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21. 发明授权

US08440619B2 Utilization of hypertension/hypercardia-preventing effect of D-allose 有权
标题翻译：利用高血压/防高效D-allose的作用
公开(公告)号：US08440619B2
公开(公告)日：2013-05-14
申请号：US12065452
申请日：2006-08-31
申请人： Masaaki Tokuda , Shoji Kimura , Ken Izumori
发明人： Masaaki Tokuda , Shoji Kimura , Ken Izumori
IPC分类号： A61K38/00 , A61K9/12 , A61K31/70 , A61P9/00
CPC分类号： A23K20/163 , A23L33/10 , A61K31/7004
摘要： The object is to provide a novel application of D-allose (e.g., use for prevention of hypertension or hypercardia). Thus, disclosed is a composition for preventing the increase in blood pressure which comprises D-allose as an active ingredient; or a composition containing D-allose and/or a derivative thereof, preferably in an amount of 0.1 to 50% by weight. Preferably, the composition is in a form selected from the group consisting of a food additive, a food material, a beverage/food, a health beverage/food, a pharmaceutical and a feeding stuff which can be used for the prevention and treatment of a cardiovascular system disorder (e.g., hypertension, hypercardia). The increase in blood pressure may be caused by salt-sensitive hypertension. Also disclosed is use of D-allose for preventing the increase in blood pressure (excluding medical practices).
摘要翻译：本发明的目的是提供D-丙氨酸的新应用（例如，用于预防高血压或高血压）。因此，公开了用于防止血压升高的组合物，其包含D-阿洛糖作为活性成分; 或含有D-丙氨酸和/或其衍生物的组合物，优选为0.1〜50重量％。优选地，组合物为选自食品添加剂，食品材料，饮料/食品，保健饮料/食品，药物和饲料的形式，其可用于预防和治疗心血管系统疾病（如高血压，高血压）。血压升高可能是盐敏感性高血压引起的。还公开了使用D-丙氨酸来防止血压升高（不包括医疗实践）。

22. 发明授权

US07501267B2 Gene sequence of L-rhamnose isomerase having new catalytic function and use thereof 有权
标题翻译：具有新催化功能的L-鼠李糖异构酶的基因序列及其应用
公开(公告)号：US07501267B2
公开(公告)日：2009-03-10
申请号：US11714887
申请日：2007-03-07
申请人： Ken Izumori , Goro Takada , Masaaki Tokuda
发明人： Ken Izumori , Goro Takada , Masaaki Tokuda
IPC分类号： C12P21/06 , C07H21/04 , C12N1/21 , C12N9/90
CPC分类号： C12N9/90 , C12P19/02 , C12P19/24 , C12Y503/01014
摘要： In the rare sugar strategy of Izumoring (FIG. 1), it is intended to establish a reaction system of producing rare sugars of many types by acquiring an isomerase which acts on various rare aldoses and, therefore, is most efficient in producing various rare ketoses. A DNA encoding the following protein (a) or (b). The above-mentioned DNA which is L-rhamnose isomerase derived from Pseudomonas stutzerii. A protein comprising the amino acid sequence represented by SEQ ID NO:2. A process for producing a recombinant protein characterized by culturing a host cell containing an expression system that can express the above-mentioned protein in a medium and collecting a recombinant protein having an L-rhamnose isomerase activity from the thus obtained culture. A method of applying FIG. 1 to the production of a rare sugar characterized in that the location of a target rare sugar in the overall picture of monosaccharides is understood and thus the optimum production pathway on which the above protein is allowed to act is designed.
摘要翻译：在采食稀少糖的策略（图1）中，旨在通过获得作用于各种罕见的醛糖的异构酶来建立许多类型的稀有糖的反应体系，因此在生产各种稀有酮糖中是最有效的。编码以下蛋白质（a）或（b）的DNA。上述提供的源自番茄假单胞菌的L-鼠李糖异构酶的DNA。包含SEQ ID NO：2所示的氨基酸序列的蛋白质。一种重组蛋白质的制造方法，其特征在于，在培养基中培养含有能够在培养基中表达上述蛋白质的表达系统的宿主细胞，从所得培养物中收集具有L-鼠李糖异构酶活性的重组蛋白质。一种应用图1的方法。 1涉及生产一种罕见的糖，其特征在于，在单糖的总体图中，目标稀有糖的位置被理解，因此设计了允许上述蛋白质起作用的最佳生产途径。

