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21. 发明申请

US20120219548A1 PODXL Protein in Colorectal Cancer 有权
标题翻译： PODXL蛋白在结肠直肠癌
公开(公告)号：US20120219548A1
公开(公告)日：2012-08-30
申请号：US13456354
申请日：2012-04-26
申请人： Karin Jirström , Mathias Uhlén , Fredrik Pontén
发明人： Karin Jirström , Mathias Uhlén , Fredrik Pontén
IPC分类号： G01N33/574 , A61P35/00 , A61K39/395
CPC分类号： G01N33/57419 , C07K16/22 , C07K16/3046 , C07K2317/76 , G01N2333/705 , G01N2333/90216 , G01N2800/52 , G01N2800/56
摘要： The present disclosure provides a method for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second group, wherein the prognosis of subjects of the first group is better than the prognosis of subjects of the second group, comprising the steps of: a) evaluating an amount of PODXL protein in at least part of a sample earlier obtained from the subject, and determining a sample value corresponding to the evaluated amount; b) comparing said sample value from step a) with a predetermined reference value; and if said sample value is higher than said reference value, c1) concluding that the subject belongs to said second group; and if said sample value is lower than or equal to said reference value, c2) concluding that the subject belongs to said first group. Related uses, means and a method of treatment are also provided.
摘要翻译：本公开提供了一种用于确定具有结肠直肠癌的哺乳动物受试者是否属于第一组或第二组的方法，其中第一组受试者的预后优于第二组受试者的预后，包括以下步骤：：a）评估早先从受试者获得的样品的至少一部分中的PODXL蛋白的量，并确定与评估量相对应的样品值; b）将来自步骤a）的所述样本值与预定参考值进行比较; 并且如果所述样本值高于所述参考值，则c1）认定所述对象属于所述第二组; 并且如果所述样本值小于或等于所述参考值，则c2）断定所述对象属于所述第一组。还提供了相关用途，手段和治疗方法。

22. 发明申请

US20120034218A1 RBM3 in Colorectal Cancer Prognostics 有权
标题翻译： RBM3在结肠直肠癌预后中的作用
公开(公告)号：US20120034218A1
公开(公告)日：2012-02-09
申请号：US13210816
申请日：2011-08-16
申请人： Mathias Uhlen , Fredrik Pontén , Karin Jirström
发明人： Mathias Uhlen , Fredrik Pontén , Karin Jirström
IPC分类号： A61K39/395 , C12Q1/68 , C07K7/06 , A61K31/7068 , A61P35/00 , C07K14/47 , C40B30/04 , G01N33/566
CPC分类号： C07K16/18 , A61K31/7068 , A61K39/39533 , A61K45/06 , C07K14/4748 , C07K16/3038 , C07K2317/34 , C12Q1/6886 , C12Q2600/106 , C12Q2600/118 , C12Q2600/158 , G01N33/57407 , G01N33/57419 , A61K2300/00
摘要： The present invention provides means, such as a method, for determining whether a mammalian subject having a colorectal cancer belongs to a first or a second group, wherein the prognosis of subjects of the first group is better than the prognosis of subjects of the second group. The method comprises the steps of: evaluating an amount of RBM3 protein or RBM3 mRNA molecule in at least part of a sample earlier obtained from the subject and determining a sample value corresponding to the evaluated amount; comparing said sample value with a predetermined reference value; andif said sample value is higher than said reference value, concluding that the subject belongs to the first group; and if said sample value is lower than or equal to said reference value, concluding that the subject belongs to the second group.
摘要翻译：本发明提供了用于确定具有结肠直肠癌的哺乳动物受试者是否属于第一组或第二组的方法，例如方法，其中第一组受试者的预后优于第二组受试者的预后。该方法包括以下步骤：评估早期从受试者获得的样品的至少部分中的RBM3蛋白或RBM3 mRNA分子的量，并确定对应于评估量的样品值; 将所述样本值与预定参考值进行比较; 并且如果所述样本值高于所述参考值，则认定所述对象属于所述第一组; 并且如果所述样本值低于或等于所述参考值，则认定所述对象属于所述第二组。

