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21. 发明授权

US5934613A Sealing for a pivoting door reverser 失效
标题翻译：密封用于枢转门反向器
公开(公告)号：US5934613A
公开(公告)日：1999-08-10
申请号：US637477
申请日：1996-04-25
申请人： Robert R. Standish , Alain Fournier
发明人： Robert R. Standish , Alain Fournier
IPC分类号： F02K1/80 , F02K1/00 , F02K1/12
CPC分类号： F02K1/805
摘要： The thrust reverser for a turbo-fan engine is comprised of: a plurality ofoors located in openings radially spaced in a shroud enclosing the engine and canalizing the jet flow from the engine, the doors being adapted to be pivoted, within a fixed structure, from a stowed position, in which they do not interfere with the jet flow, to a deployed position in which they block the jet flow and deflect it through the openings; an actuator having a body attached to the fixed structure and a rod attached to the center of each pivoting door for moving the door from the stowed position to the deployed position, and vice versa; and sealing elements comprising a main seal provided on the fixed structure and a separate annular seal located around the actuator body, the sealing elements mating with each door, when in the stowed position, and with the fixed structure to prevent pressure leakage of the jet flow.
摘要翻译：用于涡轮风扇发动机的推力反向器包括：多个门，其位于围绕发动机的护罩中径向隔开的开口中，并使来自发动机的喷流流化，门适于在固定结构内枢转，从它们不干扰喷射流的收起位置到展开位置，在该展开位置，它们阻挡喷射流并使其偏转通过开口; 具有附接到固定结构的主体的致动器和附接到每个枢转门的中心的杆，用于将门从收起位置移动到展开位置，反之亦然; 以及密封元件，其包括设置在固定结构上的主密封件和位于致动器主体周围的单独的环形密封件，当处于收起位置时，密封元件与每个门配合，并且具有固定结构，以防止喷射流的压力泄漏。

22. 发明授权

US5876969A Fusion polypeptides comprising human serum albumin, nucleic acids encoding same, and recombinant expression thereof 失效
标题翻译：包含人血清白蛋白的融合多肽，编码其的核酸及其重组表达
公开(公告)号：US5876969A
公开(公告)日：1999-03-02
申请号：US797689
申请日：1997-01-31
申请人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gerard Jung , Patrice Yeh
发明人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gerard Jung , Patrice Yeh
IPC分类号： C12N15/09 , A61K38/00 , A61K38/16 , A61K38/21 , A61K38/22 , A61K38/38 , A61K38/43 , A61K38/55 , A61K39/00 , A61K39/44 , A61K47/48 , A61K48/00 , A61P43/00 , B65B69/00 , C07H21/04 , C07K14/47 , C07K14/52 , C07K14/53 , C07K14/535 , C07K14/745 , C07K14/755 , C07K14/76 , C07K14/765 , C07K16/00 , C07K19/00 , C12N1/19 , C12N1/21 , C12N9/72 , C12N15/12 , C12N15/62 , C12N15/81 , C12P21/02 , C12P21/06 , C12R1/645 , E05B73/00 , C07K14/00 , C12N5/10
CPC分类号： B65B69/00 , A61K38/21 , A61K38/38 , A61K47/48269 , A61K47/48284 , C07K14/575 , C07K14/755 , C07K14/76 , C07K14/765 , C12N9/6456 , C07K2319/00 , C07K2319/02 , C07K2319/31 , C07K2319/33
摘要： Biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a natural variant thereof, methods for the preparation thereof, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing said fusion polypeptides.
摘要翻译：包含与人血清白蛋白或其天然变体融合的治疗活性多肽的生物活性多肽，其制备方法，编码这种融合多肽的核苷酸序列，包含该核苷酸序列的表达盒，含有该表达盒的自体复制质粒和药物含有所述融合多肽的组合物。

