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21. 发明申请

US20190015308A1 ANTI-ADHERENT ALCOHOL-BASED COMPOSITION 审中-公开
公开(公告)号：US20190015308A1
公开(公告)日：2019-01-17
申请号：US16011248
申请日：2018-06-18
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Vinod Chaudhary , Scott W. Wenzel , Kathleen C. Engelbrecht , David W. Koenig , Amy L. Vanden Heuvel , Divesh Bhatt , Paige N. Hollmaier (Anunson) , Stacy A. Mundschau
IPC分类号： A61K8/34 , C09D101/28 , C09D5/14 , A61K8/02 , A61Q17/00 , A61K8/73 , A61K8/81
摘要： The present disclosure is directed to alcohol-based anti-adherent compositions that do not adhere to or attract Gram-negative and Gram-positive bacteria once it is applied to a surface and dried. The composition may include as anti-adherent agents, hydrophilic film-formers such as cellulosics, gums, acrylates, nonionic polymers, and anionic polymers. Examples of anti-adherent agents include Hydroxypropyl methylcellulose, Cellulose gum, Acacia Senegal Gum; Polyacrylate Crosspolymer-11, VP/Dimethylaminoethylmethacrylate/Polycarbamyl Polyglycol Ester; Acrylates/Vinyl Neodecanoate Crosspolymer, hydroxypropyl methylcellulose, Hydroxypropylcellulose, Methylcellulose, Propylene Glycol Alginate, Polyacrylate Crosspolymer-6, VP/Polycarbamyl Polyglycol Ester, Acrylates/Steareth-20 Methacrylate Copolymer; Acrylates Copolymer, and any combination thereof. The anti-adherent may be applied to surfaces using a vehicle such as a wipe.

22. 发明申请

US20170322212A1 DEVICES AND METHODS FOR DETECTING NOROVIRUS ON SURFACES 审中-公开
公开(公告)号：US20170322212A1
公开(公告)日：2017-11-09
申请号：US15526939
申请日：2014-11-27
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Bao Trong Do , Jonathan Hofmekler , Cesar A. Morales , David W. Koenig , Yang Huang , Aimin He
IPC分类号： G01N33/569 , G01N33/558
CPC分类号： G01N33/56983 , G01N33/558 , G01N2333/08 , G01N2469/10
摘要： Lateral-flow assay and time-resolved fluorescence technologies provide a sensitive tool for detecting norovirus particles in a sample. A flow-through assay device employs norovirus and norovirus G2 antibodies. The lateral-flow assay includes a conjugate pad having conjugated probes. The conjugated probes are particles modified with a binding member that is configured to bind with a norovirus. The particles also have a fluorescent label. A general method of detecting the virus includes (i) preparing a sample with contaminants, (ii) processing the sample and depositing it onto the assay device, and (iii) measuring the fluorescence signal.

23. 发明申请

US20170224596A1 ANTI-ADHERENT ALCOHOL-BASED COMPOSITION 审中-公开
公开(公告)号：US20170224596A1
公开(公告)日：2017-08-10
申请号：US15500671
申请日：2015-04-01
申请人： KIMBERLY-CLARK WORLDWIDE, INC.
发明人： Vinod Chaudhary , Scott W. Wenzel , Kathleen C. Engelbrecht , David W. Koenig , Amy L. Vanden Heuvel , Divesh Bhatt , Paige N. Anunson , Stacy A. Mundschau
IPC分类号： A61K8/34 , A61K8/02 , A61Q17/00 , C09D5/14 , C09D101/28 , A61K8/73 , A61K8/81
CPC分类号： A61K8/34 , A61K8/0208 , A61K8/73 , A61K8/731 , A61K8/8152 , A61Q17/005 , C09D5/14 , C09D101/28 , C09D101/284
摘要： The present disclosure is directed to alcohol-based anti-adherent compositions that do not adhere to or attract Gram-negative and Gram-positive bacteria once it is applied to a surface and dried. The composition may include as anti-adherent agents, hydrophilic film-formers such as cellulosics, gums, acrylates, nonionic polymers, and anionic polymers. Examples of anti-adherent agents include Hydroxypropyl methylcellulose, Cellulose gum, Acacia Senegal Gum; Polyacrylate Crosspolymer-11, VP/Dimethyl-aminoethylmethacrylate/Polycarbamyl Polyglycol Ester; Acrylates/Vinyl Neodecanoate Crosspolymer, hydroxypropyl methylcellulose, Hydroxypropylcellulose, Methylcellulose, Propylene Glycol Alginate, Polyacrylate Crosspolymer-6, VP/Polycarbamyl Polyglycol Ester, Acrylates/Steareth-20 Methacrylate Copolymer; Acrylates Copolymer, and any combination thereof. The anti-adherent may be applied to surfaces using a vehicle such as a wipe.

