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21. 发明授权

US5246420A Highly steerable dilatation balloon catheter system 失效
标题翻译：高度可控的膨胀气泡导管系统
公开(公告)号：US5246420A
公开(公告)日：1993-09-21
申请号：US784841
申请日：1991-11-06
申请人： Jeff L. Kraus , Hugh R. Sharkey , Michael J. Horzewski
发明人： Jeff L. Kraus , Hugh R. Sharkey , Michael J. Horzewski
IPC分类号： A61M25/00 , A61M25/01 , A61M29/02
CPC分类号： A61M25/104 , A61M2025/0063 , A61M2025/1079 , A61M2025/1093
摘要： A dilatation balloon catheter with a non-removable guidewire is disclosed in which the guidewire is joined to the catheter tube through a distortable element, preferably a twistable tube. The element provides a strong fluid-tight connection between the guidewire and catheter tube and yet permits the guidewire to be rotated relative to the catheter tube over a wide range of rotation, with little torsional stress on either the catheter tube, the balloon or any other element of the catheter construction. In preferred embodiments, the catheter construction further includes a column support tube inside the balloon, surrounding a segment of the guidewire toward its distal end, to prevent collapse of the balloon along its longitudinal axis as the balloon is advanced into a stenosis. In these embodiments, the distortable element is joined to the catheter tube through the column support tube which thus serves as an intermediate linkage.
摘要翻译：公开了一种具有不可移除的导丝的扩张球囊导管，其中导丝通过可变形元件（优选可扭转的管）连接到导管管。该元件在导丝和导管之间提供了强大的流体密封连接，并且允许导线相对于导管在相当大的旋转范围内旋转，导管，球囊或任何其他导管结构的元件。在优选实施例中，导管构造还包括在球囊内部的柱支撑管，围绕引导线的一部分朝向其远端，以防止当球囊进入狭窄时球囊沿其纵向轴线的塌缩。在这些实施例中，可变形元件通过柱支撑管连接到导管管，因此用作中间连杆。

22. 发明授权

US08388672B2 System for improving cardiac function by sealing a partitioning membrane within a ventricle 有权
标题翻译：通过密封心室内的分隔膜来改善心脏功能的系统
公开(公告)号：US08388672B2
公开(公告)日：2013-03-05
申请号：US12422144
申请日：2009-04-10
申请人： Alexander Khairkhahan , Serjan D. Nikolic , Hugh R. Sharkey
发明人： Alexander Khairkhahan , Serjan D. Nikolic , Hugh R. Sharkey
IPC分类号： A61F2/06 , A61M29/08
CPC分类号： A61F2/2487 , A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/1214 , A61B17/12172 , A61B17/12195 , A61B2017/00243 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/0649 , A61B2017/12095
摘要： Partitioning devices that may be secured and sealed within a heart chamber for separating a patient's heart chamber into a productive portion and a non-productive portion are described herein. The partitioning devices described herein may include a reinforced membrane with outwardly biased members. The reinforced membrane may have a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. These devices may be secured within the heart chamber by sealing them to the wall of the heart chamber, for example, by inflating an inflatable element on the periphery of the device. The non-productive portion may be filled with a material, including occlusive materials. Sealing and/or filling the non-productive portion formed by the devices described herein may help prevent leakage from the non-productive region. Also described herein are systems including these devices and methods of using them, which may be suitable for treating patients with heart disease, particularly congestive heart failure.
摘要翻译：本文描述了可以在心室内固定和密封以将患者的心室分离成生产部分和非生产性部分的分隔装置。本文所述的分隔装置可以包括具有向外偏置构件的增强膜。增强膜可以具有中心毂，其具有远端延伸的支撑杆，其具有从中心线轴线径向延伸的多个脚，并且优选地具有在公共平面中对准的端部。这些装置可以通过将它们密封到心室的壁来固定在心脏腔室内，例如通过使装置的周边上的可充气元件膨胀。非生产性部分可以填充材料，包括封闭材料。密封和/或填充由本文所述的装置形成的非生产性部分可以有助于防止从非生产性区域泄漏。本文还描述了包括这些装置和使用它们的方法的系统，其可适用于治疗心脏病患者，特别是充血性心力衰竭。

