专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

21. 发明申请

WO2021152380A1 MICROFLUIDIC CHIPS WITH INTEGRATED ELECTRONIC SENSORS 审中-公开
公开(公告)号：WO2021152380A1
公开(公告)日：2021-08-05
申请号：PCT/IB2020/061682
申请日：2020-12-09
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM ISRAEL - SCIENCE &TECHNOLOGY LTD. , IBM (CHINA) INVESTMENT COMPANY LTD.
发明人： ZAFAR, Sufi , TEMIZ, Yuksel , DELAMARCHE, Emmanuel
IPC分类号： G01N27/30 , G01N27/26
摘要： Apparatuses and methods of manufacturing thereof, regarding microfluidic chips with integrated electronic sensors, comprise a conductive plug(104) of a reference electrode structure, the conductive plug(104) extending from within a microfluidic channel(108) to within a reference fluid holding chamber(102) that is in fluid isolation from the microfluidic channel(108). Thus it can eliminate a requirement to insert a reference electrode(106) into a microfluidic chip(100) at the moment of use.

22. 发明申请

WO2016156933A1 MICROFLUIDIC DEVICE WITH LONGITUDINAL AND TRANSVERSAL LIQUID BARRIERS FOR TRANSVERSAL FLOW MIXING 审中-公开
标题翻译：具有用于横向流动混合的纵向和横向液体障碍物的微流体装置
公开(公告)号：WO2016156933A1
公开(公告)日：2016-10-06
申请号：PCT/IB2015/054512
申请日：2015-06-15
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM UNITED KINGDOM LIMITED , IBM (CHINA) INVESTMENT COMPANY LIMITED
发明人： GOEKCE, Onur , DELAMARCHE, Emmanuel
IPC分类号： B01L3/00 , B01J19/00
CPC分类号： B01L3/502715 , B01F1/00 , B01F13/0064 , B01F13/0086 , B01F13/1022 , B01L3/50273 , B01L2200/027 , B01L2200/0684 , B01L2200/16 , B01L2300/0851 , B01L2300/0867 , B01L2300/089 , B01L2300/161 , B01L2400/0487 , B01L2400/06 , B01L2400/086
摘要： A microfluidic device (1) comprises a set of one or more microchannels (10) each comprising: a microchannel portion (12) with a longitudinal liquid barrier (20) extending longitudinally therein, thereby defining a first region (121) and a second region (122) in the microchannel portion (12); one or more first liquid passages (22), at the level of the longitudinal barrier (20); a liquid inlet (11), configured to allow liquid to enter the first region (121); a liquid outlet (13), configured to allow liquid to leave the microchannel portion (12); a transversal liquid barrier (30) arranged between the microchannel portion (12) and the liquid outlet (13) to hold liquid flowed from the liquid inlet (11) in the first region (121), in operation; and one or more second liquid passages (32) at the level of transversal liquid barrier (30), the device further comprising liquid pumping means (15) configured to displace liquid through each microchannel portion (12) of the set of one or more microchannels (10), wherein, the one or more first liquid passages (22) are configured so as to allow, in operation, excess liquid in the first region (121) to flow into the second region (122), transversally to the longitudinal barrier (20), and the one or more second liquid passages (32) are configured so as to allow, in operation, excess liquid in the longitudinal portion (12) to be discharged via the liquid outlet (13). A method for controlling liquid in the microfluidic device (1) is also provided.
摘要翻译：微流体装置（1）包括一组一个或多个微通道（10），每个微通道（10）包括：具有在其中纵向延伸的纵向液体屏障（20）的微通道部分（12），从而限定第一区域（121）和第二区域（122）在所述微通道部分（12）中; 在纵向屏障（20）的水平面上的一个或多个第一液体通道（22）; 液体入口（11），构造成允许液体进入第一区域（121）; 液体出口（13），被配置为允许液体离开微通道部分（12）; 布置在微通道部分（12）和液体出口（13）之间的横向液体屏障（30），用于保持在第一区域（121）中从液体入口（11）流出的液体; 以及在横向液体屏障（30）的水平面上的一个或多个第二液体通道（32），所述装置还包括液体泵送装置（15），其构造成将液体置换通过所述一组或多个微通道的每个微通道部分（12）（10），其中，所述一个或多个第一液体通道（22）构造成在操作中允许所述第一区域（121）中的多余液体流入所述第二区域（122），横向于所述纵向屏障（20），并且所述一个以上的第二液体通道（32）构造成在操作中允许所述纵向部分（12）中的多余液体经由所述液体出口（13）排出。还提供了一种用于控制微流体装置（1）中的液体的方法。

