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21. 发明申请

US20140322169A1 Recombinant Virus Products and Methods for Inhibition of Expression of DUX4 有权
标题翻译：重组病毒产物和抑制DUX4表达的方法
公开(公告)号：US20140322169A1
公开(公告)日：2014-10-30
申请号：US14234413
申请日：2012-07-24
申请人： Scott Quenton Harper , Jian Liu , Sara Garwick , Lindsay Wallace
发明人： Scott Quenton Harper , Jian Liu , Sara Garwick , Lindsay Wallace
IPC分类号： C12N15/113 , C12N15/86
CPC分类号： C12N15/86 , C12N15/113 , C12N2310/11 , C12N2310/141 , C12N2320/30 , C12N2330/51 , C12N2750/00032 , C12N2750/14132 , C12N2750/14143
摘要： The present invention relates to RNA interference-based methods for inhibiting the expression of the DUX4 gene, a double homeobox gene on human chromosome 4q35. Recombinant adeno-associated viruses of the invention deliver DNAs encoding microRNAs that knock down the expression of DUX4. The methods have application in the treatment of muscular dystrophies such as facioscapulohumeral muscular dystrophy.
摘要翻译：本发明涉及用于抑制DUX4基因（人染色体4q35上的双重同源盒基因）表达的基于RNA干扰的方法。本发明的重组腺相关病毒提供了编码降低DUX4表达的微小RNA的DNA。该方法可用于治疗肌营养不良症，例如面皮囊性肌营养不良症。

22. 发明授权

US08867016B2 Wavelength selective switch 有权
标题翻译：波长选择开关
公开(公告)号：US08867016B2
公开(公告)日：2014-10-21
申请号：US13418274
申请日：2012-03-12
申请人： Hongwei Mao , Lifu Gong , Tian Zhu , Jian Liu
发明人： Hongwei Mao , Lifu Gong , Tian Zhu , Jian Liu
IPC分类号： G02F1/13
CPC分类号： G02B6/356 , G02B6/29302 , G02B6/29313 , G02B6/2938 , G02B6/3558 , G02F1/31 , H04J14/0212 , H04J14/06 , H04Q11/0005 , H04Q2011/0026 , H04Q2011/0035
摘要： Methods, systems, and apparatus, for optical switching. In one aspect, a wavelength selective switch includes one or more optical input ports; one or more optical output ports; a first optical wavelength dispersion element configured to separate the plurality of wavelength channels of the input optical beam; a second optical wavelength dispersion element configured to combine two or more separate optical beams each having one or more different wavelengths, into a combined beam having the plurality of wavelength channels; a polarization modulator array configured to independently change a polarization orientation of an optical beam passing through; optical components for directing optical beams corresponding to respective wavelength channels to different polarizing modulation cells; and a polarization beam splitter configured to route received optical beams to particular output paths according to polarization orientation.
摘要翻译：用于光交换的方法，系统和装置。一方面，波长选择开关包括一个或多个光输入端口; 一个或多个光输出端口; 第一光波长色散元件，被配置为分离所述输入光束的所述多个波长通道; 第二光波长色散元件，被配置为将具有一个或多个不同波长的两个或更多个分离光束组合成具有多个波长通道的组合光束; 偏振调制器阵列，被配置为独立地改变通过的光束的偏振取向; 用于将对应于各个波长信道的光束引导到不同的偏振调制单元的光学部件; 以及偏振分束器，其被配置为根据偏振取向将接收的光束路由到特定的输出路径。

