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21. 发明授权

US5898000A Substrate for controlling growth direction of nerve fibers and process for preparing the same, method for controlling growth direction of nerve fibers and artificial neuronal network by the same 失效
标题翻译：用于控制神经纤维生长方向的底物及其制备方法，用于控制神经纤维生长方向和人造神经网络的方法
公开(公告)号：US5898000A
公开(公告)日：1999-04-27
申请号：US712823
申请日：1991-06-10
申请人： Takehisa Matsuda , Takashi Sugawara , Kazuhiko Inoue
发明人： Takehisa Matsuda , Takashi Sugawara , Kazuhiko Inoue
IPC分类号： C12M1/00 , C12M3/00 , C12N5/00 , C12N5/0793
CPC分类号： C12N5/0068 , C12N5/0619 , C12N2533/54 , C12N2535/10
摘要： A substrate for controlling the growth direction of serve fibers charcterized in that a nerve cell adhesive substance is fixed in the form of a desired pattern and a process for preparing the substrate, a method for controlling the growth direction of nerve fibers and a neuronal network.According to this invention, precise control of nerve fibers' growth direction is achieved.
摘要翻译：用于控制服用纤维的生长方向的底物是神经细胞粘附物质以所需图案的形式和制备基质的方法固定，控制神经纤维的生长方向和神经元网络的方法。根据本发明，可以精确控制神经纤维的生长方向。

22. 发明授权

US5486547A Surgical adhesive sheet, surgical instruments and methods of using the same 失效
公开(公告)号：US5486547A
公开(公告)日：1996-01-23
申请号：US335341
申请日：1994-11-03
申请人： Takehisa Matsuda , Tetsuo Itoh , Tohru Tani
发明人： Takehisa Matsuda , Tetsuo Itoh , Tohru Tani
IPC分类号： A61B17/00 , A61B17/11 , A61F2/00 , A61F2/06 , A61F13/00 , A61F13/02 , A61F13/15 , A61F13/20 , A61F13/36 , A61L31/10 , A61L15/26 , C08L75/04 , C08L75/08
CPC分类号： A61F2/06 , A61B17/00491 , A61B17/11 , A61F13/00012 , A61F13/0209 , A61F13/0226 , A61L31/10 , A61B17/1114 , A61B2017/1107 , A61B2017/1125 , A61F13/023 , A61F13/0273 , A61F13/15252 , A61F13/551 , A61F2/0063 , A61F2013/00463 , A61F2013/00472 , A61F2013/00489 , A61F2013/00519 , A61F2013/00604 , A61F2013/00659 , A61F2013/00719 , A61F2013/0091 , A61F2013/00927 , Y10S528/905 , Y10T428/31554 , Y10T428/31562 , Y10T428/31576 , Y10T428/3158 , Y10T428/31587 , Y10T428/31591 , Y10T428/31598
摘要： A sheet material, coated with a surgical adhesive comprising an NCO-terminated urethane prepolymer, is used for bonding of tissues, with improved handleability.Surgical instruments, comprising a non-adherent material towards an NCO-terminated urethane prepolymer, are used for application of surgical adhesive. Such instruments, comprising a rod tapered so that the tip can be partly inserted into blood vessel, are suitable for anastomosis of blood vessel.