23. 发明申请

WO2016146710A1 MICROFLUIDIC DEVICE WITH ANTI-WETTING, VENTING AREAS 审中-公开
标题翻译：具有防潮，露天区域的微流体装置
公开(公告)号：WO2016146710A1
公开(公告)日：2016-09-22
申请号：PCT/EP2016/055733
申请日：2016-03-16
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM RESEARCH GMBH
发明人： DELAMARCHE, Emmanuel , TEMIZ, Yuksel
IPC分类号： B01L3/00
CPC分类号： B01L3/502707 , B01L3/502723 , B01L2200/0615 , B01L2200/0684 , B01L2200/12 , B01L2200/141 , B01L2300/0645 , B01L2300/0851 , B01L2300/0858 , B01L2300/0867 , B01L2300/165 , B01L2400/0406 , B01L2400/0424 , B01L2400/086 , B01L2400/088 , B81C1/00
摘要： Amicrofluidic device and method for fabrication includes a microfluidic channel that has a closed portion, which comprises: a liquid pathway formed by a wetting area; and an anti- wetting area extending along and contiguously with the liquid pathway. The anti-wetting area is configured so as to provide a vent to evacuate gas along the anti-wetting area.
摘要翻译：微流体装置和制造方法包括具有封闭部分的微流体通道，其包括：由润湿区域形成的液体通路; 以及与液体通道一起并且与液体通路连续的抗湿润区域。防湿区域被构造成提供排气口以沿着防潮湿区域抽空气体。

24. 发明申请

WO2014207619A1 FABRICATION OF A MICROFLUIDIC CHIP PACKAGE OR ASSEMBLY WITH SEPARABLE CHIPS 审中-公开
标题翻译：微流芯片包装的制造或组装与可分离的CHIPS
公开(公告)号：WO2014207619A1
公开(公告)日：2014-12-31
申请号：PCT/IB2014/062346
申请日：2014-06-18
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM RESEARCH GMBH
发明人： DELAMARCHE, Emmanuel , TEMIZ, Yuksel
IPC分类号： B01L3/00 , B81C1/00 , G01N33/487
CPC分类号： B01L3/502707 , B01L2300/044 , B01L2300/0627 , B01L2300/0816 , B01L2300/0883 , B01L2300/0887 , B81C1/00888 , G01N33/487
摘要： The present invention is notably directed to methods of fabrication of a microfluidic chip package or assembly (1), comprising: providing (S1) a substrate (10, 30) having at least one block (14, 14a) comprising one or more microfluidic structures on a face (F) of the substrate; partially cutting (S2) into the substrate to obtain partial cuts (10c), such that a residual 6 thickness of the substrate at the level of the partial cuts (10c) enables singulation of said at least one block (14, 14a); cleaning (S4) said at least one block; and applying (S5 – S7) a cover-film (62) to cover said at least one block (14, 14a), whereby at least one covered block is obtained, the applied cover film still enabling singulation of each covered block, wherein each covered block corresponds to a microfluidic chip after singulation. The present invention is further directed to microfluidic chips, packing or assembly, obtainable with such 12 methods.
摘要翻译：本发明特别涉及制造微流体芯片封装或组件（1）的方法，包括：（S1）具有至少一个包含一个或多个微流体结构的块（14,14a）的衬底（10,30）在基材的表面（F）上; 部分切割（S2）到基板中以获得部分切割（10c），使得在部分切口（10c）的水平处的基板的残余6厚度使得能够对所述至少一个块（14,14a）进行分割; 清洁（S4）至少一块; 以及施加（S5-S7）覆盖膜（62）以覆盖所述至少一个块（14,14a），由此获得至少一个覆盖块，所施加的覆盖膜仍然能够对每个被覆盖的块进行分割，其中每个覆盖块对应于分离后的微流体芯片。本发明进一步涉及可用这种12种方法获得的微流控芯片，包装或组装。

