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21. 发明授权

US07744621B2 Inflatable occlusion devices, methods, and systems 有权
标题翻译：充气闭塞装置，方法和系统
公开(公告)号：US07744621B2
公开(公告)日：2010-06-29
申请号：US11294998
申请日：2005-12-06
申请人： Ram H. Paul , Jacob A. Flagle , Brian C. Case
发明人： Ram H. Paul , Jacob A. Flagle , Brian C. Case
IPC分类号： A61M29/00
CPC分类号： A61L29/005 , A61B17/12109 , A61B17/12136 , A61B17/1219 , A61B2017/1205
摘要： Described are devices, methods and systems useful for achieving occlusion of vascular vessels. Percutaneous procedures can be used to occlude and obliterate the greater saphenous vein, for example in the treatment of varicose vein condition caused by venous reflux. Certain embodiments encompass the deployment and filling of an inflatable occlusion device via a percutaneous procedure, so as to occlude or obliterate a portion of a vascular vessel.
摘要翻译：描述了用于实现血管血管阻塞的装置，方法和系统。经皮手术可用于闭塞和闭塞较大的隐静脉，例如用于治疗由静脉回流引起的静脉曲张病变。某些实施方案包括经由经皮程序展开和填充可充气闭塞装置，从而封闭或消除血管容器的一部分。

22. 发明授权

US07727253B2 Medical grasping device having embolic protection 有权
标题翻译：具有栓塞保护功能的医疗夹具
公开(公告)号：US07727253B2
公开(公告)日：2010-06-01
申请号：US10828094
申请日：2004-04-20
申请人： Andrew J. Ackerman , Roy Greenberg , Krasnodar Ivancev , Ram H. Paul
发明人： Andrew J. Ackerman , Roy Greenberg , Krasnodar Ivancev , Ram H. Paul
IPC分类号： A61M29/00
CPC分类号： A61B17/221 , A61B2017/00867 , A61B2017/22035 , A61B2017/22038 , A61B2017/2215 , A61B2090/08021 , A61F2/95
摘要： A medical grasping device (10) for vascular use, having an outer sheath (12), an elongate control member (50) extending within an outer sheath (12) to a distal tip section (54), and a proximal control assembly (22) including an actuation section (24) joined to the elongate control member (50). Adjacent to the distal tip section (54) is a grasping portion (70, 70′) that is extendable from the outer sheath (12) to create loops (74, 74′) for grasping a target object (T) for repositioning within the vascular system, or for removal from the patient, with loops being retractable into the outer sheath to hold the target object against the device (10) during movement of the device. Elongate control member (50) is preferably a cannula or tube having a lumen (58) extending completely therethrough for placement over a guide wire (28) already in the patient. One or more porous materials (120) are also provided to substantially cover at least one side of the grasping portion (74, 74′) in order to protect against distal embolization of particles which may be dislodged during a procedure using the device (10).
摘要翻译：一种用于血管使用的医疗夹持装置（10），具有外护套（12），在外护套（12）内延伸到远侧末端部分（54））的细长控制构件（50）和近端控制组件）包括连接到细长控制构件（50）的致动部分（24）。远侧末端部分（54）相邻的是抓握部分（70,70'），其可从外护套（12）延伸以产生用于抓握目标物体（T）的环（74,74'），用于重新定位血管系统或用于从患者移除的环，其中环可缩回到外护套中，以在装置移动期间将目标物体抵靠装置（10）保持。细长控制构件（50）优选地是具有完全延伸穿过其中的内腔（58）的插管或管，用于放置在已经在患者体内的引导线（28）上。还提供一个或多个多孔材料（120）以基本上覆盖抓握部分（74,74'）的至少一侧，以便防止在使用装置（10）的过程期间可能被移除的颗粒的远端栓塞。

23. 发明授权

US07670366B2 Intraluminal support device with graft 有权
标题翻译：腔内支持装置与移植物
公开(公告)号：US07670366B2
公开(公告)日：2010-03-02
申请号：US10820918
申请日：2004-04-08
申请人： Brian C. Case , Jacob A. Flagle , Ram H. Paul , Andrew K. Hoffa , Michael L. Garrison , Joseph F. Obermiller
发明人： Brian C. Case , Jacob A. Flagle , Ram H. Paul , Andrew K. Hoffa , Michael L. Garrison , Joseph F. Obermiller
IPC分类号： A61F2/06
CPC分类号： A61F2/2475 , A61F2/2418 , A61F2/848 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0026 , A61F2230/0054 , A61F2230/0095
摘要： Implantable medical devices comprising a support frame and a graft member attached to the support frame. The support frame can define one or more structural features that substantially prevent migration of the graft member along the support frame.
摘要翻译：可植入医疗装置，其包括支撑框架和附接到支撑框架的移植物构件。支撑框架可以限定一个或多个结构特征，其基本上防止移植构件沿着支撑框架的移动。

