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    • 22. 发明申请
    • BCL-2 DNAZYMES
    • WO2002099090A1
    • 2002-12-12
    • PCT/AU2002/000739
    • 2002-06-07
    • JOHNSON & JOHNSON RESEARCH PTY LTDSUN, Lun-QuanWANG, LiTURNER, Rachel, JaneSARAVOLAC, Edward, GeorgeDASS, Crispin, Rajnish
    • SUN, Lun-QuanWANG, LiTURNER, Rachel, JaneSARAVOLAC, Edward, GeorgeDASS, Crispin, Rajnish
    • C12N9/00
    • C12N15/1135C12N2310/12
    • The present invention provides DNAzymes which specifically cleaves mRNA transcribed from a member of the bcl-2 gene family selected from the group consisting of bcl-2, bcl-xl, bcl-w, bfl-1, brag-1, Mcl-1 and A1. The DNAzymes comprise (a) a catalytic domain that has the nucleotide sequence GGCTAGCTACAACGA (SEQ ID NO.1) and cleaves mRNA at any purine: pyrimidine cleavage site at which it is directed, (b) a binding domain contiguous with the 5' end of the catalytic domain, and (c) another binding domain contiguous with the 3' end of the catalytic domain. The binding domains are complementary to, and therefore hybridise with, the two regions immediately flanking the purine residue of the cleavage site within the bcl-2 gene family mRNA, at which DNAzyme-catalysed cleavage is desired. Each binding domain is at least six nucleotides in length, and both binding domains have a combined total length of at least 14 nucleotides.
    • 本发明提供了特异性切割从bcl-2基因家族成员转录的mRNA的DNA酶,其选自bcl-2,bcl-xl,bcl-w,bfl-1,brag-1,Mcl-1和 A1。 DNAzymes包含(a)具有核苷酸序列GGCTAGCTACAACGA(SEQ ID NO.1)的催化结构域,并在任何嘌呤:其所针对的嘧啶切割位点处切割mRNA,(b)与5'端连接的结合结构域 的催化结构域,和(c)与催化结构域的3'末端相邻的另一个结合结构域。 结合结构域与bcl-2基因家族mRNA内的切割位点的嘌呤残基紧邻的两个区域互补,并因此杂交,需要DNA酶催化切割。 每个结合结构域的长度至少为6个核苷酸,两个结合结构域的总长度至少为14个核苷酸。
    • 23. 发明申请
    • MEDICAL TREATMENT DEVICES HAVING ADJUSTABLE LENGTH AND/OR DIAMETER
    • 具有可调节长度和/或直径的医疗处理装置
    • WO2015042900A1
    • 2015-04-02
    • PCT/CN2013/084564
    • 2013-09-29
    • COVIDIEN LPWANG, Li
    • WANG, LiONG, Jiun KeatHONG, Chunlang
    • A61B18/14
    • A61B18/082A61B18/10A61B18/1492A61B2018/00178A61B2018/00404A61B2018/00577A61B2018/00702A61B2018/00791A61B2018/00827A61B2018/00875A61B2018/00988A61B2018/1435A61B2018/1495
    • A medical treatment device (10) having an adjustable length and /or diameter is disclosed. The medical treatment device (10) comprises: a catheter having an elongate flexible shaft (12) with a proximal end (14) and a distal end (13); a first electrically resistive heating element (92) having a first outer diameter and disposed at the distal end (13) of the shaft (12); first electrical contacts (98) on the catheter shaft (12); a second electrically resistive heating element (100) having a second, lager, outer diameter and connectable to the shaft to at least partially surround the first electrically resistive heating element (92) and having second electrical contacts (102) connectable to the first electrical contacts (92). The device enables the length and /or diameter of the heating segment to be adjusted during a treatment procedure without a need to interrupt the procedure and thereby allows a single catheter to be used at different location in a hollow anatomical structure.
