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21. 发明授权

US11136346B2 Asymmetric auxiliary group 有权
公开(公告)号：US11136346B2
公开(公告)日：2021-10-05
申请号：US16878461
申请日：2020-05-19
申请人： WAVE LIFE SCIENCES LTD.
发明人： Mamoru Shimizu , Takeshi Wada
IPC分类号： C07H23/00 , C07H1/00 , C07H19/207 , C07D405/04 , C07D473/18 , C07D473/34 , C07B53/00 , C07H19/11 , C07H19/213 , C07H21/04 , C07D207/08 , C07F7/08 , C07H19/10
摘要： To provide a chiral reagent or a salt thereof.
The chiral reagent has following chemical formula (I). In the formula (I), G1 and G2 are independently a hydrogen atom, a nitro group (—NO2), a halogen atom, a cyano group (—CN), a group of formula (II) or (III), or both G1 and G2 taken together to form a group of formula (IV).

22. 发明申请

US20210254062A1 OLIGONUCLEOTIDE COMPOSITIONS AND METHODS OF USE THEREOF 有权
公开(公告)号：US20210254062A1
公开(公告)日：2021-08-19
申请号：US17054452
申请日：2019-05-10
申请人： WAVE LIFE SCIENCES LTD.
发明人： Jason Jingxin Zhang , Chandra Vargeese , Naoki Iwamoto , Chikdu Shakti Shivalila , Nayantara Kothari , Ann Fiegen Durbin , Selvi Ramasamy , Pachamuthu Kandasamy , Jayakanthan Kumarasamy , Gopal Reddy Bommineni , Subramanian Marappan , Sethumadhavan Divakaramenon , David Charles Donnell Butler , Genliang Lu , Hailin Yang , Mamoru Shimizu , Prashant Monian
IPC分类号： C12N15/113
摘要： Among other things, the present disclosure provides designed DMD oligonucleotides, compositions, and methods of use GC thereof. In some embodiments, the present disclosure provides technologies useful for repairing mutant DMD transcripts by skipping exon 51 or exon 53, so that the transcript can be translated into an internally truncated but at least partially functional Dystrophin protein variant. In some embodiments, the present disclosure provides technologies useful for modulating DMD transcript splicing. In some embodiments, provided technologies can alter splicing of a dystrophin (DMD) DMD transcript. In some embodiments, the present disclosure provides methods for treating diseases, such as muscular dystrophy, including but not limited to Duchenne muscular dystrophy, Becker's muscular dystrophy, etc.

23. 发明申请

US20110294124A1 METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS 有权
标题翻译：磷化氢修饰核酸的合成方法
公开(公告)号：US20110294124A1
公开(公告)日：2011-12-01
申请号：US13131591
申请日：2009-12-02
申请人： Takeshi Wada , Mamoru Shimizu
发明人： Takeshi Wada , Mamoru Shimizu
IPC分类号： C12Q1/68 , C07H21/00 , G01N21/76 , C12P19/34 , G01N33/53 , G01N21/64
CPC分类号： C07H21/00 , C07H1/00
摘要： Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.
摘要翻译：本文描述了合成包含手性X-膦酸酯部分的磷原子修饰的核酸的方法。本文描述的方法通过包含化学稳定的H-膦酸酯部分与核苷/核苷酸的非手性分子的不对称反应提供具有高度对映纯度的骨架修饰的核酸。

24. 发明授权

US10428019B2 Chiral auxiliaries 有权
公开(公告)号：US10428019B2
公开(公告)日：2019-10-01
申请号：US13825627
申请日：2011-09-22
申请人： Takeshi Wada , Mamoru Shimizu
发明人： Takeshi Wada , Mamoru Shimizu
IPC分类号： C07H21/02 , C07H21/00 , C07H19/00 , C07H19/04 , C07H19/20 , C07D221/06 , C07D217/22 , C07D211/56 , C07D211/40 , C07D221/18 , C07D209/56 , C09B7/02 , C07D207/12 , C07D207/16 , C07D211/44 , C07D211/62 , C07D217/24 , C07H19/06 , C07H19/16 , C07D209/62 , C07D211/42 , C07D221/10 , C07H1/00 , C07H21/04
摘要： The disclosed and claimed compounds are chiral auxiliaries useful for efficiently producing a phosphorus atom-modified nucleic acid derivative with high stereoregularity. The disclosed and claimed compounds include those represented by the following formula (I) or formula (XI) for introducing the chiral auxiliaries.