24. 发明申请

US20170172153A1 SELF-REGENERATING ANTIMICROBIAL COMPOSITION AND METHOD OF USE 审中-公开
公开(公告)号：US20170172153A1
公开(公告)日：2017-06-22
申请号：US15129668
申请日：2015-03-18
申请人： Kimberly-Clark Worldwide, Inc.
发明人： David W. Koenig , Douglas R. Hoffman , Cindy Korir-Morrison , Amy L. Vanden Heuvel
IPC分类号： A01N63/00 , C09D5/14 , A01N25/34 , C12N7/00 , A01N25/10
CPC分类号： A01N63/00 , A01N25/10 , A01N25/34 , C09D5/14 , C09D7/65 , C12N7/00 , C12N2750/00031 , A01N63/02
摘要： A composition may be applied to animate and inanimate surfaces to render such surfaces antimicrobial for as long as the composition remains on the surface. The composition contains at least one pathogen-associated virus that is self-regenerating so that a user need not take steps to regenerate the material. The virus is or viruses are contained within a polymer matrix. The polymer matrix has the ability to maintain a desired moisture content to support the regeneration of the virus(es). Various methods of using the composition include the coating of animate and inantimate surfaces to prevent bacterial, viral, and fungal infections.

25. 发明申请

US20150238642A1 Method and System to Clean Microorganisms without Chemicals 有权
标题翻译：无化学品清洁微生物的方法和系统
公开(公告)号：US20150238642A1
公开(公告)日：2015-08-27
申请号：US14191617
申请日：2014-02-27
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Jose K. Abraham , Paige Anunson , Kathleen C. Engelbrecht , David W. Koenig
IPC分类号： A61L2/03
CPC分类号： A61L2/03 , A61L2/04 , A61L2202/26
摘要： A system for removing microorganisms from a surface is described. The system includes a conducting member, a voltage source, and an electrostatic field controller. The conducing member includes a nonwoven material incorporating conductive fibers. The controller is electrically connected to the conducting member and is configured to apply a DC voltage of about 15 volts or less to the conducting member via the voltage source. The surface to be contacted can include any surface present in households, food industry facilities, medical facilities, etc. Such surfaces can include tables, countertops, walls, cabinets, doors, door handles, door knobs, etc. The system can also be used to treat devices used in the aforementioned environments, such as food preparation equipment, medical devices, household appliances, etc. The system can reduce the amount of microorganisms on the surface by at least about 1 log (90%) without the use of chemicals, high voltages, or long exposure times.
摘要翻译：描述了从表面除去微生物的系统。该系统包括导电构件，电压源和静电场控制器。引导构件包括结合导电纤维的非织造材料。控制器电连接到导电构件，并且被配置为经由电压源向导电构件施加约15伏或更小的直流电压。要接触的表面可以包括家庭中存在的任何表面，食品工业设施，医疗设施等。这些表面可以包括桌子，台面，墙壁，橱柜，门，门把手，门把手等。还可以使用该系统用于治疗上述环境中使用的装置，例如食物制备设备，医疗器械，家用电器等。该系统可以在不使用化学物质的情况下将表面上的微生物量减少至少约1log（90％），高电压或长曝光时间。

26. 发明公开

US20230277704A1 Disinfectant Composition with Rapid Antiviral Efficacy 审中-公开
公开(公告)号：US20230277704A1
公开(公告)日：2023-09-07
申请号：US18309329
申请日：2023-04-28
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Douglas R. Hoffman , Amy L. Vanden Heuvel , Jeremy D. Paulsen , Paige N. Anunson , Lisa M. Kroll , Corey T. Cunningham , David W. Koenig
IPC分类号： A61L2/18 , A61K31/194 , A61K31/205 , A61K31/661 , A61K45/06 , A61P31/12
CPC分类号： A61L2/18 , A61K31/194 , A61K31/205 , A61K31/661 , A61K45/06 , A61P31/12 , Y02A50/30
摘要： A disinfectant composition that contains a unique combination of a primary antiviral agent and a secondary antiviral agent is provided. More particularly, the primary antiviral agent includes a polyprotic acid having a low first acid dissociation constant and the secondary antiviral agent is selected from the group consisting of an anionic N-acyl compound, metal halide salt, amine compound, amine compound, aliphatic amine oxide, alkyl glycoside, alcohol ethoxylate, and combinations thereof. By selectively controlling the particular nature of each antiviral agent and their relative concentration, the present inventors have discovered that a synergistic affect can be achieved in which the disinfectant composition is capable of exhibiting an antiviral efficacy against non-enveloped viruses.

