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    • 22. 发明申请
    • METHODS AND COMPOSITIONS FOR DIAGNOSING AND TREATING CHROMOSOME 18q RELATED DISORDERS
    • 用于诊断和治疗18q相关疾病的方法和组合物
    • WO0134771A3
    • 2002-01-17
    • PCT/US0030637
    • 2000-11-07
    • MILLENNIUM PHARM INCUNIV CALIFORNIACHEN HONGFREIMER NELSON B
    • CHEN HONGFREIMER NELSON B
    • A61K48/00C07K14/47C12Q1/68A01N43/04A01N61/00C07H21/04C12N15/00G01N33/53
    • C07K14/47A61K48/00C12Q1/6883C12Q2600/158
    • The present invention encompasses 18q interval nucleic acids, recombinant DNA molecules, cloned genes or degenerate variants thereof, 18q interval gene products and antibodies directed against such gene products, cloning vectors containing mammalian 18q interval gene molecules, and hosts that have been genetically engineered to express such molecules. The invention further relates to methods for the identification of compounds that modulate the expression of 18q interval genes and gene products and to using such compounds as therapeutic agents in the treatment of 18q interval-related disorders, e.g., neuropsychiatric disorders. The invention also relates to methods for the diagnostic evaluation, genetic testing and prognosis of 18q interval-related disorders, e.g., neuropsychiatric disorders, including schizophrenia, attention deficit disorder, a schizoaffective disorder, a bipolar affective disorder or a unipolar affective disorder, and to methods and compositions for the treatment of these disorders.
    • 本发明包括18q间隔核酸,重组DNA分子,克隆基因或其简并变体,18q间期基因产物和针对这种基因产物的抗体,含有哺乳动物18q间期基因分子的克隆载体,以及已被遗传工程化以表达的宿主 这样的分子。 本发明还涉及用于鉴定调节18q间期基因和基因产物的表达的化合物的方法,并且使用这些化合物作为治疗剂来治疗18q间期相关病症,例如神经精神障碍。 本发明还涉及18q间期相关疾病的诊断评估,基因检测和预后的方法,例如神经精神障碍,包括精神分裂症,注意力缺陷障碍,分裂情感障碍,双相情感障碍或单极情感障碍,以及 用于治疗这些疾病的方法和组合物。