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21. 发明授权

US5200420A 2,6-dialkyl-4-(benzothiazol- or benzoxazol-4-yl-1,4-dihydropyridines 失效
标题翻译： 2,6-二甲基-4-（苯并噻唑或苯并恶唑-4-基）-1,4-二氢吡啶
公开(公告)号：US5200420A
公开(公告)日：1993-04-06
申请号：US677731
申请日：1991-03-29
申请人： Siegfried Goldmann , Horst Boshagen , Jurgen Stoltefuss , Alexander Straub , Rainer Gross , Joachim Hutter , Siegbert Hebisch , Martin Bechem
发明人： Siegfried Goldmann , Horst Boshagen , Jurgen Stoltefuss , Alexander Straub , Rainer Gross , Joachim Hutter , Siegbert Hebisch , Martin Bechem
IPC分类号： A61K31/435 , A61K31/44 , A61P9/04 , A61P9/08 , A61P9/10 , A61P9/12 , C07D263/56 , C07D263/57 , C07D277/66 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , C07D491/04 , C07D491/048
CPC分类号： C07D263/57 , C07D277/66 , C07D413/04 , C07D417/04 , C07D491/04
摘要： 2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula ##STR1## in which R.sup.1 and R.sup.5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms,R.sup.2 represents nitro or cyano, orR.sup.1 and R.sup.2 together form a lactone ring of the formula ##STR2## R.sup.3 represents a radical of the formula ##STR3## R.sup.4 -R.sup.7 are defined hereinafter and physiologically acceptable salts thereof.
摘要翻译：表现出具有大量中性血管行为的正性肌力作用的2,6-二烷基-4-（苯并噻唑基或苯并恶唑-7-基）-1,4-二氢吡啶，其中R1和R5是相同或不同，代表具有至多8个碳原子的直链或支链烷基，R2代表硝基或氰基，或R1和R2一起形成下式的内酯环R3表示下式的基团：下文定义R4-R7及其生理上可接受的盐。

22. 发明授权

US5508406A Quinolyl-dihydropyridine esters, processes for their preparation, and their use in medicaments 失效
标题翻译：醌基 - 二氢吡啶酯，其制备方法及其在药物中的用途
公开(公告)号：US5508406A
公开(公告)日：1996-04-16
申请号：US230266
申请日：1994-04-20
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , A61P9/00 , A61P9/04 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/14 , C07D491/04 , C07D491/048
CPC分类号： C07D401/04 , C07D401/14 , C07D417/14 , C07D491/04
摘要： The invention relates to new 4-quinolyl-dihydropyridine esters of the general formula (I) ##STR1## in which R.sub.1 to R.sub.6 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.
摘要翻译：本发明涉及通式（I）的新的4-喹啉基 - 二氢吡啶酯，其中R1至R6具有说明书中给出的含义，其制备方法及其在药物中的用途，特别是用于治疗心脏循环障碍的药物。

23. 发明授权

US5504210A 3-quinolyl-substituted dihydropyridines and their use in medicaments 失效
标题翻译： 3-喹啉基取代的二氢吡啶类及其在药物中的用途
公开(公告)号：US5504210A
公开(公告)日：1996-04-02
申请号：US230286
申请日：1994-04-20
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , C07C47/06 , C07D215/20 , C07D215/36 , C07D215/48 , C07D401/04 , C07D401/14 , C07D491/04 , C07D491/048
CPC分类号： C07D401/04 , C07D401/14 , C07D491/04
摘要： The invention relates to new 3-quinolyl-substituted dihydropyridines, processes for their preparation and their use in medicaments, in particular in agents for the treatment of cardiovascular diseases.
摘要翻译：本发明涉及新的3-喹啉基取代的二氢吡啶，其制备方法及其在药物中的用途，特别是用于治疗心血管疾病的药剂。

