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21. 发明申请

US20110245315A1 INDOLYL OR INDOLINYL HYDROXAMATE COMPOUNDS 有权
标题翻译：吲哚或吲哚啉酸羟化物化合物
公开(公告)号：US20110245315A1
公开(公告)日：2011-10-06
申请号：US13074312
申请日：2011-03-29
申请人： Ching-Shih Chen , Jing-Ping Liou , Hsing-Jin Liu , Kuo-Sheng Hung , Pei-Wen Shan , Wen-Ta Chiu , Che-Ming Teng
发明人： Ching-Shih Chen , Jing-Ping Liou , Hsing-Jin Liu , Kuo-Sheng Hung , Pei-Wen Shan , Wen-Ta Chiu , Che-Ming Teng
IPC分类号： A61K31/4045 , C07D209/08 , A61P35/00
CPC分类号： C07D209/08 , C07D209/12 , C07D209/18 , C07D209/30 , C07D209/40
摘要： Indolyl or indolinyl compounds of formula (I): wherein bond, n, R1, R2, R3, R4, R5, and R6, are defined herein. Also disclosed is a method for treating cancer with these compounds.
摘要翻译：式（I）的吲哚基或二氢吲哚基化合物：其中键，n，R 1，R 2，R 3，R 4，R 5和R 6在本文中定义。还公开了用这些化合物治疗癌症的方法。

22. 发明申请

US20100168184A1 SMALL MOLECULE BCL-X1/BCL-2 BINDING INHIBITORS 失效
标题翻译：小分子BCL-X1 / BCL-2结合抑制剂
公开(公告)号：US20100168184A1
公开(公告)日：2010-07-01
申请号：US12652456
申请日：2010-01-05
申请人： Ching-Shih Chen , Chung-Wai Shiau
发明人： Ching-Shih Chen , Chung-Wai Shiau
IPC分类号： A61K31/352 , A61K31/427 , A61K31/4439 , A61K31/426 , A61P35/00
CPC分类号： C07D417/12 , C07D277/34 , C07D311/58 , C07D417/14
摘要： Bcl-xL/Bcl-2 binding inhibitors useful in the treatment of unwanted proliferating cells, including cancers and precancers, in subjects in need of such treatment. Also provided are methods of treating a subject having unwanted proliferating cells comprising administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject in need of such treatment. Also provided are methods of preventing the proliferation of unwanted proliferating cells, such as cancers and precancers, in a subject comprising the step of administering a therapeutically effective amount of a Bcl-xL/Bcl-2 binding inhibitor described herein to a subject at risk of developing a condition characterized by unwanted proliferating cells.
摘要翻译： Bcl-xL / Bcl-2结合抑制剂可用于治疗需要这种治疗的受试者中不需要的增殖细胞，包括癌症和预处理剂。还提供了治疗具有不想要的增殖细胞的受试者的方法，包括向需要这种治疗的受试者施用治疗有效量的本文所述的Bcl-xL / Bcl-2结合抑制剂。还提供了防止不想要的增殖细胞如癌症和预处理剂在受试者中增殖的方法，包括将治疗有效量的本文所述的Bcl-xL / Bcl-2结合抑制剂施用于患有风险的受试者的步骤发展以不想要的增殖细胞为特征的病症。