23. 发明授权

US5462976A Photocurable glycosaminoglycan derivatives, crosslinked glycosaminoglycans and method of production thereof 失效
标题翻译：光固化型糖胺聚糖衍生物，交联糖胺聚糖及其生产方法
公开(公告)号：US5462976A
公开(公告)日：1995-10-31
申请号：US13799
申请日：1993-02-05
申请人： Takehisa Matsuda , Minoo J. Moghaddam , Katsukiyo Sakurai
发明人： Takehisa Matsuda , Minoo J. Moghaddam , Katsukiyo Sakurai
IPC分类号： A61K47/36 , A61K31/715 , A61K31/726 , A61K31/727 , A61K31/737 , A61K47/48 , A61L27/00 , A61L27/20 , A61L31/04 , A61L33/00 , A61L33/08 , A61L33/10 , A61P43/00 , C08B37/00 , C08B37/08 , C08B37/10 , C08F251/00 , C08L5/00 , C08L5/08 , C08L5/10 , C08L51/02 , C08J3/28
CPC分类号： B82Y5/00 , A61K47/48961 , A61L27/20 , A61L31/042 , A61L33/08 , C08B37/0063
摘要： Photocurable glycosaminoglycan (GAG) derivatives and crosslinked glycosaminoglycans, which are highly safe and biocompatible, a method of preparing such photocurable GAG derivatives readily moldable by casting using a solvent when desired, by which method unreacted substances causative of adverse effects can be readily eliminated, and a method of producing the crosslinked GAGs and medical materials based on the photocurable GAG derivatives or crosslinked GAGs are provided. The photocurable GAG derivatives comprise a glycosaminoglycan and a photoreactive compound bound thereto and can be produced, for example, by subjecting hydroxyl or carboxyl groups of the glycosaminoglycan to esterification reaction or amidation reaction, respectively, with the photoreactive compound. The crosslinked GAGs are derived from the photocurable GAG derivatives by intermolecular crosslinking of the photoreactive compound bound thereto.
摘要翻译：可光固化的糖胺聚糖（GAG）衍生物和交联的糖胺聚糖，其是高度安全和生物相容的，制备这种可光固化的GAG衍生物的方法，其易于通过在需要时使用溶剂浇铸而成型，由此可以容易地消除引起不利影响的未反应物质，以及提供了基于可光固化的GAG衍生物或交联的GAG生产交联的GAG和医疗材料的方法。可光固化的GAG衍生物包含糖胺聚糖和结合到其上的光反应性化合物，并且可以例如通过使糖胺聚糖的羟基或羧基与光反应性化合物分别进行酯化反应或酰胺化反应来制备。交联的GAG通过与其结合的光反应性化合物的分子间交联衍生自可光固化的GAG衍生物。

24. 发明授权

US5202227A Control of cell arrangement 失效
标题翻译：细胞安排的控制
公开(公告)号：US5202227A
公开(公告)日：1993-04-13
申请号：US531596
申请日：1990-06-01
申请人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： C12M3/04 , C12N5/00 , C12N5/071 , G03F7/00 , G03F7/008
CPC分类号： G03F7/008 , C12N5/0068 , C12N5/069 , G03F7/00 , C12N2533/30 , C12N2533/52 , C12N2535/10
摘要： A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner. The device is prepared by a process which comprises applying a photosensitive, cell adhesive or cell non-adhesive polymer to a surface having a reverse cell adhesivity property to that of the applied polymer, and patternwise irradiating a light to the photosensitive polymer layer followed by development; a process which comprises patternwise irradiating UV or radiation to a cell non-adhesive surface to produce a cell adhesive functional group such as carboxyl group or amino group in the irradiated portion; or a process which comprises patternwise irradiating UV or radiation to a cell adhesive or non-adhesive surface made of plastics to produce a polymerization initiation site in the irradiated portion, and graft-polymerizing at least one monomer having the reverse cell adhesivity property to the plastic surface to produce a polymer on the irradiated portion of plastic surface.

25. 发明授权

US08123798B2 Biofilm formation inhibitor and treatment device thereof 有权
公开(公告)号：US08123798B2
公开(公告)日：2012-02-28
申请号：US11719819
申请日：2005-11-16
申请人： Takehisa Matsuda , Ryo Maeyama
发明人： Takehisa Matsuda , Ryo Maeyama
IPC分类号： A61F2/06 , A61F2/00
摘要： A treatment device such as a biliary stent, capable of effectively and continuously inhibiting biofilm formation, and a biofilm formation inhibitor suitable for coating on the treatment device by killing all bacteria including E. coli and by suppressing the growth of these bacteria, are provided. A biofilm formation inhibitor having an effective amount of catechin for inhibiting biofilm formation and a carrier that is suitable for adhesion of said catechin to a treatment device to be placed in the living body, are provided.

26. 发明申请

US20090099646A1 BIOFILM FORMATION INHIBITOR AND TREATMENT DEVICE THEREOF 有权
标题翻译：生物膜形成抑制剂及其处理装置
公开(公告)号：US20090099646A1
公开(公告)日：2009-04-16
申请号：US11719819
申请日：2005-11-16
申请人： Takehisa Matsuda , Ryo Maeyama
发明人： Takehisa Matsuda , Ryo Maeyama
IPC分类号： A61F2/06 , A61K31/352
CPC分类号： A01N25/10 , A01N43/16 , A01N65/08 , A61L31/16 , A61L2300/404 , A01N25/24
摘要： A treatment device such as a biliary stent, capable of effectively and continuously inhibiting biofilm formation, and a biofilm formation inhibitor suitable for coating on the treatment device by killing all bacteria including E. coli and by suppressing the growth of these bacteria, are provided. A biofilm formation inhibitor having an effective amount of catechin for inhibiting biofilm formation and a carrier that is suitable for adhesion of said catechin to a treatment device to be placed in the living body, are provided.
摘要翻译：提供了能够有效连续地抑制生物膜形成的治疗装置，例如胆管支架，以及适用于通过杀死包括大肠杆菌在内的所有细菌并抑制这些细菌的生长而在治疗装置上涂覆的生物膜形成抑制剂。提供了具有抑制生物膜形成的有效量的儿茶素的生物膜形成抑制剂和适合于将所述儿茶素粘附到待置于生物体中的治疗装置的载体。

