host devices over the twisted pair link. The determined available speeds for each of the fibre channel host devices may be exchanged via at least one fast link pulse signal. The common speed negotiated may be a highest available speed for the communication of data between the fibre channel host devices.
摘要翻译：公开了用于光纤通道系统中双绞线链路速度协商的方法和系统的某些方面。方法的方面可以包括基于在光纤信道主机设备之间协商的公共速度，经由双绞线链路通信耦合的光纤通道主机设备之间传送数据。可以通过双绞线链路来确定光纤通道主机设备之间的数据通信的至少一个可用速度。可以经由至少一个快速链路脉冲信号来交换每个光纤通道主机设备的确定的可用速度。协商的通用速度可能是光纤通道主机设备之间数据通信的最高可用速度。

27. 发明申请

US20070072909A1 Methods for making 4-tetrazolyl-4-phenylpiperidine compounds 有权
标题翻译：制备4-四唑基-4-苯基哌啶化合物的方法
公开(公告)号：US20070072909A1
公开(公告)日：2007-03-29
申请号：US11495221
申请日：2006-07-28
申请人： Kevin Brown , Timothy Doyle , John Whitehead
发明人： Kevin Brown , Timothy Doyle , John Whitehead
IPC分类号： A61K31/454 , A61K31/165 , A61K31/41 , C07D403/02
CPC分类号： C07D211/64 , C07D257/04 , C07D307/22 , C07D401/04
摘要： Methods, composition, and intermediates are disclosed that are useful for making 4-Tetrazolyl-4-phenylpiperidine Compounds according to Formula I, where Ar1 is —C3-C8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups; Ar2 is phenyl, naphthyl, anthryl, phenanthryl or -(5-7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups; Z1 and Z2 are each independently a —(C1-C4 alkyl) group; R1 is —(CH2)nC(O)N(R3)(R4) where R3 and R4 are each independently H or —(C1-C4 alkyl); R2 is halogen, —C1-C3 alkyl, —O—(C1-C3 alkyl), —NH(C1-C3 alkyl) or —N(C1-C3 alkyl)2; n is an integer ranging from 1 to 4; m is an integer ranging from 0 to 4; and, in certain embodiments, the phenyl moiety attached to the 4-position of the piperidine ring of a compound according to Formula I can be optionally substituted with one or more R2 groups.
摘要翻译：公开了可用于制备根据式I的4-四唑基-4-苯基哌啶化合物的方法，组合物和中间体，其中Ar 1是-C 3 -C 3 - 苯基，萘基，蒽基，菲基或 - （5-7元）杂芳基，各自是未取代的或被一个或多个R 2 O 2基团取代; Ar 2是苯基，萘基，蒽基，菲基或 - （5-7-元）杂芳基，各自是未取代的或被一个或多个R 2 O 2基团取代; Z 1和Z 2各自独立地为 - （C 1 -C 4 -C 4烷基）基团; R 1是（CH 2）n C（O）N（R 3）（R 0）其中R 3和R 4各自独立地为H或 - （C 1 -C 4）烷基，烷基）; R 2是卤素，-C 1 -C 3烷基，-O-（C 1 -C 3 - （C 1 -C 3烷基）或-NH（C 1 -C 3烷基）或-N（C 1 -C 3烷基） 3 烷基）2。 n为1〜4的整数; m为0〜4的整数; 并且在某些实施方案中，与式I化合物的哌啶环的4-位连接的苯基部分可任选被一个或多个R 2 O 2基团取代。

28. 发明申请

US20070025496A1 Computed Tomography Scanning 有权
标题翻译：计算机断层扫描
公开(公告)号：US20070025496A1
公开(公告)日：2007-02-01
申请号：US11531471
申请日：2006-09-13
申请人： Kevin Brown , David Jaffray , Jeffrey Siewerdsen , Marcel van Herk , Jan-Jakob Sonke
发明人： Kevin Brown , David Jaffray , Jeffrey Siewerdsen , Marcel van Herk , Jan-Jakob Sonke
IPC分类号： A61B6/00 , G01N23/00 , G21K1/12 , H05G1/60
CPC分类号： G06T5/009 , A61N5/1064 , G06T5/003 , G06T7/0016 , G06T7/20 , G06T11/005 , G06T2207/10081 , G06T2207/20068 , G06T2207/20192 , G06T2207/30061 , G06T2207/30096 , G06T2211/412
摘要： Artifacts in the reconstructed volume data of cone beam CT systems can be removed by the application of respiration correlation techniques to the acquired projection images. To achieve this, the phase of the patients breathing is monitored while acquiring projection images continuously. On completion of the acquisition, projection images that have comparable breathing phases can be selected from the complete set, and these are used to reconstruct the volume data using similar techniques to those of conventional CT. Any phase can be selected and therefore the effect of breathing can be studied. It is also possible to use a feature in the projection images such as the patient's diaphragm to determine the breathing phase. This feature in the projection images can be used to control delivery of therapeutic radiation dependent on the patient's breathing cycle, to ensure that the tumor is in the correct position when the radiation is delivered.
摘要翻译：通过对所获取的投影图像应用呼吸相关技术，可以去除锥束CT系统的重建体数据中的伪像。为了实现这一点，在持续拍摄投影图像的同时监测患者呼吸的阶段。完成采集后，可以从完整组中选择具有相似呼吸相位的投影图像，并使用与常规CT类似的技术来重建体积数据。可以选择任何相位，因此可以研究呼吸的效果。也可以使用诸如患者隔膜的投影图像中的特征来确定呼吸阶段。投影图像中的该特征可以用于控制取决于患者呼吸周期的治疗辐射的传递，以确保当辐射被递送时肿瘤处于正确的位置。