23. 发明申请

US20090170865A1 Treatment of Prostate Cancer with Angiogenesis-Targeting Quinazoline-Based Anti-Cancer Compounds 审中-公开
标题翻译：用血管发生靶向喹唑啉类抗癌化合物治疗前列腺癌
公开(公告)号：US20090170865A1
公开(公告)日：2009-07-02
申请号：US12323073
申请日：2008-11-25
申请人： Natasha Kyprianou , Jason B. Garrison , Ching-Shih Chen
发明人： Natasha Kyprianou , Jason B. Garrison , Ching-Shih Chen
IPC分类号： A61K31/517 , C12N5/06
CPC分类号： A61K31/517
摘要： Provided is a method of inhibiting the growth of prostate cancer cells comprising administering an effective amount of DZ-50 (2-[4-biphenyl-4-sulfonyl)-piperazin-1-yl]-6,7-diisopropoxyquinazolin-4-yl-amine) to a patient in need thereof. In another aspect, a method is provided for inhibiting the initiation of prostate cancer comprising administering an effective amount of DZ-50 to a patient in need thereof. In yet another aspect, a method is provided for inhibiting the formation of a prostate tumor-derived metastatic lesion comprising administering an effective amount of DZ-50 to a patient in need thereof. In any of the aforementioned methods, a quinazoline-based drug which induces apoptosis of a prostate cancer cell may be coadministered with DZ-50. Also provided is a composition comprising DZ-50, a quinazoline-based drug which induces apoptosis of a prostate cancer cell, and a pharmaceutically acceptable carrier.
摘要翻译：提供了抑制前列腺癌细胞生长的方法，其包括给予有效量的DZ-50（2- [4-联苯-4-磺酰基] - 哌嗪-1-基] -6,7-二异丙氧基喹唑啉-4-基 - 胺）给有需要的患者。另一方面，提供了一种抑制前列腺癌起始的方法，包括向有需要的患者施用有效量的DZ-50。在另一方面，提供了一种用于抑制前列腺肿瘤衍生的转移性病变的形成的方法，包括向有需要的患者施用有效量的DZ-50。在任何上述方法中，诱导前列腺癌细胞凋亡的基于喹唑啉的药物可以与DZ-50共同施用。还提供了包含诱导前列腺癌细胞凋亡的基于喹唑啉的药物DZ-50和药学上可接受的载体的组合物。

24. 发明申请

US20090048265A1 NOVEL ANTITUMOR AGENTS AND METHODS OF THEIR USE 有权
标题翻译：新型抗菌剂及其使用方法
公开(公告)号：US20090048265A1
公开(公告)日：2009-02-19
申请号：US11570966
申请日：2005-06-17
申请人： Ching-Shih Chen , Yeng-Jeng Shaw
发明人： Ching-Shih Chen , Yeng-Jeng Shaw
IPC分类号： A61K31/517 , C07D239/95 , C07D403/04 , A61P35/00
CPC分类号： A61K31/7072 , C07D239/95 , C07D405/12 , C07D409/12
摘要： Antitumor compounds based on the α1-adrenoceptor antagonist, doxazosin, as well as compositions and methods of use. The disclosed compounds induce apoptosis in cancer cells.
摘要翻译：基于α1-肾上腺素受体拮抗剂的抗肿瘤化合物，多沙唑嗪，以及组合物和使用方法。所公开的化合物诱导癌细胞凋亡。

25. 发明申请

US20080146815A1 PDK-1/AKT SIGNALING INHIBITORS 有权
标题翻译： PDK-1 / AKT信号抑制剂
公开(公告)号：US20080146815A1
公开(公告)日：2008-06-19
申请号：US11864612
申请日：2007-09-28
申请人： Ching-Shih Chen
发明人： Ching-Shih Chen
IPC分类号： C07D257/04 , C07D231/10
CPC分类号： C07D231/12
摘要： A new class of phosphoinositide-dependent kinase-1 (PDK-1) inhibitors of formula I: wherein X is selected from the group consisting of alkyl and haloalkyl; Ar is an aryl radical selected from the group consisting of phenyl, biphenyl, naphthyl, anthryl, phenanthryl, and fluorenyl; and wherein Ar is optionally substituted with one or more radicals selected from the group consisting of halo, C1-C4 alkyl, C1-C4 haloalkyl, azido, C1-C4 azidoalkyl, aryl, alkylaryl, haloaryl, haloalkylaryl, and combinations thereof, and R is selected from the group consisting of nitrile, acetonitrile, ethylnitrile, propylnitrile, carboxamide, amidine, tetrazole, oxime, hydrazone, acetamidine, aminoacetamide, guanidine, and urea. Also provided are methods of using the compounds for the treatment and prevention of cancer in humans.
摘要翻译：新型的式I的磷酸肌醇依赖性激酶-1（PDK-1）抑制剂：其中X选自烷基和卤代烷基; Ar是选自苯基，联苯基，萘基，蒽基，菲基和芴基的芳基; 并且其中Ar任选被一个或多个选自以下的基团取代：卤素，C 1 -C 4烷基，C 1〜 C 4卤代烷基，叠氮基，C 1 -C 4 - 叠氮基烷基，芳基，烷基芳基，卤代芳基，卤代烷基芳基及其组合，并且选择R 腈，乙腈，丙腈，甲酰胺，脒，四唑，肟，腙，乙脒，氨基乙酰胺，胍和尿素组成的组。还提供了使用该化合物治疗和预防人类癌症的方法。

