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21. 发明申请

US20100012523A1 Small Volume In Vitro Sensor and Methods of Making 有权
公开(公告)号：US20100012523A1
公开(公告)日：2010-01-21
申请号：US12569201
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/26 , C12Q1/26
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

22. 发明授权

US07563350B2 Small volume in vitro analyte sensor 有权
标题翻译：体积小体积分析物传感器
公开(公告)号：US07563350B2
公开(公告)日：2009-07-21
申请号：US10663153
申请日：2003-09-15
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

23. 发明授权

US06618934B1 Method of manufacturing small volume in vitro analyte sensor 有权
标题翻译：制造体积小体积分析物传感器的方法
公开(公告)号：US06618934B1
公开(公告)日：2003-09-16
申请号：US09594285
申请日：2000-06-15
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H05K336
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

24. 发明授权

US06461496B1 Small volume in vitro analyte sensor with diffusible or non-leachable redox mediator 有权
标题翻译：小体积体外分析物传感器，具有可扩散或不可浸出的氧化还原介体
公开(公告)号：US06461496B1
公开(公告)日：2002-10-08
申请号：US09427808
申请日：1999-10-27
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于使用诸如库仑法，电流分析法和电位法的技术来确定生物流体如血液或血清中的生物分子如葡萄糖或乳酸盐的浓度。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

25. 发明授权

US08650751B2 Methods of making small volume in vitro analyte sensors 有权
标题翻译：制作体积小体积分析物传感器的方法
公开(公告)号：US08650751B2
公开(公告)日：2014-02-18
申请号：US12569350
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H01R43/20
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于测定生物流体如血液或血清中生物分子如葡萄糖或乳酸的浓度，使用诸如库仑法，电流分析法; 和电位法。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

26. 发明申请

US20130066430A1 CRANIAL BURR HOLE PLUG WITH ADAPTABLE MOUNTING SURFACE 有权
标题翻译：带适配安装表面的CRANIAL BURR孔插头
公开(公告)号：US20130066430A1
公开(公告)日：2013-03-14
申请号：US13614943
申请日：2012-09-13
申请人： Jeffery V. Funderburk
发明人： Jeffery V. Funderburk
IPC分类号： A61F2/28
CPC分类号： A61F2/2875 , A61N1/0539
摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The plug base is configured to accommodate a variety of cranium forms without requiring deformation of the plug base. A plug base holding tool is used to secure the plug base to the cranium, wherein the tool aligns fasteners with the plug base for insertion through the plug base and into the cranium. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base to secure the medical device. The retainer includes a clamping mechanism that secures the elongated medical device in the burr hole plug, wherein the movement of the clamping mechanism is controlled to prevent skewing of the clamping mechanism.
摘要翻译：毛刺孔塞包括构造成围绕钻孔安装的塞子基座。插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。插头基座构造成适应各种颅骨形状，而不需要插头基座的变形。使用插头基座固定工具将插头基座固定到颅骨上，其中工具将紧固件与插头基座对准，以便通过插头基座插入颅骨。毛刺孔塞还包括保持器，其构造成安装在插头基座的孔内以固定医疗装置。保持器包括将细长的医疗装置固定在毛刺孔塞中的夹持机构，其中控制夹持机构的运动以防止夹紧机构的偏斜。

27. 发明授权

US08272125B2 Method of manufacturing in vitro analyte sensors 有权
标题翻译：制造体外分析物传感器的方法
公开(公告)号：US08272125B2
公开(公告)日：2012-09-25
申请号：US12569179
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H01R9/00 , H05K3/02
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： Provided are methods of manufacturing a plurality of electrochemical sensors. The methods include forming a plurality of working electrodes on a first electrode region of a substrate, forming a plurality of counter electrodes on a second electrode region of the substrate, disposing a spacer layer on one of the first and second electrode regions, folding the substrate with the spacer layer between the first electrode region and the second electrode region to form a layered structure, and separating or cutting the layered structure to form individual electrochemical sensors.
摘要翻译：提供制造多个电化学传感器的方法。所述方法包括在基板的第一电极区域上形成多个工作电极，在基板的第二电极区域上形成多个对置电极，在第一和第二电极区域之一上设置间隔层，折叠基板其中间隔层在第一电极区域和第二电极区域之间以形成层状结构，并且分离或切割层状结构以形成单独的电化学传感器。

28. 发明授权

US08182670B2 Small volume in vitro analyte sensor and methods of making 有权
公开(公告)号：US08182670B2
公开(公告)日：2012-05-22
申请号：US12569164
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： G01N27/327
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.

29. 发明申请

US20120012630A1 CHARGER BELT 审中-公开
标题翻译：充电带
公开(公告)号：US20120012630A1
公开(公告)日：2012-01-19
申请号：US13184228
申请日：2011-07-15
申请人： Mun Pook Lui , Jeffery V. Funderburk , Joey Chen
发明人： Mun Pook Lui , Jeffery V. Funderburk , Joey Chen
IPC分类号： A45F3/00 , B23P19/04
CPC分类号： A61N1/3787 , A41F9/002 , Y10T29/49826
摘要： Electrical energy is transcutaneously transmitted from an external charger to an implanted medical device, wherein the external charger includes a charger head that is positioned on the patient to align with the implanted medical device for efficient charging. To secure the charger head in alignment with the implanted medical device, a belt with a buckle is provided for securing the charger head. The belt is adjustable in length by sliding end portions of the belt through a buckle and joining respective fabrics on the belt. The position of the buckle can also be adjusted for ease of patient use. Additional features of the belt provide for heat management to improve patient comfort and an additional strap to further adjust the length of the belt.
摘要翻译：电能从外部充电器经皮传递到植入医疗装置，其中外部充电器包括位于患者身上以与植入的医疗装置对准的充电头，用于有效充电。为了将充电头固定在与植入的医疗装置对准的位置，提供带扣的皮带以固定充电头。通过将带的端部滑过带扣并将相应的织物连接在带上，带可以长度调节。也可以调节带扣的位置，以方便患者使用。皮带的附加特征提供热管理以改善患者舒适度和附加皮带，以进一步调节皮带的长度。

30. 发明授权

US08087162B2 Methods of making small volume in vitro analyte sensors 有权
标题翻译：制作体积小体积分析物传感器的方法
公开(公告)号：US08087162B2
公开(公告)日：2012-01-03
申请号：US12569408
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H05K3/20
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于测定生物流体如血液或血清中生物分子如葡萄糖或乳酸的浓度，使用诸如库仑法，电流分析法; 和电位法。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

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