23. 发明授权

US08257428B2 System for improving cardiac function 有权
标题翻译：改善心脏功能的系统
公开(公告)号：US08257428B2
公开(公告)日：2012-09-04
申请号：US10436959
申请日：2003-05-12
申请人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic
发明人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic
IPC分类号： A61F2/06
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/0649 , A61B2017/12095
摘要： A system for improving cardiac function is provided. A foldable and expandable frame having at least one anchoring formation is attached to an elongate manipulator and placed in a catheter tube while folded. The tube is inserted into a left ventricle of a heart where the frame is ejected from the tube and expands in the left ventricle. Movements of the elongate manipulator cause the anchor to penetrate the heart muscle and the elongate manipulator to release the frame. The installed frame minimizes the effects of an akinetic portion of the heart forming an aneurysmic bulge.
摘要翻译：提供了一种改善心脏功能的系统。具有至少一个锚固结构的可折叠和可扩张的框架附接到细长的操纵器并且在折叠时放置在导管中。将管插入心脏的左心室，其中框架从管中弹出并在左心室中扩张。细长机械手的运动导致锚固体穿透心脏肌肉和细长操纵器以释放框架。安装的框架最小化形成动脉瘤隆起的心脏的运动部分的影响。

24. 发明授权

US08226697B2 Method for treating intervertebral disc 有权
标题翻译：治疗椎间盘的方法
公开(公告)号：US08226697B2
公开(公告)日：2012-07-24
申请号：US11872437
申请日：2007-10-15
申请人： Hugh R. Sharkey , John Ashley , Joel Saal , Jeffrey A. Saal , Le T. Le
发明人： Hugh R. Sharkey , John Ashley , Joel Saal , Jeffrey A. Saal , Le T. Le
IPC分类号： A61F7/00 , A61B18/14
CPC分类号： A61B17/1671 , A61B10/02 , A61B17/00491 , A61B17/29 , A61B17/320016 , A61B17/320068 , A61B17/3203 , A61B17/3421 , A61B17/3496 , A61B17/7061 , A61B17/8836 , A61B18/00 , A61B18/08 , A61B18/082 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2017/00084 , A61B2017/0011 , A61B2017/00119 , A61B2017/00261 , A61B2017/00274 , A61B2017/003 , A61B2017/00336 , A61B2017/00455 , A61B2017/00867 , A61B2017/22044 , A61B2017/22049 , A61B2017/22082 , A61B2017/22087 , A61B2017/2905 , A61B2017/2927 , A61B2017/320008 , A61B2017/320044 , A61B2017/3445 , A61B2017/3488 , A61B2018/00011 , A61B2018/00267 , A61B2018/00434 , A61B2018/0044 , A61B2018/00547 , A61B2018/00577 , A61B2018/00595 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/046 , A61B2018/1266 , A61B2018/1405 , A61B2018/1407 , A61B2018/1425 , A61B2018/1435 , A61B2018/1472 , A61B2018/1807 , A61B2090/0454 , A61B2090/061 , A61B2090/064 , A61B2090/3937 , A61B2217/005 , A61B2218/002 , A61B2218/007 , A61F2/442 , A61F2002/30677 , A61F2007/0298 , A61M25/0084 , A61M25/0133 , A61M25/0144 , A61M25/0147 , A61M25/0155 , A61M25/0158 , A61M25/09 , A61N1/06 , A61N1/40 , A61N1/403