24. 发明授权

US5364855A 4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines, processes for their preparation and their use in medicaments 失效
标题翻译： 4-噌啉基和4-萘啶基 - 二氢吡啶类，其制备方法及其在药物中的应用
公开(公告)号：US5364855A
公开(公告)日：1994-11-15
申请号：US6592
申请日：1993-01-21
申请人： Alexander Straub , Jurgen Stoltefuss , Siegfried Goldmann , Rainer Gross , Martin Bechem , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Alexander Straub , Jurgen Stoltefuss , Siegfried Goldmann , Rainer Gross , Martin Bechem , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/455 , A61K31/44 , A61K31/4427 , A61K31/50 , A61P9/04 , C07D213/75 , C07D237/28 , C07D401/04 , C07D471/04 , C07D491/04 , C07D491/048 , C07D519/00 , A61K31/495 , C07D401/10
CPC分类号： C07D401/04 , C07D471/04 , C07D491/04
摘要： The invention relates to new 4-cinnolinyl- and 4-naphthyridinyl-dihydropyridines of the general formula I ##STR1## in which R.sup.1 to R.sup.5 have the meaning given in the description, to processes for their preparation and to their use in medicaments, in particular in compositions having positively inotropic action.
摘要翻译：本发明涉及通式Ⅰ的新的4-噌啉基和4-萘啶基 - 二氢吡啶类，其中R1至R5具有说明书中给出的含义，其制备方法及其在药物中的用途，特别是在具有正性肌力作用的组合物中。

25. 发明授权

US5262429A Aryl-quinolyl-substituted 1,4-dihydropyridine-dicarboxylic acid compounds which have useful pharmaceutical utility 失效
标题翻译：具有有用的药物效用的芳基 - 喹啉基取代的1,4-二氢吡啶 - 二羧酸化合物
公开(公告)号：US5262429A
公开(公告)日：1993-11-16
申请号：US959843
申请日：1992-10-13
申请人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Rainer Gross , Martin Bechem , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Jurgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Rainer Gross , Martin Bechem , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/47 , A61P9/08 , A61P9/10 , A61P9/12 , C07D401/04 , C07D401/14 , C07D409/14
CPC分类号： C07D401/04 , C07D409/14
摘要： The invention relates to novel aryl-quinolyl-substituted 1,4-dihydropyridine-di-carboxylic acid derivatives, to processes for their preparation and to their use in drugs, especially for the preparation drugs for the treatment of cardiovascular diseases.
摘要翻译：本发明涉及新的芳基 - 喹啉基取代的1,4-二氢吡啶二羧酸衍生物，其制备方法及其在药物中的应用，特别是用于制备治疗心血管疾病的药物。