23. 发明申请

US20060148061A1 Gene sequence of l-rhamnose isomerase having new catalytic function and use thereof 有权
标题翻译：具有新催化功能的L-鼠李糖异构酶的基因序列及其用途
公开(公告)号：US20060148061A1
公开(公告)日：2006-07-06
申请号：US10541822
申请日：2004-01-09
申请人： Ken Izumori , Goro Takada , Masaaki Tokuda
发明人： Ken Izumori , Goro Takada , Masaaki Tokuda
IPC分类号： C07H21/04 , C12P21/06 , C12P19/02 , C12N9/90 , C12N15/74 , C12N1/21
CPC分类号： C12N9/90 , C12P19/02 , C12P19/24 , C12Y503/01014
摘要： In the rare sugar strategy of Izumoring (FIG. 1), it is intended to establish a reaction system of producing rare sugars of many types by acquiring an isomerase which acts on various rare aldoses and, therefore, is most efficient in producing various rare ketoses. A DNA encoding the following protein (a) or (b). The above-mentioned DNA which is L-rhamnose isomerase derived from Pseudomonas stutzerii. A protein comprising the amino acid sequence represented by SEQ ID NO:2. A process for producing a recombinant protein characterized by culturing a host cell containing an expression system that can express the above-mentioned protein in a medium and collecting a recombinant protein having an L-rhamnose isomerase activity from the thus obtained culture. A method of applying FIG. 1 to the production of a rare sugar characterized in that the location of a target rare sugar in the overall picture of monosaccharides is understood and thus the optimum production pathway on which the above protein is allowed to act is designed.
摘要翻译：在采食稀少糖的策略（图1）中，旨在通过获得作用于各种罕见的醛糖的异构酶来建立许多类型的稀有糖的反应体系，因此在生产各种稀有酮糖中是最有效的。编码以下蛋白质（a）或（b）的DNA。上述提供的源自番茄假单胞菌的L-鼠李糖异构酶的DNA。包含SEQ ID NO：2所示的氨基酸序列的蛋白质。一种重组蛋白质的制造方法，其特征在于，在培养基中培养含有能够在培养基中表达上述蛋白质的表达系统的宿主细胞，从所得培养物中收集具有L-鼠李糖异构酶活性的重组蛋白质。一种应用图1的方法。 1涉及生产一种罕见的糖，其特征在于，在单糖的总体图中，目标稀有糖的位置被理解，因此设计了允许上述蛋白质起作用的最佳生产途径。

24. 发明授权

US09668958B2 Noncarious material and anticarious agent containing rare sugar 有权
公开(公告)号：US09668958B2
公开(公告)日：2017-06-06
申请号：US13369780
申请日：2012-02-09
申请人： Tetsuo Iida , Takashi Ichihara , Ken Izumori , Masaaki Tokuda , Takaaki Ogawa
发明人： Tetsuo Iida , Takashi Ichihara , Ken Izumori , Masaaki Tokuda , Takaaki Ogawa
IPC分类号： A61K8/60 , A61Q11/00 , A61K31/047 , A61K31/7004 , C07H3/02
CPC分类号： A61K8/60 , A61K31/047 , A61K31/7004 , A61Q11/00 , C07H3/02
摘要： To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor. A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.

25. 发明申请

US20080306011A1 Method of Controlling the Proliferation of Vascular Endothelial Cells and Inhibiting Lumen Formation 审中-公开
标题翻译：控制血管内皮细胞增殖和抑制腔形成的方法
公开(公告)号：US20080306011A1
公开(公告)日：2008-12-11
申请号：US11569635
申请日：2005-05-26
申请人： Masaaki Tokuda , Ikuko Tsukamoto , Ryoji Konishi , Yasuo Kubota , Ken Izumori
发明人： Masaaki Tokuda , Ikuko Tsukamoto , Ryoji Konishi , Yasuo Kubota , Ken Izumori
IPC分类号： A61K31/7004 , C07H3/02 , C07H3/08 , A61P3/10 , C12N5/06
CPC分类号： C07H3/08 , A23L33/10 , A61K31/7004 , C07H3/02
摘要： [PROBLEMS] To find out a specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation and utilize these effects. To provide this rare sugar as a preventive/remedy for diseases with angiogenesis, a cosmetic or a functional food.[MEANS FOR SOLVING PROBLEMS] A method of controlling the proliferation of vascular endothelial cells characterized by utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose. A method of inhibiting lumen formation of vascular endothelial cells characterized by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-gulose, D-talose, L-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose.
摘要翻译： [问题]找出具有抑制血管内皮细胞增殖和管腔形成的作用的特定稀有糖并利用这些效果。提供这种稀有糖作为血管生成疾病，化妆品或功能性食物的预防/补救。【解决问题的手段】控制血管内皮细胞增殖的方法，其特征在于利用D-甘露糖，D-异丙肾上腺素，2-脱氧-D-葡萄糖，3-脱氧-D-葡萄糖的血管内皮细胞增殖抑制作用，葡萄糖，L-山梨糖，2-脱氧-D-核糖和/或2-脱氧-L-核糖。一种抑制血管内皮细胞管腔形成的方法，其特征在于利用D-阿洛糖，D-阿卓糖，D-古洛糖，D-塔洛糖，L-阿洛糖，2-脱氧-D-葡萄糖的血管内皮细胞管腔形成抑制作用，3-脱氧-D-葡萄糖，D-核糖，L-核糖，2-脱氧-D-核糖和/或2-脱氧-L-核糖。