摘要： A device is described that may be positioned at a location in an intervertebral disc for diagnosis or treatment of the disc. Treatment may include, for example, applying energy or removing material, and may decrease intradiscal pressure. Radiofrequency energy may be applied. A percutaneous method of repairing a fissure in the annulus pulposus comprises placing an energy source adjacent to the fissure and providing sufficient energy to the fissure to raise the temperature to at least about 45-70° C. and for a sufficient time to cause the collagen to weld. An intervertebral fissure also can be treated by placing a catheter with a lumen adjacent to the fissure and injecting sealant into the fissure via the catheter, thereby sealing the fissure. An intervertebral fissure additionally can be treated by providing a catheter having a distal end, a proximal end, a longitudinal axis, and an intradiscal section at the catheter's distal end on which there is at least one functional element. The next step is applying a force longitudinally to the proximal of the catheter which is sufficient to advance the intradiscal section through the nucleus pulposus and around an inner wall of an annulus fibrosus, but which force is insufficient to puncture the annulus fibrosus. Next the functional element is positioned at a selected location of the disc by advancing or retracting the catheter and optionally twisting the proximal end of the catheter. Then the functional unit treats the annular fissure. Optionally, there is an additional step of adding a substance to seal the fissure. An externally guidable intervertebral disc apparatus also is disclosed.
摘要翻译：描述了可以定位在椎间盘中的位置以用于椎间盘的诊断或治疗的装置。治疗可以包括例如施加能量或去除材料，并且可以降低椎间盘内的压力。可以应用射频能量。修复环带中裂缝的经皮方法包括将能量源放置在裂缝附近并为裂缝提供足够的能量以将温度升高至至少约45-70℃，并且足够的时间使胶原蛋白焊接。也可以通过将具有腔的导管放置在裂缝附近并通过导管将密封剂注入到裂缝中，从而密封裂缝来治疗椎间裂。另外可以通过在导管的远端提供具有远端，近端，纵向轴线和椎间盘内节段的导管来治疗椎间裂缝，在该导管的至少一个功能元件上。下一步是向导管的近端施加一个力，这足以使椎间盘内部分通过髓核并绕纤维环的内壁延伸，但是哪个力不足以刺穿纤维环。接下来，功能元件通过前进或缩回导管并且可选地扭转导管的近端来定位在盘的选定位置。然后功能单元处理环形裂缝。任选地，存在添加物质以密封裂缝的附加步骤。还公开了一种外部引导性椎间盘装置。