26. 发明授权

US4904665A Benzylaminoaryl-dihydropyridinelactones and their use in medicaments 失效
标题翻译：苄基氨基芳基 - 二氢吡啶内酯及其在药物中的用途
公开(公告)号：US4904665A
公开(公告)日：1990-02-27
申请号：US158184
申请日：1988-02-18
申请人： Siegfried Goldmann , Rainer Gross , Martin Bechem , Michael Kayser , Matthias Schramm , Siegbert Hebisch
发明人： Siegfried Goldmann , Rainer Gross , Martin Bechem , Michael Kayser , Matthias Schramm , Siegbert Hebisch
IPC分类号： A61K31/44 , A61P3/08 , A61P9/00 , A61P9/06 , A61P9/08 , A61P9/10 , C07D211/90 , C07D491/04 , C07D491/048
CPC分类号： C07D491/04 , C07D211/90
摘要： A benzylaminoaryl-dihydropyridinelactone compound of the formula (I) ##STR1## in which R.sup.1 represents hydrogen, halogen, cyano, nitro, C.sub.6 -C.sub.12 -aryl, C.sub.1 -C.sub.8 -alkyl, C.sub.1 -C.sub.8 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, trifluoromethyl, trifluoromethoxy, trifluoromethylthio, difluoromethoxy, di-C.sub.1 -C.sub.5 -alkylamino, C.sub.1 -C.sub.6 -alkoxycarboxyl or C.sub.1 -C.sub.6 -alkylsulphonyl,R.sup.2 represents hydrogen, or represents a straight-chain, branched or cyclic, saturated or unsaturated hydrocarbon radical having up to 10 carbon atoms which is optionally substituted by C.sub.1 -C.sub.6 -alkoxy, C.sub.1 -C.sub.6 -alkylthio, C.sub.1 -C.sub.6 -alkylsulphonyl, halogen, cyano, hydroxyl, pyridyl, thienyl, pyrimidyl, piperidinyl, phenyl or an amino group, where the amino group carries two identical or different substituents from the series comprising C.sub.1 -C.sub.5 -alkyl, phenyl or benzyl,R.sup.3 represents C.sub.1 -C.sub.5 -alkyl, or represents cyano, hydroxymethyl or formyl, andR.sup.4 represents hydrogen, halogen, C.sub.1 -C.sub.5 -alkyl or trifluoromethyl,and its isomers, isomeric mixtures, racemates or optical antipodes, and physiologically acceptable salts thereof. The compound being useful to improve the contractility of the heart and the tonus of the smooth muscles.
摘要翻译：式（I）的苄基氨基芳基 - 二氢吡啶内酯化合物其中R 1表示氢，卤素，氰基，硝基，C 6 -C 12 - 芳基，C 1 -C 8 - 烷基，C 1 -C 8 - 烷氧基，C 1 -C 6 - 烷硫基，三氟甲基，三氟甲氧基，三氟甲硫基，二氟甲氧基，二-C 1 -C 5烷基氨基，C 1 -C 6 - 烷氧基羧基或C 1 -C 6烷基磺酰基，R 2表示氢，或表示直链，支链或环状饱和或不饱和烃具有至多10个碳原子的基团，其任选被C 1 -C 6 - 烷氧基，C 1 -C 6 - 烷硫基，C 1 -C 6 - 烷基磺酰基，卤素，氰基，羟基，吡啶基，噻吩基，嘧啶基，哌啶基，苯基或氨基取代，其中氨基从包含C 1 -C 5 - 烷基，苯基或苄基的系列中携带两个相同或不同的取代基，R 3表示C 1 -C 5 - 烷基，或表示氰基，羟甲基或甲酰基，R 4表示氢，卤素，C 1 -C 5 - 烷基或三氟甲基，及其异构体，异构体混合物，外消旋体或光学抗体 es及其生理上可接受的盐。该化合物可用于改善心脏和平滑肌紧张的收缩性。

27. 发明授权

US5478937A Certain cinnoline carboxaldehydes and naphthyridine carboxaldehydes useful as intermediates 失效
标题翻译：某些噌啉羧醛和萘啶甲醛可用作中间体
公开(公告)号：US5478937A
公开(公告)日：1995-12-26
申请号：US377063
申请日：1995-01-23
申请人： Alexander Straub , Siegfried Goldmann , Jurgen Stoltefuss , Martin Bechem , Ranier Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
发明人： Alexander Straub , Siegfried Goldmann , Jurgen Stoltefuss , Martin Bechem , Ranier Gross , Siegbert Hebisch , Joachim Hutter , Howard-Paul Rounding
IPC分类号： A61K31/455 , A61K31/44 , A61K31/4427 , A61K31/4433 , A61K31/495 , A61K31/50 , A61K31/502 , A61P9/00 , A61P9/04 , C07D237/28 , C07D401/04 , C07D409/04 , C07D413/04 , C07D417/04 , C07D471/04 , C07D491/04 , C07D491/048 , C07D495/04 , C07D519/00 , C07F9/59
CPC分类号： C07D409/04 , C07D417/04 , C07D471/04 , C07D491/04 , C07D495/04
摘要： The present invention relates to new 2-amino-4-heteroaryl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 to R.sub.4 have the meaning given in the description, processes for their preparation and their use in medicaments, in particular in compositions for the treatment of cardiovascular disorders.
摘要翻译：本发明涉及通式（I）的新的2-氨基-4-杂芳基-1,4-二氢吡啶，其中R1至R4具有说明书中给出的含义，其制备方法和它们在药物中的用途，特别是用于治疗心血管疾病的组合物。