26. 发明申请

US20060142368A1 Compounds and methods for inducing apoptosis in proliferating cells 审中-公开
标题翻译：用于诱导增殖细胞凋亡的化合物和方法
公开(公告)号：US20060142368A1
公开(公告)日：2006-06-29
申请号：US11354528
申请日：2006-02-15
申请人： Ching-Shih Chen , Xueqin Song , Ho-Pi Lin
发明人： Ching-Shih Chen , Xueqin Song , Ho-Pi Lin
IPC分类号： A61K31/415
CPC分类号： A61K31/415
摘要： Compounds useful for inducing apoptosis in proliferative cells, particularly cancer cells, including but not limited to prostate cancer, leukemia, non-small cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, bladder cancer, lymphoma, and breast cancer. These compounds are particularly useful in the treatment of androgen-independent cancers, including hormone-refractory prostate cancer. Further provided are methods of treating cancer in a subject in need of such treatment using the compounds of the present invention. Further provided are methods for using the compounds of the present invention to treat, inhibit, or delay the onset of cancer in a subject. Further provided are methods of inducing apoptosis in rapidly proliferating cells, particularly, though not necessarily cancer cells, using the compounds of the present invention.
摘要翻译：包括但不限于前列腺癌，白血病，非小细胞肺癌，结肠癌，CNS癌，黑素瘤，卵巢癌，肾癌，膀胱癌，淋巴瘤和增殖细胞中的诱导细胞凋亡的化合物，乳腺癌。这些化合物特别可用于治疗与雄激素无关的癌症，包括激素难治性前列腺癌。还提供了使用本发明的化合物治疗需要这种治疗的受试者的癌症的方法。还提供了使用本发明化合物治疗，抑制或延迟受试者的癌症发作的方法。还提供了使用本发明的化合物诱导快速增殖的细胞，特别是尽管不一定是癌细胞的细胞凋亡的方法。

27. 发明授权

US07026346B2 Compounds and methods for inducing apoptosis in proliferating cells 失效
公开(公告)号：US07026346B2
公开(公告)日：2006-04-11
申请号：US10409502
申请日：2003-04-08
申请人： Ching-Shih Chen , Xueqin Song , Ho-Pi Lin
发明人： Ching-Shih Chen , Xueqin Song , Ho-Pi Lin
IPC分类号： A61K31/415 , C07D231/10
CPC分类号： C07D231/12 , C07D261/08 , C07D263/38 , C07D307/58 , C07D333/18 , C07D401/04 , C07D403/04 , C07D405/04 , C07D409/04
摘要： Compounds useful for inducing apoptosis in proliferative cells, particularly cancer cells, including but not limited to prostate cancer, leukemia, non-smalll cell lung cancer, colon cancer, CNS cancer, melanoma, ovarian cancer, renal cancer, bladder cancer, lymphoma, and breast cancer. These compounds are particularly useful in the treatment of androgen-independent cancers, including hormone-refractory prostate cancer. Further provided are methods of treating cancer in a subject in need of such treatment using the compounds of the present invention. Further provided are methods for using the compounds of the present invention to treat, inhibit, or delay the onset of cancer in a subject. Further provided are methods of inducing apoptosis in rapidly proliferating cells, particularly, though not necessarily cancer cells, using the compounds of the present invention.