23. 发明授权

US08837038B2 Fiber geometrical management for TEM00 mode pulse energy scaling of fiber lasers and amplifiers 有权
标题翻译：光纤几何管理用于TEM00模式脉冲能量定标的光纤激光器和放大器
公开(公告)号：US08837038B2
公开(公告)日：2014-09-16
申请号：US13615472
申请日：2012-09-13
申请人： Jian Liu
发明人： Jian Liu
IPC分类号： H01S3/067 , G02B6/024 , G02B6/122 , G02B6/12
CPC分类号： H01S3/06729 , C03B2203/302 , G02B6/02 , G02B6/024 , G02B6/1228 , G02B2006/12038 , H01S3/06745 , H01S3/06754
摘要： Methods and systems for managing pulse energy scaling are disclosed, including generating electromagnetic radiation; coupling the electromagnetic radiation to a fiber geometrical management system comprising: a tapered fiber comprising: an elliptical or rectangular core centrally positioned within a single or double cladding shell, wherein the core comprises a fiber material and a doped gain medium; an input face wherein the doped core comprises a major axis and a minor axis, wherein the ratio of the major to minor axis at the input face ranges from about 1 to about 100; an output face wherein the doped core comprises a major axis and a minor axis, wherein the ratio of the major to minor axis at the output face ranges from about 1 to about 100; and wherein the major (minor) axis is adiabatically or linearly tapered from the input face to the output face. Other embodiments are described and claimed.
摘要翻译：公开了用于管理脉冲能量缩放的方法和系统，包括产生电磁辐射; 将所述电磁辐射耦合到光纤几何管理系统，所述光纤几何管理系统包括：锥形光纤，包括：中心地位于单包层或双包层外壳内的椭圆形或矩形芯，其中所述芯包括纤维材料和掺杂增益介质; 输入面，其中所述掺杂芯包括长轴和短轴，其中所述输入面处的所述主轴与所述短轴的比率在约1至约100的范围内; 输出面，其中所述掺杂芯包括长轴和短轴，其中所述输出面处的所述主轴与所述短轴的比率在约1至约100的范围内; 并且其中主（次）轴从输入面到输出面绝热或线性渐缩。描述和要求保护其他实施例。

24. 发明申请

US20140221333A1 BTK INHIBITORS 审中-公开
标题翻译： BTK抑制剂
公开(公告)号：US20140221333A1
公开(公告)日：2014-08-07
申请号：US14233478
申请日：2012-07-19
申请人： Adrianus Petrus Antonius De Man , Jan-Gerard Sterrenburg , Han C.A. Raaijmakers , Allard Kaptein , Arthura A. Oubrie , Johannes Bernardus Maria Rewinkel , Christiaan Gerardus Johannes Maria Jans , Jacobus C.H.M. Wijkamans , Tjeerd A. Barf , Alan B. Cooper , Ronald M. Kim , Sobhana Babu Boga , Hugh Y. Zhu , Xiaolei Gao , Xin Yao , Rajan Anand , Hao Wu , Shilan Liu , Chundao Yang , Abdul-Basit Alhassan , James Wang , Younong Yu , Jian Liu , Henry M. Vaccaro
发明人： Adrianus Petrus Antonius De Man , Jan-Gerard Sterrenburg , Han C.A. Raaijmakers , Allard Kaptein , Arthura A. Oubrie , Johannes Bernardus Maria Rewinkel , Christiaan Gerardus Johannes Maria Jans , Jacobus C.H.M. Wijkamans , Tjeerd A. Barf , Alan B. Cooper , Ronald M. Kim , Sobhana Babu Boga , Hugh Y. Zhu , Xiaolei Gao , Xin Yao , Rajan Anand , Hao Wu , Shilan Liu , Chundao Yang , Abdul-Basit Alhassan , James Wang , Younong Yu , Jian Liu , Henry M. Vaccaro
IPC分类号： C07D487/04 , C07D513/04 , A61K31/55 , A61K31/5377 , A61K31/53 , A61K31/4985 , A61K31/541
CPC分类号： C07D487/04 , A61K31/4985 , A61K31/53 , A61K31/5377 , A61K31/541 , A61K31/55 , A61K45/06 , C07D471/04 , C07D513/04 , C07D519/00
摘要： Provided are 6-5 membered fused pyridine ring compounds according to Formula (I) or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds and their use in therapy. In particular, provided is the use of membered fused pyridine ring compounds in the treatment of Bruton's Tyrosine Kinase (Btk) mediated disorders.
摘要翻译：提供根据式（I）的6-5元稠合吡啶环化合物或其药学上可接受的盐，包含这些化合物的药物组合物及其在治疗中的用途。特别地，提供了使用元稠合的吡啶环化合物来治疗布鲁丁的酪氨酸激酶（Btk）介导的病症。