27. 发明申请

US20050131192A1 Polymer and process for producing polymer 审中-公开
标题翻译：聚合物和生产聚合物的方法
公开(公告)号：US20050131192A1
公开(公告)日：2005-06-16
申请号：US10499331
申请日：2002-10-30
申请人： Takehisa Matsuda , Tetsuo Itoh , Tatsuya Ohsumi
发明人： Takehisa Matsuda , Tetsuo Itoh , Tatsuya Ohsumi
IPC分类号： A61L24/04 , C08G18/10 , C08G18/48 , C08G18/50 , C08G18/77 , C08L71/02 , C09J175/04 , C08G18/00
CPC分类号： C09J175/04 , A61L24/04 , A61L24/046 , C08G18/10 , C08G18/4837 , C08G18/5015 , C08G18/5021 , C08G18/5072 , C08G18/773 , C08L71/02 , C08L75/04 , C08G18/302
摘要： The object of the present invention is to provide a polymer best suited for use as a medical adhesive excellent in wet adhesion strength (water-resistant adhesive strength). In the present invention, a polymer capable of forming a cured film and useful as a medical adhesive, which has a viscosity at 37° C. of 0.5 to 2,000 Pa·s and shows a saturated water absorption of 0.2 to 5 ml/g, is used. The above-mentioned polymer preferably shows an initial water absorption rate of 0.01 to 0.5 ml/g·min, the wet elongation percentage of the cured film is preferably 100 to 1,500%, and the wet 100% modulus of the cured film is preferably 0.01 to 10 MPa. Additionally, it is preferable that the above-mentioned polymer contains oxyethylene groups and in which the oxyethylene group content is 30 to 100% by weight based on the weight of the polymer.
摘要翻译：本发明的目的是提供一种最适合用作湿粘合强度（耐水粘合强度）优异的医用粘合剂的聚合物。在本发明中，能够形成固化膜并用作医用粘合剂的聚合物在37℃下的粘度为0.5〜2,000Pa·s，饱和吸水倍数为0.2〜5ml / g，用来。上述聚合物优选初始吸水率为0.01〜0.5ml / g·min，固化膜的湿延伸率优选为100〜1500％，固化膜的湿100％模量优选为0.01 至10MPa。此外，上述聚合物优选含有氧化乙烯基，其中氧乙烯基含量相对于聚合物的重量为30〜100重量％。

28. 发明授权

US6075066A Material to be worn on the eyeball 失效
标题翻译：材料要佩戴在眼球上
公开(公告)号：US6075066A
公开(公告)日：2000-06-13
申请号：US869983
申请日：1997-06-05
申请人： Takehisa Matsuda , Hiroshi Nakao
发明人： Takehisa Matsuda , Hiroshi Nakao
IPC分类号： G02C7/04 , A61K9/00 , G02B1/04
CPC分类号： A61K9/0051 , G02B1/043
摘要： The present invention provides semi-spherical materials to be worn on the eyeball, such as contact lenses for visual acuity correction or medical treatment use, cornea protecting materials, controlled drug release contact lenses and the like, which comprise, as a main component, a glycosaminoglycan existing in the living body as an extracellular matrix component of connective tissues and satisfy various requirements such as dimentional stability, transparency, surface water wettability, tissue compatibility, oxygen permeability and the like. In other words, the material to be worn on the eyeball has a shape of semi-spherical surface compatible in shape with the mammalian eyeball and has biological and surface-physical compatibilities with ophthalmic tissues and comprises, as a main component, a substantially transparent photocured crosslinked-glycosaminoglycan obtained by allowing photoreactive groups covalently bonded to a glycosaminoglycan to crosslink mutually by photoirradiation.
摘要翻译： PCT No.PCT / JP95 / 00419 Sec。 371日期1996年3月1日 102（e）1996年3月1日PCT 1995年3月14日PCT PCT。 WO95 / 25287 PCT出版物日期1995年9月21日本发明提供了要戴在眼球上的半球形材料，例如用于视力矫正或医疗治疗用途的隐形眼镜，角膜保护材料，受控药物释放隐形眼镜等，其包括：主要成分，作为结缔组织的细胞外基质成分存在于生物体中的糖胺聚糖，满足各种要求，如维度稳定性，透明性，表面水润湿性，组织相容性，透氧性等。换句话说，穿戴在眼球上的材料具有与哺乳动物眼球形状相容的半球形表面形状，并且与眼组织具有生物学和表面物理的相容性，并且包含作为主要成分的基本上透明的光固化通过使与光聚合相互作用的光活性基团与糖胺聚糖相互交联而获得的交联糖胺聚糖。