28. 发明授权

US5507413A Automatic liquid soap dispenser 失效
标题翻译：液体皂液自动分配器
公开(公告)号：US5507413A
公开(公告)日：1996-04-16
申请号：US297284
申请日：1994-08-29
申请人： Ching-Shih Chen
发明人： Ching-Shih Chen
IPC分类号： A47K5/12 , G01F11/02 , B67D5/08
CPC分类号： A47K5/1217 , G01F11/021 , G01F11/029 , Y10S4/903
摘要： An automatic liquid soap dispenser includes a liquid soap container which receives liquid soap therein and which has a bottom wall that is formed with an outlet port. A tubular body is secured to a bottom surface of the bottom wall such that a through-hole at a closed rear portion of the tubular body is aligned with the outlet port. The closed rear portion of the tubular body is further formed with an upright soap outlet adjacent to the through-hole. A movable blocking member is provided adjacent to said closed rear portion and is movable to block and unblock the through-hole so as to control the flow of the liquid soap through the soap outlet. The plunger has a piston which extends fittingly and movably into the tubular body via an open front portion of the latter, and a flexible shaft portion connected to the piston. A driving unit is activated by a detecting unit upon detection of a target. The shaft portion of the plunger is coupled eccentrically to the driving unit so that activation of the driving unit results in reciprocal linear movement of the piston within the tubular body to dispense a predetermined amount of the liquid soap through the soap outlet. A switch unit is activated when the piston of the plunger completes one cycle of the reciprocal linear movement and deactivates the driving unit when activated.
摘要翻译：自动液体皂分配器包括在其中容纳液体皂的液体肥皂容器，并且具有形成有出口的底壁。管状体固定到底壁的底表面，使得管状体的封闭后部的通孔与出口对准。管状体的封闭后部还形成有与通孔相邻的直立肥皂出口。一个可移动的阻挡件邻近所述封闭的后部设置并且可移动以阻挡和解除通孔，从而控制液体肥皂通过肥皂出口的流动。柱塞具有活塞，该活塞经由其后部的敞开的前部而适配地且可移动地延伸到管状体中，以及连接到活塞的柔性轴部。在检测到目标时，由检测单元激活驱动单元。柱塞的轴部分偏心地联接到驱动单元，使得驱动单元的启动导致活塞在管状体内的往复线性运动，以通过肥皂出口分配预定量的液体肥皂。当活塞的活塞完成往复线性运动的一个循环并且当激活时停用驱动单元时，开关单元被激活。

29. 发明授权

US08680133B2 Alkyl indole-3-carbinol-derived antitumor agents 有权
标题翻译：烷基吲哚-3-甲醇衍生的抗肿瘤剂
公开(公告)号：US08680133B2
公开(公告)日：2014-03-25
申请号：US13429779
申请日：2012-03-26
申请人： Ching-Shih Chen , Jing-Ru Weng
发明人： Ching-Shih Chen , Jing-Ru Weng
IPC分类号： A61K31/404 , C07D209/04
CPC分类号： A61K31/404 , C07D209/12
摘要： Compounds and methods for treating cancer or inducing apoptosis in proliferating cells. The compounds are shown in formula I: wherein X is selected from hydroxyl, thiol, and amino; Y is selected from carboxyl and sulfonyl; R1, R2, R3, and R4 are selected from hydrogen, lower alkyl, and combinations thereof; R5, R6, and R7 are selected from hydrogen, halo, ni tro, amino, methoxy, and combinations thereof; and pharmaceutically acceptable salts thereof.
摘要翻译：用于在增殖细胞中治疗癌症或诱导细胞凋亡的化合物和方法。化合物示于式I中：其中X选自羟基，硫醇和氨基; Y选自羧基和磺酰基; R 1，R 2，R 3和R 4选自氢，低级烷基及其组合; R5，R6和R7选自氢，卤素，氨基，甲氧基及其组合; 及其药学上可接受的盐。

30. 发明授权

US08658647B2 Integrin-linked kinase inhibitors 有权
标题翻译：整合素连接的激酶抑制剂
公开(公告)号：US08658647B2
公开(公告)日：2014-02-25
申请号：US13300872
申请日：2011-11-21
申请人： Ching-Shih Chen , Su-Lin Lee , Samuel K. Kulp
发明人： Ching-Shih Chen , Su-Lin Lee , Samuel K. Kulp
IPC分类号： A61K31/496 , C07D403/10
CPC分类号： C07D231/14 , C07D231/12
摘要： A number of compounds and use of the compounds in a method for treating or preventing cancer in a subject by administering to the subject a pharmaceutical composition including a compound of formula I or a pharmaceutically acceptable salt thereof are described. The compounds can also be used to inhibit integrin-linked kinase in a cell, which has an effect on the Akt signaling pathway.
摘要翻译：描述了通过向受试者施用包含式I化合物或其药学上可接受的盐的药物组合物来治疗或预防受试者癌症的方法中的许多化合物和化合物的用途。该化合物也可用于抑制细胞中的整联蛋白连接的激酶，其对Akt信号通路具有影响。

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