25. 发明授权

US08792158B2 2 micron femtosecond fiber laser 有权
标题翻译： 2微米飞秒光纤激光器
公开(公告)号：US08792158B2
公开(公告)日：2014-07-29
申请号：US13452817
申请日：2012-04-20
申请人： Jian Liu , Peng Wan , Lihmei Yang
发明人： Jian Liu , Peng Wan , Lihmei Yang
IPC分类号： H01S3/067
CPC分类号： H01S3/067 , H01S3/06725 , H01S3/06754 , H01S3/083 , H01S3/1112 , H01S3/1118 , H01S3/161 , H01S3/1616 , H01S3/1698
摘要： Methods and systems for generating femtosecond fiber laser pulses are disclose, including generating a signal laser pulse from a seed laser oscillator; using a first amplifier stage comprising an input and an output, wherein the signal laser pulse is coupled into the input of the first stage amplifier and the output of the first amplifier stage emits an amplified and stretched signal laser pulse; using an amplifier chain comprising an input and an output, wherein the amplified and stretched signal laser pulse from the output of the first amplifier stage is coupled into the input of the amplifier chain and the output of the amplifier chain emits a further amplified, stretched signal laser pulse. Other embodiments are described and claimed.
摘要翻译：公开了用于产生飞秒光纤激光脉冲的方法和系统，包括从种子激光振荡器产生信号激光脉冲; 使用包括输入和输出的第一放大器级，其中所述信号激光脉冲耦合到所述第一级放大器的输入中，并且所述第一放大级的输出发射放大和拉伸的信号激光脉冲; 使用包括输入和输出的放大器链，其中来自第一放大器级的输出的放大和拉伸的信号激光脉冲耦合到放大器链的输入端，并且放大器链的输出发射进一步放大的拉伸信号激光脉冲。描述和要求保护其他实施例。

26. 发明授权

US08785180B2 Biochemical reactor 有权
标题翻译：生化反应器
公开(公告)号：US08785180B2
公开(公告)日：2014-07-22
申请号：US12871539
申请日：2010-08-30
申请人： Siliang Zhang , Yuefang Zhang , Jian Liu , Xujun Yuan , Meijin Guo , Liqing He , Gongjian Chen , Ming Zhang , Guoqiang Sun , Wenfeng Ma , Ju Chu , Yingping Zhuang , Yonghong Wang , Mingzhi Huang , Haifeng Hang , Jianye Xia
发明人： Siliang Zhang , Yuefang Zhang , Jian Liu , Xujun Yuan , Meijin Guo , Liqing He , Gongjian Chen , Ming Zhang , Guoqiang Sun , Wenfeng Ma , Ju Chu , Yingping Zhuang , Yonghong Wang , Mingzhi Huang , Haifeng Hang , Jianye Xia
IPC分类号： C12M1/34 , C12M3/00 , G01N21/64 , G01N21/25 , C12M1/00 , C12M1/06
CPC分类号： G01N21/6428 , C12M27/02 , C12M41/06 , C12M41/36 , C12M41/46 , G01N21/253 , G02B21/0016
摘要： A biochemical reactor involves an online cell examination microscope thereon. The online cell examination microscope comprises a main body, an objective lens, an observation entrance window, a sampling device, an external light source system. Said observation entrance window lies in front of said main body and the sampling device lies in front of said observation entrance window. An objective lens and said external light source system lie behind the observation entrance window in the main body. A reflector prism is installed between the external light source system and the objective lens. A reflector lies behind the objective lens and in front of the observation entrance window. An annular diaphragm is placed in front of the reflecting prism. A CCD or an area image sensor is arranged on the upper side of the reflectance prism.
摘要翻译：生化反应器包括其上的在线细胞检查显微镜。在线细胞检查显微镜包括主体，物镜，观察入口窗，取样装置，外部光源系统。所述观察入口窗位于所述主体的前方，并且所述取样装置位于所述观察入口窗前。物镜和外部光源系统位于主体的观察入口窗后面。反射棱镜安装在外部光源系统和物镜之间。反射器位于物镜的后面，在观察入口窗前。环形隔膜放置在反射棱镜的前面。 CCD或区域图像传感器布置在反射棱镜的上侧。