25. 发明授权

US08082043B2 Method for treating intervertebral disc degeneration 有权
标题翻译：椎间盘退变的治疗方法
公开(公告)号：US08082043B2
公开(公告)日：2011-12-20
申请号：US11930783
申请日：2007-10-31
申请人： Hugh R. Sharkey , Joel Saal , Jeffrey Saal , John Ashley
发明人： Hugh R. Sharkey , Joel Saal , Jeffrey Saal , John Ashley
IPC分类号： A61F7/00 , A61B18/08
CPC分类号： A61B17/1671 , A61B10/02 , A61B17/00491 , A61B17/29 , A61B17/320016 , A61B17/3203 , A61B17/3421 , A61B17/3496 , A61B17/7061 , A61B17/8836 , A61B18/00 , A61B18/082 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2017/00084 , A61B2017/0011 , A61B2017/00119 , A61B2017/00261 , A61B2017/00274 , A61B2017/003 , A61B2017/00336 , A61B2017/00455 , A61B2017/00867 , A61B2017/22044 , A61B2017/22049 , A61B2017/22082 , A61B2017/22087 , A61B2017/2905 , A61B2017/2927 , A61B2017/320008 , A61B2017/320044 , A61B2017/3445 , A61B2017/3488 , A61B2018/00011 , A61B2018/00267 , A61B2018/00434 , A61B2018/0044 , A61B2018/00547 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/046 , A61B2018/1266 , A61B2018/1405 , A61B2018/1407 , A61B2018/1425 , A61B2018/1435 , A61B2018/1472 , A61B2018/1807 , A61B2090/0454 , A61B2090/061 , A61B2090/064 , A61B2090/3937 , A61B2217/005 , A61B2218/002 , A61B2218/007 , A61F2/442 , A61F2002/30677 , A61F2007/0298 , A61M25/0084 , A61M25/0133 , A61M25/0144 , A61M25/0147 , A61M25/0155 , A61M25/0158 , A61M25/09 , A61N1/06 , A61N1/40
摘要： A percutaneous method treats degenerate disc disease characterized by a circumferential bulge. The method provides a catheter having a distal end, a proximal end, and a longitudinal axis, the distal end having an intradiscal section with at least one energy delivery device. The next step is applying a force longitudinally to the proximal end of the catheter which is sufficient to advance the intradiscal section through a nucleus pulposus and around an inner wall of an annulus, but which force is insufficient for the intradiscal section to puncture the annulus fibrosus. Next the energy delivery device is positioned at a selected location of the annulus by advancing or retracting the catheter and optionally twisting the proximal end of the catheter. The thermal energy delivery device is positioned adjacent the annulus and used to heat and stiffen the disc. Optionally, there is an additional step of adding a substance to reinforce the area. Optionally, access to the disc is provided by an introducer having an introducer lumen with an opening at a terminus of the introducer. An externally guidable intervertebral disc apparatus also is disclosed.
摘要翻译：经皮方法治疗以圆周隆起为特征的退行性椎间盘疾病。该方法提供了具有远端，近端和纵向轴线的导管，远端具有具有至少一个能量输送装置的椎间盘内截面。下一步是向导管的近端纵向施加一个力，这足以使椎间盘内部分通过髓核并环绕环的内壁，但哪个力不足以使椎间盘内的部分刺穿纤维环。接下来，能量输送装置通过使导管前进或缩回并且可选地扭转导管的近端来定位在环的选定位置。热能输送装置位于环形空间附近，用于加热和加强盘片。任选地，还有一个添加物质以加强该区域的步骤。任选地，通过导引器提供对盘的访问，所述导引器具有在引导器的末端具有开口的导引器内腔。还公开了一种外部引导性椎间盘装置。

26. 发明授权

US07887477B2 Method of improving cardiac function using a porous membrane 有权
标题翻译：使用多孔膜改善心脏功能的方法
公开(公告)号：US07887477B2
公开(公告)日：2011-02-15
申请号：US10302272
申请日：2002-11-22
申请人： Serjan D. Nikolic , Hugh R. Sharkey
发明人： Serjan D. Nikolic , Hugh R. Sharkey
IPC分类号： A61N1/362
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00004 , A61B2017/00243 , A61B2017/00597 , A61B2017/00632 , A61B2017/00668 , A61B2017/1205 , A61F2/2442 , A61N1/05
摘要： A porous membrane is inserted into a ventricle of a heart. The porous membrane creates a relatively hemostatic volume in which a thrombus can grow. Blood can still pass through fenestrations of the membrane into and out of the hemostatic volume. The fenestrations reduce pressures that act on the membrane, and so reduce stresses within the membrane. The flow characteristics through the hemostatic volume promote growth of the thrombus from a base of the hemostatic volume. The thrombus grows to slightly larger than the original size of the hemostatic volume so as to provide support for the membrane. Any remaining stresses within the membrane are thereby substantially eliminated. The thrombus shrinks over an ensuing period of time, with the membrane merely acting as a barrier to which an outer wall of the myocardium retracts. The function of the membrane is then complete, and may be absorbed.
摘要翻译：将多孔膜插入心脏的心室。多孔膜产生血栓可以生长的相对止血体积。血液仍然可以通过膜的开窗进入和离开止血体积。开窗减少作用在膜上的压力，从而减少膜内的应力。通过止血体积的流动特性促进血栓从止血体积的基底生长。血栓生长到略大于止血体积的原始尺寸，以便为膜提供支撑。从而基本上消除了膜内的任何剩余应力。血栓在随后的一段时间内收缩，膜仅作为心肌外壁缩回的屏障。然后膜的功能完成，可以被吸收。

