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21. 发明专利

JPH107529A HAIR GROWING AGENT 失效
公开(公告)号：JPH107529A
公开(公告)日：1998-01-13
申请号：JP8133097
申请日：1997-03-31
申请人： KUREHA CHEMICAL IND CO LTD
发明人： WATANABE TAKEO , KOMENO TADASHI , HATANAKA MITSUO , TAKAHASHI EISAKU , KIMURA FUMIHIKO , CHIBA TADAHIKO
IPC分类号： A61K8/00 , A61K8/73 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain a hair growing agent comprising a composition containing one or more kinds selected from trehalose and a cyclodextrin and a water-soluble polymer. SOLUTION: This hair growing agent is obtained by compounding 0.5-20wt.% of one or more kinds of components selected from trehalose and a cyclodextrin and 0.1-10wt.% of a water-soluble polymer and further adequately a known additive and formulating the obtained mixture into an aqueous solution, an aqueous suspension, a milk lotion, a cream, a gel, an aerosol, etc., preferably a lotion. As the water-soluble polymer, a polysaccharide (e.g. tamarind gum) and/or a synthetic polymer (e.g. a polyvinyl alcohol) is suitable, and one or more kinds are selected for use. The composition enables the activation of hair matrix cells (hair growing or restoring) based on the effect by which a resting period is converted into a growing period in a hair cycle (breaking a resting period) when applied on the hair matrix cells. The composition can be used for an animal including a human in vivo or in vitro.

22. 发明专利

JPH09241134A MULTI-COATING TYPE HAIR-GROWING AGENT AND GROWTH OF HAIR 失效
公开(公告)号：JPH09241134A
公开(公告)日：1997-09-16
申请号：JP7528196
申请日：1996-03-05
申请人： KUREHA CHEMICAL IND CO LTD
发明人： WATANABE TAKEO , HATANAKA MITSUO , ONO TOSHIHIKO , KIMURA FUMIHIKO , CHIBA TADAHIKO , ARAHORI HIDEO
IPC分类号： A61K8/00 , A61K8/34 , A61K8/42 , A61K8/49 , A61K8/60 , A61K8/73 , A61K8/97 , A61K8/98 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain a multi-coating type hair-growing agent capable of giving a hair-growing effect under a multi-coating treatment comprising repeated coating and drying treatments by adding a specific polymer to one or both of two kinds of hair-growing solutions and, if desired, further adding a specified sugar. SOLUTION: This hair-growing agent comprises two kinds of solutions containing hair-growing ingredients, wherein at least one of the solutions contains one or more kinds of hydrophilic polymers. The hair-growing ingredient includes Glycyrrhiza extract, dipotassium glycyrrhizinate, Swertia japonica extract, capsicum tincture, and L-menthol. The hydrophilic polymer includes ammonium alginate, carboxymethylcellulose sodium salt and polyvinyl alcohol. If desired, glucose, maltose, fructooligosaccharide, etc., may be added to at least one of the solutions. The solvent for the solutions is preferably ethyl alcohol, isopropyl alcohol, etc.

23. 发明专利

JPH10279439A TRICHOGENOUS AGENT 失效
公开(公告)号：JPH10279439A
公开(公告)日：1998-10-20
申请号：JP9850497
申请日：1997-03-31
申请人： KUREHA CHEMICAL IND CO LTD
发明人： WATANABE TAKEO , HATANAKA MITSUO , ONO TOSHIHIKO , KIMURA FUMIHIKO , CHIBA TADAHIKO , MIURA HIROMITSU
IPC分类号： A61K8/00 , A61K8/34 , A61K8/46 , A61K8/49 , A61K8/73 , A61K8/97 , A61Q5/00 , A61Q7/00 , A61K7/06
摘要： PROBLEM TO BE SOLVED: To obtain the subject agent high having a trichlogenous effect by adding a specific substance selected from substances usually used as constituent ingredients for trichogenous agents to a lower alcohol-water mixture containing α,α-trehalose and a water-soluble polymer. SOLUTION: This trichlorgenous agent is prepared by adding a Swertia japonica extract (0.1-0.5 pt.wt.), hinokitiol (0.01-0.05 pt.wt.), vitamin E acetate (0.1-0.4 pt.wt.), L-menthol (0.02-0.1 pt.wt.), D-pantothenyl alcohol and/or D- pantothenyl ethyl ether (0.01-0.6 pt.wt.), β-glycyrrhetic acid (0.05-0.3 pt.wt.), sodium lauryl sulfate (0.05-0.3 pt.wt.) and nicotinic acid amide (0.05-0.3 pt.wt.) to a lower alcohol (65-80 pts.wt.)-water (20-32 pts.wt.) mixture containing α,α- trehalose (0.3-1.8 pts.wt.) and a water-soluble polymer (0.21-1.8 pts.wt.).

