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    • 21. 发明申请
    • SYSTEMS AND METHODS FOR ROTATING AND COATING AN IMPLANTABLE DEVICE
    • 用于旋转和涂覆可植入设备的系统和方法
    • US20130177696A1
    • 2013-07-11
    • US13781249
    • 2013-02-28
    • David O'NeillMatthew Coates
    • David O'NeillMatthew Coates
    • A61F2/07
    • A61F2/07A61F2/91B05B12/122B05B13/0228B05B17/0623B05D1/002B05D1/02B05D2254/02B05D2254/04
    • A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The implantable device is rotated at a relative speed. The relative speed may be more than 120 revolutions per minute. An application material is applied to the implantable device using the ultrasonic material delivery apparatus. The relative speed may be sufficient to reduce the size of at least a portion of droplets of the application material. A system for rotating an implantable device is disclosed. The system includes an implantable device and a rotation system configured to rotate the implantable device. A longitudinal axis of the implantable device and a longitudinal axis of a rotation member of the rotation system may be offset a desired dimension. An inside diameter of the implantable device may be larger than an outside diameter of a rotation member.
    • 公开了一种将涂层施加到可植入装置的方法。 该方法包括相对于超声波材料输送装置定位可植入装置。 可植入装置以相对速度旋转。 相对速度可能超过每分钟120转。 使用超声波材料输送装置将施加材料施加到可植入装置。 相对速度可能足以减小应用材料的至少一部分液滴的尺寸。 公开了一种用于旋转可植入装置的系统。 该系统包括可植入装置和被配置为旋转可植入装置的旋转系统。 可植入装置的纵向轴线和旋转系统的旋转构件的纵向轴线可以偏离期望的尺寸。 可植入装置的内径可以大于旋转构件的外径。
    • 22. 发明授权
    • Systems and methods for rotating and coating an implantable device
    • 用于旋转和涂覆可植入装置的系统和方法
    • US08389041B2
    • 2013-03-05
    • US12817544
    • 2010-06-17
    • David O'NeillMatthew Coates
    • David O'NeillMatthew Coates
    • A61L33/00B05D3/00B05D7/00B23Q3/00
    • A61F2/07A61F2/91B05B12/122B05B13/0228B05B17/0623B05D1/002B05D1/02B05D2254/02B05D2254/04
    • A method for applying a coating to an implantable device is disclosed. The method includes positioning an implantable device relative to an ultrasonic material delivery apparatus. The implantable device is rotated at a relative speed. The relative speed may be more than 120 revolutions per minute. An application material is applied to the implantable device using the ultrasonic material delivery apparatus. The relative speed may be sufficient to reduce the size of at least a portion of droplets of the application material. A system for rotating an implantable device is disclosed. The system includes an implantable device and a rotation system configured to rotate the implantable device. A longitudinal axis of the implantable device and a longitudinal axis of a rotation member of the rotation system may be offset a desired dimension. An inside diameter of the implantable device may be larger than an outside diameter of a rotation member.
    • 公开了一种将涂层施加到可植入装置的方法。 该方法包括相对于超声波材料输送装置定位可植入装置。 可植入装置以相对速度旋转。 相对速度可能超过每分钟120转。 使用超声波材料输送装置将施加材料施加到可植入装置。 相对速度可能足以减小应用材料的至少一部分液滴的尺寸。 公开了一种用于旋转可植入装置的系统。 该系统包括可植入装置和被配置为旋转可植入装置的旋转系统。 可植入装置的纵向轴线和旋转系统的旋转构件的纵向轴线可以偏离期望的尺寸。 可植入装置的内径可以大于旋转构件的外径。
    • 25. 发明授权
    • Flat bed side assembly
    • 平床侧组装
    • US4416484A
    • 1983-11-22
    • US359264
    • 1982-03-18
    • David O'Neill
    • David O'Neill
    • B60P3/42B62D33/033B60P1/64
    • B62D33/033B60P3/42
    • A flat bed side assembly including a barrier portion, a socket portion, a support portion and a holder portion; the barrier portion including a plurality of generally rectangular panels disposed generally vertically in an end to end relationship around the periphery of a flat bed; the socket portion including a plurality of pocket sections arranged around the periphery of the flat bed adjacent the lower edges of the panels, each of the pocket sections extending downwardly from a plane through the flat bed; the support portion including a plurality of elongated bar members having cross-sectional configurations substantially the same as those of the pocket sections, each bar member having its lower end disposed within one pocket section, the bar members extending upwardly from the pocket sections generally vertically; the holder portion including a plurality of bracket members with at least one bracket member engaging each of the bar members, each bracket member including a plate section, a strip section having its ends affixed to the plate section and being bent into a configuration to provide an opening having substantially the same cross-sectional configuration as that of the bar members for separable engagement therewith, a hook member extending from one end of the plate section, the hook member including a connector section extending substantially perpendicularly from a transverse edge of the plate section a distance substantially equal to the thickness of a barrier panel, a projecting section extending from an edge of the connector section remote from the plate section in the same direction as the plate section and substantially parallel thereto.