27. 发明授权

US08782571B2 Multiple patterning process for forming trenches or holes using stitched assist features 有权
标题翻译：用于使用缝合辅助特征形成沟槽或孔的多重构图工艺
公开(公告)号：US08782571B2
公开(公告)日：2014-07-15
申请号：US13414971
申请日：2012-03-08
申请人： Yuyang Sun , Norman S. Chen , Jian Liu
发明人： Yuyang Sun , Norman S. Chen , Jian Liu
IPC分类号： G06F17/50
CPC分类号： G03F7/70 , G03F1/68 , G03F1/70 , G03F1/76
摘要： One illustrative method disclosed herein involves identifying an overall target pattern comprised of at least one hole-type feature, decomposing the overall target pattern into at least a first sub-target pattern and a second sub-target pattern, wherein the first sub-target pattern and the second sub-target pattern each comprise at least one common hole-type feature, generating a first set of mask data information corresponding to the first sub-target pattern, and generating a second set of mask data information corresponding to the second sub-target pattern.
摘要翻译：本文公开的一种说明性方法涉及识别由至少一个孔型特征组成的总体目标图案，将总体目标图案分解为至少第一子目标图案和第二子目标图案，其中第一子目标图案并且所述第二子目标图案各自包括至少一个公共孔型特征，产生与所述第一子目标图案相对应的第一组掩模数据信息，以及生成与所述第二子目标图形对应的第二组掩模数据信息，目标模式。

28. 发明授权

US08675193B2 Near-field material processing system 有权
标题翻译：近场材料处理系统
公开(公告)号：US08675193B2
公开(公告)日：2014-03-18
申请号：US13454042
申请日：2012-04-23
申请人： Jian Liu , Huan Huang
发明人： Jian Liu , Huan Huang
IPC分类号： G01J3/30
CPC分类号： G01N21/718 , G01N33/0057
摘要： Methods and systems for real time feedback and control of near-field material processing are disclosed, including generating electromagnetic radiation from a USP laser coupled to a central processing unit; coupling the electromagnetic radiation to an acousto-optic modulator; coupling the electromagnetic radiation to a beam delivery system; coupling the electromagnetic radiation to a beam delivery fiber; using the electromagnetic radiation to generate a plasma on a target mounted to an adjustable stage coupled to the central processing unit; coupling the electromagnetic radiation from the plasma to a plasma spectrum collection system; coupling the electromagnetic radiation to a spectrum analysis unit; coupling the electromagnetic radiation to a detector; and coupling the detector to the central processing unit; wherein the central processing unit uses the output from the detector as feedback in making adjustments to the USP laser and the adjustable stage. Other embodiments are described and claimed.
摘要翻译：公开了用于近场材料处理的实时反馈和控制的方法和系统，包括从耦合到中央处理单元的USP激光产生电磁辐射; 将电磁辐射耦合到声光调制器; 将电磁辐射耦合到光束传送系统; 将电磁辐射耦合到束输送光纤; 使用所述电磁辐射在安装到可耦合到所述中央处理单元的可调节台上的目标上产生等离子体; 将来自等离子体的电磁辐射耦合到等离子体谱采集系统; 将电磁辐射耦合到频谱分析单元; 将电磁辐射耦合到检测器; 并将检测器耦合到中央处理单元; 其中中央处理单元使用来自检测器的输出作为对USP激光器和可调节级进行调整的反馈。描述和要求保护其他实施例。