24. 发明授权

US07527643B2 Exchangeable delivery system for expandable prosthetic devices 有权
标题翻译：用于可扩张假体装置的可交换输送系统
公开(公告)号：US07527643B2
公开(公告)日：2009-05-05
申请号：US11139930
申请日：2005-05-27
申请人： Brain C. Case , Charles W. Agnew , Ram H. Paul
发明人： Brain C. Case , Charles W. Agnew , Ram H. Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/958 , A61F2/95 , A61F2/966
摘要： Exchangeable delivery systems, methods of making delivery systems, and methods of delivering a self-expandable prosthetic device are provided. Delivery systems according to embodiments of the invention include an elongate tubular member defining a passageway with a distal end defining an exchange port, and a distal tip member slideably disposed partially within the distal end of the passageway.
摘要翻译：提供可交换的输送系统，制备输送系统的方法以及递送自膨胀假体装置的方法。根据本发明的实施例的递送系统包括限定具有限定交换口的远端的通道的细长管状构件，以及部分地可滑动地设置在通道的远端内的远侧末端构件。

25. 发明申请

US20080058955A1 PROSTHETIC TESTICLE 审中-公开
标题翻译：假药
公开(公告)号：US20080058955A1
公开(公告)日：2008-03-06
申请号：US11844198
申请日：2007-08-23
申请人： Gary Bradford Shirley , Ram H. Paul , Brian C. Case
发明人： Gary Bradford Shirley , Ram H. Paul , Brian C. Case
IPC分类号： A61F2/02 , A46B11/00
CPC分类号： A61L27/56 , A61F2/0059 , A61F2/022 , A61F2230/0076 , A61F2250/0068 , A61L27/34 , A61L27/3641 , C08L75/04
摘要： A prosthetic testicle is provided that is able to mimic the movement and feel of a natural testicle while at the same time being able to remodel itself into native tissue. Additionally, the prosthetic testicle is able to provide long-term delivery of drugs into the patient.
摘要翻译：提供了一种能够模仿天然睾丸运动和手感的假体睾丸，同时能够将自身改造成天然组织。此外，假体睾丸能够向患者提供药物的长期输送。

26. 发明申请

US20160058538A1 LOW PROFILE INTRALUMINAL FILTERS 有权
标题翻译：低剖面内径过滤器
公开(公告)号：US20160058538A1
公开(公告)日：2016-03-03
申请号：US14839279
申请日：2015-08-28
申请人： Ram H. Paul , Charles W. Agnew
发明人： Ram H. Paul , Charles W. Agnew
IPC分类号： A61F2/01
CPC分类号： A61F2/01 , A61F2002/016 , A61F2210/0014 , A61F2230/0019
摘要： A low profile intraluminal filter includes first and second wire members that define arcuate paths having only a single sigmoidal curve. Connectors join the wire members to form an opening between the wire members. Each connecting member of a plurality of connecting members is connected to the first and second wire members and extends across the opening. The plurality of connecting members provides a plurality of open cells that permit passage of fluid flow through the opening when the filter is deployed within a body vessel.
摘要翻译：薄型管腔内过滤器包括限定仅具有单个S形曲线的弓形路径的第一和第二线构件。连接器连接线构件以在线构件之间形成开口。多个连接构件的每个连接构件连接到第一和第二线构件并延伸穿过开口。多个连接构件提供多个开放单元，当过滤器展开在体内容器内时允许流体流过开口。

27. 发明申请

US20130079867A1 Valve Frame 审中-公开
公开(公告)号：US20130079867A1
公开(公告)日：2013-03-28
申请号：US13681362
申请日：2012-11-19
申请人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul
发明人： Grant T. Hoffman , Sean D. Chambers , Ram H. Paul
IPC分类号： A61F2/24
CPC分类号： A61F2/2475 , A61F2/24 , A61F2/2418 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058
摘要： The disclosure relates to support frames for prosthetic implantable valves. The support frames may include a plurality of symmetrically arrayed interconnected U-shaped member structures. Preferred support frames are tubular structures enclosing a longitudinal axis and including a plurality of U-shaped member structures facing a distal or a proximal end of the support frame. Each U-shaped member structure may be connected to a single longitudinally adjacent U-shaped member facing in an opposite longitudinal direction, as well as two laterally adjacent U-shaped members.

