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21. 发明授权

US08414489B2 Fabrication of multi-sensor arrays 有权
标题翻译：多传感器阵列的制作
公开(公告)号：US08414489B2
公开(公告)日：2013-04-09
申请号：US11034371
申请日：2005-01-12
申请人： Rajiv Shah , Shaun M. Pendo , Rebecca K. Gottlieb , Gil Bruso , Gopikrishnan Soundararajan , Katherine T. Wolfe
发明人： Rajiv Shah , Shaun M. Pendo , Rebecca K. Gottlieb , Gil Bruso , Gopikrishnan Soundararajan , Katherine T. Wolfe
IPC分类号： A61B5/00 , A61B5/05
CPC分类号： A61B5/14532 , A61B5/0031 , A61B5/14865 , A61B5/412 , C12Q1/006
摘要： The disclosure provides methods for fabricating a long-term analyte sensor for measuring at least one analyte in the body of a user. The analyte sensors made by these methods include a plurality of analyte contacting sensor elements and at least one structure for relaying information to and from the sensor. The analyte sensor so fabricated further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.
摘要翻译：本公开提供了制造用于测量使用者身体中的至少一种分析物的长期分析物传感器的方法。通过这些方法制造的分析物传感器包括多个分析物接触传感器元件和用于将信息传递到传感器和从传感器传递信息的至少一个结构。如此制造的分析物传感器还包括至少一个传感器保护膜，该传感器保护膜可以以不同时间使得传感器元件被激活（例如暴露于外部环境）的方式被控制，以延长传感器的使用寿命。在说明性的分析物传感器中，分析物是葡萄糖。

22. 发明授权

US08394463B1 Crosslinking compounds at negative pressures and materials made by such methods 有权
标题翻译：在负压下交联化合物和通过这些方法制备的材料
公开(公告)号：US08394463B1
公开(公告)日：2013-03-12
申请号：US12692001
申请日：2010-01-22
申请人： Chia-Hung Chiu , Marco Sillus , Barry Pham , Ly Phou , Gil Bruso , Christopher R. Enegren , Heath Jensen , Michael Paul Minor , Rajiv Shah
发明人： Chia-Hung Chiu , Marco Sillus , Barry Pham , Ly Phou , Gil Bruso , Christopher R. Enegren , Heath Jensen , Michael Paul Minor , Rajiv Shah
IPC分类号： C08J7/16
CPC分类号： G01N27/3272 , C08J3/246
摘要： Embodiments of the invention provide methods of crosslinking various compounds and materials made by these methods. Materials made by embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本发明的实施方案提供了交联通过这些方法制备的各种化合物和材料的方法。由本发明的实施方案制备的材料包括用于治疗糖尿病的葡萄糖传感器。

23. 发明授权

US08292808B2 Implantable sensor method and system 有权
标题翻译：植入式传感器方法和系统
公开(公告)号：US08292808B2
公开(公告)日：2012-10-23
申请号：US12211783
申请日：2008-09-16
申请人： Michael E. Miller , Rajiv Shah
发明人： Michael E. Miller , Rajiv Shah
IPC分类号： A61B5/00 , A61B5/05 , A61M31/00
CPC分类号： A61B5/6847 , A61B5/0031 , A61B5/04 , A61B5/145 , A61B5/14503 , A61B5/14532 , A61B5/14552 , A61B5/14865 , A61B5/6882 , A61B17/3468 , A61M1/1698 , A61M5/14276 , A61M5/1723 , A61M2230/20 , A61M2230/201 , G06F19/00
摘要： Systems and methods for non-vascular sensor implantation and for measuring physiological parameters in areas of a body where the physiological parameters are heterogeneous. An implant unit is implanted in an area of a body and a foreign body capsule is allowed to form around the implant unit area. A sensor may be directed into a body cavity such as, for example, the peritoneal space, subcutaneous tissues, the foreign body capsule, or other area. A subcutaneous area of the body may be tunneled for sensor placement. Spatially separated sensing elements may be used for detecting individual amounts of the physiological parameter. An overall amount of the physiological parameter may be determined by calculating a statistical measurement of the individual sensed amounts in the area. Another embodiment of the invention, a multi-analyte measuring device, may include a substrate having an electrode array on one side and an integrated circuit on another side.
摘要翻译：用于非血管传感器植入和用于测量生理参数异质的身体的生理参数的系统和方法。植入单元植入身体的一个区域，允许在植入单元区域周围形成异物胶囊。传感器可以被引导到诸如腹膜空间，皮下组织，异物胶囊或其他区域的体腔中。身体的皮下区域可以被隧道用于传感器放置。空间分离的感测元件可用于检测生理参数的各个量。生理参数的总量可以通过计算该区域中各个感测量的统计测量来确定。本发明的多分析物测量装置的另一实施例可以包括在一侧具有电极阵列的基板和在另一侧的集成电路。