27. 发明授权

US07309336B2 Catheter for delivery of energy to a surgical site 有权
标题翻译：导管将能量输送到手术部位
公开(公告)号：US07309336B2
公开(公告)日：2007-12-18
申请号：US10898671
申请日：2004-07-26
申请人： John E. Ashley , Hugh R. Sharkey , Joel Saal , Jeffrey A. Saal
发明人： John E. Ashley , Hugh R. Sharkey , Joel Saal , Jeffrey A. Saal
IPC分类号： A61B18/18
CPC分类号： A61B18/082 , A61B10/02 , A61B17/00491 , A61B17/1671 , A61B17/29 , A61B17/320016 , A61B17/3203 , A61B17/3421 , A61B17/3496 , A61B18/00 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2017/00084 , A61B2017/0011 , A61B2017/00119 , A61B2017/00261 , A61B2017/00274 , A61B2017/003 , A61B2017/00336 , A61B2017/00455 , A61B2017/00867 , A61B2017/22044 , A61B2017/22049 , A61B2017/22082 , A61B2017/22087 , A61B2017/2905 , A61B2017/2927 , A61B2017/320008 , A61B2017/320044 , A61B2017/32113 , A61B2017/3445 , A61B2017/3488 , A61B2018/00011 , A61B2018/00267 , A61B2018/00434 , A61B2018/0044 , A61B2018/00547 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/046 , A61B2018/1266 , A61B2018/1405 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1435 , A61B2018/1455 , A61B2018/1472 , A61B2018/1807 , A61B2090/0454 , A61B2090/061 , A61B2090/064 , A61B2090/3937 , A61B2217/005 , A61B2217/007 , A61B2218/002 , A61B2218/007 , A61F2/442 , A61F2002/30677 , A61F2007/0298 , A61M25/0144 , A61M25/0155 , A61M25/0158 , A61M2025/0063 , A61M2025/0064 , A61M2025/0163 , A61N1/06 , A61N1/40
摘要： A catheter for delivering energy to a surgical site is disclosed. The catheter includes at a proximal end a handle and at a distal end a probe. The catheter includes at least one energy delivery device and an activation element. The at least one energy delivery device is located at the distal end of the catheter to deliver energy to portions of the surgical site. The activation element is located at the distal end of the catheter, to transition the probe from a linear to a multi-dimensional shape, within the surgical site. Methods for deploying the probe from the linear to multi-dimensional shape are disclosed.In another embodiment of the invention the catheter includes a heating element fabricated on a substrate by photo-etching to deliver thermal energy to portions of the surgical site. In another embodiment of the invention the catheter includes an energy delivery element, a tip and a blade. The energy delivery element is located at the distal end of the catheter to deliver energy to portions of the intervertebral disc. The blade is positioned within a first lumen of the tip and is extensible beyond the tip, to cut selected portions within the intervertebral disc. In another embodiment of the invention a catheter includes both energy and material transfer elements and an interface on the handle thereof. The interface couples the energy delivery element and the material transfer element to external devices for energy and material transfer to and from the intervertebral disc.
摘要翻译：公开了一种用于向外科手术部位输送能量的导管。导管在近端处包括手柄，并且在远端处包括探针。导管包括至少一个能量输送装置和激活元件。所述至少一个能量输送装置位于所述导管的远端，以将能量传递到手术部位的部分。激活元件位于导管的远端，以将探针从线性过渡到多维形状，在手术部位内。公开了将探针从线性部分展开到多维形状的方法。在本发明的另一个实施例中，导管包括通过光蚀刻在衬底上制造的加热元件，以将热能传递到手术部位的部分。在本发明的另一个实施例中，导管包括能量输送元件，尖端和刀片。能量输送元件位于导管的远端，以将能量传递给椎间盘的部分。刀片定位在尖端的第一内腔内并且可延伸超过尖端，以切割椎间盘内的所选部分。在本发明的另一个实施例中，导管包括能量和材料转移元件以及其手柄上的界面。该界面将能量输送元件和材料传递元件耦合到外部装置，以将能量和材料转移到椎间盘和从椎间盘传递。