25. 发明申请

WO2013072790A1 MICROFLUIDIC DEVICE WITH DEFORMABLE VALVE 审中-公开
标题翻译：具有可变阀的微流体装置
公开(公告)号：WO2013072790A1
公开(公告)日：2013-05-23
申请号：PCT/IB2012/055643
申请日：2012-10-17
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM JAPAN, LTD. , CORISBIOCONCEPT SPRL , IBM RESEARCH GMBH
发明人： AVRAIN, Laetitia , DELAMARCHE, Emmanuel , HITZBLECK, Martina , LAURENT, Thierry , MERTENS, Pascal , SMEKENS, Valérie
IPC分类号： F04B53/10 , B81B3/00 , F16K7/16 , G01N37/00
CPC分类号： B01L3/00 , B01L3/502738 , B01L3/502746 , B01L7/52 , B01L2200/0684 , B01L2300/0816 , B01L2300/0864 , B01L2300/14 , B01L2400/0406 , B01L2400/0481 , B01L2400/0487 , B01L2400/0655 , B01L2400/0688 , B01L2400/082 , B01L2400/086 , F16K99/0001 , F16K99/0015 , F16K99/0017 , F16K99/0026 , F16K2099/008 , F16K2099/0084
摘要： The invention is notably directed to a microfluidic device (100) comprising: a first microchannel (31), a second microchannel (32), and a valve (50) comprising at least an input port (51) and an output port (52), said ports respectively connected to the first microchannel and the second microchannel, the valve designed to control a flow of a liquid (L) along a flow direction (z) defined by the ports, wherein the valve further comprises one or more walls (54, 56, 58, 20) joining the ports and defining a hollow chamber (53) that is wider than each of the microchannels in a direction perpendicular to the flow direction, said walls at least partly deformable along a deformation direction (– y) intersecting the flow direction, such that the walls can be given at least a first deformation state (S1) and a second deformation state (S2), the liquid being pulled along the flow direction substantially more in the second deformation state than in the first deformation state, by capillarity.
摘要翻译：本发明特别涉及一种微流体装置（100），包括：第一微通道（31），第二微通道（32）和至少包括输入端口（51）和输出端口（52）的阀（50），所述端口分别连接到所述第一微通道和所述第二微通道，所述阀被设计成沿着由所述端口限定的流动方向（z）控制液体（L）的流动，其中所述阀还包括一个或多个壁（54 ，56,58,20），其连接所述端口并且限定在垂直于所述流动方向的方向上比每个所述微通道宽的中空室（53），所述壁沿着与所述流动方向垂直的变形方向（ - y）至少部分地变形，流动方向，使得壁能够被给予至少第一变形状态（S1）和第二变形状态（S2），液体在第二变形状态下比沿第一变形状态大大地沿着流动方向被拉动，由毛细作用。

26. 发明申请

WO2019229554A1 AUTHENTICATION OF PACKAGED PRODUCTS 审中-公开
公开(公告)号：WO2019229554A1
公开(公告)日：2019-12-05
申请号：PCT/IB2019/053520
申请日：2019-04-30
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM (CHINA) INVESTMENT COMPANY LTD. , IBM DEUTSCHLAND GMBH
发明人： GOEKÇE, Onur , DELAMARCHE, Emmanuel , FREIRE-STOEGBUCHNER, Eduarda , CAMENISCH, Jan
IPC分类号： G06Q30/00
摘要： Methods are provided for producing an authenticated packaged product. The method includes providing on the product a security code encoding security data for the product, packing the product in packaging, and providing a tag carrying encrypted product data on the packaging. The product data comprises the security data for the product. The method further comprises storing a decryption key for the encrypted product data at a network server, and providing on the packaging access data for accessing the decryption key at the network server. Corresponding methods and systems are provided for verifying authenticity of such an authenticated packaged product.