    • 公开了一种具有可调长度和/或直径的医疗装置(10)。 医疗装置(10)包括:导管,其具有带有近端(14)和远端(13)的细长柔性轴(12)。 第一电阻加热元件(92),其具有第一外径并设置在所述轴(12)的远端(13)处; 导管轴(12)上的第一电触点(98); 第二电阻加热元件(100),其具有第二较大的外径并且可连接到所述轴以至少部分地围绕所述第一电阻加热元件(92)并且具有可连接到所述第一电触头的第二电触点(102) (92)。 该装置能够在治疗过程中调节加热段的长度和/或直径,而不需要中断该过程,从而允许在中空解剖结构中的不同位置使用单个导管。
    • 26. 发明申请
    • A SENSOR ARRANGEMENT
    • 传感器布置
    • WO2011028185A1
    • 2011-03-10
    • PCT/SG2010/000331
    • 2010-09-07
    • AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCHHAN, GuchangQIU, JinjunWANG, LiYEO, Wee KayWANG, Chenchen
    • HAN, GuchangQIU, JinjunWANG, LiYEO, Wee KayWANG, Chenchen
    • G11B5/133G11B5/33G11B11/14
    • G11B5/3954B82Y10/00B82Y25/00G11B2005/3996
    • In an embodiment, a sensor arrangement may be provided. The sensor arrangement may include a sensor including a first spin valve. The first spin valve may include a first free layer structure; a first pinning structure disposed over the first free layer structure; and a first anti-ferromagnetic layer disposed over the first pinning structure. The sensor may further include a second spin valve. The second spin valve may include a second free layer structure; a second pinning structure disposed over the second free layer structure; and a second anti-ferromagnetic layer disposed over the second pinning structure. The sensor may also include a separator structure positioned between the first spin valve and the second spin valve such that the separator structure may be in contact with the first free layer structure and the second free layer structure. The first pinning structure may include an odd number of first ferromagnetic layers and the second pinning structure may include an even number of second ferromagnetic layers so as to enable the sensor to provide a differential signal when a current flows through the sensor.
    • 在一个实施例中,可以提供传感器装置。 传感器装置可包括包括第一自旋阀的传感器。 第一自旋阀可以包括第一自由层结构; 设置在所述第一自由层结构上的第一钉扎结构; 以及设置在所述第一钉扎结构上的第一反铁磁层。 传感器还可以包括第二自旋阀。 第二自旋阀可以包括第二自由层结构; 设置在所述第二自由层结构上的第二钉扎结构; 以及设置在第二钉扎结构上的第二反铁磁层。 传感器还可以包括位于第一自旋阀和第二自旋阀之间的分离器结构,使得分离器结构可以与第一自由层结构和第二自由层结构接触。 第一钉扎结构可以包括奇数个第一铁磁层,并且第二钉扎结构可以包括偶数个第二铁磁层,以便当电流流过传感器时能够使传感器提供差分信号。
    • 30. 发明申请
    • SEMICONDUCTOR LIGHT-EMITTING DEVICE WITH PASSIVATION LAYER
    • 具有钝化层的半导体发光器件
    • WO2010020067A1
    • 2010-02-25
    • PCT/CN2008/001491
    • 2008-08-19
    • LATTICE POWER (JIANGXI) CORPORATIONJIANG, FengyiLIU, JunlinWANG, Li
    • JIANG, FengyiLIU, JunlinWANG, Li
    • H01L33/12
    • H01L33/44H01L33/0079
    • A light-emitting device and method for the fabrication thereof. The device includes a substrate, a first doped semiconductor layer situated above the substrate, a second doped semiconductor layer situated above the first doped semiconductor layer, and a multi-quantum-well (MQW) situated between the first and the second doped semiconductor layers. The device also includes a first electrode coupled to the first doped semiconductor layer and a second electrode coupled to the second doped semiconductor layer. The device further includes a first passivation layer which substantially covers the sidewalls of the first and second doped semiconductor layers, the MQW active layer, and the part of the horizontal surface of the second doped semiconductor layer which is not covered by the second electrode. The first passivation layer is formed through an oxidation technique. The device further includes a second passivation layer overlaying the first passivation layer.
    • 一种发光装置及其制造方法。 该器件包括衬底,位于衬底上方的第一掺杂半导体层,位于第一掺杂半导体层上方的第二掺杂半导体层以及位于第一和第二掺杂半导体层之间的多量子阱(MQW)。 该器件还包括耦合到第一掺杂半导体层的第一电极和耦合到第二掺杂半导体层的第二电极。 该器件还包括第一钝化层,其基本上覆盖第一和第二掺杂半导体层的侧壁,MQW有源层以及第二掺杂半导体层的未被第二电极覆盖的部分水平表面。 第一钝化层通过氧化技术形成。 该器件还包括覆盖第一钝化层的第二钝化层。