28. 发明授权

US07282061B2 Method of treating intervertebral disc 有权
标题翻译：治疗椎间盘的方法
公开(公告)号：US07282061B2
公开(公告)日：2007-10-16
申请号：US10712007
申请日：2003-11-14
申请人： Hugh R. Sharkey , John Ashley , Joel Saal , Jeffrey A. Saal , Le Trong Le
发明人： Hugh R. Sharkey , John Ashley , Joel Saal , Jeffrey A. Saal , Le Trong Le
IPC分类号： A61F7/00
CPC分类号： A61B17/1671 , A61B10/02 , A61B17/00491 , A61B17/29 , A61B17/320016 , A61B17/320068 , A61B17/3203 , A61B17/3421 , A61B17/3496 , A61B17/7061 , A61B17/8836 , A61B18/00 , A61B18/08 , A61B18/082 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2017/00084 , A61B2017/0011 , A61B2017/00119 , A61B2017/00261 , A61B2017/00274 , A61B2017/003 , A61B2017/00336 , A61B2017/00455 , A61B2017/00867 , A61B2017/22044 , A61B2017/22049 , A61B2017/22082 , A61B2017/22087 , A61B2017/2905 , A61B2017/2927 , A61B2017/320008 , A61B2017/320044 , A61B2017/3445 , A61B2017/3488 , A61B2018/00011 , A61B2018/00267 , A61B2018/00434 , A61B2018/0044 , A61B2018/00547 , A61B2018/00577 , A61B2018/00595 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/046 , A61B2018/1266 , A61B2018/1405 , A61B2018/1407 , A61B2018/1425 , A61B2018/1435 , A61B2018/1472 , A61B2018/1807 , A61B2090/0454 , A61B2090/061 , A61B2090/064 , A61B2090/3937 , A61B2217/005 , A61B2218/002 , A61B2218/007 , A61F2/442 , A61F2002/30677 , A61F2007/0298 , A61M25/0084 , A61M25/0133 , A61M25/0144 , A61M25/0147 , A61M25/0155 , A61M25/0158 , A61M25/09 , A61N1/06 , A61N1/40 , A61N1/403
摘要： A device is described that may be positioned at a location in an intervertebral disc for diagnosis or treatment of the disc. Treatment may include, for example, applying energy or removing material, and may decrease intradiscal pressure. Radiofrequency energy may be applied. A percutaneous method of repairing a fissure in the annulus pulposus comprises placing an energy source adjacent to the fissure and providing sufficient energy to the fissure to raise the temperature to at least about 45-70° C. and for a sufficient time to cause the collagen to weld. An intervertebral fissure also can be treated by placing a catheter with a lumen adjacent to the fissure and injecting sealant into the fissure via the catheter, thereby sealing the fissure. An intervertebral fissure additionally can be treated by providing a catheter having a distal end, a proximal end, a longitudinal axis, and an intradiscal section at the catheter's distal end on which there is at least one functional element. The next step is applying a force longitudinally to the proximal of the catheter which is sufficient to advance the intradiscal section through the nucleus pulposus and around an inner wall of an annulus fibrosus, but which force is insufficient to puncture the annulus fibrosus. Next the functional element is positioned at a selected location of the disc by advancing or retracting the catheter and optionally twisting the proximal end of the catheter. Then the functional unit treats the annular fissure. Optionally, there is an additional step of adding a substance to seal the fissure. An externally guidable intervertebral disc apparatus also is disclosed.
摘要翻译：描述了可以定位在椎间盘中的位置以用于椎间盘的诊断或治疗的装置。治疗可以包括例如施加能量或去除材料，并且可以降低椎间盘内的压力。可以应用射频能量。修复环带中裂缝的经皮方法包括将能量源放置在裂缝附近并为裂缝提供足够的能量以将温度升高至至少约45-70℃，并且足够的时间使胶原蛋白焊接。也可以通过将具有腔的导管放置在裂缝附近并通过导管将密封剂注入到裂缝中，从而密封裂缝来治疗椎间裂。另外可以通过在导管的远端提供具有远端，近端，纵向轴线和椎间盘内节段的导管来治疗椎间裂缝，在该导管的至少一个功能元件上。下一步是向导管的近端施加一个力，这足以使椎间盘内部分通过髓核并绕纤维环的内壁延伸，但是哪个力不足以刺穿纤维环。接下来，功能元件通过前进或缩回导管并且可选地扭转导管的近端来定位在盘的选定位置。然后功能单元处理环形裂缝。任选地，存在添加物质以密封裂缝的附加步骤。还公开了一种外部引导性椎间盘装置。