25. 发明授权

US09394333B2 Method for the synthesis of phosphorus atom modified nucleic acids 有权
标题翻译：磷原子修饰核酸合成方法
公开(公告)号：US09394333B2
公开(公告)日：2016-07-19
申请号：US13131591
申请日：2009-12-02
申请人： Takeshi Wada , Mamoru Shimizu
发明人： Takeshi Wada , Mamoru Shimizu
IPC分类号： C07H21/00 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C07H21/00 , C07H1/00
摘要： Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.
摘要翻译：本文描述了合成包含手性X-膦酸酯部分的磷原子修饰的核酸的方法。本文描述的方法通过包含化学稳定的H-膦酸酯部分与核苷/核苷酸的非手性分子的不对称反应提供具有高度对映纯度的骨架修饰的核酸。

26. 发明申请

US20130253178A1 2'-O-MODIFIED RNA 有权
标题翻译： 2'-O修饰的RNA
公开(公告)号：US20130253178A1
公开(公告)日：2013-09-26
申请号：US13990441
申请日：2011-11-28
申请人： Mamoru Shimizu , Takeshi Wada , Kouichiro Arai
发明人： Mamoru Shimizu , Takeshi Wada , Kouichiro Arai
IPC分类号： C07H21/02 , C07H19/10 , C07H19/06 , C07H1/00
CPC分类号： C07H21/02 , C07H1/00 , C07H19/06 , C07H19/067 , C07H19/10 , C07H19/167 , C07H23/00 , Y02P20/55
摘要： [Problem]To provide a 2′-modified ribonucleoside or the like which has a high duplex-forming ability.[Solution]The present invention is generally based on the finding in embodiments that a modified form of a ribonucleoside or the like having an alkoxymethyl protective group can be imparted with a high duplex-forming ability by introducing, as a substituent, a halogen atom into the protective group moiety. As explained before, a modified form of RNA having an alkoxymethyl protective group has a low duplex-forming ability. A modified form of RNA having a halogen-substituted alkoxymethyl protective group, however, exhibits a high duplex-forming ability that is comparable to the duplex-forming ability of a 2′-O-methyl modified nucleic acid.
摘要翻译： [问题]提供具有高双相形成能力的2'-修饰的核糖核苷等。 [解决方案]本发明通常基于实施方案中发现，通过将卤素原子引入作为取代基的卤素原子，可以赋予具有烷氧基甲基保护基的核糖核苷等的修饰形式具有高双相形成能力保护基团部分。如前所述，具有烷氧基甲基保护基的RNA的修饰形式具有低的双链体形成能力。然而，具有卤素取代的烷氧基甲基保护基的RNA的修饰形式表现出与2'-O-甲基修饰的核酸的双链体形成能力相当的高双相形成能力。

27. 发明授权

US06898476B2 Management of working status with large-scaled display 失效
标题翻译：大规模展示管理工作状态
公开(公告)号：US06898476B2
公开(公告)日：2005-05-24
申请号：US09855664
申请日：2001-05-16
申请人： Kazuyoshi Watanabe , Takashi Oguchi , Mitsuaki Maruyama , Mamoru Shimizu , Taketoshi Ichikawa
发明人： Kazuyoshi Watanabe , Takashi Oguchi , Mitsuaki Maruyama , Mamoru Shimizu , Taketoshi Ichikawa
IPC分类号： G05B15/02 , G05B19/418 , G06Q10/08 , G06Q50/00 , G06Q50/04 , G06Q50/28 , G06F19/00 , G09G5/08
CPC分类号： G05B15/02 , G05B2219/31428 , G05B2219/31472 , G06Q10/087
摘要： The object of the present invention is to ensure information sharing in a factory and enhance the production efficiency.The management system of the present invention utilizes a liquid crystal projector PRJ to project an image of management information on a large-scaled display in the factory. A screen SCR is located at a specific position that allows each worker to simultaneously recognize the display and the object of the display (for example, in the case of a storehouse, the storage status of products). The contents of the display are varied according to the location of the display: for example, (1) instructions and actual conditions of storage of products in the storehouse; and (2) requirement of parts from assembly lines to a parts warehouse and status of delivery of parts from the parts warehouse. In a staff room of managers, information with regard to a first process, which is upstream most in the work flow in the factory (status of carrying-in work of parts and materials from outside) and information with regard to a last process, which is downstream most in the work flow (status of shipment) are displayed simultaneously. Such display enables workers in various sections and managers to accurately grasp the working status in the factory in real time, thus attaining the smooth operations and enhancing the production efficiency.
摘要翻译：本发明的目的是确保工厂中的信息共享并提高生产效率。本发明的管理系统利用液晶投影仪PRJ在工厂中在大型显示器上投影管理信息的图像。屏幕SCR位于特定位置，允许每个工作人员同时识别显示器和显示器的对象（例如，在仓库的情况下，产品的存储状态）。显示器的内容根据显示屏的位置而有所不同：例如，（1）仓库中产品存储的说明和实际条件; 和（2）从装配线到零件仓库的零件要求以及零件仓库零件的运送状态。在管理人员的工作室，关于工厂工作流程上游最多的第一过程（来自外部的部件和材料的进入状况）以及关于最后一个过程的信息的第一过程的信息，其中在工作流程（出货状态）中的下游大部分是同时显示的。这种展示使各部门的工作人员能够及时准确把握工厂的工作状况，从而实现运行平稳，提高生产效率。