29. 发明申请

US20130261285A1 METHOD FOR PREPARING ATOSIBAN ACETATE 有权
标题翻译：制备阿托品酸酯的方法
公开(公告)号：US20130261285A1
公开(公告)日：2013-10-03
申请号：US13579030
申请日：2011-12-22
申请人： Qing Xiao , Jian Liu , Hongling Li , Yaping Ma , Jiancheng Yuan
发明人： Qing Xiao , Jian Liu , Hongling Li , Yaping Ma , Jiancheng Yuan
IPC分类号： C07K7/64
CPC分类号： C07K7/64 , C07K7/16
摘要： The present invention provides a method for preparing atosiban acetate. The method comprises the following steps of: synthesizing to obtain linear atosiban; dissolving the linear atosiban in an acetonitrile aqueous solution, adjusting the pH value with ammonia water, adding H2O2 for oxidizing, filtering, purifying, and transferring salt to obtain the atosiban acetate. In the present invention, an appropriate route is provided, the linear atosiban is synthesized by adopting a solid phase method, and the atosiban is obtained by liquid phase oxidation. The method has the advantages of capabilities of solving the problem of insolubility of the linear atosiban, reducing the reaction size to the maximum extent and shortening reaction time, and being high in yield and easy to industrialize.
摘要翻译：本发明提供了一种制备醋酸托西班醋酸酯的方法。该方法包括以下步骤：合成得到线性阿托西班; 将线性阿托西班溶解在乙腈水溶液中，用氨水调节pH值，加入H 2 O 2进行氧化，过滤，纯化和转移盐，得到醋酸阿托品。在本发明中，提供了适当的途径，通过采用固相法合成线性阿托西班，通过液相氧化获得阿托西班。该方法具有解决线性阿托西班不溶性问题的能力，最大限度地减少反应尺寸，缩短反应时间，产率高，易于工业化的优点。

30. 发明授权

US08541744B1 Method and apparatus for wavelength locking free optical frequency comb based differential absorption Lidar 有权
标题翻译：用于波长锁定自由光学频率梳差分吸收激光的方法和装置
公开(公告)号：US08541744B1
公开(公告)日：2013-09-24
申请号：US13791924
申请日：2013-03-09
申请人： Jian Liu
发明人： Jian Liu
IPC分类号： G01N21/00
CPC分类号： G01S17/10 , G01N21/39 , G01N2021/1793 , G01N2021/394 , G01S7/4802 , G01S7/4817 , G01S7/484 , G01S7/486 , G01S17/42 , G01S17/95 , Y02A90/19
摘要： Methods and systems for wavelength locking free OFC based DIAL are disclosed, including generating electromagnetic radiation from a mode-locked fiber laser; coupling the electromagnetic radiation to an acousto-optic modulator; coupling the electromagnetic radiation to a power amplifier; collimating and coupling the amplified electromagnetic radiation into a scanner; steering the collimated and amplified electromagnetic radiation onto a target; using a telescope to collect a portion of the backscattered electromagnetic radiation from the target; coupling the collected portion of the backscattered electromagnetic radiation into a DWDM; using a photon counting receiver coupled to the DWDM to measure a multiple OFC on-resonant band intensity and a multiple OFC off-resonant band intensity; and comparing the multiple OFC on-resonant band intensity with the multiple OFC off-resonant band intensity in order to determine one or more concentrations of one or more molecules within the target. Other embodiments are described and claimed.
摘要翻译：公开了用于波长锁定的基于OFC的DIAL的方法和系统，包括从锁模光纤激光器产生电磁辐射; 将电磁辐射耦合到声光调制器; 将电磁辐射耦合到功率放大器; 将放大的电磁辐射准直并耦合到扫描仪中; 将准直和放大的电磁辐射转向目标; 使用望远镜收集来自目标的反向散射电磁辐射的一部分; 将所收集的背散射电磁辐射部分耦合到DWDM中; 使用耦合到DWDM的光子计数接收器来测量多个OFC导通共振频带强度和多个OFC非共振频带强度; 以及将多个OFC共振频带强度与多个OFC非共振频带强度进行比较，以便确定目标内的一个或多个分子的一种或多种浓度。描述和要求保护其他实施例。

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