24. 发明专利

JPH06190021A DIVIDED PACKAGE OF INTERNALLY TAKING ADSORBENT AND PREPARATION THEREOF 失效
公开(公告)号：JPH06190021A
公开(公告)日：1994-07-12
申请号：JP24603693
申请日：1993-09-08
申请人： KUREHA CHEMICAL IND CO LTD
发明人： ONO SAICHI , CHIBA TADAHIKO , UEHARA YASUO
IPC分类号： A61J1/14
摘要： PURPOSE:To suppress deformation caused by the change in the vol. of air wrapped in an internally taking adsorbent filled in a divided package by making vol. expansion coefficient at a specified temp. of the divided package wherein the internally taking adsorbent discharging a specified vol. of air per 1g during temp. elevation of a specified value is wrapped to be a specified value. CONSTITUTION:Vol. expansion coefficient from 10 deg.C to 30 deg.C of a divided package wherein an internally taking adsorbent discharging 1.3-10ml air per 1g during temp. elevation from 10 deg.C to 30 deg.C is wrapped, is made 0-0.064ml/ deg.C.g. The method for preparing it is that the temp. of the internally taking adsorbent is made at a temp. being 5 deg.C higher than room temp. to 300 deg.C and after it is filled, it is sealed or that after the internally taking adsorbent is filled in the divided package, it is sealed at the atmospheric pressure or lower. In the divided package of this internally taking adsorbent, as there scarcely exists deformation of the divided package caused by the change in the vol. of air wrapped in the internally taking adsorbent, troubles based on the change in vol. of the divided package during packaging in a box, storage and transportation of the internally taking adsorbent, can be solved.

25. 发明专利

JPH02174722A GRANULAR LIPID OF PROTEIN POLYSACCHARIDE DERIVED FROM CORIOLUS VERSICOLOR 失效
公开(公告)号：JPH02174722A
公开(公告)日：1990-07-06
申请号：JP22528589
申请日：1989-08-31
申请人： KUREHA CHEMICAL IND CO LTD
发明人： FUJII MASAHIKO , TAKAHASHI NORIO , ONO SAICHI , CHIBA TADAHIKO
IPC分类号： A61K9/16 , A61K36/06 , A61K36/07 , A61K38/00 , A61P31/04 , A61P31/12 , A61P35/00 , C07K14/00 , C07K14/37 , C07K14/41
摘要： PURPOSE:To obtain granular preparation having eliminated problems of difficulty in administration caused by hard drinking in prescription by granulating a protein polysaccharide derived from Coriolus versicolor by specific granulation and adjusting bulk density and solubility in water to specific ranges. CONSTITUTION:A protein polysaccharide (e.g. Krestin) derived from Coriolus versicolor is spray dried to give powder, which is granulated by any method of granulation using roller compactor, granulation using tableting machine, fluidizing granulation, extrusion granulation, rolling granulation or spiral granulation to give granular preparation having 0.50-0.90g/cm , especially 0.60-0.80g/cm bulk density,

26. 发明专利

JPH02167229A GRANULAR PHARMACEUTICAL OF PROTEIN POLYSACCHARIDE SUBSTANCE DERIVED FROM CORIOLUS VERSICOLOR QUEL. 失效
公开(公告)号：JPH02167229A
公开(公告)日：1990-06-27
申请号：JP22528489
申请日：1989-08-31
申请人： KUREHA CHEMICAL IND CO LTD
发明人： FUJII MASAHIKO , TAKAHASHI NORIO , ONO SAICHI , CHIBA TADAHIKO
IPC分类号： A61K9/16 , A61K36/06 , A61K36/07 , A61K38/00 , A61P31/04 , A61P31/12 , A61P35/00 , C07K14/00 , C07K14/37 , C07K14/41
摘要： PURPOSE:To obtain a granular pharmaceutical, consisting of a protein polysaccharide substance derived from Coriolus versicolor Quel., disintegrating agent and additive acting as a binder, having a bulk density and solubility within specific ranges and capable of improving difficulty in drinking in administration without impairing pharmacological activity. CONSTITUTION:A granular pharmaceutical, obtained by granulating a protein polysaccharide substance derived from Coriolus versicolor Quel., e.g. a mixture of >=50 to =75 to 10 to 10 to , especially 0.35-0.75g/cm bulk density and >=4 to

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