26. 发明授权

US10869494B2 Sweetener containing D-psicose and foods and drinks obtained by using the same 有权
公开(公告)号：US10869494B2
公开(公告)日：2020-12-22
申请号：US12514216
申请日：2007-03-26
申请人： Hideki Fujihara , Kazuhiro Okuma , Tetsuo Iida , Ken Izumori , Masaaki Tokuda , Kazuhiro Fukada
发明人： Hideki Fujihara , Kazuhiro Okuma , Tetsuo Iida , Ken Izumori , Masaaki Tokuda , Kazuhiro Fukada
IPC分类号： A23L27/30 , A61K8/60 , A23L2/60 , A23C9/13 , A61Q11/00 , A23G4/06 , A23G4/10 , A23G3/42 , A23G3/36 , A61K47/26
CPC分类号： A23L27/33 , A23C9/13 , A23G3/36 , A23G3/42 , A23G4/06 , A23G4/10 , A23L2/60 , A23L27/34 , A23L27/36 , A61K8/60 , A61Q11/00 , A61K47/26
摘要： Providing a D-psicose-containing sweetener with the modification of the taste of D-psicose, comprising D-psicose, a sugar alcohol and/or a high intensity sweetener, preferably containing D-psicose as the main component, particularly a low-calorie sweetener and/or a sweetener giving refreshing feel in the oral cavity, as well as foods and drinks obtained by using the D-psicose-containing sweetener with the modification of the taste of D-psicose, and other products given with sweetness. The sugar alcohol is one or more sugar alcohols selected from the group consisting of sorbitol, mannitol, lactitol, maltitol, xylitol and erythritol, while the high intensity sweetener is one or more high intensity sweeteners as selected from aspartame, acesulfame K, sodium cyclamate, sodium saccharin, Sucralose (under trade name), stevia sweetener, dulcin, taumatin, neotame and monellin.

27. 发明授权

US07691619B2 Sequence of thermotolerant L-rhamnose isomerase gene and use of the same 有权
标题翻译：耐热L-鼠李糖异构酶基因的序列及其用途
公开(公告)号：US07691619B2
公开(公告)日：2010-04-06
申请号：US11660959
申请日：2005-08-23
申请人： Ken Izumori , Goro Takata , Masaaki Tokuda
发明人： Ken Izumori , Goro Takata , Masaaki Tokuda
IPC分类号： C12N9/90 , C12P19/24 , C12P19/02 , C12P21/04 , C07H21/04
CPC分类号： C12P19/24 , C12N9/90
摘要： The invention relates to an isolated protein including an amino acid sequence represented by SEQ ID NO:2 and having an L-rhamnose isomerase activity. This novel enzyme has a higher reaction efficiency between D-psicose and D-allose and is excellent in thermal stability.
摘要翻译：本发明涉及包含SEQ ID NO：2所示的氨基酸序列并具有L-鼠李糖异构酶活性的分离蛋白质。该新型酶具有较高的D-木糖和D-丙氨酸的反应效率，热稳定性优异。