23. 发明授权

US08067190B2 Use of protein SATB2 as a marker for colorectal cancer 有权
标题翻译：使用蛋白质SATB2作为结肠直肠癌的标志物
公开(公告)号：US08067190B2
公开(公告)日：2011-11-29
申请号：US12302248
申请日：2007-06-04
申请人： Mathias Uhlén , Fredrik Pontén
发明人： Mathias Uhlén , Fredrik Pontén
IPC分类号： G01N33/574 , G01N33/53
CPC分类号： G01N33/57419 , G01N2333/4703
摘要： The invention provides new methods, means and uses in connection with detection, characterization and prognosis of colo-rectal cancer, via the identification of the SATB2 protein as a marker for this cancer type.
摘要翻译：本发明通过鉴定SATB2蛋白作为该癌症类型的标志物，提供了与直肠癌的检测，表征和预后有关的新方法，手段和用途。

24. 发明申请

US20110144198A1 BREAST CANCER PROGNOSTICS 审中-公开
标题翻译：乳腺癌预后
公开(公告)号：US20110144198A1
公开(公告)日：2011-06-16
申请号：US12992615
申请日：2008-05-16
申请人： Mathias Uhlén , Karin Jirström , Fredrik Pontén
发明人： Mathias Uhlén , Karin Jirström , Fredrik Pontén
IPC分类号： A61K31/366 , G01N33/53 , A61P35/00
CPC分类号： G01N33/57415 , C12Q1/26 , G01N33/573 , G01N2333/90209
摘要： The present invention provides new methods, uses and means for breast cancer prognostics. The provided method for establishing a prognosis for a mammalian subject having a breast cancer, comprises the steps of: obtaining a hormone receptor status of the subject; obtaining an HMGCR protein value of the subject; and correlating the hormone receptor status and the HMGCR protein of the subject to a prognosis for the subject.
摘要翻译：本发明提供乳腺癌预后的新方法，用途和手段。所提供的用于确定具有乳腺癌的哺乳动物受试者的预后的方法包括以下步骤：获得受试者的激素受体状态; 获得受试者的HMGCR蛋白值; 并将受试者的激素受体状态和HMGCR蛋白与受试者的预后相关联。

25. 发明授权

US07727133B2 Sealing device 失效
标题翻译：密封装置
公开(公告)号：US07727133B2
公开(公告)日：2010-06-01
申请号：US10539511
申请日：2003-10-29
申请人： Jörgen T. Lundberg , Fredrik Pontén
发明人： Jörgen T. Lundberg , Fredrik Pontén
IPC分类号： F16C13/00 , B01D33/067
CPC分类号： F16J15/3472 , D21C9/18 , F16J15/363
摘要： Apparatus for creating a seal between an axle journal and a bearing housing is disclosed, particularly for use in apparatus for dewatering or washing material suspensions. The apparatus includes a stator ring, a pair of diagonally disposed guide pins supporting the stator ring with respect to the bearing housing so that the stator ring can be angled in a plane with respect to the pair of guide pins, a sealing ring for creating a seal between the stator ring and the axle journal, a bellows for creating a seal between the bearing housing and the stator ring, and at least one resilient member for urging the stator ring in abutment against the sealing ring.
摘要翻译：公开了用于在轴颈和轴承壳体之间形成密封件的装置，特别是用于脱水或洗涤材料悬架的设备中。该设备包括定子环，一对相对于轴承壳体支撑定子环的对角设置的引导销，使得定子环可以在相对于一对引导销的平面中成角度;密封环，用于产生定子环和轴颈之间的密封，用于在轴承壳体和定子环之间形成密封的波纹管，以及用于推压定子环抵靠密封环的至少一个弹性构件。

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