29. 发明授权

US07267683B2 Method for treating intervertebral discs 有权
标题翻译：治疗椎间盘的方法
公开(公告)号：US07267683B2
公开(公告)日：2007-09-11
申请号：US10712063
申请日：2003-11-14
申请人： Hugh R. Sharkey , John Ashley , Joel Saal , Jeffrey A. Saal , Le T. Le
发明人： Hugh R. Sharkey , John Ashley , Joel Saal , Jeffrey A. Saal , Le T. Le
IPC分类号： A61F7/00
CPC分类号： A61B17/1671 , A61B10/02 , A61B17/00491 , A61B17/29 , A61B17/320016 , A61B17/320068 , A61B17/3203 , A61B17/3421 , A61B17/3496 , A61B17/7061 , A61B17/8836 , A61B18/00 , A61B18/08 , A61B18/082 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2017/00084 , A61B2017/0011 , A61B2017/00119 , A61B2017/00261 , A61B2017/00274 , A61B2017/003 , A61B2017/00336 , A61B2017/00455 , A61B2017/00867 , A61B2017/22044 , A61B2017/22049 , A61B2017/22082 , A61B2017/22087 , A61B2017/2905 , A61B2017/2927 , A61B2017/320008 , A61B2017/320044 , A61B2017/3445 , A61B2017/3488 , A61B2018/00011 , A61B2018/00267 , A61B2018/00434 , A61B2018/0044 , A61B2018/00547 , A61B2018/00577 , A61B2018/00595 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/046 , A61B2018/1266 , A61B2018/1405 , A61B2018/1407 , A61B2018/1425 , A61B2018/1435 , A61B2018/1472 , A61B2018/1807 , A61B2090/0454 , A61B2090/061 , A61B2090/064 , A61B2090/3937 , A61B2217/005 , A61B2218/002 , A61B2218/007 , A61F2/442 , A61F2002/30677 , A61F2007/0298 , A61M25/0084 , A61M25/0133 , A61M25/0144 , A61M25/0147 , A61M25/0155 , A61M25/0158 , A61M25/09 , A61N1/06 , A61N1/40 , A61N1/403
摘要： A device is described that may be positioned at a location in an intervertebral disc for diagnosis or treatment of the disc. Treatment may include, for example, applying energy or removing material, and may decrease intradiscal pressure. Radiofrequency energy may be applied. A percutaneous method of repairing a fissure in the annulus pulposus comprises placing an energy source adjacent to the fissure and providing sufficient energy to the fissure to raise the temperature to at least about 45-70° C. and for a sufficient time to cause the collagen to weld. An intervertebral fissure also can be treated by placing a catheter with a lumen adjacent to the fissure and injecting sealant into the fissure via the catheter, thereby sealing the fissure. An intervertebral fissure additionally can be treated by providing a catheter having a distal end, a proximal end, a longitudinal axis, and an intradiscal section at the catheter's distal end on which there is at least one functional element. The next step is applying a force longitudinally to the proximal of the catheter which is sufficient to advance the intradiscal section through the nucleus pulposus and around an inner wall of an annulus fibrosus, but which force is insufficient to puncture the annulus fibrosus. Next the functional element is positioned at a selected location of the disc by advancing or retracting the catheter and optionally twisting the proximal end of the catheter. Then the functional unit treats the annular fissure. Optionally, there is an additional step of adding a substance to seal the fissure. An externally guidable intervertebral disc apparatus also is disclosed.
摘要翻译：描述了可以定位在椎间盘中的位置以用于椎间盘的诊断或治疗的装置。治疗可以包括例如施加能量或去除材料，并且可以降低椎间盘内的压力。可以应用射频能量。修复环带中裂缝的经皮方法包括将能量源放置在裂缝附近并为裂缝提供足够的能量以将温度升高至至少约45-70℃，并且足够的时间使胶原蛋白焊接。也可以通过将具有腔的导管放置在裂缝附近并通过导管将密封剂注入到裂缝中，从而密封裂缝来治疗椎间裂。另外可以通过在导管的远端提供具有远端，近端，纵向轴线和椎间盘内节段的导管来治疗椎间裂缝，在该导管的至少一个功能元件上。下一步是向导管的近端施加一个力，这足以使椎间盘内部分通过髓核并绕纤维环的内壁延伸，但是哪个力不足以刺穿纤维环。接下来，功能元件通过前进或缩回导管并且可选地扭转导管的近端来定位在盘的选定位置。然后功能单元处理环形裂缝。任选地，存在添加物质以密封裂缝的附加步骤。还公开了一种外部引导性椎间盘装置。