23. 发明授权

US5714377A Modified fungal cells and method for producing recombinant products 失效
标题翻译：改良真菌细胞及其制备方法
公开(公告)号：US5714377A
公开(公告)日：1998-02-03
申请号：US381931
申请日：1995-04-18
申请人： Widmar Tanner , Sabine Strahl-Bolsinger , Reinhard Fleer , Alain Fournier
发明人： Widmar Tanner , Sabine Strahl-Bolsinger , Reinhard Fleer , Alain Fournier
IPC分类号： C12N15/09 , C12N20060101 , C12N1/15 , C12N1/19 , C12N9/10 , C12N15/29 , C12N15/54 , C12N15/80 , C12N15/81 , C12P21/00 , C12P21/02 , C12Q1/68 , C12R1/865 , C07H21/04 , C12N1/16
CPC分类号： C12N9/1051 , C12N15/80 , C12N15/81
摘要： This invention relates to improved fungal cells and methods for producing recombinant products of improved quality and in high yields. More specifically, the present invention relates to fungal cells carrying specific modifications within their DNA sequences which cause them to exhibit at least a reduced capacity for O-glycosylating homologous and/or heterologous proteins, and the use of these cells as host cells to produce high yields of recombinant products.
摘要翻译： PCT No.PCT / EP93 / 02179 Sec。 371日期1995年04月18日 102（e）1995年4月18日PCT PCT 1993年8月16日PCT公布。出版物WO94 / 04687 日本1994年3月3日本发明涉及改良真菌细胞及其制备质量好，产量高的重组产物的方法。更具体地，本发明涉及在其DNA序列内具有特异性修饰的真菌细胞，其导致它们至少具有降低的O-糖基化同源和/或异源蛋白质的能力，以及这些细胞作为宿主细胞产生高的能力重组产物的产量。

24. 发明授权

US5593858A Highly stable recombinant yeasts for the production of recombinant proteins 失效
标题翻译：用于生产重组蛋白质的高度稳定的重组酵母
公开(公告)号：US5593858A
公开(公告)日：1997-01-14
申请号：US190103
申请日：1994-05-20
申请人： Reinhard Fleer , Alain Fournier , Patrice Yeh
发明人： Reinhard Fleer , Alain Fournier , Patrice Yeh
IPC分类号： C07K14/76 , C12N1/19 , C12N9/12 , C12N9/88 , C12N15/09 , C12N15/81 , C12P21/02 , C12R1/645 , C12N1/15
CPC分类号： C12N9/12 , C07K14/76 , C12N15/815 , C12N9/88
摘要： Novel recombinant yeasts are disclosed which are highly stable in a complex medium. Said yeasts are of the Kluyveromyces genus in which an essential gene is non-functional, containing a vector bearing a functional copy of said gene.
摘要翻译： PCT No.PCT / FR92 / 00769 Sec。 371日期1994年5月20日 102（e）日期1994年5月20日PCT提交1992年8月3日PCT公布。出版物WO93 / 03159 日期：1993年2月18日公开了在复合培养基中高度稳定的新型重组酵母。所述酵母是克鲁维酵母属，其中必需基因是非功能性的，其含有具有所述基因功能性拷贝的载体。

25. 发明授权

US09340575B2 Agonists and antagonists of the urotensinergic system 有权
标题翻译：激素和拮抗剂的泌尿生素系统
公开(公告)号：US09340575B2
公开(公告)日：2016-05-17
申请号：US14114757
申请日：2012-05-03
申请人： David Chatenet , Alain Fournier , Myriam Letourneau
发明人： David Chatenet , Alain Fournier , Myriam Letourneau
IPC分类号： A61K51/08 , A61K38/12 , C07K7/64 , C07K5/10 , C07K14/575 , G01N33/50 , C07K7/02 , C07K7/08 , A61K38/22
CPC分类号： C07K5/10 , A61K38/2228 , A61K51/08 , A61K51/088 , C07K7/02 , C07K7/083 , C07K14/57509 , G01N33/5061 , G01N33/5088 , G01N2333/5751
摘要： Novel urotensin II receptor (UT) agonists and antagonists are described herein. More specifically, novel derivatives of urotensin II-related peptide (URP) are described herein.
摘要翻译：本文描述了新的尿激肽原II受体（UT）激动剂和拮抗剂。更具体地，本文描述了尿素调节素II相关肽（URP）的新型衍生物。