    • 平板床组件,包括阻挡部分,插座部分,支撑部分和保持部分; 所述阻挡部分包括围绕平坦床的周边的端对端关系大致竖直设置的多个大致矩形的面板; 所述插座部分包括围绕所述平板的周边设置的邻近所述面板的下边缘的多个袋部分,每个所述袋部分从平面向下延伸穿过所述平板; 所述支撑部分包括具有与所述袋部分基本上相同的横截面构造的多个细长杆状构件,每个杆构件的下端设置在一个袋状部分内,所述杆构件通常垂直地从所述袋部向上延伸; 所述保持器部分包括多个托架构件,所述多个托架构件具有与每个所述杆构件接合的至少一个托架构件,每个托架构件包括板部分,其端部固定到所述板部分并弯曲成构造以提供 开口具有与用于可分离接合的杆构件基本相同的横截面构造,钩构件从板部的一端延伸,钩构件包括从板部的横向边缘基本上垂直延伸的连接器部分 基本上等于阻挡板的厚度的距离;突出部分,其从所述连接器部分的边缘沿着与所述板部分相同的方向远离所述板部延伸并且基本上平行于所述突出部分。
    • 26. 发明授权
    • Methods for predicting survival in metastatic melanoma patients
    • 预测转移性黑色素瘤患者生存的方法
    • US09410205B2
    • 2016-08-09
    • US12932068
    • 2011-02-17
    • Dusan BogunovicNina BhardwajDavid O'Neill
    • Dusan BogunovicNina BhardwajDavid O'Neill
    • G01N33/574C12Q1/68
    • C12Q1/6886C12Q2600/106C12Q2600/118C12Q2600/158G01N33/5743G01N2800/52
    • Cellular and genetic signatures and methods of using same for subcategorizing stage III melanoma tumors are described herein. The signatures and methods are particularly useful with regard to establishing more distinct criteria on which basis to differentiate stage IIIB and IIIC melanoma patients. Assessment of the cellular and genetic signatures of a melanoma sample using methods described herein yields information on which basis differential survival duration and sensitivity to various cancer therapies can be predicted for a Stage IIIB or Stage IIIC melanoma patients. As described herein, gene expression profiling, determination of mitotic index (MI), and quantification of tumor infiltrating leukocytes (TILs) and CD3+ cells in metastatic lesions may be utilized to predict or assess drug response, drug sensitivity, and clinical outcome in metastatic melanoma patients.
    • 本文描述了细胞和遗传标记以及将其用于次级分类III期黑素瘤肿瘤的方法。 签署和方法对于建立更明确的标准来区分IIIB期和IIIC期黑素瘤患者是特别有用的。 使用本文所述的方法评估黑素瘤样品的细胞和遗传标记产生关于IIIB期或IIIC期黑素瘤患者可以预测基础差异存活期和对各种癌症疗法的敏感性的信息。 如本文所述,转移性病变中的基因表达谱,有丝分裂指数(MI)的测定和肿瘤浸润性白细胞(TIL)和CD3 +细胞的定量可用于预测或评估转移性黑素瘤中的药物反应,药物敏感性和临床结果 耐心。