29. 发明授权

US07072427B2 Method and apparatus for reducing DC offsets in a communication system 有权
标题翻译：用于减少通信系统中的直流偏移的方法和装置
公开(公告)号：US07072427B2
公开(公告)日：2006-07-04
申请号：US10289377
申请日：2002-11-07
申请人： Gregory S. Rawlins , Kevin Brown , Michael W. Rawlins , David F. Sorrells
发明人： Gregory S. Rawlins , Kevin Brown , Michael W. Rawlins , David F. Sorrells
IPC分类号： H04B1/10
CPC分类号： H03G3/20 , H04B1/30
摘要： Methods and apparatuses for reducing DC offsets in a communication system are described. In a first aspect, a feedback loop circuit reduces DC offset in a wireless local area network (WLAN) receiver channel. The frequency response of the feedback loop circuit can be variable. In a second aspect, a circuit provides gain control in a WLAN receiver channel. The stored DC offset is subtracted from the receiver channel. First and second automatic gain control (AGC) amplifiers are coupled in respective portions of the receiver channel. In a third aspect, a feedback loop circuit reduces DC offset in a WLAN receiver channel. The feedback loop circuit includes a storage element that samples and stores receiver channel DC offset. The loop is opened, and the DC offset stored in the storage element is subtracted from the receiver channel. Circuits for monitoring DC offset, and for providing control signals for controlling the frequency response of the DC offset reducing circuits are also provided.
摘要翻译：描述用于减少通信系统中的DC偏移的方法和装置。在第一方面，反馈回路电路减少无线局域网（WLAN）接收机信道中的DC偏移。反馈回路电路的频率响应是可变的。在第二方面，电路在WLAN接收机信道中提供增益控制。从接收机通道中减去存储的直流偏移。第一和第二自动增益控制（AGC）放大器耦合在接收机通道的相应部分中。在第三方面，反馈回路电路减少WLAN接收机信道中的DC偏移。反馈回路电路包括采样和存储接收机通道DC偏移的存储元件。打开该循环，并从接收器通道中减去存储在存储元件中的DC偏移。还提供了用于监控DC偏移的电路，以及用于提供用于控制DC偏移减小电路的频率响应的控制信号。

30. 发明申请

US20060140335A1 System and method for helical cone-beam computed tomography with exact reconstruction 审中-公开
标题翻译：具有精确重建的螺旋锥束计算机断层扫描系统和方法
公开(公告)号：US20060140335A1
公开(公告)日：2006-06-29
申请号：US10545265
申请日：2004-02-09
申请人： Dominic Heuscher , Frederic Noo , Kevin Brown , Jed Pack
发明人： Dominic Heuscher , Frederic Noo , Kevin Brown , Jed Pack
IPC分类号： H05G1/60 , A61B6/00 , G01N23/00 , G21K1/12
CPC分类号： G06T11/006 , A61B6/027 , G06T2211/416 , G06T2211/421
摘要： A helical conebeam computed tomography imaging system includes an x-ray source (12) that produces an x ray conebeam, and an x-ray detector array (16) that detects the x ray conebeam after passing through an examination region (14). The x-ray detector array (16) generates projection data in a detector coordinate system defined with reference to the detector array (16). A derivative processor (60) computes a derivative of the projection data with respect to a helix angle of the helical trajectory at fixed projection direction to generate differentiated projection data. A convolution processor (64) convolves the differentiated projection data with a kernel function to produce filtered projection data. The convolving is performed in the detector coordinate system. A backprojector (42, 82) backprojects the filtered projection data to obtain an image representation.
摘要翻译：螺旋锥束计算机断层摄影成像系统包括产生x射线锥束的X射线源（12）和在通过检查区域（14）之后检测x射线锥束的x射线检测器阵列（16）。 X射线检测器阵列（16）在参考检测器阵列（16）定义的检测器坐标系中产生投影数据。衍生处理器（60）计算相对于在固定投影方向的螺旋轨迹的螺旋角的投影数据的导数，以产生微分投影数据。卷积处理器（64）将差分投影数据与内核函数进行卷积，以产生经滤波的投影数据。在检测器坐标系中进行卷积。背投影机（42,82）反向投影经过滤的投影数据以获得图像表示。

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