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    • 23. 发明授权
    • Lyopohilization method
    • 除菌方法
    • US06684524B1
    • 2004-02-03
    • US10048783
    • 2002-02-01
    • Bernd SennhennMartin Kramer
    • Bernd SennhennMartin Kramer
    • F26B506
    • F26B5/06
    • The invention relates to a lyophilization method which comprises the following steps: reducing the pressure in the drying chamber until the onset of a visible crystallization of the solvent at a temperature in the drying chamber which is above the solidification point of the preparation; reducing the temperature in the drying chamber to a temperature which is below the solidification point of the preparation or is identical to it, until completion of the crystallization of the solvent, resulting in a frozen solvent; and sublimation of the frozen solvent by means of reduced pressure.
    • 本发明涉及一种冻干方法,包括以下步骤:降低干燥室中的压力,直至在干燥室中高于制剂固化点的温度下溶剂的可见结晶开始; 将干燥室中的温度降低到低于制剂固化点或与之相同的温度,直到溶剂结晶完成,导致冷冻溶剂; 并通过减压升华冷冻溶剂。