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    • 22. 发明授权
    • Sodium pump antibody agonists and methods of treating heart disease using the same
    • 钠泵抗体激动剂和使用其治疗心脏病的方法
    • US09040046B2
    • 2015-05-26
    • US13359723
    • 2012-01-27
    • Kai Xu
    • Kai Xu
    • C07K16/40A61K39/00
    • C07K16/18A61K2039/505C07K16/40C07K2317/21C07K2317/24C07K2317/34C07K2317/75
    • Antibodies that are agonists of sodium pump (Na+/K+ ATPase; NKA) activity are provided. In particular, antibodies that specifically bind epitopes on the beta-1 (β1) subunit of NKA are disclosed. These antibodies have the ability to increase the activity of the catalytic alpha subunit of NKA upon β1 subunit binding. Due to their activity, the antibodies also have the ability to trigger a positive inotropic effect in cardiac tissues (i.e., increase cardiac contraction). The present invention thus includes, but is not limited to, NKA β1 subunit peptide epitopes, antibodies that specifically bind the epitopes, methods of agonizing NKA activity through administration of the peptides or the antibodies, and methods of treating and/or preventing heart disease through administration of the peptides or the antibodies.
    • 提供钠泵激动剂(Na + / K + ATP酶; NKA)活性的抗体。 特别地,公开了特异性结合NKA的β-1(&bgr。1)亚基上的表位的抗体。 这些抗体具有增加NKA在α亚单位结合上的催化α亚基的活性的能力。 由于其活性,抗体还具有在心脏组织中引发正性肌力作用的能力(即增加心脏收缩)。 因此,本发明包括但不限于NKA和bgr1亚单位肽表位,特异性结合表位的抗体,通过施用肽或抗体激动NKA活性的方法,以及治疗和/或预防心脏的方法 通过施用肽或抗体的疾病。
    • 24. 发明申请
    • Computer Implemented Systems and Methods for Interacting with Employee Data
    • 计算机实现的与员工数据交互的系统和方法
    • US20150006416A1
    • 2015-01-01
    • US13929608
    • 2013-06-27
    • Kai XuMichelangelo Capraro
    • Kai XuMichelangelo Capraro
    • G06Q10/10
    • G06Q10/105
    • The present disclosure includes systems and methods for interacting with employee data. In one embodiment, a computer may access a plurality of employee data records having a particular job function on a first date and a second date. The computer may display, in a first portion of a display, graphical elements corresponding to employee data records having the particular job function on the first date. The computer may display, in a second portion of the display, graphical elements corresponding to employee data records having the particular job function on the second date. One or more other portions of the display may include graphical elements corresponding to employee data records having the particular job function on only one of the first date and the second date together with one or more corresponding graphical elements indicating reasons for a changed job function.
    • 本公开包括用于与员工数据交互的系统和方法。 在一个实施例中,计算机可以在第一日期和第二日期访问具有特定作业功能的多个员工数据记录。 计算机可以在显示器的第一部分中显示对应于在第一日期具有特定作业功能的雇员数据记录的图形元素。 计算机可以在显示器的第二部分中显示对应于在第二日期具有特定作业功能的员工数据记录的图形元素。 显示器的一个或多个其他部分可以包括与仅在第一日期和第二日期中的一个上具有特定作业功能的员工数据记录对应的图形元素以及指示改变的作业功能的原因的一个或多个相应的图形元素。
    • 30. 发明申请
    • AUSTEMPERING/MARQUENCHING POWDER METAL PARTS
    • 美味/粉碎粉末金属部件
    • US20060182648A1
    • 2006-08-17
    • US11382295
    • 2006-05-09
    • Kai XuRyan Sun
    • Kai XuRyan Sun
    • B22F1/00B22F1/02
    • C22C33/0264B22F3/16B22F2003/247B22F2003/248B22F2998/10B22F2999/00B22F3/20B22F3/18B22F3/17B22F3/02B22F3/10B22F1/0085
    • A powder metal part is made by compaction at room temperature or an elevated temperature followed by sintering, a secondary densification, heat treating, and optional secondary operations. The particulate materials preferably include iron, 0-2.0 wt % copper, 0.15-0.9 wt % carbon, 0.5-2.0 wt % molybdenum, 0.5-4.5 wt % nickel, 0-4.0 wt % chromium, and 0-1.5 wt % silicon. At least one secondary densification is applied to the part after compaction and pre-sinter/sinters steps to achieve medium to high density. The secondary densification is part of a double-press double-sinter (DPDS) or is a mechanical working depending on the application requirements. The powder metal is heat treated by austempering or marquenching followed by tempering. A unique composite microstructure is achieved from austempering by controlling the powder chemistry and the holding time at an elevated temperature. The combination of a secondary densification and austempering or marquenching produces a high performance powder metal part for demanding applications.
    • 粉末金属部件通过在室温或升高的温度下压实制备,然后进行烧结,二次致密化,热处理和任选的二次操作。 颗粒材料优选包括铁,0-2.0重量%铜,0.15-0.9重量%碳,0.5-2.0重量%钼,0.5-4.5重量%镍,0-4.0重量%铬和0-1.5重量%硅。 在压实和预烧结/烧结步骤之后,至少一种二次致密化被施加到部件上以实现中等到高密度。 二次致密化是双压双烧结(DPDS)的一部分,或根据应用要求进行机械加工。 粉末金属通过奥氏体淬火或淬火进行热处理,随后进行回火处理。 通过控制粉末化学和在高温下的保持时间,通过奥氏体回火实现独特的复合微观结构。 二次致密化和奥氏体淬火或捣碎的组合产生高性能粉末金属部件,用于要求苛刻的应用。