30. 发明授权

US07069087B2 Apparatus and method for accessing and performing a function within an intervertebral disc 失效
标题翻译：用于访问和执行椎间盘内功能的装置和方法
公开(公告)号：US07069087B2
公开(公告)日：2006-06-27
申请号：US09792628
申请日：2001-02-22
申请人： Hugh R. Sharkey , Sepehr Fariabi , John Ashley , Joel Saal , Jeffrey Saal
发明人： Hugh R. Sharkey , Sepehr Fariabi , John Ashley , Joel Saal , Jeffrey Saal
IPC分类号： A61F7/00 , A61F2/00 , A61B18/18
CPC分类号： A61B17/1671 , A61B17/3421 , A61B2017/00261 , A61B2017/003 , A61B2017/22044 , A61B2017/22049 , A61B2017/3488 , A61M25/0084 , A61M25/09
摘要： Apparatus and methods are disclosed for accessing the interior of an intervertebral disc to perform a function within the disc. One such apparatus comprises a catheter having a lumen; and a guide wire having a distal portion and a proximal portion, and configured to be positioned within and moved relative to the lumen of the catheter; wherein the guide wire is capable of navigating itself within an intradiscal section of the intervertebral disc to a selected section of the disc and the catheter is capable of being advanced relative to the guide wire such that the catheter follows a path of the guide wire within the intradiscal section of the disc to the selected section. These apparatus and methods may be used for the treatment of intervertebral disc disorders such as sealing fissures of the annulus fibrosus, which may or may not be accompanied with contained or escaped extrusions. These apparatus and methods may also be used, for example, for the removal or addition of material to the intervertebral disc.
摘要翻译：公开了用于访问椎间盘内部以执行椎间盘内的功能的装置和方法。一种这样的装置包括具有内腔的导管; 以及导线，其具有远侧部分和近端部分，并且构造成定位在所述导管的内腔内并相对于所述导管的内腔移动; 其中所述导丝能够在椎间盘的椎间盘内段内自身导航到所述盘的选定部分，并且所述导管能够相对于所述导丝前进，使得所述导管沿着所述导丝的路径盘片的椎间盘内部分到选定的部分。这些装置和方法可以用于治疗椎间盘疾病，例如纤维环纤维的密封裂缝，其可能伴随着包含或逃逸的挤出物，也可能不伴随其中。这些装置和方法也可以用于例如去除或添加到椎间盘的材料。

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