28. 发明授权

US08366761B2 Delivery system with medical device release by evertable sleeve 有权
标题翻译：带可拆卸套管释放医疗器械的输送系统
公开(公告)号：US08366761B2
公开(公告)日：2013-02-05
申请号：US13562674
申请日：2012-07-31
申请人： Ram H. Paul , Brian C. Case , Brian P. Feng , Frances Kristen Bailey
发明人： Ram H. Paul , Brian C. Case , Brian P. Feng , Frances Kristen Bailey
IPC分类号： A61F2/06
CPC分类号： A61F2/95 , A61B17/12109 , A61B17/12131 , A61B2017/12054 , A61B2017/3435 , A61F2/966
摘要： A medical device delivery system has a tubular member defining a passageway and an inner member slideably disposed within the passageway. An expandable intraluminal medical device is disposed on a chamber of the inner member, and an evertable sleeve is attached to the inner member proximal to the chamber and to an inner surface of the tubular member. Relative movement between the tubular and outer members moves the evertable sleeve from a first position substantially overlying the expandable intraluminal medical device to a second position substantially proximal to the chamber.
摘要翻译：医疗装置输送系统具有限定通道的管状构件和可滑动地设置在通道内的内部构件。可扩展的管腔内医疗装置设置在内部构件的腔室上，并且可翻转套筒附接到靠近腔室的内部构件和管状构件的内表面。管状和外部构件之间的相对运动将可翻转套管从基本上覆盖可膨胀管腔内医疗装置的第一位置移动到基本上靠近腔室的第二位置。

29. 发明授权

US07780647B2 Medical device with therapeutic agents 有权
标题翻译：带治疗剂的医疗器械
公开(公告)号：US07780647B2
公开(公告)日：2010-08-24
申请号：US11930722
申请日：2007-10-31
申请人： Ram H. Paul , Daniel J. Sirota , Paul D. Amarant
发明人： Ram H. Paul , Daniel J. Sirota , Paul D. Amarant
IPC分类号： A61M25/00
CPC分类号： A61M25/00 , A61M25/0017 , A61M2025/0057
摘要： A medical device is adapted for at least partial implantation into a body and includes first and second sections along the length of the device. A first therapeutic agent is associated with the first section and a second therapeutic agent is associated with the second section. The first therapeutic agent can be one or more antiproliferative, such as paclitaxel, a paclitaxel derivative, or a paclitaxel pro-drug, anti-coagulant, antithrombotic, thrombolytic, fibrinolytic, or combination thereof. The second therapeutic agent can be one or more antimicrobials, such as one or more antibiotics. Each of the first and second therapeutic agents can either be posited on one or more surfaces of the respective section, or impregnated within the section. The device can include a separator to space the first and second sections. A method of making a medical device and a method of establishing access to a vessel within a body are also provided.
摘要翻译：医疗装置适于至少部分植入体内，并且包括沿着装置长度的第一和第二部分。第一治疗剂与第一部分相关联，第二治疗剂与第二部分相关联。第一种治疗剂可以是一种或多种抗增殖剂，例如紫杉醇，紫杉醇衍生物或紫杉醇前药，抗凝血剂，抗血栓形成剂，溶栓剂，纤维蛋白溶解剂或其组合。第二治疗剂可以是一种或多种抗微生物剂，例如一种或多种抗生素。第一和第二治疗剂中的每一个可以被放置在相应部分的一个或多个表面上，或浸渍在该部分内。该装置可以包括用于分隔第一和第二部分的分离器。还提供了制造医疗装置的方法和建立对体内容器的通路的方法。

30. 发明申请

US20100023114A1 VALVE DEVICE WITH BIASED LEAFLETS 审中-公开
标题翻译：具有偏心叶片的阀装置
公开(公告)号：US20100023114A1
公开(公告)日：2010-01-28
申请号：US12508606
申请日：2009-07-24
申请人： Sean Chambers , Ram H. Paul
发明人： Sean Chambers , Ram H. Paul
IPC分类号： A61F2/06
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2230/0067 , A61F2230/008
摘要： Valve devices useful in the treatment of various valve-related disorders and/or conditions are described. A valve device includes a leaflet and a means for biasing the leaflet in an open configuration. A method of making a valve device comprises the steps of determining a desired closing pressure; determining a desired opening pressure, selecting one or more valve leaflets; selecting an appropriate means for biasing the leaflet in an open configuration based on the determined closing and opening pressures; and attaching the one or more valve leaflets to the means for biasing the leaflet in an open configuration.
摘要翻译：描述了可用于治疗各种与瓣膜相关的疾病和/或病症的瓣膜装置。阀装置包括传单和用于将开口偏压在打开构型中的装置。制造阀装置的方法包括以下步骤：确定期望的关闭压力; 确定期望的打开压力，选择一个或多个瓣膜传单; 基于所确定的关闭和打开压力，选择适当的装置以将所述传单偏置在打开构型中; 以及将所述一个或多个瓣膜小叶附接到用于将所述小叶偏压成打开构型的装置。

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