27. 发明授权

US11311429B2 Methods and products for dynamic control of environments by selective metabolic function of microbes 有权
公开(公告)号：US11311429B2
公开(公告)日：2022-04-26
申请号：US17426910
申请日：2019-01-31
申请人： Kimberly-Clark Worldwide, Inc.
发明人： David W. Koenig , Jonathan Hofmekler , Lindsay A. Peed , Jeffery R. Seidling , Scott W. Wenzel
IPC分类号： A61F13/15 , A61F13/84 , A61F13/511 , A61L15/28 , A61L15/46 , A61F13/514
摘要： Methods and products for maintaining a target pH range of an environment including at least one organism are provided. A method can include releasing a carbon source to the environment. A method can further include allowing the carbon source to be metabolized by the at least one organism and lower a pH of the environment. The method can also include releasing a nitrogen source to the environment. The method can additionally include allowing the nitrogen source to be metabolized by the at least one organism and increase the pH of the environment. The releasing of the carbon source to the environment and the releasing of the nitrogen source to the environment can be selectively timed to control the pH of the environment to the target pH range of the environment.

28. 发明申请

US20220096287A1 METHODS AND PRODUCTS FOR DYNAMIC CONTROL OF ENVIRONMENTS BY SELECTIVE METABOLIC FUNCTION OF MICROBES 有权
公开(公告)号：US20220096287A1
公开(公告)日：2022-03-31
申请号：US17426910
申请日：2019-01-31
申请人： Kimberly-Clark Worldwide, Inc.
发明人： David W. Koenig , Jonathan Hofmekler , Lindsay A. Peed , Jeffery R. Seidling , Scott W. Wenzel
IPC分类号： A61F13/84 , A61F13/15 , A61F13/511 , A61F13/514 , A61L15/28 , A61L15/46
摘要： Methods and products for maintaining a target pH range of an environment including at least one organism are provided. A method can include releasing a carbon source to the environment. A method can further include allowing the carbon source to be metabolized by the at least one organism and lower a pH of the environment. The method can also include releasing a nitrogen source to the environment. The method can additionally include allowing the nitrogen source to be metabolized by the at least one organism and increase the pH of the environment. The releasing of the carbon source to the environment and the releasing of the nitrogen source to the environment can be selectively timed to control the pH of the environment to the target pH range of the environment.

29. 发明申请

US20220062356A1 COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING INCONTINENCE, OVERACTIVE BLADDER, OR MENSTRUAL CRAMPING 有权
公开(公告)号：US20220062356A1
公开(公告)日：2022-03-03
申请号：US17415020
申请日：2019-12-20
申请人： Gregor Reid , Jeremy P. Burton , Behnam Abbasian , Kimberly-Clark Worldwide, Inc.
发明人： Kathleen C. Engelbrecht , David W. Koenig , Elizabeth M. Doney , Gregor Reid , Jeremy Burton , Behnam Abbasian
IPC分类号： A61K35/747
摘要： Methods and compositions for preventing or treating incontinence, overactive bladder, or menstrual cramping in a subject are described. A method can include providing a composition. The composition can include a modification agent. The modification agent can include a strain of Lactobacillus or a ferment or a metabolite thereof. The modification agent can provide neuromodulation activity by up-regulating at least one of maoA enzymes, maoB enzymes, and grin-1 genes. The method can also include administering the composition to the subject to prevent or treat incontinence, overactive bladder, or menstrual cramping. In some aspects, the modification agent can decrease a level of extracellular ATP in a target environment.

30. 发明授权

US11168287B2 Anti-adherent compositions and methods of inhibiting the adherence of microbes to a surface 有权
公开(公告)号：US11168287B2
公开(公告)日：2021-11-09
申请号：US16301580
申请日：2016-05-26
申请人： Kimberly-Clark Worldwide, Inc.
发明人： Kathleen C. Engelbrecht , Stacy A. Mundschau , David W. Koenig , Scott W. Wenzel
IPC分类号： C11D3/48 , C11D17/04 , C11D3/37 , C11D3/20 , C11D3/26 , A61K8/02 , A61K8/88 , A61K8/81 , A61K8/85 , A61K8/86 , A61K8/90 , A61K8/37 , A61K8/40 , A61Q17/00 , A01N25/08 , A01N43/50 , A01N37/02 , A01N37/06 , A01N37/34 , A01N37/42 , A01N31/02 , A01N25/00 , C08L71/02 , A61K47/34 , A61K9/00 , A61K47/32 , A61K9/06 , A61Q19/10
摘要： Methods of inhibiting microbes from attaching to a surface and anti-adherent compositions are disclosed. One method can include providing an anti-adherent composition that includes an anti-adherent agent configured to inhibit microbes from attaching to the surface. The anti-adherent agent can be: Acrylates Copolymer, Trimethylpentanediol/Adipic Acid/Glycerin crosspolymer, Trimethylpentanediol/Adipic Acid Copolymer, Ethylhexyl Stearate, Ethylhexyl Salicylate, Acrylates/C12-22 Alkylmethacrylate Copolymer, Octocrylene, Ethylene Oxide/Propylene Oxide Block Copolymer, Polyquaternium-101, or any combinations thereof. The method can include applying the composition to the surface and allowing at least some of the composition to remain on the surface such that the anti-adherent agent inhibits microbes from attaching to the surface. The anti-adherent composition can include a humectant and can be non-antimicrobial.

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