28. 发明授权

US5502062A 2-amino-4-quinolyl-dihydropyridines, processes for their preparation, and their use 失效
标题翻译： 2-氨基-4-喹啉基 - 二氢吡啶，其制备方法及其用途
公开(公告)号：US5502062A
公开(公告)日：1996-03-26
申请号：US230187
申请日：1994-04-20
申请人： Ju/ rgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hu/ tter , Howard-Paul Rounding
发明人： Ju/ rgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim Hu/ tter , Howard-Paul Rounding
IPC分类号： A61K31/47 , A61K31/43 , A61P9/00 , A61P9/04 , C07D401/04 , C07D401/14 , C07D409/14 , C07D491/04 , C07D491/048 , C07D491/08 , A61K31/44
CPC分类号： C07D401/04 , C07D491/04
摘要： The present invention relates to new 2-amino-4-quinolyl-1,4-dihydropyridines of the general formula (I) ##STR1## in which R.sub.1 -R.sub.4 have the meaning given in the description, to processes for their preparation and to their use in medicaments, especially in agents for the treatment of cardiac circulatory disorders.
摘要翻译：本发明涉及通式（I）的新的2-氨基-4-喹啉基-1,4-二氢吡啶，其中R1-R4具有说明书中给出的含义，其制备方法以及它们在药物中的用途，特别是用于治疗心脏循环障碍的药物。

29. 发明授权

US5629320A 3-quinolyl-substituted dihydropyridines, and their use in medicaments 失效
标题翻译： 3-喹啉基取代的二氢吡啶，以及它们在药物中的用途
公开(公告)号：US5629320A
公开(公告)日：1997-05-13
申请号：US448930
申请日：1995-05-25
申请人： J urgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim H utter , Howard-Paul Rounding
发明人： J urgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim H utter , Howard-Paul Rounding
IPC分类号： A61K31/47 , C07C47/06 , C07D215/20 , C07D215/36 , C07D215/48 , C07D401/04 , C07D401/14 , C07D491/04 , C07D491/048 , A61K31/395
CPC分类号： C07D401/04 , C07D401/14 , C07D491/04
摘要： This invention relates to 3-quinolyl-substituted dihydropyridine derivatives, such as ##STR1## or a pharmaceutically acceptable salt thereof. These compounds are used in treating cardiovascular disease.
摘要翻译：本发明涉及3-喹啉基取代的二氢吡啶衍生物，例如“IMAGE”或其药学上可接受的盐。这些化合物用于治疗心血管疾病。

30. 发明授权

US5550245A 3-quinolyl-substituted dihydropyridines, processes for their preparation and their use in medicaments 失效
标题翻译： 3-喹啉基取代的二氢吡啶类，其制备方法及其在药物中的用途
公开(公告)号：US5550245A
公开(公告)日：1996-08-27
申请号：US450461
申请日：1995-05-25
申请人： J urgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim H utter , Howard-Paul Rounding
发明人： J urgen Stoltefuss , Siegfried Goldmann , Alexander Straub , Martin Bechem , Rainer Gross , Siegbert Hebisch , Joachim H utter , Howard-Paul Rounding
IPC分类号： A61K31/47 , C07C47/06 , C07D215/20 , C07D215/36 , C07D215/48 , C07D401/04 , C07D401/14 , C07D491/04 , C07D491/048 , C07D403/92
CPC分类号： C07D401/04 , C07D401/14 , C07D491/04
摘要： Intermediate of the formula ##STR1## wherein R.sup.5 represents a cyclic, straight-chain or branched, saturated or unsaturated hydrocarbon radical having up to 12 carbon atoms, which is optionally interrupted up to twice in an identical or different manner by oxygen or sulphur, as intermediates for substituents on novel dihydropyridine cardiovascular compounds.
摘要翻译：式（XVIII）的中间体，其中R 5表示具有至多12个碳原子的环状，直链或支链，饱和或不饱和的烃基，其任选地以相同或不同的方式被氧或两次中断硫，作为新型二氢吡啶心血管化合物上取代基的中间体。

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