28. 发明申请

US20090305999A1 UTILIZATION OF HYPERTENSION/HYPERCARDIA-PREVENTING EFFECT OF D-ALLOSE 有权
标题翻译：高血压/高血压的使用 - 预防D-ALLOSE的影响
公开(公告)号：US20090305999A1
公开(公告)日：2009-12-10
申请号：US12065452
申请日：2006-08-31
申请人： Masaaki Tokuda , Shoji Kimura , Ken Izumori
发明人： Masaaki Tokuda , Shoji Kimura , Ken Izumori
IPC分类号： A61K31/7004 , A61P9/12
CPC分类号： A23K20/163 , A23L33/10 , A61K31/7004
摘要： The object is to provide a novel application of D-allose (e.g., use for prevention of hypertension or hypercardia). Thus, disclosed is a composition for preventing the increase in blood pressure which comprises D-allose as an active ingredient; or a composition containing D-allose and/or a derivative thereof, preferably in an amount of 0.1 to 50% by weight. Preferably, the composition is in a form selected from the group consisting of a food additive, a food material, a beverage/food, a health beverage/food, a pharmaceutical and a feeding stuff which can be used for the prevention and treatment of a cardiovascular system disorder (e.g., hypertension, hypercardia). The increase in blood pressure may be caused by salt-sensitive hypertension. Also disclosed is use of D-allose for preventing the increase in blood pressure (excluding medical practices).
摘要翻译：本发明的目的是提供D-丙氨酸的新颖应用（例如，用于预防高血压或高血压）。因此，公开了用于防止血压升高的组合物，其包含D-阿洛糖作为活性成分; 或含有D-丙氨酸和/或其衍生物的组合物，优选为0.1-50重量％。优选地，组合物为选自食品添加剂，食品材料，饮料/食品，保健饮料/食品，药物和饲料的形式，其可用于预防和治疗心血管系统疾病（如高血压，高血压）。血压升高可能是盐敏感性高血压引起的。还公开了使用D-丙氨酸来防止血压升高（不包括医疗实践）。

29. 发明申请

US20100222285A1 METHOD OF CONTROLLING THE PROLIFERATION OF VASCULAR ENDOTHELIAL CELLS AND INHIBITING LUMEN FORMATION 审中-公开
标题翻译：控制血管内皮细胞增殖和抑制肿瘤形成的方法
公开(公告)号：US20100222285A1
公开(公告)日：2010-09-02
申请号：US12775807
申请日：2010-05-07
申请人： Masaaki Tokuda , Ikuko Tsukamoto , Ryoji Konishi , Yasuo Kubota , Ken Izumori
发明人： Masaaki Tokuda , Ikuko Tsukamoto , Ryoji Konishi , Yasuo Kubota , Ken Izumori
IPC分类号： A61K31/7004 , A61P3/10 , A61P9/00
CPC分类号： C07H3/08 , A23L33/10 , A61K31/7004 , C07H3/02
摘要： A specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation is disclosed. This rare sugar is provided as a preventive/remedy for diseases with angiogenesis, a cosmetic or a functional food. The proliferation of vascular endothelial cells is controlled utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deloxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose. Lumen formation of vascular endothelial cells is inhibited by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-glucose, D-talose, L-allose, 2-deloxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose.
摘要翻译：公开了具有抑制血管内皮细胞增殖和内膜形成的作用的特定稀有糖。这种罕见的糖被提供作为血管生成疾病，化妆品或功能性食物的预防/补救。血管内皮细胞的增殖受D-甘露糖，D-丙氨酸，2-脱氧-D-葡萄糖，3-脱氧-D-葡萄糖，L-山梨糖，2-脱氧-D-葡萄糖，L-山梨糖， D-核糖和/或2-脱氧-L-核糖。通过利用D-阿洛糖，D-阿糖，D-葡萄糖，D-塔洛糖，L-阿洛糖，2-脱氧-D-葡萄糖，3-甲氧基-D-葡萄糖，脱氧-D-葡萄糖，D-核糖，L-核糖，2-脱氧-D-核糖和/或2-脱氧-L-核糖。

30. 发明申请

US20100166678A1 NONCARIOUS MATERIAL AND ANTICARIOUS AGENT CONTAINING RARE SUGAR 有权
标题翻译：非常重的材料和含有稀有糖的强力剂
公开(公告)号：US20100166678A1
公开(公告)日：2010-07-01
申请号：US12514182
申请日：2007-03-27
申请人： Tetsuo Iida , Takashi Ichihara , Ken Izumori , Masaaki Tokuda , Takaaki Ogawa
发明人： Tetsuo Iida , Takashi Ichihara , Ken Izumori , Masaaki Tokuda , Takaaki Ogawa
IPC分类号： A61K8/60 , A61Q11/00
CPC分类号： A61K8/60 , A61K31/047 , A61K31/7004 , A61Q11/00 , C07H3/02
摘要： Object: To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor.Means for Resolution: A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.
摘要翻译：目的：提供一种用于预防牙周病（牙周病的预防剂）的组合物，该组合物具有优异的抑制性，对于长时间使用是安全和稳定的并且对风味的影响较小。解决方法：通过将选自D-木糖，D-山梨糖和D-塔格糖的D-形式的稀有糖混合制备的非致龋材料，L型的稀有糖选自L- 果糖，L-灵巧蛋白和L-塔格糖，或作为稀有糖衍生物的全醇，单独或组合使用。包含D-灵糖蛋白，D-山梨糖，D-塔格糖，L-果糖，L-灵巧蛋白和/或L-塔格糖的抑制剂。与儿茶素组合使用的抑菌剂。

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