26. 发明申请

US20120082619A1 Labelled adrenomedullin derivatives and their use for imaging and therapy 有权
标题翻译：标记的肾上腺髓质素衍生物及其用于成像和治疗
公开(公告)号：US20120082619A1
公开(公告)日：2012-04-05
申请号：US13067914
申请日：2011-07-07
申请人： Jocelyn Dupuis , Alain Fournier
发明人： Jocelyn Dupuis , Alain Fournier
IPC分类号： A61K49/00 , A61K38/17 , A61K51/08
CPC分类号： A61K51/08 , A61K51/088 , C07K14/575
摘要： The present invention relates to an adrenomedullin derivative including an adrenomedullin peptide, or a fragment thereof chelated or otherwise bound to at least one active agent. Examples of active agents include a paramagnetic element, a radioactive element and a fibrinolytic agent, among others. Paramagnetic agents have a distribution that is relatively easily shown through Magnetic Resonance Imaging (MRI). Radioactive agents have applications in imaging and delivery of radiations, depending on the specific element included in the active agent. Delivery of fibrinolytic agents mainly to a specific organ, such as for example to the lungs, allows to substantially improve the specificity and efficacy of thrombolytic therapy by allowing local delivery of the fibrinolytic agent, thereby reducing the risks of major bleeding in the therapy of the organ. If the organ is the lungs, a non-limiting example of pathology treatable with the fibrinolytic agent is pulmonary embolus.
摘要翻译：本发明涉及包含与至少一种活性剂螯合或以其它方式结合的肾上腺髓质素肽或其片段的肾上腺髓质素衍生物。活性剂的实例包括顺磁元件，放射性元素和纤维蛋白溶解剂等。顺磁剂具有通过磁共振成像（MRI）相对容易地显示的分布。取决于活性剂中包含的特定元素，放射性剂可用于成像和辐射辐射。纤维蛋白溶解剂主要递送到特定器官，例如肺，允许通过允许局部输送纤维蛋白溶解剂来大大改善溶栓治疗的特异性和功效，从而降低治疗中的大出血的风险器官。如果器官是肺，则可用纤维蛋白溶解剂治疗的病理学的非限制性实例是肺栓塞。

27. 发明授权

US07681833B2 Turboprop unit for aircraft with improved aerodynamic installation 失效
标题翻译：具有改进的空气动力学安装的飞机的涡轮螺旋桨飞机
公开(公告)号：US07681833B2
公开(公告)日：2010-03-23
申请号：US11587355
申请日：2005-04-19
申请人： Alain Fournier , Bernard Laboure , Robert Standish
发明人： Alain Fournier , Bernard Laboure , Robert Standish
IPC分类号： B64D27/00
CPC分类号： B64D29/08 , B64D29/00
摘要： A turboprop engine includes a power jet mounted coaxially to the engine axis (X-X′), and has a fan case and a gas ejecting system provided with two afterbody half-cowlings (10b) each of which is pivotable around an axis (A2) between open and closed positions, wherein the half-cowlings are connected to the downstream of the fan case through a ‘V-blade/V-groove’ system. In a first embodiment, the pivot axes (A2) make an angle α>3° to the engine axis (X, X′) and a joint plane (Z2-Z2) between the afterbody half-cowlings and the downstream of the fan case makes to the plane (Y, Y′) perpendicular to the engine axis (X, X′) an angle β in such a way that the difference between the angle α and the angle β is less than or equal to 3°. In the other embodiment, the axes are converged to each other in a downstream direction.
摘要翻译：涡轮螺旋桨发动机包括与发动机轴线（XX'）同轴安装的动力喷射器，并且具有风扇壳体和气体喷射系统，该气体喷射系统设置有两个后半罩（10b），每个后半罩（10b）可围绕轴线（A2）打开和关闭位置，其中半罩通过“V形叶片/ V形槽”系统连接到风扇壳体的下游。在第一实施例中，枢转轴线（A2）与发动机轴线（X，X'）之间的角度α> 3°，并且在车身半罩与风扇壳体的下游之间形成接合平面（Z2-Z2）垂直于发动机轴线（X，X'）的平面（Y，Y'）成角度＆bgr; 角度α和角度bgr之间的差异; 小于或等于3°。在另一实施例中，轴在下游方向上彼此会聚。