24. 发明授权

US08249683B2 Real-time self-calibrating sensor system and method 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US08249683B2
公开(公告)日：2012-08-21
申请号：US12826497
申请日：2010-06-29
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

25. 发明申请

US20110184380A1 SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY 有权
标题翻译：用于提供封闭环路输注配方交付的系统和方法
公开(公告)号：US20110184380A1
公开(公告)日：2011-07-28
申请号：US13009531
申请日：2011-01-19
申请人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： TIMOTHY J. STARKWEATHER , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.
摘要翻译：一种用于提供闭环输注制剂递送的系统和方法，其通过调整算法的可编程控制参数，基于感测到的生物学状态来精确地计算输送量。该算法计算具有比例，导数和基础速率分量的传送量。可以实时调整控制参数以补偿由日常事件导致的感测生物学状态的变化。交付量的安全限制可能包含在算法中。该算法可以由处理控制器内的计算元件执行，用于控制闭环灌注制剂递送。生物状态由感测装置感测到，该感测装置向控制器提供信号。所述控制器基于所述信号计算输注制剂输送量，并将命令发送到输送由所述命令确定的输注制剂量的输注制剂输送装置。

26. 发明申请

US20110112506A1 SYSTEM AND METHOD FOR PROVIDING CLOSED LOOP INFUSION FORMULATION DELIVERY 有权
公开(公告)号：US20110112506A1
公开(公告)日：2011-05-12
申请号：US13009519
申请日：2011-01-19
申请人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
发明人： Timothy J. Starkweather , Ronald J. Lebel , Rajiv Shah , Michael E. Miller
IPC分类号： A61M5/168
CPC分类号： A61M5/1723 , A61M5/172 , A61M2005/14208 , A61M2230/201 , G06F19/00 , G06F19/3468 , G16H50/30
摘要： A system and method for providing closed loop infusion formulation delivery which accurately calculates a delivery amount based on a sensed biological state by adjusting an algorithm's programmable control parameters. The algorithm calculates a delivery amount having proportional, derivative, and basal rate components. The control parameters may be adjusted in real time to compensate for changes in a sensed biological state that may result from daily events. Safety limits on the delivery amount may be included in the algorithm. The algorithm may be executed by a computing element within a process controller for controlling closed loop infusion formulation delivery. The biological state is sensed by a sensing device which provides a signal to the controller. The controller calculates an infusion formulation delivery amount based on the signal and sends commands to an infusion formulation delivery device which delivers an amount of infusion formulation determined by the commands.

27. 发明申请

US20110082356A1 ANALYTE SENSOR APPARATUSES HAVING INTERFERENCE REJECTION MEMBRANES AND METHODS FOR MAKING AND USING THEM 审中-公开
标题翻译：具有干扰抑制膜的分析仪传感器装置及其制造和使用方法
公开(公告)号：US20110082356A1
公开(公告)日：2011-04-07
申请号：US12572087
申请日：2009-10-01
申请人： Qingling Yang , Rajiv Shah , Megan E. Little , Chia-Hung Chiu
发明人： Qingling Yang , Rajiv Shah , Megan E. Little , Chia-Hung Chiu
IPC分类号： A61B5/1473 , G01N27/26 , C12Q1/26 , B05D3/00 , C08F120/26 , C08G73/00 , C08L33/10 , C09D133/10
CPC分类号： C12Q1/006 , Y02P20/582
摘要： Embodiments of the invention provide amperometric analyte sensors having optimized elements such as interference rejection membranes as well as methods for making and using such sensors. While embodiments of the innovation can be used in a variety of contexts, typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本发明的实施例提供了具有优化元件的电流分析传感器，例如干扰抑制膜以及制造和使用这种传感器的方法。尽管可以在多种情况下使用创新的实施例，但是本发明的典型实施例包括用于糖尿病管理的葡萄糖传感器。