27. 发明申请

WO2017077409A1 CONTINUOUS, CAPACITANCE-BASED MONITORING OF LIQUID FLOWS IN A MICROFLUIDIC DEVICE 审中-公开
标题翻译：微流控装置中连续，电容式液体流动监测
公开(公告)号：WO2017077409A1
公开(公告)日：2017-05-11
申请号：PCT/IB2016/056131
申请日：2016-10-13
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM (CHINA) INVESTMENT COMPANY LTD. , IBM RESEARCH GMBH
发明人： DELAMARCHE, Emmanuel , TEMIZ, Yuksel
IPC分类号： G01R27/26 , G01N27/22
CPC分类号： B01L3/50273 , B01L3/502715 , B01L2200/027 , B01L2200/0605 , B01L2200/0621 , B01L2200/143 , B01L2300/0645 , B01L2300/0816 , B01L2300/0861 , B01L2400/0406 , G01F1/00 , G01N27/22
摘要： A microfluidic chip (10) comprising a microchannel (11,11a) fillable with a liquid (5), the microchannel (11,11a) comprises a pair of electrodes (21,22,21a,22a), and a liquid flow path (12) defined between the electrodes (21,22,21a,22a), wherein each of the electrodes (21,22,21a,22a) extends along the flow path (12) and parallel to a direction of a liquid (5) filling the microchannel (11,11a), in operation, and an electrical circuitry connected to each of the electrodes (21,22,21a,22a) and configured to continuously measure, via the electrodes (21,22,21a,22a), a capacitance of the electrodes (21,22,21a,22a) being wet by a liquid (5) continuously filling the flow path (12), as a function of time, in operation.
摘要翻译：微流体芯片（10）包括可用液体（5）填充的微通道（11,11a），微通道（11,11a）包括一对电极（21,22,21a，22a ）和限定在电极（21,22,21a，22a）之间的液体流动路径（12），其中每个电极（21,22,21a，22a）沿着流动路径（12）延伸并平行于在操作中填充微通道（11,11a）的液体（5）的方向以及连接到每个电极（21,22,21a，22a）并被配置为经由电极（21,22,21a， 22,21a，22a），在操作中，电极（21,22,21a，22a）的电容由连续填充流动路径（12）的液体（5）随时间而变湿。

28. 发明申请

WO2016128544A1 MICROFLUIDIC PROBE HEAD FOR PROVIDING A SEQUENCE OF SEPARATE LIQUID VOLUMES SEPARATED BY SPACERS 审中-公开
标题翻译：用于提供分隔开的分离液体体积的序列的微流体探头
公开(公告)号：WO2016128544A1
公开(公告)日：2016-08-18
申请号：PCT/EP2016/052996
申请日：2016-02-12
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM RESEARCH GMBH
发明人： AUTEBERT, Julien , DELAMARCHE, Emmanuel , KAIGALA, Govind , KASHYAP, Aditya , VAN KOOTEN, Xander Frank
IPC分类号： B01L3/02 , B01L3/00 , G01N35/10
CPC分类号： B01L3/502715 , B01L3/0262 , B01L3/0293 , B01L3/502784 , B01L2200/0621 , B01L2200/0636 , B01L2200/0673 , B01L2300/0861 , B01L2300/089 , B01L2400/0478 , B01L2400/0484 , B01L2400/0487 , B01L2400/086 , G01N1/28 , G01N35/08 , G01N2001/028
摘要： A microfluidic probe head for providing a sequence of separate liquid volumes separated by spacers, the separate liquid volumes comprising a respective target substance associated with a respective target area, the microfluidic probe head comprising: an inlet and an outlet, a first fluid channel fluidly connected to the inlet, the first fluid channel being configured for delivering an injection liquid from the inlet to a respective target area, the respective target area being covered by an immersion liquid and comprising a respective target substance, a second fluid channel fluidly connected to the outlet, the second fluid channel being configured for delivering liquid volumes from the respective target area to the outlet, each liquid volume including at least some of the injection liquid, at least some of the immersion liquid and a respective target substance, and a spacer insertion unit fluidly connected to the second fluid channel, the spacer insertion unit being configured for inserting spacers into the second fluid channel between the liquid volumes to thereby provide the sequence of separate liquid volumes separated by spacers.
摘要翻译：一种微流体探针头，用于提供由间隔物隔开的一系列分开的液体体积，所述分离的液体体积包含与相应目标区域相关联的相应目标物质，所述微流体探针头包括：入口和出口，第一流体通道流体连接所述第一流体通道被配置为将注射液体从所述入口输送到相应的目标区域，所述相应的目标区域被浸没液体覆盖并且包括相应的目标物质，流体连接到所述出口的第二流体通道第二流体通道被配置用于将液体体积从相应的目标区域输送到出口，每个液体体积包括至少一些注射液体，至少一些浸没液体和相应的目标物质，以及间隔物插入单元流体连接到第二流体通道，间隔件插入单元构造成用于插入将间隔物排入液体体积之间的第二流体通道，从而提供由间隔物隔开的单独液体体积的顺序。

