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21. 发明专利

AU2009201867A8 Compounds and compositions as LXR modulators 未知
公开(公告)号：AU2009201867A8
公开(公告)日：2013-05-30
申请号：AU2009201867
申请日：2009-05-12
申请人： IRM LLC
发明人： ANACLERIO BETH , ELLIS DAVID ARCHER , LI XIAOLIN , MOLTENI VALENTINA , NABAKKA JULIET , SAEZ ENRIQUE , WITYAK JOHN
IPC分类号： C07D417/04 , C07D285/12 , C07D417/12
摘要： P\OPER\MJC peifcions\307tX)% Ne div doc-5/l/21 I2I)9 The invention provides compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with the activity of liver X receptors (LXRs).

22. 发明专利

CA2845798A1 COMPOUNDS AND COMPOSITIONS AS PDGFR KINASE INHIBITORS 未知
公开(公告)号：CA2845798A1
公开(公告)日：2013-03-07
申请号：CA2845798
申请日：2012-08-31
申请人： IRM LLC , NOVARTIS PHARMACEUTICALS UK LTD
发明人： LIANG FANG , GIBNEY MICHAEL , YEH VINCE , LI XIAOLIN , MOLTENI VALENTINA , SHAW DUNCAN , BERMAN ASHLEY MITCHELL , LEWIS SARAH , LOREN JON , FURMINGER VIKKI
IPC分类号： C07D471/04 , A61K31/437 , A61P37/00
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of PDGFR (PDGFRa, PDGFRß) kinases or c-kit and PDGFR (PDGFRa, PDGFRß) kinases.

23. 发明专利

CA2845791A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS 未知
公开(公告)号：CA2845791A1
公开(公告)日：2013-03-07
申请号：CA2845791
申请日：2012-08-29
申请人： IRM LLC
发明人： LOREN JON , LI XIAOLIN , LIU XIAODONG , MOLTENI VALENTINA , NABAKKA JULIET , NGUYEN BAO , PETRASSI HANK MICHAEL JAMES , YEH VINCE , RUCKER PAUL VINCENT
IPC分类号： C07D471/04 , A61K31/437 , A61P11/06
摘要： The invention provides compounds and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRa, PDGFRß) kinases.

24. 发明专利

CA2845785A1 COMPOUNDS AND COMPOSITIONS AS C-KIT KINASE INHIBITORS 未知
公开(公告)号：CA2845785A1
公开(公告)日：2013-03-07
申请号：CA2845785
申请日：2012-08-28
申请人： IRM LLC
发明人： LIU XIAODONG , LI XIAOLIN , LOREN JON , MOLTENI VALENTINA , NABAKKA JULIET , NGUYEN BAO , PETRASSI HANK MICHAEL JAMES , YEH VINCE
IPC分类号： C07D471/04 , A61K31/437 , A61P3/00 , A61P11/00 , A61P17/00 , A61P29/00
摘要： The invention provides compounds of formulae (I) and (II) and pharmaceutical compositions thereof, which are useful as protein kinase inhibitors, as well as methods for using such compounds to treat, ameliorate or prevent a condition associated with abnormal or deregulated kinase activity. In some embodiments, the invention provides methods for using such compounds to treat, ameliorate or prevent diseases or disorders that involve abnormal activation of c-kit or c-kit and PDGFR (PDGFRa, PDGFRß) kinases.

25. 发明专利

EA016329B1 СОЕДИНЕНИЯ И КОМПОЗИЦИИ, КАК ИНГИБИТОРЫ КИНАЗЫ c-KIT И PDGFR 未知
公开(公告)号：EA016329B1
公开(公告)日：2012-04-30
申请号：EA200901484
申请日：2008-05-02
申请人： IRM LLC
发明人： LI XIAOLIN , LIU XIAODONG , MOLTENI VALENTINA
IPC分类号： C07D401/14 , A61K31/506 , A61P35/00 , A61P37/00
摘要： Визобретенииописанысоединенияформулы Iгдезначениярадикаловприведеныв описании, фармацевтическиекомпозиции, включающиетакиесоединения, испособыприменениятакихсоединенийдлялеченияилипредупреждениязаболеванийилинарушений, связанныхс аномальнойилихарактеризующейсянарушеннойрегуляциейактивностьюкиназы, вособенностизаболеванийилинарушений, которыевключаютаномальнуюактивациюкиназ c-kit, ТРФРРαи ТРФРРβ.

26. 发明专利

AT551342T 未知
公开(公告)号：AT551342T
公开(公告)日：2012-04-15
申请号：AT09711557
申请日：2009-02-20
申请人： IRM LLC
发明人： LI XIAOLIN , LIU XIAODONG , LOREN JON , MOLTENI VALENTINA , NABAKKA JULIET , YEH VINCE , CHIANELLI DONATELLA
IPC分类号： C07D471/04 , A61K31/4375 , A61P9/00 , A61P25/00 , A61P29/00 , A61P35/00 , A61P37/00
摘要： The invention provides a novel class of compounds of Formula I: (I) pharmaceutical compositions comprising such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFRα and PDGFR&bgr; kinases.