28. 发明申请

US20100331647A1 LONG TERM ANALYTE SENSOR ARRAY 有权
标题翻译：长期分析仪传感器阵列
公开(公告)号：US20100331647A1
公开(公告)日：2010-12-30
申请号：US12503753
申请日：2009-07-15
申请人： Rajiv Shah , Rebecca K. Gottlieb , Eric A. Grovender , Shaun M. Pendo , Paul Citron , William P. Van Antwerp
发明人： Rajiv Shah , Rebecca K. Gottlieb , Eric A. Grovender , Shaun M. Pendo , Paul Citron , William P. Van Antwerp
IPC分类号： A61B5/1468
CPC分类号： A61B5/14865 , A61B5/14532 , A61B5/412 , G01N33/5438
摘要： A long term analyte sensor for measuring at least one analyte in the body of a user and which includes a housing, a plurality of analyte contacting sensor elements and at least one structure for relaying information away from the sensor. This plurality of analyte contacting sensor elements are typically disposed in an array. The analyte sensor further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.
摘要翻译：一种用于测量使用者身体中的至少一种分析物的长期分析物传感器，其包括壳体，多个分析物接触传感器元件和用于将信息远离传感器中继的至少一个结构。该多个分析物接触传感器元件通常以阵列方式设置。分析物传感器还包括至少一个传感器保护膜，该传感器保护膜可以以不同时间使传感器元件被激活（例如暴露于外部环境）的方式被控制，以便延长传感器的使用寿命。在说明性的分析物传感器中，分析物是葡萄糖。

29. 发明授权

US07774038B2 Real-time self-calibrating sensor system and method 有权
标题翻译：实时自校准传感器系统及方法
公开(公告)号：US07774038B2
公开(公告)日：2010-08-10
申请号：US11323216
申请日：2005-12-30
申请人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
发明人： Lu Wang , Rajiv Shah , Wayne A. Morgan , Barry Keenan
IPC分类号： A61B5/05 , A61B5/00 , G01N33/50 , G01N33/487
CPC分类号： A61B5/1495 , A61B5/0031 , A61B5/14532 , A61B5/1468 , A61B5/1473 , A61B5/14865 , A61B2560/0223 , A61M2005/1726
摘要： A system and method for calibrating a sensor of a characteristic monitoring system in real time utilizes a self-calibration module for periodic determination of, and compensation for, the IR drop across unwanted resistances in a cell. A current-interrupt switch is used to open the self-calibration module circuit and either measure the IR drop using a high-frequency (MHz) ADC module, or estimate it through linear regression of acquired samples of the voltage across the sensor's working and reference electrodes (Vmeasured) over time. The IR drop is then subtracted from the closed-circuit value of Vmeasured to calculate the overpotential that exists in the cell (Vimportant). Vimportant may be further optimized by subtracting the value of the open-circuit voltage (Voc) across the sensor's working and reference electrodes. The values of Vmeasured and Vimportant are then controlled by respective first and second control units to compensate for the IR drop.
摘要翻译：用于校准特征监测系统的传感器的系统和方法实时地利用自校准模块来周期性地确定和补偿细胞中不需要的电阻的IR降。使用电流中断开关来打开自校准模块电路，并使用高频（MHz）ADC模块测量IR降压，或通过传感器工作和参考电压的采集样本的线性回归进行估计电极（Vmeasured）随着时间的推移。然后从Vmeasured的闭路电流值中减去IR降，以计算存在于电池（Vimportant）中的超电势。可以通过减去传感器的工作参考电极和参考电极之间的开路电压（Voc）的值来进一步优化V重量。然后由相应的第一和第二控制单元控制V测量和V重量的值以补偿IR下降。

30. 发明申请

US20100030045A1 ANALYTE SENSOR APPARATUSES COMPRISING MULTIPLE IMPLANTABLE SENSOR ELEMENTS AND METHODS FOR MAKING AND USING THEM 有权
标题翻译：包含多个可植入传感器元件的分析传感器装置及其制造和使用方法
公开(公告)号：US20100030045A1
公开(公告)日：2010-02-04
申请号：US12184117
申请日：2008-07-31
申请人： Rebecca K. Gottlieb , Rajiv Shah , Eric Allan Larson , Chia Chiu
发明人： Rebecca K. Gottlieb , Rajiv Shah , Eric Allan Larson , Chia Chiu
IPC分类号： A61B5/1473
CPC分类号： A61B5/14532 , A61B5/1473 , A61B5/14865 , A61B5/6848 , A61B5/6849 , C12Q1/006
摘要： Embodiments of the invention provide analyte sensors having optimized elements and/or configurations of elements as well as methods for making and using such sensors. Typical embodiments of the invention include glucose sensors used in the management of diabetes.
摘要翻译：本发明的实施例提供了具有优化的元件和/或元件构造的分析物传感器以及用于制造和使用这种传感器的方法。本发明的典型实施方案包括用于治疗糖尿病的葡萄糖传感器。

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