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    • 29. 发明授权
    • Isolated polypeptides used for treatment of inflammatory diseases and inhibiting cancer metastasis
    • 用于治疗炎性疾病和抑制癌症转移的分离的多肽
    • US08530421B2
    • 2013-09-10
    • US13503262
    • 2010-08-24
    • Jang-Hee HahnKyoung-Jin LeeSun-Hee LeeHyun-Mi Ju
    • Jang-Hee HahnKyoung-Jin LeeSun-Hee LeeHyun-Mi Ju
    • A61K38/00A61K39/00C12P21/02C07K16/46C07K14/00C07K5/00C07K7/00
    • A61K38/16
    • The present invention relates to a polypeptide derived from a highly conserved region (HCR) I-III of an extracellular region of a CD99 and CD99 family such as CD99L2 and PBDX(or XG), which are a kind of transmembrane protein, or a fused protein thereof. The polypeptide or the fused protein thereof has an activating function of inhibiting the extravasation of white blood cells, or inhibiting the growth and/or metastasis of cancer cells. The present invention also provides a polynucleotide coding the polypeptide, a vector including same, and a transformant transformed by the vector. In addition, the present invention provides a pharmaceutical composition including the polypeptide or the fused protein thereof for preventing or treating inflammatory diseases. Further, the present invention provides a is pharmaceutical composition including the polypeptide or the fused protein thereof inhibiting the growth and/or metastasis of cancer cells, i.e., a pharmaceutical composition for preventing or treating cancer.
    • 本发明涉及一种衍生自CD99和CD99家族例如CD99L2和PBDX(或XG)的胞外区的高度保守区(HCR)I-III的多肽,其是一种跨膜蛋白,或融合 蛋白质。 多肽或其融合蛋白具有抑制白细胞外渗或抑制癌细胞生长和/或转移的活化功能。 本发明还提供了编码多肽的多核苷酸,包含其的载体和由载体转化的转化体。 此外,本发明提供了包含用于预防或治疗炎性疾病的多肽或其融合蛋白质的药物组合物。 此外,本发明提供了包含抑制癌细胞的生长和/或转移的多肽或其融合蛋白的药物组合物,即用于预防或治疗癌症的药物组合物。