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21. 发明申请

US20050090748A1 Methods and apparatus for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
标题翻译：将物质或器械急性或慢性传播至血管外治疗部位的方法和装置
公开(公告)号：US20050090748A1
公开(公告)日：2005-04-28
申请号：US10458153
申请日：2003-06-10
申请人： Joshua Makower , Theodore Lamson , J. Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
发明人： Joshua Makower , Theodore Lamson , J. Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
IPC分类号： A61M31/00 , A61B17/00 , A61B17/12 , A61B18/24 , A61M5/14 , A61M25/00 , A61M25/01 , A61M25/06 , A61B8/14
CPC分类号： A61M25/065 , A61B17/00491 , A61B17/0057 , A61B17/12022 , A61B17/12109 , A61B17/12122 , A61B17/12136 , A61B17/12186 , A61B18/24 , A61B2017/00243 , A61B2017/00247 , A61B2017/00575 , A61B2018/00392 , A61M25/0069 , A61M25/0084 , A61M25/0102 , A61M2025/018
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).
摘要翻译：用于将物质或装置输送到位于人或动物患者体内的血管外的位置的方法和装置。将血管壁穿透导管插入脉管系统中，定位并定向在目标血管外部位附近的血管内，并且穿透器从导管前进，以便沿目标部位的方向向外穿过血管壁。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，穿透器可以缩回到穿过导管的血管壁中，并且可以移除穿透导管的血管壁，使输送导管留在适当位置，以便将物质慢慢地或连续地递送到和/或获得信息或样品从目标网站。或者，具有闭塞构件或气囊的输送导管可以推入静脉或小静脉中，并且阻塞构件或气囊可以在通过导管注射物质期间和之后用于闭塞静脉或小静脉的内腔，使得该物质不会被正常的静脉血流带走，并将在静脉或小静脉中保持足够的时间以达到其预期效果（例如，通过由该静脉或小静脉排出的毛细血管床进入相邻组织）。

22. 发明授权

US08672920B2 Devices, systems and methods for acute or chronic delivery of substances or apparatus to extravascular treatment sites 有权
标题翻译：用于急性或慢性传播物质或器械至血管外治疗部位的装置，系统和方法
公开(公告)号：US08672920B2
公开(公告)日：2014-03-18
申请号：US11927888
申请日：2007-10-30
申请人： Joshua Makower , Theodore Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
发明人： Joshua Makower , Theodore Lamson , J. Christopher Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
IPC分类号： A61M31/00
CPC分类号： A61M25/0108 , A61B6/12 , A61M5/007 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2210/12
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessel lumens. A penetrating catheter is inserted into a blood vessel lumen and a penetrator is advanced from the catheter in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the delivery catheter may remain in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member may be advanced into a vein or venule and used to occlude the lumen of the vein or venule during and after injection of a substance such that the substance will not be carried away by normal venous blood flow.
摘要翻译：用于将物质或设备运送到位于血管内腔外的靶位置的方法和装置。将穿透性导管插入血管内腔中，并且穿透器沿导向器朝向目标部位的方向前进。此后，输送导管穿过穿透器的内腔到目标部位。然后将所需的物质或装置输送到目标部位或从目标部位获得。在一些应用中，输送导管可以保持在适当位置以便从目标部位慢慢或连续地输送物质到和/或获得信息或样品。或者，具有闭塞构件的输送导管可以推入静脉或小静脉中，并用于在注射物质期间和之后闭塞静脉或小静脉的内腔，使得物质不会被正常的静脉血流带走。

23. 发明申请

US20080058759A1 Devices, Systems and Methods for Acute or Chronic Delivery of Substances or Apparatus to Extravascular Treatment Sites 审中-公开
公开(公告)号：US20080058759A1
公开(公告)日：2008-03-06
申请号：US11927874
申请日：2007-10-30
申请人： Joshua Makower , Theodore Lamson , J. Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
发明人： Joshua Makower , Theodore Lamson , J. Flaherty , John Reggie , John Chang , Joseph Catanese , David Tholfsen
IPC分类号： A61M31/00 , A61M25/00 , A61M25/02 , A61M25/098
CPC分类号： A61M25/0108 , A61B6/12 , A61M5/007 , A61M25/0084 , A61M2025/0086 , A61M2025/0087 , A61M2025/009 , A61M2210/12
摘要： Methods and apparatus for delivery of substances or apparatus to target sites located outside blood vessels within the body of a human or animal patient. A vessel wall penetrating catheter is inserted into the vasculature, positioned and oriented within a blood vessel near the target extravascular site and a penetrator is advanced from the catheter so as to penetrate outwardly through the wall of the blood vessel in the direction of the target site. Thereafter, a delivery catheter is passed through a lumen of the penetrator to the target site. A desired substance or apparatus is then delivered to or obtained from the target site. In some applications, the penetrator may be retracted into the vessel wall penetrating catheter and the vessel wall penetrating catheter may be removed, leaving the delivery catheter in place for chronic or continuous delivery of substance(s) to and/or obtaining of information or samples from the target site. Alternatively, a delivery catheter having an occlusion member or balloon may be advanced into a vein or venule and the occlusion member or balloon may be used to occlude the lumen of the vein or venule during and after injection of a substance through the catheter, such that the substance will not be carried away by normal venous blood flow and will remain in the vein or venule for a sufficient period of time to have its intended effect (e.g. to enter adjacent tissues through capillary beds drained by that vein or venule).

24. 发明申请

US20050007501A1 Visual management system 有权
标题翻译：视觉管理系统
公开(公告)号：US20050007501A1
公开(公告)日：2005-01-13
申请号：US10861237
申请日：2004-06-04
申请人： Joseph Catanese , Paul Delano
发明人： Joseph Catanese , Paul Delano
IPC分类号： H04N5/445 , H04N5/45 , H04N5/64 , H04N9/74
CPC分类号： H04N5/45 , H04N5/445 , H04N5/44591 , H04N21/42653 , H04N21/4312 , H04N21/4316 , H04N21/4438
摘要： A process for dividing an electronic screen, such as a television or computer screen, into discrete, independently operating sub-screens includes the step of electronically linking the screen to a screen operating system. This operating system is capable of selectively dividing the screen into two or more sub-screens which support audio or visual data in an active mode simultaneously and independently. This is performed through the use of a plurality of data access lines which provide data simultaneously to the two or more sub-screens such that the data can be simultaneously accessed and manipulated in more than one sub-screen such that each sub-screen actively supports data generated from a dedicated software program. Such invention may be implemented in customized encoded hardware or a combination of hardware and software.
摘要翻译：将电子屏幕（例如电视或计算机屏幕）分割成离散的，独立操作的子屏幕的过程包括将屏幕电子连接到屏幕操作系统的步骤。该操作系统能够有选择地将屏幕分成两个或更多个子屏幕，这些子屏幕以活动模式同时且独立地支持音频或视觉数据。这通过使用多个数据访问线来执行，这些数据访问线同时向两个或多个子屏幕提供数据，使得可以在多于一个子屏幕中同时访问和操纵数据，使得每个子屏幕主动地支持从专用软件程序生成的数据。这样的发明可以在定制的编码硬件或硬件和软件的组合中实现。

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