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21. 发明授权

US07855269B2 Method for treating inflammation 有权
标题翻译：治疗炎症的方法
公开(公告)号：US07855269B2
公开(公告)日：2010-12-21
申请号：US09951268
申请日：2001-09-13
申请人： Yasmin A. Chandrasekher , Stephen R. Jaspers
发明人： Yasmin A. Chandrasekher , Stephen R. Jaspers
IPC分类号： C07K14/00
CPC分类号： A61K38/1793 , C07K14/7155 , C07K2319/30
摘要： A method for treating down-regulating IL-19 or mda7 by administering the soluble IL-20RA/IL-20R heterodimeric receptor.
摘要翻译：通过施用可溶性IL-20RA / IL-20R异二聚体受体来治疗下调IL-19或mda7的方法。

22. 发明申请

US20090192291A1 PRODUCTION OF HOMOTRIMERIC FUSION PROTEINS 审中-公开
标题翻译：共培养融合蛋白的生产
公开(公告)号：US20090192291A1
公开(公告)日：2009-07-30
申请号：US12353713
申请日：2009-01-14
申请人： James W. West , Cameron S. Brandt , Stephen R. Jaspers
发明人： James W. West , Cameron S. Brandt , Stephen R. Jaspers
IPC分类号： C07K14/00
CPC分类号： C07K14/47 , C07K14/705 , C07K14/70575 , C07K14/70578 , C07K14/78 , C07K2319/00 , C07K2319/03 , C12N15/62
摘要： The present invention provides method for producing trimeric tumor necrosis factor receptors that are potent inhibitors of their cognate ligands. More particularly, the present invention provides polypeptides that comprise: (1) an extracellular domain of the transmembrane activator and CAML (calcium-signal modulating cyclophilin ligand) interactor (TACI), and (2) a trimerizing polypeptide. Suitable TACI extracellular domains include: (1) amino acid residues 30 to 110 of SEQ ID NO:4, (2) amino acid residues 1 to 110 of SEQ ID NO:4, (3) amino acid residues 30 to 154 of SEQ ID NO:4, and (4) amino acid residues 1 to 154 of SEQ ID NO:4. Illustrative trimerizing polypeptides include a trimerizing fragment of Heat Shock Binding Protein-1. The present invention further provides homotrimeric complexes of fusion proteins comprising a TACI extracellular domain and a trimerizing polypeptide.
摘要翻译：本发明提供了产生三聚体肿瘤坏死因子受体的方法，所述三聚体肿瘤坏死因子受体是其相关配体的有效抑制剂。更具体地，本发明提供多肽，其包含：（1）跨膜激活剂的胞外结构域和CAML（钙信号调节亲环蛋白配体）相互作用体（TACI），和（2）三聚体多肽。合适的TACI细胞外结构域包括：（1）SEQ ID NO：4的氨基酸残基30至110，（2）SEQ ID NO：4的氨基酸残基1至110，（3）SEQ ID NO：4的氨基酸残基30至154 NO.4和（4）SEQ ID NO：4的氨基酸残基1至154。示例性的三聚化多肽包括热休克结合蛋白-1的三聚体片段。本发明还提供了包含TACI胞外域和三聚多肽的融合蛋白的同源三聚体。

23. 发明申请

US20090075341A1 IL-21 ANTAGONISTS 有权
标题翻译： IL-21拮抗剂
公开(公告)号：US20090075341A1
公开(公告)日：2009-03-19
申请号：US12179003
申请日：2008-07-24
申请人： Pallavur V. Sivakumar , Stephen R. Jaspers
发明人： Pallavur V. Sivakumar , Stephen R. Jaspers
IPC分类号： C12P21/08 , C07K16/24 , C12N5/06
CPC分类号： C07K16/244 , A61K39/3955 , A61K2039/505 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2319/30 , Y10S530/809
摘要： Monoclonal antibodies are identified that bind the IL-21 protein. These antibodies are used to identify regions of the IL-21 protein to where binding neutralizes IL-21 activity. Hybridomas and methods of producing anti-IL-21 monoclonal antibodies are described. The monoclonal antibodies are useful in treating IL-21-mediated diseases, which may include autoimmune and inflammatory diseases such as pancreatitis, type I diabetes (IDDM), Graves Disease, inflammatory bowel disease (IBD), Crohn's Disease, ulcerative colitis, irritable bowel syndrome, multiple sclerosis, rheumatoid arthritis, diverticulosis, systemic lupus erythematosus, psoriasis, ankylosing spondylitis, scleroderma, systemic sclerosis, psoriatic arthritis, osteoarthritis, atopic dermatitis, vitiligo, graft vs. host disease (GVHD), cutaneous T cell lymphoma (CTCL), Sjogren's syndrome, glomerulonephritis, IgA nephropathy, graft versous host disease, transplant rejection, atopic dermatitis, anti-phospholipid syndrome, and asthma, and other autoimmune diseases.
摘要翻译：鉴定结合IL-21蛋白的单克隆抗体。这些抗体用于鉴定结合中和IL-21活性的IL-21蛋白的区域。描述了杂交瘤和产生抗IL-21单克隆抗体的方法。单克隆抗体可用于治疗IL-21介导的疾病，其可能包括自身免疫性和炎性疾病如胰腺炎，I型糖尿病（IDDM），格雷夫斯病，炎性肠病（IBD），克罗恩病，溃疡性结肠炎，肠易激综合征综合征，多发性硬化症，类风湿性关节炎，憩室病，系统性红斑狼疮，牛皮癣，强直性脊柱炎，硬皮病，系统性硬化症，银屑病关节炎，骨关节炎，特应性皮炎，白癜风，移植物抗宿主病（GVHD），皮肤T细胞淋巴瘤，干燥综合征，肾小球肾炎，IgA肾病，移植物宿主病，移植排斥反应，特应性皮炎，抗磷脂综合征，哮喘和其他自身免疫性疾病。