29. 发明申请

WO2016128543A1 MICROFLUIDIC PROBE HEAD FOR PROCESSING A SEQUENCE OF LIQUID VOLUMES SEPARATED BY SPACERS 审中-公开
标题翻译：用于处理由间隔物分离的液体体积的序列的微流体探头
公开(公告)号：WO2016128543A1
公开(公告)日：2016-08-18
申请号：PCT/EP2016/052995
申请日：2016-02-12
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM RESEARCH GMBH
发明人： AUTEBERT, Julien , DELAMARCHE, Emmanuel , KAIGALA, Govind , VAN KOOTEN, Xander Frank
IPC分类号： B01L3/02 , B01L3/00 , G01N35/10
CPC分类号： B01L3/502715 , B01L3/0262 , B01L3/0293 , B01L3/502769 , B01L3/502784 , B01L2200/027 , B01L2200/0636 , B01L2200/0673 , B01L2300/0848 , B01L2300/0861 , B01L2300/089 , B01L2400/0487 , B01L2400/086 , G01N35/00871 , G01N35/10 , G01N2035/1034
摘要： A microfluidic probe head for processing a sequence of separate liquid volumes separated by spacers, the microfluidic probe head comprising: an inlet and an outlet, a first fluid channel and a second fluid channel, and a fluid bypass connecting the first fluid channel and the second fluid channel to each other, wherein, the first fluid channel is configured for delivering the sequence of separate liquid volumes from the inlet toward a deposition area, the fluid bypass connects the first fluid channel and the second fluid channel, to allow the spacers to be removed from the first fluid channel and thereby obtain a free sequence of separate liquid volumes, without spacers, the first fluid channel is configured for delivering the free sequence of separate liquid volumes to the deposition area, and the second fluid channel is configured for delivering the removed spacers from the fluid bypass to the outlet.
摘要翻译：一种微流体探针头，用于处理由间隔物隔开的一系列分开的液体体积，所述微流体探针头包括：入口和出口，第一流体通道和第二流体通道，以及连接第一流体通道和第二流体通道的流体旁路流体通道彼此之间，其中，第一流体通道构造成用于将分离的液体体积的序列从入口传送到沉积区域，流体旁路连接第一流体通道和第二流体通道，以允许间隔物为从第一流体通道移除，从而获得没有间隔物的单独的液体体积的自由序列，第一流体通道被配置为将分离的液体体积的自由序列输送到沉积区域，并且第二流体通道被配置为输送将流体旁路的间隔物移除到出口。

30. 发明申请

WO2014049465A1 MICROFLUIDIC SURFACE PROCESSING SYSTEMS WITH SELF-REGULATED DISTANCE-TO-SURFACE CONTROL 审中-公开
标题翻译：具有自调节距离到表面控制的微流表面处理系统
公开(公告)号：WO2014049465A1
公开(公告)日：2014-04-03
申请号：PCT/IB2013/058097
申请日：2013-08-29
申请人： INTERNATIONAL BUSINESS MACHINES CORPORATION , IBM (CHINA) INVESTMENT COMPANY LTD. , IBM RESEARCH GMBH
发明人： DELAMARCHE, Emmanuel , HITZBLECK, Martina , KAIGALA, Govind , LOVCHIK, Robert
IPC分类号： B01J19/00
CPC分类号： G05D7/0694 , B01L3/0293 , B81C99/0025 , G01N1/31 , G01N1/32 , G01N2035/1034 , Y10T137/0318 , Y10T137/8593
摘要： The present invention is notably directed to methods and system that enable self-regulated and automated distance-to-surface control of a microfluidic surface processing system. This system (1) comprises: a microfluidic probe head (10), comprising a processing fluid circuit (20) designed for dispensing a surface processing fluid (25) from a processing fluid aperture (21) thereof; a mechanism (40), preferably a linkage mechanism, configured to apply a force to or modulate a force applied to the microfluidic probe head towards a surface (S) to be processed; and a lifting fluid circuit (30), said circuit being: integral with the microfluidic probe head; distinct from the processing fluid circuit; and designed for dispensing a lifting fluid (35) from a lifting fluid aperture (31) thereof, with pressure such as to counter the force applied or modulated by the mechanism (40), at the level of said surface (S). The invention extends to related methods of operation.
摘要翻译：本发明特别涉及能够对微流体表面处理系统进行自调节和自动距离到表面控制的方法和系统。该系统（1）包括：微流体探针头（10），包括设计成用于从其处理流体孔（21）分配表面处理流体（25）的处理流体回路（20）优选地连接机构的机构（40），其被构造成施加力或调制施加到所述微流体探针头的力朝向待处理的表面（S）; 和提升流体回路（30），所述回路与微流体探针头成一体; 不同于处理流体回路; 并且设计成用于从其提升流体孔（31）分配提升流体（35），其压力例如抵抗由所述机构（40）施加或调制的力在所述表面（S）的水平处。本发明涉及相关操作方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式