29. 发明授权

US5593814A Control of cell arrangement 失效
标题翻译：细胞排列控制
公开(公告)号：US5593814A
公开(公告)日：1997-01-14
申请号：US308204
申请日：1994-09-19
申请人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： C12M3/04 , C12N5/00 , C12N5/071 , G03F7/00 , G03F7/008 , G03F7/012
CPC分类号： G03F7/008 , C12N5/0068 , C12N5/069 , G03F7/00 , C12N2533/30 , C12N2533/52 , C12N2535/10
摘要： A device for controlling cell arrangement having a pattern composed of a cell adhesive surface and a cell non-adhesive surface, which has a good selectivity of cell adhesion and which can provide a fine pattern of cells in high resolution by culturing cells in a usual manner. The device is prepared by a process which comprises applying a photosensitive, cell adhesive or cell non-adhesive polymer to a surface having a reverse cell adhesivity property to that of the applied polymer, and patternwise irradiating a light to the photosensitive polymer layer followed by development; a process which comprises patternwise irradiating UV or radiation to a cell non-adhesive surface to produce a cell adhesive functional group such as carboxyl group or amino group in the irradiated portion; or a process which comprises patternwise irradiating UV or radiation to a cell adhesive or non-adhesive surface made of plastics to produce a polymerization initiation site in the irradiated portion, and graft-polymerizing at least one monomer having the reverse cell adhesivity property to the plastic surface to produce a polymer on the irradiated portion of plastic surface.
摘要翻译：一种用于控制细胞排列的装置，其具有由细胞粘合剂表面和细胞非粘合剂表面组成的图案，其具有良好的细胞粘附选择性，并且可以通过以常规方式培养细胞而以高分辨率提供细胞图案。该装置通过一种方法制备，该方法包括将光敏，细胞粘合剂或细胞非粘合性聚合物施加到具有与施加的聚合物相反的反电池粘附性的表面，并将光图案照射到感光性聚合物层，随后显影 ; 包括将UV或辐射图案化地照射到细胞非粘合剂表面以在照射部分中产生诸如羧基或氨基的细胞粘附官能团的方法; 或包括以下步骤：将UV或辐射图案化地照射到由塑料制成的细胞粘合剂或非粘合剂表面，以在照射部分中产生聚合起始部位，并将至少一种具有反电池粘附性的单体接枝聚合到塑料表面以在塑料表面的照射部分上产生聚合物。

30. 发明授权

US5128170A Method for manufacturing medical device having a highly biocompatible surface 失效
标题翻译：用于制造具有高生物量表面的医疗装置的方法
公开(公告)号：US5128170A
公开(公告)日：1992-07-07
申请号：US520902
申请日：1990-05-09
申请人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
发明人： Takehisa Matsuda , Kazuhiko Inoue , Nobutaka Tani
IPC分类号： A61L27/34 , A61L29/08 , A61L31/10 , A61L33/06
CPC分类号： A61L27/34 , A61L29/085 , A61L31/10 , A61L33/06
摘要： A medical device having a highly biocompatible surface wherein hydrophilic polymer is bonded onto a surface of the medical device covalently through a nitrogen atom, and a method for manufacturing a medical device having a highly biocompatible surface comprising the steps of applying a hydrophilic polymer having azido group and/or a composition comprising a compound having at least two azido group and a hydrophilic polymer onto the surface of the medical device, and irradiating the biocompatible material with light so that the hydrophilic polymer is bonded to the medical device surface. The device has sufficient biocompatibility, medical functional capability and economical efficiency. The method easily provides a medical device with sufficient biocompatibility without impairing the device's medical functional capability and economical efficiency.

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