24. 发明授权

US07445919B2 Zsig33-like peptides and polynucleotides 有权
标题翻译： Zsig33样肽和多核苷酸
公开(公告)号：US07445919B2
公开(公告)日：2008-11-04
申请号：US10921371
申请日：2004-08-19
申请人： Stephen R. Jaspers , Paul O. Sheppard
发明人： Stephen R. Jaspers , Paul O. Sheppard
IPC分类号： C12N9/00 , C12N15/00 , C07H21/04 , C12Q1/00 , C12P21/04
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译：本发明涉及与zsig33肽相关的多核苷酸，包括激动剂，拮抗剂和抗体。还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。

25. 发明授权

US06361985B1 Beta-1,3-galactosyltransferase homolog, ZNSSP6 失效
标题翻译： β-1,3-半乳糖基转移酶同源物，ZNSSP6
公开(公告)号：US06361985B1
公开(公告)日：2002-03-26
申请号：US09482180
申请日：2000-01-12
申请人： Darrell C. Conklin , Gayle Yamamoto , Zeren Gao , Stephen R. Jaspers
发明人： Darrell C. Conklin , Gayle Yamamoto , Zeren Gao , Stephen R. Jaspers
IPC分类号： C12N910
CPC分类号： C12N9/1051
摘要： The present invention relates to polynucleotide and polypeptide molecules for znssp6, a novel member of the galactosyltransferase family. The polypeptides, and polynucleotides encoding them, are cell-cell interaction and glycoprotein synthesis modulating and may be used for delivery and therapeutics. The present invention also includes antibodies to the znssp6 polypeptides.
摘要翻译：本发明涉及用于znssp6（半乳糖基转移酶家族的新成员）的多核苷酸和多肽分子。多肽和编码它们的多核苷酸是调节细胞 - 细胞相互作用和糖蛋白合成，并可用于递送和治疗。本发明还包括针对znssp6多肽的抗体。

26. 发明授权

US6114307A Methods for stimulating pancreatic islet cell regeneration 失效
标题翻译：刺激胰岛细胞再生的方法
公开(公告)号：US6114307A
公开(公告)日：2000-09-05
申请号：US991890
申请日：1997-12-16
申请人： Stephen R. Jaspers , Katherine H. Sprugel , Hong Ping Ren , Jacqueline M. Humes , Darrell C. Conklin
发明人： Stephen R. Jaspers , Katherine H. Sprugel , Hong Ping Ren , Jacqueline M. Humes , Darrell C. Conklin
IPC分类号： A61K38/00 , C07K14/64 , C12N15/16 , A61K38/17 , A61K38/28 , C07K14/47 , C07K14/62
CPC分类号： C07K14/64 , A61K38/00 , Y10S514/866
摘要： The present invention provides compositions for stimulating an increase in islet proliferation and .beta.-cell mass using an insulin homolog polypeptide. The present invention also includes methods for treating diabetes by stimulating islet proliferation and .beta.-cell mass increases and affecting insulin levels.
摘要翻译：本发明提供了使用胰岛素同系物多肽刺激胰岛增殖和β-细胞量的增加的组合物。本发明还包括通过刺激胰岛增殖和β-细胞大量增加并影响胰岛素水平来治疗糖尿病的方法。