28. 发明授权

US4970244A Photopolymerization initiator and method of photopolymerization by use of said initiator 失效
标题翻译：光聚合引发剂和使用所述引发剂的光聚合方法
公开(公告)号：US4970244A
公开(公告)日：1990-11-13
申请号：US740278
申请日：1985-06-03
申请人： Takeshi Komai , Mamoru Shimizu
发明人： Takeshi Komai , Mamoru Shimizu
IPC分类号： C08F2/00 , C07C67/00 , C07C407/00 , C07C409/38 , C08F2/50 , C08F4/36 , G03F7/028 , G03F7/031
CPC分类号： G03F7/031 , C07C409/38 , C08F2/50
摘要： Photopolymerization initiators of the general formula: ##STR1## wherein R.sub.1 and R.sub.1 ' independently stand for a tertiary alkyl group or a tertiary aralkyl group and R.sub.2 and R.sub.2 ' independently stand for a hydrogen atom, a tertiary alkoxy group, or a tertiary aralkyloxy group are disclosed. They are useful for effecting polymerization of radically polymerizable unsaturated compounds.

29. 发明授权

US4777191A Photopolymerization initiator and method of photopolymerization by use of said initiator 失效
标题翻译：光聚合引发剂和使用所述引发剂的光聚合方法
公开(公告)号：US4777191A
公开(公告)日：1988-10-11
申请号：US117920
申请日：1987-11-05
申请人： Takeshi Komai , Mamoru Shimizu
发明人： Takeshi Komai , Mamoru Shimizu
IPC分类号： C08F2/00 , C07C67/00 , C07C407/00 , C07C409/38 , C08F2/50 , C08F4/36 , G03F7/028 , G03F7/031 , C08F20/06 , C08F20/10
CPC分类号： G03F7/031 , C07C409/38 , C08F2/50
摘要： Photopolymerization initiators of the general formula: ##STR1## wherein R.sub.1 and R.sub.1 ' independently stand for a tertiary alkyl group or a tertiary aralkyl group and R.sub.2 and R.sub.2 ' independently stand for a hydrogen atom, a tertiary alkoxy group, or a tertiary aralkyloxy group are disclosed. They are useful for effecting polymerization of radically polymerizable unsaturated compounds. Tetra peroxy esters of benzophenone are preferred.
摘要翻译：其中R1和R1独立地代表叔烷基或叔芳烷基，R2和R2'独立地代表氢原子，叔烷氧基或叔芳烷氧基是通式为的光聚合引发剂：披露它们可用于实现自由基聚合的不饱和化合物的聚合。二苯甲酮的四过氧酯是优选的。

30. 发明授权

US08822671B2 2'-O-modified RNA 有权
标题翻译： 2'-O-修饰的RNA
公开(公告)号：US08822671B2
公开(公告)日：2014-09-02
申请号：US13990441
申请日：2011-11-28
申请人： Mamoru Shimizu , Takeshi Wada , Kouichiro Arai
发明人： Mamoru Shimizu , Takeshi Wada , Kouichiro Arai
IPC分类号： C07H21/02 , C07H19/10 , C07H23/00 , C07H19/06 , C07H1/00 , C07H19/067 , C07H19/167
CPC分类号： C07H21/02 , C07H1/00 , C07H19/06 , C07H19/067 , C07H19/10 , C07H19/167 , C07H23/00 , Y02P20/55
摘要： A 2′-modified ribonucleoside having an alkoxymethyl protective group can be imparted with a high duplex-forming ability by introducing, as a substituent, a halogen atom into the protective group moiety. A modified form of RNA having a halogen-substituted alkoxymethyl protective group exhibits a high duplex-forming ability that is comparable to the duplex-forming ability of a 2′-O-methyl modified nucleic acid.
摘要翻译：具有烷氧基甲基保护基的2'-修饰的核糖核苷可通过将卤素原子引入保护基部分而赋予高双相形成能力。具有卤素取代的烷氧基甲基保护基的RNA的修饰形式表现出与2'-O-甲基修饰的核酸的双链体形成能力相当的高双相形成能力。

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