27. 发明专利

AT544761T 未知
公开(公告)号：AT544761T
公开(公告)日：2012-02-15
申请号：AT08747412
申请日：2008-05-01
申请人： IRM LLC
发明人： LI XIAOLIN , LIU XIAODONG , MOLTENI VALENTINA
IPC分类号： C07D401/14 , A61K31/444 , A61P35/00 , C07D405/14
摘要： The invention provides a novel class of pyrimidine derivatives, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of c-kit, PDGFRα and PDGFR&bgr; kinases.

28. 发明专利

TN2009000145A1 未知
公开(公告)号：TN2009000145A1
公开(公告)日：2010-10-18
申请号：TN2009000145
申请日：2009-04-17
申请人： IRM LLC
发明人： CHIANELLI DONATELLA , COW CHRISTOPHER , HE YUN , JIANG SONGCHUN , LI XIAOLIN , LIU XIAODONG , LIU ZUOSHENG , LOREN JON , MOLTENI VALENTINA , NABAKKA JULIET , REN PINGDA , SIM TAEBO , WANG XIAODONG , YOU SHULI
IPC分类号： C07D471/04

29. 发明专利

CO6170361A2 COMPOSICIONES Y METODOS PARA MODULAR RECEPTORES DE C-KIT Y PDGFR 未知
公开(公告)号：CO6170361A2
公开(公告)日：2010-06-18
申请号：CO09039151
申请日：2009-04-17
申请人： IRM LLC
发明人： CHIANELLI DONATELLA , COW CHRISTOPHER , HE YUN , JIANG SONGCHUN , LI XIAOLIN , LIU XIAODONG , LIU ZUOSHENG , LOREN JON , MOLTENI VALENTINA , NABAKKA JULIET , REN PINGDA , SIM TAEBO , WANG XIAOJING , YOU SHULI
IPC分类号： C07D471/04
摘要： 1.- Un compuesto de Formula (I):o sales farmacéuticamente aceptables del mismo, en donde: Y y Z son independientemente CR o N; L es NR- C(O), C(O)NR, C(O)NRC(O)NR, NRC(O)NR, NRC(O)NRC(O), NRC(S)NRCO, NRS(O)0-2 o NRCONRS(O) 0-2;R1 y R3 son independientemente halo, (CR2) kR6, (CR2) kNR7R8, (CR2) kOR9, (CR2) kSR9, o un C1-6 alquilo, C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido; R2 es (CR2) kR6, (CR2) 1-4OR9, (CR2) 1-4NR7R8, u un C1-6 alquilo, C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido; R4 es (CR2) kR6, (CR2) kOR9, o un C1-6 alquilo, C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido; R5 es H, halo o C1-6 alquilo; R6 es un C3-7 cicloalquilo opcionalmente sustituido, o un arilo, heterociclo o heteroarilo de 5-12 miembros opcionalmente sustituido; R7 y R8 son independientemente H, (CR2) kNR7R8, (CR2)kOR9, (CR2) k-R6, o un C1-6 alquilo,C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido; o R7 y R8 junto con N en cada NR7R8 pueden formar un anillo opcionalmente sustituido; R9 es H, (CR2) k- R6, o un C1-6 alquilo, C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido; cada R es H o C1-6alquil con un carbono que es opcionalmente sustituido o reemplazado por N, O, =0, S; o dos grupos alquileno en (CR2) k pueden formar un alquenilo o alquinilo; cada C1-6 o alquilo, C2-6 alquenilo o C2-6 alquinilo opcionalmente sustituido es opcionalmente halogenado u opcionalmente sustituido con N, O ó S;k es 0- 6; y n es 0-2; siempre y cuando L es C(O) NRC(O)NR, NRC(O)NR, NRC(O) NRC(O), NRC(S) NRCO o NRCONRS(O) 0-2 cuando R1 es halo, (CR2) kNR7R8 o C5-8 heterocicloalquilo y R2 es C1-6 alquilo. 2.- El compuesto de la Reivindicación 1, en donde Y es CH. 3.- El compuesto de la Reivindicación 1, en donde Z es N.

30. 发明专利

ECSP10010044A COMPUESTOS DE 5-(4-(HALO-ALCOXI)-FENIL)-PIRIMIDIN-2-AMINA Y COMPOSICIONES COMO INHIBIDORES DE CINASA 未知
公开(公告)号：ECSP10010044A
公开(公告)日：2010-04-30
申请号：ECSP10010044
申请日：2010-03-19
申请人： IRM LLC
发明人： YOU SHULI , MOLTENI VALENTINA , LI XIAOLIN , CHIANELLI DONATELLA , LOREN JON , NABAKKA JULIET , LIU XIAODONG
IPC分类号： A61K31/505 , A61P7/04 , C07D239/42
摘要： La invención proporciona compuestos de la fórmula (1), y composiciones farmacéuticas de los mismos, los cuales son útiles como inhibidores de cinasa de proteína, así como métodos para utilizar tales compuestos con el fin de tratar, disminuir, o prevenir una condición asociada con una actividad de cinasa anormal o mal regulada. En algunas modalidades, la invención proporciona métodos para utilizar tales compuestos con el fin de tratar, disminuir, o prevenir enfermedades o trastornos que involucren una activación anormal de las cinasas c-kit, PDGFR?, PDGFRß, CSF1R, Abl, BCR-Abl, CSK, JNK1, JNK2, p38, p70S6K, TGFß, SRC, EGFR, trkB, FGFR3, Fes, Lck, Syk, RAF, MKK4, MKK6, SAPK2ß, BRK, Fms, KDR, c-raf o b-raf.

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