27. 发明授权

US6046028A Polynucleotides encoding insulin homolog zins3 失效
标题翻译：编码胰岛素同源物的多核苷酸3
公开(公告)号：US6046028A
公开(公告)日：2000-04-04
申请号：US950720
申请日：1997-10-15
申请人： Darrell C. Conklin , Catherine E. Lofton-Day , Si Lok , Stephen R. Jaspers
发明人： Darrell C. Conklin , Catherine E. Lofton-Day , Si Lok , Stephen R. Jaspers
IPC分类号： A01K67/027 , C07K14/62 , C07K14/64 , C07K16/26 , C12N5/10 , C12N15/09 , C12N15/17 , C12N15/63
CPC分类号： C07K14/64 , A01K2217/05
摘要： The present invention relates to polynucleotides encoding for novel insulin homolog polypeptides that have been designated Zins3. The human and mouse polynucleotides and corresponding polypeptides are described, and comprise a B chain, A chain, and C-peptide, or portions thereof. The polynucleotide sequence maps to human chromosome 12.
摘要翻译：本发明涉及编码已被命名为Zins3的新型胰岛素同系物多肽的多核苷酸。描述了人和小鼠多核苷酸和相应的多肽，并且包含B链，A链和C-肽或其部分。多核苷酸序列映射到人染色体12。

28. 发明授权

US08226948B1 Anti-human IL-21 monoclonal antibodies 有权
标题翻译：抗人IL-21单克隆抗体
公开(公告)号：US08226948B1
公开(公告)日：2012-07-24
申请号：US13348366
申请日：2012-01-11
申请人： Stephen R. Jaspers , Mark W. Rixon , Stacey R. Dillon , Frederick J. Ramsdell , Cecile M. Krejsa , Eugene C. Yi
发明人： Stephen R. Jaspers , Mark W. Rixon , Stacey R. Dillon , Frederick J. Ramsdell , Cecile M. Krejsa , Eugene C. Yi
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S530/809
摘要： Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinat IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells TH cells or TH17 cells.
摘要翻译：提出人抗人IL-21单克隆抗体和产生它们的杂交瘤。这些抗体中的某些具有结合天然人IL-21，人IL-21的突变重组IL-21蛋白和/或肽区的能力。这些人抗IL-21抗体可用于治疗自身免疫性和炎性疾病，特别是由T滤泡辅助细胞，B细胞，TH细胞或TH17细胞介导的疾病。

29. 发明授权

US08133487B2 Soluble heterodimeric cytokine receptor 有权
标题翻译：可溶性异二聚体细胞因子受体
公开(公告)号：US08133487B2
公开(公告)日：2012-03-13
申请号：US12695069
申请日：2010-01-27
申请人： Yasmin A. Chandrasekher , Julia E. Novak , Donald C. Foster , Wenfeng Xu , Stephen R. Jaspers
发明人： Yasmin A. Chandrasekher , Julia E. Novak , Donald C. Foster , Wenfeng Xu , Stephen R. Jaspers
IPC分类号： A61K38/00 , A61K39/00 , A61P17/00
CPC分类号： C07K14/7155 , A61K38/00 , C07K2319/00
摘要： The present invention provides methods of treating psoriasis in a subject (i.e., psoriasis associated with a joint disease), by administering to the subject an effective dose of a composition comprising a soluble IL-22R/IL-20RB heterodimeric polypeptide, wherein the heterodimeric polypeptide comprises an IL-22R extracellular domain covalently linked to an IL-20RB extracellular domain.
摘要翻译：本发明提供了通过向受试者施用有效剂量的包含可溶性IL-22R / IL-20RB异源二聚体多肽的组合物来治疗受试者中的牛皮癣（即，与关节疾病相关的牛皮癣）的方法，其中所述异二聚体多肽包含与IL-20RB细胞外结构域共价连接的IL-22R细胞外结构域。

30. 发明授权

US08124089B2 Anti-human IL-21 monoclonal antibodies 有权
公开(公告)号：US08124089B2
公开(公告)日：2012-02-28
申请号：US12483098
申请日：2009-06-11
申请人： Stephen R. Jaspers , Mark W. Rixon , Stacey R. Dillon , Frederick J. Ramsdell , Cecile M. Krejsa , Eugene C. Yi
发明人： Stephen R. Jaspers , Mark W. Rixon , Stacey R. Dillon , Frederick J. Ramsdell , Cecile M. Krejsa , Eugene C. Yi
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , Y10S530/809
摘要： Human anti-human IL-21 monoclonal antibodies and the hybridomas that produce them are presented. Certain of these antibodies have the ability to bind native human IL-21, a mutant recombinat IL-21 protein and/or peptide regions of human IL-21. These human anti-IL-21 antibodies are useful in therapeutic treatment of autoimmune and inflammatory diseases, particularly diseases mediated by T follicular helper cells, B cells TH cells or TH17 cells.

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