28. 再颁专利

USRE40940E1 Yeast promoter and use thereof 有权
标题翻译：酵母启动子及其用途
公开(公告)号：USRE40940E1
公开(公告)日：2009-10-20
申请号：US09790512
申请日：2001-02-23
申请人： Reinhard Fleer , Alain Fournier , Jean-Francois Mayaux , Patrice Yeh
发明人： Reinhard Fleer , Alain Fournier , Jean-Francois Mayaux , Patrice Yeh
IPC分类号： C12N1/16 , C12N15/81 , C07H21/04
CPC分类号： C12N15/815
摘要： The present invention concerns DNA sequences from the K. lactis PGK gene having transcriptional promoter activity. to expression vectors comprising these sequences and to their use for the production of proteins.
摘要翻译：本发明涉及具有转录启动子活性的乳酸克鲁维酵母PGK基因的DNA序列，包含这些序列的表达载体及其用于产生蛋白质的用途。

29. 发明授权

US07410779B2 Fusion polypeptides of human serum albumin and a therapeutically active polypeptide 失效
标题翻译：人血清白蛋白的融合多肽和治疗活性多肽
公开(公告)号：US07410779B2
公开(公告)日：2008-08-12
申请号：US11330353
申请日：2006-01-12
申请人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gérard Jung , Patrice Yeh
发明人： Reinhard Fleer , Alain Fournier , Jean-Dominique Guitton , Gérard Jung , Patrice Yeh
IPC分类号： C12N21/06 , C12N15/00 , C07H21/04 , C07K14/00
CPC分类号： B65B69/00 , A61K38/21 , A61K38/38 , A61K47/642 , A61K47/643 , C07K14/575 , C07K14/755 , C07K14/76 , C07K14/765 , C07K2319/00 , C07K2319/02 , C07K2319/31 , C07K2319/33 , C12N9/6456 , A61K2300/00
摘要： The invention includes biologically active polypeptides comprising a therapeutically active polypeptide fused to human serum albumin or a variant of human serum albumin, methods for the preparation of such fusion polypeptides, nucleotide sequences encoding such fusion polypeptides, expression cassettes comprising such nucleotide sequences, self-replicating plasmids containing such expression cassettes, and pharmaceutical compositions containing such fusion polypeptides.
摘要翻译：本发明包括生物活性多肽，其包含与人血清白蛋白或人血清白蛋白变体融合的治疗活性多肽，制备这种融合多肽的方法，编码这种融合多肽的核苷酸序列，包含该核苷酸序列的表达盒，自我复制含有这种表达盒的质粒和含有这种融合多肽的药物组合物。

30. 发明申请

US20070217913A1 Turboprop Unit For Aircraft With Improved Aerodynamic Installation 失效
标题翻译：具有改进的气动安装的飞机涡轮螺旋桨发动机单元
公开(公告)号：US20070217913A1
公开(公告)日：2007-09-20
申请号：US11587355
申请日：2005-04-19
申请人： Alain Fournier , Bernard Laboure , Robert Standish
发明人： Alain Fournier , Bernard Laboure , Robert Standish
IPC分类号： F02C1/00
CPC分类号： B64D29/08 , B64D29/00
摘要： A turboprop engine includes a power jet mounted coaxially to the engine axis (X-X′), and has a fan case and a gas ejecting system provided with two afterbody half-cowlings (10b) each of which is pivotable around an axis (A2) between open and closed positions, wherein the half-cowlings are connected to the downstream of the fan case through a ‘V-blade/V-groove’ system. In a first embodiment, the pivot axes (A2) make an angle α>3° to the engine axis (X, X′) and a joint plane (Z2-Z2) between the afterbody half-cowlings and the downstream of the fan case makes to the plane (Y, Y′) perpendicular to the engine axis (X, X′) an angle β in such a way that the difference between the angle α and the angle β is less than or equal to 3°. In the other embodiment, the axes are converged to each other in a downstream direction.
摘要翻译：涡轮螺旋桨发动机包括与发动机轴线（X-X'）同轴安装的动力喷射器，并且具有风扇壳体和气体喷射系统，该气体喷射系统设置有两个后半体罩（10b），每个后半体罩可绕轴线枢转打开位置和关闭位置之间的距离，其中半罩通过“V形叶片/ V形槽”系统连接到风扇壳体的下游。在第一实施例中，枢转轴线（A 2 2）与发动机轴线（X，X'）和接合平面（Z <2>）之间形成α> 3°的角度，在车体半罩与风扇壳体的下游之间形成垂直于发动机轴线（X，X'）的平面（Y，Y'）的角度β 角度α和角度β之间的差值小于或等于3°的方式。在另一实施例中，轴在下游方向上彼此会聚。

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